{"id":1093,"date":"2023-07-18T22:22:26","date_gmt":"2023-07-18T14:22:26","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1093"},"modified":"2023-07-18T22:22:26","modified_gmt":"2023-07-18T14:22:26","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e4%b8%a4%e6%ac%be%e9%9d%9e%e7%bd%97%e6%b0%8fher2-%e5%be%b7%e6%9b%b2%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97%e3%80%81%e9%a9%ac","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1093","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u4e24\u6b3e\u975e\u7f57\u6c0fHER2 | \u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u3001\u9a6c\u5409\u59a5\u6614\u5355\u6297 | \u4e73\u817a\u764c\u7b49"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff08trastuzumab deruxtecan\u3001T-DXd\uff09\uff1a<\/strong><\/p>\n\n\n\n

\u662f\u963f\u65af\u5229\u5eb7\u548c\u7b2c\u4e00\u4e09\u5171\u5171\u540c\u5f00\u53d1\u7684\u4e00\u6b3e\u660e\u661f\u751f\u7269\u5236\u5242\uff0c\u5c5e\u4e8e\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u3002<\/p>\n\n\n\n

\u4e8e2019\u5e7412\u6708\u83b7FDA\u6279\u51c6\uff08ENHERTU\u00ae trastuzumab deruxtecan\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u9002\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u79cd\u6216\u4e00\u79cd\u4ee5\u4e0a\u6297HER2\u836f\u7269\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027HER2\u9633\u6027\u6210\u4eba\u4e73\u817a\u764c\u60a3\u8005\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u80c3\u764c\u7b49\u3002 <\/p>\n\n\n\n

2023\u5e742\u6708\uff0c\u836f\u7269\u6b63\u5f0f\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff08\u4f18\u8d6b\u5f97\u00ae\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff09\u3002<\/p>\n\n\n\n

\u9a6c\u5409\u59a5\u6614\u5355\u6297\uff08Margetuximab\uff09\uff1a<\/strong><\/p>\n\n\n\n

\u7531MacroGenics\u516c\u53f8\u5f00\u53d1\uff0c2018\u5e74\u7531\u518d\u9f0e\u533b\u836f\u5f15\u8fdb\u56fd\u5185\u3002<\/p>\n\n\n\n

2020\u5e74\u836f\u7269\u83b7FDA\u6279\u51c6\uff08Margenza\u00ae margetuximab\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9633\u6027\uff08HER2+\uff09\u4e73\u817a\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

\u56fd\u5185\u6682\u672a\u4e0a\u5e02\uff0c\u518d\u9f0e\u533b\u836f\u5b98\u7f51\u547d\u540d\u4e3a\u9a6c\u5409\u59a5\u6614\u5355\u6297\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

\u5173\u4e8eHER2\u81f4\u75c5\u57fa\u56e0\u7684\u76f8\u5173\u4ecb\u7ecd\u53ef\u4ee5\u53c2\u89c1\u524d\u7bc7\u5185\u5bb9\uff1a<\/p>\n\n\n\n

\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u7ed3\u6784<\/strong><\/p>\n\n\n

\n
\"\"
https:\/\/www.enhertuhcp.com\/en\/gastric\/about-enhertu\/mechanism-of-action<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u4e3b\u8981\u7531\u4ee5\u4e0b\u6210\u5206\u7ec4\u6210\uff1a\u200b<\/p>\n\n\n\n

\u6297\u4f53\uff1a\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u5305\u542b\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u76f8\u540c\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u7684\u6297HER2\u514d\u75ab\u7403\u86cb\u767dG1\uff08IgG1\uff09\u5355\u514b\u9686\u6297\u4f53\uff08mAb\uff09\u3002<\/p>\n\n\n\n

\u8fde\u63a5\u5b50\uff1a\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u4e2d\u7684\u8fde\u63a5\u5b50\u662f\u53ef\u88c2\u89e3\u7684\u56db\u80bd\u8fde\u63a5\u5b50\uff0c\u7528\u4e8e\u5c06\u6297\u4f53\u4e0e\u5176\u4ed6\u6210\u5206\u8fde\u63a5\u8d77\u6765\u3002<\/p>\n\n\n\n

\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\uff08DXd\uff09\uff1a\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u4f5c\u4e3aADC\u836f\u7269\uff0cpayload\u4e3a\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242DXd\u3002\u5b83\u4e0e\u8fde\u63a5\u5b50\u5171\u4ef7\u8fde\u63a5\uff0c\u5e76\u901a\u8fc7\u6297\u4f53\u4f20\u9012\u5230\u9776\u4f4d\u70b9\u3002<\/p>\n\n\n\n

