{"id":1081,"date":"2023-07-11T14:59:49","date_gmt":"2023-07-11T06:59:49","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1081"},"modified":"2023-07-11T14:59:49","modified_gmt":"2023-07-11T06:59:49","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e7%bd%97%e6%b0%8f4%e6%ac%be%e9%9d%b6%e5%90%91her2-%e6%9b%b2%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97%e3%80%81%e5%b8%95%e5%a6%a5","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1081","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u7f57\u6c0f4\u6b3e\u9776\u5411HER2 | \u66f2\u59a5\u73e0\u5355\u6297\u3001\u5e15\u59a5\u73e0\u5355\u6297\u3001\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\u3001Phesgo | \u4e73\u817a\u764c\u7b49"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

\u66f2\u59a5\u73e0\u5355\u6297\uff08Trastuzumab\uff09\uff1a<\/strong>\u662f\u7f57\u6c0f\u516c\u53f8\u7684\u201c\u4e09\u9a7e\u9a6c\u8f66\u201d\u4e4b\u4e00\uff08\u5229\u59a5\u6614\u5355\u6297\u3001\u66f2\u59a5\u73e0\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\uff09\u3002\u7528\u4e8e\u6cbb\u7597HER2\u9633\u6027\u7684\u4e73\u817a\u764c\u548c\u80c3\u764c\u3002
\u8be5\u836f\u72691998\u5e74\u83b7FDA\u6279\u51c6\uff08HERCEPTIN\u00ae trastuzumab\uff09\uff0c\u6210\u4e3a\u7b2c\u4e00\u4e2a\u9488\u5bf9HER2\u9633\u6027\u4e73\u817a\u764c\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u3002\u56fd\u5185\u5df2\u4e0a\u5e02\uff08\u8d6b\u8d5b\u6c40\u00ae\u66f2\u59a5\u73e0\u5355\u6297\uff09\u3002<\/p>\n\n\n\n

\u5e15\u59a5\u73e0\u5355\u6297\uff08Pertuzumab\uff09:<\/strong><\/p>\n\n\n\n

\u7f57\u6c0f\u516c\u53f8\u5f00\u53d1\u7684\u53e6\u5916\u4e00\u6b3eHER2\u836f\u7269\uff0c\u8be5\u836f\u7269\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u4e00\u8d77\u4f7f\u7528\uff0c\u4ee5\u589e\u5f3a\u5bf9HER2\u9633\u6027\u4e73\u817a\u764c\u7684\u6cbb\u7597\u6548\u679c\u3002
\u836f\u7269\u4e8e2012\u5e74\u83b7\u5f97FDA\u7684\u6279\u51c6\uff08PERJETA\u00ae pertuzumab\uff09\u3002\u56fd\u5185\u5df2\u7ecf\u4e0a\u5e02\uff08\u5e15\u6377\u7279\u00ae\u5e15\u59a5\u73e0\u5355\u6297\uff09\u3002<\/p>\n\n\n\n

\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\uff08Trastuzumab emtansine\uff09:<\/strong>\u7f57\u6c0f\u516c\u53f8\u5f00\u53d1\u7684HER2 ADC\u836f\u7269\uff0c2012\u5e74\u83b7\u5f97FDA\u6279\u51c6\uff08KADCYLA\u00ae trastuzumab emtansine\uff09\u3002\u56fd\u5185\u5df2\u7ecf\u4e0a\u5e02\uff08\u8d6b\u8d5b\u83b1\u00ae\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\uff09\u3002<\/p>\n\n\n\n

Phesgo (pertuzumab \/ trastuzumab \/ hyaluronidase):<\/strong>Phesgo\u662f\u5e15\u59a5\u73e0\u5355\u6297\u3001\u66f2\u59a5\u73e0\u5355\u6297\u548c\u900f\u660e\u8d28\u9178\u9176\u7684\u590d\u5408\u5236\u5242\uff0c2020\u5e74\u83b7\u5f97FDA\u6279\u51c6\uff08Phesgo\u00ae pertuzumab, trastuzumab, and hyaluronidase\uff09\u3002\u56fd\u5185\u5c1a\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

EGFR\u5bb6\u65cf<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u5bb6\u65cf\u662f\u4e00\u7c7b\u8de8\u819c\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\uff0c\u5305\u62ecErbB1\uff08EGFR\u3001HER1\uff09\u3001ErbB2\uff08HER2\/NEU\uff09\u3001ErbB3\uff08HER3\uff09\u548cErbB4\uff08HER4\uff09\u3002<\/p>\n\n\n\n

