{"id":1049,"date":"2023-06-23T21:53:41","date_gmt":"2023-06-23T13:53:41","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1049"},"modified":"2023-07-18T22:32:15","modified_gmt":"2023-07-18T14:32:15","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-3%e6%ac%beegfr%e7%94%9f%e7%89%a9%e5%88%b6%e5%89%82-%e8%a5%bf%e5%a6%a5%e6%98%94%e5%8d%95%e6%8a%97%e3%80%81%e5%b8%95%e5%b0%bc","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1049","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | 3\u6b3eEGFR\u751f\u7269\u5236\u5242 | \u897f\u59a5\u6614\u5355\u6297\u3001\u5e15\u5c3c\u5355\u6297\u3001Necitumumab | \u5934\u9888\u90e8\u3001\u7ed3\u76f4\u80a0\u764c\u7b49"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">EGFR\uff08\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09\u662f\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u4e0e\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08EGF\uff09\u7ed3\u5408\uff0c\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\u548c\u5206\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ad8\u8868\u8fbe\u6216\u5f02\u5e38\u8868\u8fbe\u7684EGFR\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u5e7f\u6cdb\u5b58\u5728\uff0c\u6291\u5236EGFR\u901a\u8def\u53ef\u4ee5\u6291\u5236\u76f8\u5173\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u67093\u6b3e\u963b\u65adEGFR\u7684\u5355\u6297\u836f\u7269\u4e0a\u5e02\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Erbitux\u00aeCetuximab\u30022004\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7531\u793c\u6765\u516c\u53f8\u7814\u53d1\u3002\u76ee\u524d\u56fd\u5185\u5df2\u7ecf\u4e0a\u5e02\uff08\u7231\u5fc5\u59a5\u00ae\u897f\u59a5\u6614\u5355\u6297\uff09\u7531\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\u9500\u552e\u3002<\/li>\n\n\n\n<li>Vectibix\u00ae Panitumumab\u30022006\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7531\u5b89\u8fdb\u516c\u53f8\u7814\u53d1\u3002\u76ee\u524d\u56fd\u5185\u672a\u4e0a\u5e02\uff0c\u5b89\u8fdb\u516c\u53f8\u5411CDE\u63d0\u4ea4\u7684\u7533\u62a5\u6750\u6599\u4e2d\uff08\u53d7\u7406\u53f7\uff1aJTS1900022\uff09\uff0c\u4e2d\u6587\u540d\u4e3a\u5e15\u5c3c\u5355\u6297\u3002<\/li>\n\n\n\n<li>Portrazza\u00ae Necitumumab\u30022015\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7531\u793c\u6765\u516c\u53f8\u7814\u53d1\u3002\u76ee\u524d\u56fd\u5185\u672a\u4e0a\u5e02\uff0c\u4e2d\u6587\u540d\u97f3\u8bd1\u4e3a\u5948\u897f\u59a5\u6728\u5355\u6297\uff08\u65e0\u51fa\u5904\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e6\u5916\u8fd8\u6709\u5f3a\u751f\u516c\u53f8\u7684EGFR\u00d7METR\u53cc\u6297\u836f\u7269Amivantamab\uff0c\u5c06\u5728\u4e0b\u4e00\u7bc7\u4e2d\u4ecb\u7ecd\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u86cb\u767d\u6fc0\u9176<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u86cb\u767d\u6fc0\u9176\u662f\u4e00\u7c7b\u5e7f\u6cdb\u5b58\u5728\u4e8e\u751f\u7269\u4f53\u4e2d\u7684\u9176\uff0c\u5b83\u4eec\u901a\u8fc7\u5c06\u78f7\u9178\u57fa\u56e2\u8f6c\u79fb\u81f3\u86cb\u767d\u8d28\u7684\u7279\u5b9a\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u4ece\u800c\u8c03\u63a7\u86cb\u767d\u8d28\u7684\u6d3b\u6027\u3001\u7a33\u5b9a\u6027\u548c\u529f\u80fd\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u86cb\u767d\u6fc0\u9176\u5206\u7c7b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-20-1024x422.png\" alt=\"\" class=\"wp-image-1050\" width=\"664\" height=\"274\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-20-1024x422.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-20-300x124.