{"id":1009,"date":"2023-06-02T09:53:04","date_gmt":"2023-06-02T01:53:04","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1009"},"modified":"2023-06-02T09:53:04","modified_gmt":"2023-06-02T01:53:04","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-bcma-adc-belantamab-mafodotin-%e9%a9%ac%e8%b4%9d%e5%85%b0%e4%bb%96%e5%8d%95%e6%8a%97-%e5%a4%9a%e5%8f%91%e6%80%a7%e9%aa%a8","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1009","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | BCMA ADC | Belantamab mafodotin \u9a6c\u8d1d\u5170\u4ed6\u5355\u6297 | \u591a\u53d1\u6027\u9aa8\u9ad3\u7624MM"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Belantamab mafodotin\u662f\u7531\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u6b3eADC\u836f\u7269\uff0c\u9776\u70b9\u4e3a\u6076\u6027\u6d46\u7ec6\u80de\u8868\u9762\u7684B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u3002\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u72692020\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff08BLENREP\u00ae belantamab mafodotin\uff09\u3002\u56fd\u5185\u5c1a\u5904\u4e8e\u6ce8\u518c\u7533\u62a5\u9636\u6bb5\uff0c\u4e2d\u6587\u540d\u6309\u7167\u89c4\u5219\u97f3\u8bd1\u4e3a\u9a6c\u8d1d\u5170\u4ed6\u5355\u6297\uff08\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08B-cell maturation antigen\uff1bBCMA\uff09\uff0c\u5e7f\u6cdb\u8868\u8fbe\u4e8e\u6b63\u5e38\u6d46\u7ec6\u80de\u3001\u665a\u671fB\u7ec6\u80de\u548c\u6076\u6027\u6d46\u7ec6\u80de\u7684\u8868\u9762\uff0c\u662f\u4fc3\u8fdb\u6b63\u5e38\u6d46\u7ec6\u80de\u6210\u719f\u548c\u957f\u671f\u5b58\u6d3b\u7684\u5173\u952e\u56e0\u5b50\uff0c\u4e5f\u662f\u6d46\u7ec6\u80de\u6076\u53d8\u6210\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ec6\u80de\u540e\u589e\u6b96\u548c\u751f\u5b58\u7684\u5fc5\u9700\u56e0\u5b50\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Belantamab mafodotin\u7684\u7ed3\u6784<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"635\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-1024x635.png\" alt=\"\" class=\"wp-image-1010\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-1024x635.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-300x186.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-768x476.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-1536x953.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-1218x755.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-880x546.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image.png 1598w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Pharmaceuticals (Basel) . 2021\u00a0Feb 11;14(2):145.<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Belantamab mafodotin\u662fFDA\u6279\u51c6\u7684\u53c8\u4e00\u4e2aADC\u836f\u7269\u3002\u5b83\u7531 IgG1\u6297\u4f53\uff0c\u901a\u8fc7\u6297\u86cb\u767d\u9176\u964d\u89e3\u7684\u8fde\u63a5\u5b50\uff0c\u8fde\u63a5\u5fae\u7ba1\u6291\u5236\u5242MMAF\u7ec4\u6210\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MMAF\uff08Monomethyl auristatin 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class=\"wp-block-paragraph\">\u533a\u522b\u5728\u4e8e\uff0cMMAE\u5e38\u901a\u8fc7\u53ef\u5207\u5272\u578b\u8fde\u63a5\u5b50\u9012\u9001\uff0c\u758f\u6c34\u6027\u5f3a\uff0c\u5bb9\u6613\u7a7f\u900f\u7ec6\u80de\u819c\u78f7\u8102\u53cc\u5c42\uff0c\u4f46\u7a33\u5b9a\u6027\u4f4e\u3002<br><br>\u800cMMAF\u5e38\u901a\u8fc7\u4e0d\u53ef\u5207\u5272\u8fde\u63a5\u5b50\u9012\u9001\uff0c\u4e0d\u6613\u964d\u89e3\uff0c\u8840\u6d46\u4e2d\u66f4\u7a33\u5b9a\uff0c\u4f46\u8fd9\u53ef\u80fd\u4f1a\u5f71\u54cd\u836f\u7269\u7597\u6548\u6216\u7ec6\u80de\u901a\u900f\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Belantamab mafodotin\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"399\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-1-1024x399.png\" alt=\"\" class=\"wp-image-1011\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-1-1024x399.png 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class=\"wp-block-list\">\n<li>\u4e0eBCMA\u7ed3\u5408\u540e\uff0cADC\u836f\u7269\u5185\u541e\u8fdb\u5165\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u5728\u7ec6\u80de\u5185\u91ca\u653eMMAF\uff0c\u4f7f\u5316\u7597\u836f\u7269\u76f4\u63a5\u4f5c\u7528\u4e8e\u76ee\u6807\u7ec6\u80de\uff0c\u5e76\u6700\u5c0f\u5316\u5bf9\u6b63\u5e38\u5065\u5eb7\u7ec6\u80de\u7684\u4f24\u5bb3\u3002<\/li>\n\n\n\n<li>\u4f5c\u4e3a\u6865\u6881\uff0c\u5c06\u80bf\u7624\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u7b49\u8fde\u63a5\u8d77\u6765\uff0c\u53d1\u6325\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08ADCC\uff09\uff1b<\/li>\n\n\n\n<li>\u4f5c\u4e3a\u6865\u6881\uff0c\u5c06\u80bf\u7624\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u8fde\u63a5\u8d77\u6765\uff0c\u53d1\u6325\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u541e\u566c\u4f5c\u7528\uff08ADCP\uff09\u3002<\/li>\n<\/ol>\n\n\n\n<p 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(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Belantamab mafodotin \u9a6c\u8d1d\u5170\u4ed6\u5355\u6297FDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7528\u4e8e\u6cbb\u7597\u6210\u5e74\u60a3\u8005\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002\u60a3\u8005\u81f3\u5c11\u63a5\u53d7\u4e864\u79cd\u6cbb\u7597\uff0c\u5305\u62ec\u6297CD38\u5355\u6297\u3001\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u548c\u514d\u75ab\u8c03\u8282\u5242\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"807\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-3-1024x807.png\" alt=\"\" class=\"wp-image-1013\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-3-1024x807.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-3-300x237.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-3-768x606.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-3-1218x960.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-3-880x694.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-3.png 1456w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u908b\u9062\u5927\u738b\u5750\u5728\u9a6c\u80cc\u4e0a\uff0c\u9a6c\u5728\u5403\u4e00\u53e3\u9aa8\u5934\u9505\u4e2d\uff0c\u716e\u719f\u7684B\u7ec6\u80de\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u716e\u719f\u7684B\u7ec6\u80de\u4ee3\u8868\u836f\u7269\u9776\u70b9\uff0cB\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08B-cell maturation 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