    \n
  1. ErbB1\uff08EGFR\u3001HER1\uff09\uff1a\u4e00\u822c\u60c5\u51b5\u4e0b\u4f7f\u7528EGFR\u8fd9\u4e2a\u540d\u5b57\u3002
    \u5b83\u662f\u8fd9\u4e2a\u5bb6\u65cf\u7684\u540d\u79f0\u6765\u6e90\uff0c\u80fd\u591f\u4e0e\u4e00\u7cfb\u5217\u7684\u914d\u4f53\u7ed3\u5408\uff0c\u5982\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08EGF\uff09\u548c\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b1\uff08TGF-\u03b1\uff09\u7b49\u3002\u914d\u4f53\u7ed3\u5408\u540e\uff0cEGFR\u53ef\u4ee5\u5f62\u6210\u540c\u6e90\u6216\u5f02\u6e90\u4e8c\u805a\u4f53\uff0c\u4ece\u800c\u6fc0\u6d3b\u5176\u916a\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\uff0c\u5f15\u53d1\u591a\u6761\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u3002<\/li>\n\n\n\n
  2. ErbB2\uff08HER2\/NEU\uff09\uff1a\u4e00\u822c\u60c5\u51b5\u4e0b\u4f7f\u7528HER2\u8fd9\u4e2a\u540d\u5b57\u3002
    \u8fd9\u4e2a\u6210\u5458\u7684\u7279\u70b9\u662f\u5176\u9ad8\u4eb2\u548c\u529b\u7684\u4e8c\u805a\u4f53\u5f62\u6210\u80fd\u529b\uff0c\u5373\u4f7f\u5728\u6ca1\u6709\u914d\u4f53\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u4e5f\u80fd\u5f62\u6210\u3002
    HER2\u7684\u8fc7\u5ea6\u8868\u8fbe\u6216\u6269\u589e\u5728\u4e73\u817a\u764c\u548c\u5176\u4ed6\u764c\u75c7\u4e2d\u88ab\u53d1\u73b0\uff0c\u4e0e\u80bf\u7624\u53d1\u5c55\u53ca\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002<\/li>\n\n\n\n
  3. ErbB3\uff08HER3\uff09\uff1a\u5c3d\u7ba1\u5176\u80de\u5185\u57df\u7f3a\u4e4f\u6216\u8005\u5177\u6709\u6781\u5f31\u7684\u6fc0\u9176\u6d3b\u6027\uff0c\u4f46HER3\u53ef\u4ee5\u4e0e\u5176\u4ed6\u5bb6\u65cf\u6210\u5458\u5f62\u6210\u5f02\u6e90\u4e8c\u805a\u4f53\uff08\u5c24\u5176\u662f\u4e0eHER2\uff09\uff0c\u5e76\u8c03\u8282\u591a\u79cd\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\u3002<\/li>\n\n\n\n
  4. ErbB4\uff08HER4\uff09\uff1a\u4e0eEGFR\u548cHER2\u76f8\u6bd4\uff0cHER4\u7684\u7814\u7a76\u8f83\u5c11\u3002\u5b83\u80fd\u591f\u4e0e\u591a\u79cd\u914d\u4f53\u7ed3\u5408\uff0c\u5e76\u53c2\u4e0e\u8c03\u8282\u591a\u79cd\u751f\u7269\u8fc7\u7a0b\u3002<\/li>\n<\/ol>\n\n\n\n

    4\u6b3eHER2\u5355\u6297\uff1a<\/strong><\/p>\n\n\n\n

    \u66f2\u59a5\u73e0\u5355\u6297\u548c\u5e15\u59a5\u73e0\u5355\u6297<\/strong><\/p>\n\n\n

    \n
    \"\"
    Cancers (Basel) . 2023 Mar 26;15(7):1987.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

    \u66f2\u59a5\u73e0\u5355\u6297\u548c\u5e15\u59a5\u73e0\u5355\u6297\u90fd\u662f\u9488\u5bf9HER2\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8eHER2\u9633\u6027\u7684\u4e73\u817a\u764c\u7684\u6cbb\u7597\u3002\u7136\u800c\uff0c\u5b83\u4eec\u7ed3\u5408HER2\u53d7\u4f53\u7684\u4f4d\u7f6e\u548c\u4f5c\u7528\u673a\u5236\u662f\u6709\u6240\u4e0d\u540c\u7684\u3002<\/p>\n\n\n\n

    \u66f2\u59a5\u73e0\u5355\u6297\uff0c\u901a\u8fc7\u7ed3\u5408\u5230HER2\u7684\u80de\u5916\u7ed3\u6784\u57dfIV\uff0c\u963b\u6b62\u5176\u4e0e\u5176\u4ed6HER2\u5f62\u6210\u540c\u6e90\u4e8c\u805a\u4f53\uff0c\u4ece\u800c\u6291\u5236\u4e0b\u6e38\u7684\u4fe1\u53f7\u4f20\u5bfc\u8def\u5f84\uff0c\u963b\u6b62\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u3002<\/p>\n\n\n\n

    \u6b64\u5916\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u8fd8\u53ef\u4ee5\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u901a\u8fc7\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\u6548\u5e94\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n

    \u5e15\u59a5\u73e0\u5355\u6297\u5219\u7ed3\u5408\u5230HER2\u7684\u80de\u5916\u7ed3\u6784\u57dfII\uff0c\u963b\u6b62HER2\u4e0e\u5176\u4ed6EGFR\u5bb6\u65cf\u53d7\u4f53\uff08HER1\u3001HER3\u3001HER4\uff09\u5f62\u6210\u4e8c\u805a\u4f53\uff0c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n\n\n\n