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-20-768x316.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-20-1218x502.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-20-880x363.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-20.png 1478w\" sizes=\"auto, (max-width: 664px) 100vw, 664px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636e\u5176\u5e95\u7269\u7279\u5f02\u6027\u548c\u4f5c\u7528\u673a\u5236\uff0c\u86cb\u767d\u6fc0\u9176\u53ef\u4ee5\u5206\u4e3a\u591a\u4e2a\u7c7b\u522b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u916a\u6c28\u9178\u6fc0\u9176 (Tyrosine kinases, TKs):\u8fd9\u7c7b\u6fc0\u9176\u4e13\u95e8\u50ac\u5316\u916a\u6c28\u9178\u6b8b\u57fa\u4e0a\u7684\u78f7\u9178\u5316\u3002\u5b83\u4eec\u5728\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u3001\u751f\u957f\u548c\u5206\u5316\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/li>\n\n\n\n<li>\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176 (Serine\/Threonine kinases, STKs):\u8fd9\u7c7b\u6fc0\u9176\u50ac\u5316\u4e1d\u6c28\u9178\u6216\u82cf\u6c28\u9178\u6b8b\u57fa\u4e0a\u7684\u78f7\u9178\u5316\u3002\u5b83\u4eec\u53c2\u4e0e\u591a\u79cd\u751f\u7269\u8fc7\u7a0b\uff0c\u5305\u62ec\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u548c\u86cb\u767d\u8d28\u964d\u89e3\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u916a\u6c28\u9178\u6fc0\u9176\u6839\u636e\u5176\u6d3b\u6027\u7ed3\u6784\u57df\uff0c\u53c8\u53ef\u5206\u4e3a:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff1a\u8fd9\u7c7b\u6fc0\u9176\u5305\u542b\u4e00\u4e2a\u7ec6\u80de\u5916\u914d\u4f53\u7ed3\u5408\u57df\uff0c\u8d77\u5230\u53d7\u4f53\u7684\u4f5c\u7528\uff0c\u4ee5\u53ca\u4e00\u4e2a\u7ec6\u80de\u5185\u6fc0\u9176\u6d3b\u6027\u57df\u3002\uff08\u5982EGFR\u5bb6\u65cf\uff0cVEGFR\u5bb6\u65cf\u7b49\uff09<\/li>\n\n\n\n<li>\u975e\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff1a\u8fd9\u7c7b\u6fc0\u9176\u4e3b\u8981\u4f4d\u4e8e\u7ec6\u80de\u8d28\u6216\u7ec6\u80de\u6838\u5185\uff0c\u7f3a\u4e4f\u7ec6\u80de\u5916\u7ed3\u6784\u57df\uff0c\u65e0\u6cd5\u7ed3\u5408\u914d\u4f53\uff0c\u9700\u8981\u901a\u8fc7\u5176\u4ed6\u53d7\u4f53\u7ed3\u5408\u914d\u4f53\uff0c\u4ea7\u751f\u6fc0\u6d3b\u4fe1\u53f7\u3002\uff08\u5982BTK\uff0cJAK\u7b49\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ec6\u80de\u5185\u4fe1\u53f7\u4f20\u5bfc\u8fc7\u7a0b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-26-1024x661.png\" alt=\"\" class=\"wp-image-1056\" width=\"664\" height=\"428\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-26-1024x661.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-26-300x194.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-26-768x496.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-26-1218x786.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-26-880x568.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-26.png 1328w\" sizes=\"auto, (max-width: 664px) 100vw, 664px\" \/><figcaption class=\"wp-element-caption\"><em>N Engl J Med . 2008 Mar 13;358(11):1160-74.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e2a\u8fc7\u7a0b\u53ef\u4ee5\u5206\u4e3a\u4e09\u4e2a\u6b65\u9aa4\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u914d\u4f53\u7ed3\u5408\uff1a\u9996\u5148\uff0c\u5728EGFR\u6216\u5176\u76f8\u5173\u53d7\u4f53\uff08HER2\u3001HER3\u6216HER4\uff09\u7684\u7ec6\u80de\u5916\u90e8\u5206\uff0c\u7279\u5f02\u6027\u7684\u914d\u4f53\u4e0e\u53d7\u4f53\u7ed3\u5408\u3002<\/li>\n\n\n\n<li>\u53d7\u4f53\u4e8c\u805a\u5316\u548c\u916a\u6c28\u9178\u78f7\u9178\u5316\uff1a\u914d\u4f53\u7684\u7ed3\u5408\u5bfc\u81f4EGFR\u4e0e\u81ea\u8eab\u5f62\u6210\u529f\u80fd\u6027\u6d3b\u8dc3\u7684\u540c\u6e90\u4e8c\u805a\u4f53\uff08EGFR-EGFR\u4e8c\u805a\u4f53\uff09\u6216\u4e0eHER2\u3001HER3\u6216HER4\u5f62\u6210\u5f02\u6e90\u4e8c\u805a\u4f53\uff08EGFR-HER2, EGFR-HER3, \u6216 