\u62d3\u6251\u5f02\u6784\u9176<\/strong><\/p>\n\n\n

\n
\"\"
https:\/\/healthjade.com\/topoisomerase\/<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

DNA\u7684\u53cc\u87ba\u65cb\u7ed3\u6784\u5728\u590d\u5236\u8fc7\u7a0b\u4e2d\u9700\u8981\u88ab\u89e3\u65cb\uff0c\u624d\u80fd\u8fdb\u884c\u65b0\u94fe\u7684\u5408\u6210\u3002<\/p>\n\n\n\n

\u7136\u800c\uff0c\u8fd9\u4e2a\u89e3\u65cb\u8fc7\u7a0b\u4f1a\u5728\u53cc\u87ba\u65cb\u540e\u7aef\u5f15\u53d1\u8fc7\u5ea6\u8d85\u87ba\u65cb\u7684\u5f62\u6210\uff0c\u8fd9\u4f1a\u5bfc\u81f4DNA\u89e3\u65cb\u548c\u5408\u6210\u7684\u963b\u788d\u3002<\/p>\n\n\n\n

\u62d3\u6251\u5f02\u6784\u9176\u7684\u4e3b\u8981\u529f\u80fd\u662f\u89e3\u9664DNA\u5206\u5b50\u4e2d\u7684\u8d85\u87ba\u65cb\u7d27\u5f20\uff0c\u4ee5\u7ef4\u6301DNA\u7ed3\u6784\u7684\u7a33\u5b9a\uff0c\u5e76\u786e\u4fddDNA\u7684\u6b63\u5e38\u590d\u5236\u548c\u8f6c\u5f55\u3002<\/p>\n\n\n\n

\u62d3\u6251\u5f02\u6784\u9176\u5206\u4e3a\u4e24\u578b\uff1a<\/strong><\/p>\n\n\n\n

I\u578b\u62d3\u6251\u5f02\u6784\u9176\u80fd\u5207\u5f00DNA\u53cc\u94fe\u4e2d\u7684\u4e00\u6761\u94fe\uff0c\u5e76\u4f7f\u672a\u5207\u7684\u94fe\u7a7f\u8fc7\u5207\u53e3\uff0c\u4ee5\u677e\u89e3\u53cc\u94fe\u4e4b\u95f4\u7684\u76d8\u7ed5\u5f20\u529b\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u4e0d\u9700\u8981ATP\u3002<\/p>\n\n\n\n

\u2161\u578b\u62d3\u6251\u5f02\u6784\u9176\u66f4\u590d\u6742\uff0c\u5b83\u80fd\u5207\u5f00DNA\u53cc\u94fe\uff0c\u5e76\u8ba9\u672a\u5207\u7684DNA\u94fe\u7a7f\u8fc7\u5207\u53e3\u3002\u7136\u540e\uff0c\u5b83\u4f1a\u91cd\u65b0\u7f1d\u5408\u5207\u53e3\uff0c\u5e76\u5728\u9700\u8981ATP\u7684\u60c5\u51b5\u4e0b\u91cd\u590d\u8fd9\u4e2a\u8fc7\u7a0b\u3002<\/p>\n\n\n\n

\u5fb7\u66f2\u59a5\u73e0\u5355\u6297<\/strong><\/p>\n\n\n

\n
\"\"
https:\/\/www.chemoexperts.com\/fam-trastuzumab-deruxtecan-nxki-enhertu.html<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u901a\u8fc7\u4e09\u79cd\u673a\u5236\u53d1\u6325\u4f5c\u7528\uff1a<\/p>\n\n\n\n

\u6291\u5236\u4e8c\u805a\u4f53\u5f62\u6210\uff1aHER2\u4e8c\u805a\u4f53\u662f\u764c\u7ec6\u80de\u751f\u957f\u548c\u6269\u6563\u6240\u5fc5\u9700\u7684\u3002\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u901a\u8fc7\u4e0eHER2\u7684\u4e24\u4e2a\u53d7\u4f53\u4e9a\u57fa\u7ed3\u5408\u6765\u6291\u5236\u4e8c\u805a\u4f53\u7684\u5f62\u6210\u3002<\/p>\n\n\n\n

