{"id":1000,"date":"2023-05-31T12:53:47","date_gmt":"2023-05-31T04:53:47","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1000"},"modified":"2023-05-31T12:56:48","modified_gmt":"2023-05-31T04:56:48","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-slamf7%e5%8f%8c%e9%87%8d%e8%b0%83%e8%8a%82%e5%89%82-elotuzumab-%e4%be%9d%e6%b4%9b%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97-%e5%a4%9a","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1000","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | SLAMF7\u53cc\u91cd\u8c03\u8282\u5242 | Elotuzumab \u4f9d\u6d1b\u59a5\u73e0\u5355\u6297 | \u591a\u53d1\u6027\u9aa8\u9ad3\u7624MM"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

Elotuzumab\u7531\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u4e0e\u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\uff0c\u9776\u70b9\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ec6\u80de\uff08\u6076\u6027\u6d46\u7ec6\u80de\uff09\u548cNK\u7ec6\u80de\u8868\u9762SLAMF7\u3002<\/p>\n\n\n\n

\u836f\u72692015\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff08EMPLICITI\u00aeElotuzumab\uff09\u3002\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/p>\n\n\n\n

\u56fd\u5185\u8be5\u836f\u672a\u4e0a\u5e02\uff0c\u4e5f\u672a\u67e5\u5230\u76f8\u5173\u6ce8\u518c\u7533\u62a5\u3002\u4e2d\u6587\u540d\u97f3\u8bd1\u4e3a\u4f9d\u6d1b\u59a5\u73e0\u5355\u6297\uff08\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

SLAMF7\u5c5e\u4e8e\u4fe1\u53f7\u6dcb\u5df4\u7ec6\u80de\u6fc0\u6d3b\u5206\u5b50\uff08SLAM\uff09\u5bb6\u65cf\u6210\u54587\uff0c\u662f\u4e00\u79cd\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\u6210\u5458\uff0c\u76f8\u5bf9\u5206\u5b50\u91cf\u4e3a66 kDa\u3002<\/p>\n\n\n\n

SLAMF7\u7684\u8868\u8fbe<\/strong><\/p>\n\n\n

\n
\"\"
Clin Transl Sci . 2018 May;11(3):261-266.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

SLAMF7\u4e3b\u8981\u5728\u514d\u75ab\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u5305\u62ec\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u3001\u6d46\u7ec6\u80de\u7b49\u3002<\/p>\n\n\n\n

\u5728\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0cSLAMF7\u5728\u4eba\u7c7b\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u4e0a\u5448\u4f4e\u6c34\u5e73\u8868\u8fbe\u3002\u7136\u800c\uff0c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\uff0cSLAMF7\u8868\u8fbe\u6c34\u5e73\u663e\u8457\u4e0a\u8c03\uff0c\u4e14\u5728\u8fdb\u5c55\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e2d\uff0cSLAMF7\u57fa\u56e0\u9891\u7e41\u6269\u589e\u3002<\/p>\n\n\n\n

Elotuzumab\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n

\n
\"\"
https:\/\/www.emplicitihcp.com\/about\/mechanism-of-action<\/figcaption><\/figure>\n<\/div>\n\n\n

Elotuzumab\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff08\u65e2\u6fc0\u6d3b\uff0c\u53c8\u6291\u5236\uff09\uff0c\u53d1\u6325\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u3002<\/p>\n\n\n\n

    \n
  • \u7ed3\u5408\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK cell\uff09\u8868\u9762\u7684SLAMF7\uff0c\u76f4\u63a5\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u3002<\/li>\n\n\n\n
  • \u6807\u8bb0\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u8868\u9762\u7684SLAMF7\uff0c\u4ece\u800c\u548cNK\u7ec6\u80de\u8868\u9762\u7684CD16\u7ed3\u5408\uff0c\u5f15\u53d1\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08ADCC\uff09\uff0c\u4fc3\u4f7f\u514d\u75ab\u7cfb\u7edf\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/li>\n<\/ul>\n\n\n\n

    \u8fd9\u79cd\u53cc\u91cd\u4f5c\u7528\u673a\u5236\u4f7f\u5f97Elotuzumab\u5728\u6cbb\u7597\u6076\u6027\u80bf\u7624\uff08\u5982\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff09\u65f6\u5177\u6709\u8f83\u5f3a\u7684\u6297\u80bf\u7624\u6548\u679c\u3002<\/p>\n\n\n\n

    2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

    Elotuzumab FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

    \n
    \"\"
    \u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

    Elotuzumab \u4f9d\u6d1b\u59a5\u73e0\u5355\u6297FDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n

      \n
    • \u4e0e\u6765\u90a3\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u8054\u5408\uff0c\u6cbb\u7597\u5df2\u7ecf\u63a5\u53d7\u8fc7\u4e00\u5230\u4e09\u6b21\u6cbb\u7597\u7684\u6210\u5e74\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002<\/li>\n\n\n\n
    • \uff08pomalidomide\uff09\u548c\u5730\u585e\u7c73\u677e\u8054\u5408\uff0c\u6cbb\u7597\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e24\u6b21\u6cbb\u7597\uff0c\u5305\u62ec\u6765\u90a3\u5ea6\u80fa\u548c\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u7684\u6210\u5e74\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002<\/li>\n<\/ul>\n\n\n\n

      3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
      \n
      \"\"
      \u4e00\u53ea\u9a86\u9a7c\u548c\u4e00\u53ea\u732a\uff0c\u9a86\u9a7c\u62ff\u7740\u5927\u9aa8\u5934\uff0cSLAM\u4e00\u4e0b\u6253\u5728\u732a\u5934\u4e0a\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

      \u4e00<\/strong>\u53ea\u9a86\u9a7c<\/strong>\u548c\u732a<\/strong>\uff0c\u53d6\u8c10\u97f3\u4ee3\u8868\u4f9d\u6d1b\u59a5\u73e0<\/strong>\u5355\u6297\u3002<\/p>\n\n\n\n

      \u5927\u9aa8\u5934\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7\uff0c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624MM\u3002<\/p>\n\n\n\n

      SLAM\u731b\u6253\uff0c\u4ee3\u8868\u836f\u7269\u9776\u70b9SLAMF7\u3002<\/p>\n\n\n\n

      \u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"

      \u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0…<\/p>\n","protected":false},"author":1,"featured_media":1007,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1000"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1000\/revisions"}],"predecessor-version":[{"id":1005,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1000\/revisions\/1005"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1007"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}