EGFR-HER4\u4e8c\u805a\u4f53\uff09\u3002<br>\u8fd9\u4e2a\u4e8c\u805a\u4f53\u7684\u5f62\u6210\u5bfc\u81f4EGFR\u7684\u7ec6\u80de\u5185\u7ed3\u6784\u57df\u4e2d\u7279\u5b9a\u7684\u916a\u6c28\u9178\u6b8b\u57fa\u53d1\u751fATP\u4f9d\u8d56\u6027\u7684\u78f7\u9178\u5316\u3002<\/li>\n\n\n\n<li>\u6fc0\u6d3b\u7ec6\u80de\u5185\u4fe1\u53f7\u901a\u8def\uff1a\u8fd9\u79cd\u78f7\u9178\u5316\u89e6\u53d1\u4e86\u4e00\u7cfb\u5217\u590d\u6742\u7684\u7ec6\u80de\u5185\u4fe1\u53f7\uff0c\u9996\u5148\u5728\u7ec6\u80de\u8d28\u4e2d\uff0c\u7136\u540e\u5728\u7ec6\u80de\u6838\u4e2d\u3002<br>EGFR\u4e3b\u8981\u6fc0\u6d3b\u4e24\u4e2a\u7ec6\u80de\u5185\u901a\u8def\uff1a<br>a) RAS-RAF-MEK-MAPK\u901a\u8def\u63a7\u5236\u57fa\u56e0\u8f6c\u5f55\uff0c\u7ec6\u80de\u5468\u671f\u4eceG1\u671f\u5230S\u671f\u7684\u8fdb\u5c55\uff0c\u4ee5\u53ca\u7ec6\u80de\u589e\u6b96\u3002b) PI3K-Akt\u901a\u8def\u6fc0\u6d3b\u4e00\u7cfb\u5217\u6297\u51cb\u4ea1\u548c\u4fc3\u751f\u5b58\u4fe1\u53f7\u3002<br>\u53e6\u5916\u8fd8\u6709 JAK-STATs\u7b49\u5e38\u89c1\u901a\u8def\u3002<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u8fc7\u53bb\uff0c\u6297\u80bf\u7624\u6cbb\u7597\u4e3b\u8981\u4f9d\u8d56\u4e8e\u7ec6\u80de\u6bd2\u836f\u7269\uff0c\u8fd9\u4e9b\u836f\u7269\u901a\u8fc7\u76f4\u63a5\u5e72\u6270\u7ec6\u80de\u5206\u88c2\uff0c\u4ee5\u53ca\u7834\u574f\u7ec6\u80de\u5468\u671f\u6765\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7136\u800c\uff0c\u8fd9\u4e9b\u836f\u7269\u901a\u5e38\u7f3a\u4e4f\u9009\u62e9\u6027\uff0c\u5e76\u4e14\u53ef\u80fd\u5bf9\u6b63\u5e38\u7ec6\u80de\u4e5f\u4ea7\u751f\u4e25\u91cd\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u6765\uff0c\u6297\u80bf\u7624\u6cbb\u7597\u7684\u7126\u70b9\u5df2\u8f6c\u5411\u66f4\u52a0\u9776\u5411\u7684\u65b9\u6cd5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5e38\u89c1\u80bf\u7624\u9776\u5411\u836f\u7269\u53ca\u4f5c\u7528\u9776\u70b9<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22-1024x641.png\" alt=\"\" class=\"wp-image-1052\" width=\"790\" height=\"494\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22-1024x641.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22-300x188.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22-768x481.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22-1536x962.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22-1218x763.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22-880x551.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-22.png 1650w\" sizes=\"auto, (max-width: 790px) 100vw, 790px\" \/><figcaption class=\"wp-element-caption\"><em>Front Pharmacol . 2022 Nov 11;13:1050758.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u80bf\u7624\u9776\u5411\u836f\u7269\u4e3b\u8981\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff08\u5982\u66ff\u5c3c\u7c7b\u836f\u7269\uff09\uff1b<\/li>\n\n\n\n<li>\u751f\u7269\u5236\u5242\uff08\u5982\u5355\u514b\u9686\u6297\u4f53\u3001\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7b49\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u524d\u6cbf\u836f\u7269\u7684\u4e3b\u8981\u4f18\u52bf\u662f\u5b83\u4eec\u901a\u5e38\u5bf9\u80bf\u7624\u7ec6\u80de\u6709\u66f4\u9ad8\u7684\u9009\u62e9\u6027\uff0c\u5e76\u4e14\u5177\u6709\u8f83\u5c11\u7684\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u5bb6\u65cf<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-23-1024x766.png\" alt=\"\" class=\"wp-image-1053\" width=\"628\" height=\"470\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-23-1024x766.