\u836f\u7269\u5185\u541e\u91ca\u653eDXd\uff1a\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u643a\u5e26\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242DXd\u3002\u5f53\u836f\u7269\u4e0eHER2\u9633\u6027\u764c\u7ec6\u80de\u7ed3\u5408\u65f6\uff0cDXd\u4f1a\u88ab\u91ca\u653e\u5230\u764c\u7ec6\u80de\u4e2d\u3002DXd\u6291\u5236\u62d3\u6251\u5f02\u6784\u9176I\u6d3b\u6027\uff0c\u5bfc\u81f4DNA\u590d\u5236\u53d7\u963b\u3002<\/p>\n\n\n\n

\u6297\u4f53\u4f9d\u8d56\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08ADCC\uff09\uff1a\u5f53\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u4e0eHER2\u9633\u6027\u764c\u7ec6\u80de\u7ed3\u5408\u65f6\uff0c\u6fc0\u6d3b\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u7b49\u514d\u75ab\u7ec6\u80de\uff0c\u6740\u6b7b\u764c\u7ec6\u80de\u3002<\/p>\n\n\n\n

\u9a6c\u5409\u59a5\u6614\u5355\u6297<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

\u9a6c\u5409\u59a5\u6614\u5355\u6297\uff08Margetuximab\uff09\u4e5f\u662f\u4e00\u79cd\u9776\u5411\u963b\u65adHER2\u86cb\u767d\u7684\u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n\n\n\n

\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u6700\u5927\u7684\u533a\u522b\u5728\u4e8e\uff0c\u5176Fc\u90e8\u5206\u7ecf\u8fc7\u4fee\u6539\uff0c\u4ee5\u589e\u52a0\u4e0e\u6d3b\u5316Fc\u53d7\u4f53FCGR3A\uff08CD16A\uff09\u7684\u7ed3\u5408\uff0c\u5e76\u51cf\u5c11\u4e0e\u6291\u5236\u6027Fc\u53d7\u4f53FCGR2B\uff08CD32B\uff09\u7684\u7ed3\u5408\u3002<\/p>\n\n\n\n

\u8fd9\u610f\u5473\u7740\u9a6c\u5409\u59a5\u6614\u5355\u6297\u53ef\u6bd4\u66f2\u59a5\u73e0\u5355\u6297\u66f4\u6709\u6548\u5730\u6740\u6b7b\u764c\u7ec6\u80de\u3002\u88ab\u79f0\u4e3a\u201c\u5f3a\u5316\u7248\u8d6b\u8d5b\u6c40\u201d\u3002<\/p>\n\n\n\n

2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

\u9776\u5411HER2\u751f\u7269\u5236\u5242\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

\n
\"\"
\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
\n
\"\"
\u5ce8\u7709\u5e08\u592a\u5403\u4e86\u6912\u9ebb\u9e21\uff0c\u8fa3\u5f97\u62ff\u51fa\u5370\u6709\u66f2\u8c31\u7684\u624b\u5e15\u64e6\u773c\u6cea\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

\u53c2\u8003\u4e0a\u6587\u7684\u8bb0\u5fc6\u65b9\u6cd5\uff0c\u5c065\u6b3eHER2\u836f\u7269\u4e00\u8d77\u8bb0\u4f4f\u3002<\/p>\n\n\n\n

\u5370\u6709\u66f2<\/strong>\u8c31\u7684\u624b\u5e15<\/strong>\uff0c\u4ee3\u8868\u66f2\u59a5\u73e0\u5355\u6297\uff0c\u5e15\u59a5\u73e0\u5355\u6297\u3002\u5ce8\u7709<\/strong>\u5e08\u592a\u4ee3\u8868\u6069\u7f8e\u66f2\u59a5\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n

\u6912\u9ebb\u9e21<\/strong>\u4ee3\u8868\u9a6c\u5409\u59a5\u6614\u5355\u6297\uff0c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u4e3a\u5728\u66f2\u59a5\u73e0\u5355\u6297\u7684\u57fa\u7840\u4e0a\u52a0\u5165\u4e86DXd\uff0c\u201c\u5fb7\u201d\u4ee3\u8868DXd\u3002<\/p>\n\n\n\n

\u5ce8\u7709\u6d3e\u53ea\u6536\u5973\u5f1f\u5b50\uff0c\u4ee3\u8868\u9776\u70b9HER2\uff0c\u9002\u5e94\u75c7\u4e5f\u4e3a\u5973\u6027\u5e38\u6709\u7684\u4e73\u817a\u764c\u3002<\/p>\n\n\n\n

\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"

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