    \u56e0\u6b64\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5e15\u59a5\u73e0\u5355\u6297\u4f5c\u7528\u673a\u5236\u4e92\u8865\uff0c\u8054\u5408\u4f7f\u7528\u6548\u679c\u66f4\u597d\u3002<\/p>\n\n\n\n

    Phesgo<\/strong>\u4e3a\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5e15\u59a5\u73e0\u5355\u6297\u7684\u590d\u5408\u7269\u3002<\/p>\n\n\n\n

    \u7531\u4e8e\u66f2\u59a5\u73e0\u5355\u6297\u4e3b\u8981\u6291\u5236\u540c\u6e90\u4e8c\u805a\u4f53\uff08HER2-HER2\uff09\uff0c\u800c\u5e15\u59a5\u73e0\u5355\u6297\u6291\u5236\u975e\u540c\u6e90\u4e8c\u805a\u4f53\uff08HER2-HER1\u3001HER2-HER3\u3001HER2-HER4\uff09\uff0c\u5e76\u4e14\u4e24\u8005\u90fdHER2\u7ed3\u5408\u4f4d\u70b9\u4e0d\u540c\uff0c\u56e0\u6b64\u4e24\u8005\u53ef\u4ee5\u8054\u5408\u5e94\u7528\uff0c\u5171\u540c\u963b\u6b62HER2\u4e8c\u805a\u4f53\u7684\u5f62\u6210\uff0c\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002<\/p>\n\n\n\n

    \u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297<\/strong><\/p>\n\n\n

    \n
    \"\"
    Cancers (Basel) . 2023 Mar 26;15(7):1987.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

    \u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\u662f\u4e00\u79cd\u7531\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5fae\u7ba1\u6291\u5236\u5242DM1\u901a\u8fc7\u8fde\u63a5\u5b50\u7ec4\u5408\u800c\u6210\u7684\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u3002<\/p>\n\n\n\n

    \u4f5c\u7528\u673a\u5236\u4e3a\u66f2\u59a5\u73e0\u5355\u6297\u901a\u8fc7\u7279\u5f02\u6027\u8bc6\u522b\u5e76\u7ed3\u5408\u5230\u764c\u7ec6\u80de\u8868\u9762\u7684HER2\u53d7\u4f53\uff0c\u7136\u540e\u88ab\u764c\u7ec6\u80de\u5185\u541e\uff0c\u63a5\u7740\u5728\u764c\u7ec6\u80de\u5185\u90e8\uff0cDM1\u836f\u7269\u88ab\u91ca\u653e\u51fa\u6765\uff0c\u53ef\u4ee5\u6291\u5236\u5fae\u7ba1\u7684\u805a\u5408\uff0c\u5bfc\u81f4\u7ec6\u80de\u5468\u671f\u963b\u6ede\uff0c\u6700\u540e\u5bfc\u81f4\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n

    2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

    4\u6b3e\u7f57\u6c0fHER2\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

    \n
    \"\"
    \u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

    3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
    \n
    \"\"
    \u5931\u4f20\u5df2\u4e45\uff0c\u5370\u5728\u624b\u5e15\u4e0a\u7684\u7b11\u50b2\u6c5f\u6e56\u66f2\u8c31\u91cd\u73b0\u5929\u4e0b\uff0c\u88ab\u5ce8\u7709\u6d3e\u706d\u7edd\u5e08\u592a\u83b7\u5f97\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

    \u624b\u5e15<\/strong>\u4e0a\u7684\u66f2<\/strong>\u8c31\uff0c\u4ee3\u8868\u5e15\u59a5\u73e0<\/strong>\u5355\u6297\u548c\u66f2\u59a5\u73e0<\/strong>\u5355\u6297\u3002\u52a0\u4e0a\u5ce8\u7709<\/strong>\u6d3e\uff0c\u4e00\u8d77\u4ee3\u8868\u6069\u7f8e<\/strong>\u66f2\u59a5\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n

    \u56e0\u4e3a\u5ce8\u7709\u6d3e\u53ea\u6536\u5973\u5f1f\u5b50\uff0c\u56e0\u6b64\u82f1\u6587\u4e3aHER\uff0c\u4ee3\u8868\u836f\u7269\u9776\u70b9HER2\u3002<\/p>\n\n\n\n

    \u9002\u5e94\u75c7\u4e5f\u4e3a\u9488\u5bf9\u5973\u6027\u7684\u80bf\u7624\uff08\u7537\u6027\u4e5f\u4f1a\u6709\uff09\uff0c\u4e73\u817a\u764c\u3002<\/p>\n\n\n\n

    \u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0…<\/p>\n","protected":false},"author":1,"featured_media":1088,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1081","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1081"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1081\/revisions"}],"predecessor-version":[{"id":1089,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1081\/revisions\/1089"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1088"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1081"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1081"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1081"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}