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-23-300x224.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-23-768x575.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-23-880x658.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-23-360x270.png 360w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-23.png 1072w\" sizes=\"auto, (max-width: 628px) 100vw, 628px\" \/><figcaption class=\"wp-element-caption\"><em>J Bone Oncol . 2015 Jan 23;4(1):1-12.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8e\u5927\u5206\u5b50\u5355\u6297\u836f\u7269\u65e0\u6cd5\u8fdb\u5165\u7ec6\u80de\u5185\u53d1\u6325\u4f5c\u7528\uff0c\u56e0\u6b64\u5355\u6297\u836f\u7269\u4f5c\u7528\u9776\u70b9\u5747\u4e3a\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4ed6\u5e38\u89c1\u7684\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u5982\u4e0a\u56fe\uff0c\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u5c06\u4f1a\u5728\u63a5\u4e0b\u6765\u7684\u7ae0\u8282\u4e2d\u4e00\u4e00\u4ecb\u7ecd\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3\u6b3e\u9776\u5411EGFR\u751f\u7269\u5236\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24-1024x332.png\" alt=\"\" class=\"wp-image-1054\" width=\"684\" height=\"221\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24-1024x332.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24-300x97.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24-768x249.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24-1536x498.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24-1218x395.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24-880x285.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-24.png 1707w\" sizes=\"auto, (max-width: 684px) 100vw, 684px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#6513b2\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><strong>3\u6b3e\u836f\u7269FDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u897f\u59a5\u6614\u5355\u6297\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>RAS \u57fa\u56e0\u91ce\u751f\u578b\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/li>\n\n\n\n<li>\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">panitumumab \u5e15\u5c3c\u5355\u6297\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>RAS \u57fa\u56e0\u91ce\u751f\u578b\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">necitumumab \u5948\u897f\u59a5\u6728\u5355\u6297\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-27-1024x758.png\" alt=\"\" class=\"wp-image-1057\" width=\"642\" height=\"474\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-27-1024x758.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-27-300x222.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-27-768x568.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-27-1536x1137.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-27-1218x901.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/06\/image-27-880x651.png 880w, 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class=\"wp-block-paragraph\">\u558a<strong>\u6015\u4f60<\/strong>\u554a\uff0c\u4ee3\u8868<strong>\u5e15\u5c3c<\/strong>\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u725b\u5976\u6d47\u5728\u5934\u4e0a\uff0c\u4ee3\u8868\u836f\u7269\u662f\u7528\u6765\u6cbb\u7597\u5934\u9888\u90e8\u7b49\u764c\u75c7\u7684\u3002<\/p>\n\n\n\n<p 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