{"id":1109,"date":"2023-07-27T09:31:04","date_gmt":"2023-07-27T01:31:04","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1109"},"modified":"2023-07-27T09:33:10","modified_gmt":"2023-07-27T01:33:10","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e6%8a%97%e8%82%bf%e7%98%a4vegfr-%e8%b4%9d%e4%bc%90%e7%8f%a0%e5%8d%95%e6%8a%97%e3%80%81%e9%9b%b7%e8%8e%ab%e8%a5%bf%e5%b0%a4","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1109","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u6297\u80bf\u7624VEGFR | \u8d1d\u4f10\u73e0\u5355\u6297\u3001\u96f7\u83ab\u897f\u5c24\u5355\u6297\u3001\u963f\u67cf\u897f\u666e\u7b49 | \u5b9e\u4f53\u80bf\u7624"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

VEGFR\u4ee3\u8868\u201c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u201d\uff08Vascular Endothelial Growth Factor Receptor\uff09\u3002\u4e0e\u524d\u6587\u4e2dEGFR\u7c7b\u4f3c\uff0c\u5747\u5c5e\u4e8e\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0cVEGFR\u53c2\u4e0e\u8840\u7ba1\u751f\u6210\u3001\u8840\u7ba1\u901a\u900f\u6027\u548c\u8840\u7ba1\u7a33\u6001\u7b49\u8fc7\u7a0b\u3002<\/p>\n\n\n\n

VEGF \u6291\u5236\u5242\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u3002\u5982\uff1a<\/p>\n\n\n\n

\u5b89\u7ef4\u6c40\u00ae \u8d1d\u4f10\u73e0\u5355\u6297
AVASTIN\u00ae bevacizumab\uff1a<\/strong><\/p>\n\n\n\n

\u7531\u7f57\u6c0f\u516c\u53f8\u5f00\u53d1\uff0c2004\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u3002\u56fd\u5185\u4e8e2010\u5e74\u83b7\u6279\u3002\u7528\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80be\u764c\u3001\u5375\u5de2\u764c\u3001\u5bab\u9888\u764c\u548c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7b49\u3002<\/p>\n\n\n\n

ZALTRAP\u00ae aflibercept<\/strong><\/p>\n\n\n\n

\u963f\u67cf\u897f\u666e:<\/strong><\/p>\n\n\n\n

\u8bf4\u5230\u963f\u67cf\u897f\u666e\u4e0d\u5f97\u4e0d\u63d0\u4e00\u4e0b\u8d5b\u8bfa\u83f2\u516c\u53f8\u7684\u9057\u61be\u3002<\/p>\n\n\n\n

\u963f\u67cf\u897f\u666e\u6700\u521d\u7531\u518d\u751f\u5143\u516c\u53f8\u7814\u53d1\uff0c\u8d77\u521d\u805a\u7126\u4e8e\u764c\u75c7\u6cbb\u7597\u3002<\/p>\n\n\n\n

2003\u5e74\u5b89\u4e07\u7279\uff08\u540e\u5408\u5e76\u5165\u8d5b\u8bfa\u83f2\uff09\u516c\u53f8\u83b7\u5f97\u963f\u67cf\u897f\u666e\u7684\u6743\u76ca\u3002\u7531\u4e8e\u51b3\u7b56\u5931\u8bef\uff0c2005\u5e74\uff0c\u5408\u5e76\u540e\u7684\u8d5b\u8bfa\u83f2\u5b89\u4e07\u7279\u4e0e\u518d\u751f\u5143\u4fee\u8ba2\u534f\u8bae\uff0c\u5c06\u963f\u67cf\u897f\u666e\u773c\u75c5\u6743\u76ca\u9000\u8fd8\u518d\u751f\u5143\uff0c\u5e76\u652f\u4ed8\u7ed9\u518d\u751f\u51432500\u4e07\u7f8e\u5143\u3002\u81ea\u5df1\u4ec5\u4fdd\u7559\u80bf\u7624\u6743\u76ca\u3002<\/p>\n\n\n\n

2006\u5e74\uff0c\u518d\u751f\u5143\u4e0e\u62dc\u8033\u8fbe\u6210\u5408\u4f5c\uff0c\u62dc\u8033\u83b7\u5f97\u963f\u67cf\u897f\u666e\u7684\u7f8e\u56fd\u5916\u773c\u75c5\u6743\u76ca\uff0c\u5e76\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff08Eylea\u00ae\u827e\u529b\u96c5\u00ae\uff09\u3002<\/p>\n\n\n\n

\u4e4b\u540e\u827e\u529b\u96c5\u00ae\u4e00\u8dc3\u6210\u4e3a\u91cd\u78c5\u70b8\u5f39\u836f\u7269\u3002\u518d\u751f\u5143\u4e5f\u51ed\u501f\u827e\u529b\u96c5\u00ae\uff0c\u4ece\u4e00\u4e2a\u5c0f\u578b\u516c\u53f8\u8f6c\u578b\u4e3a\u5982\u4eca\u7684\u89c4\u6a21\u3002\u800c\u8d5b\u8bfa\u83f2\u516c\u53f8\u4fdd\u7559\u7684\u963f\u67cf\u897f\u666e\u80bf\u7624\u6743\u76ca\uff0c\u9500\u552e\u989d\u4ec5\u4e3a\u773c\u90e8\u9002\u5e94\u75c7\u7684\u96f6\u5934\u3002<\/p>\n\n\n\n

\u56fd\u5185\u963f\u67cf\u897f\u666e\u7684\u773c\u90e8\u9002\u5e94\u75c7\u836f\u7269\u5df2\u7ecf\u4e0a\u5e02\uff0c\u4f46\u80bf\u7624\u9002\u5e94\u75c7\u836f\u7269\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

\u5e0c\u5189\u62e9\u00ae \u96f7\u83ab\u897f\u5c24\u5355\u6297<\/strong><\/p>\n\n\n\n

CYRAMZA\u00ae ramucirumab\uff1a<\/strong><\/p>\n\n\n\n

\u7531\u793c\u6765\u516c\u53f8\u5f00\u53d1\uff0c2014 \u5e74\u83b7FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u809d\u764c\u7b49\u3002<\/p>\n\n\n\n

\u56fd\u5185\u7531\u4fe1\u8fbe\u751f\u7269\u9500\u552e\uff0c\u5df2\u7ecf\u4e0a\u5e02\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

VEGFR\u662f\u4e00\u79cd\u4e0e\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u7ed3\u5408\u7684\u53d7\u4f53\uff0c\u5b83\u5728\u8c03\u63a7\u8840\u7ba1\u751f\u6210\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

VEGFR\u4e9a\u578b\u53ca\u7ed3\u5408\u53d7\u4f53\u7c7b\u578b<\/p>\n\n\n

\n
\"\"
Future Med Chem . 2012 Sep;4(14):1839-52.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

VEGF \u6709\u4e94\u79cd\u4e9a\u578b\uff1a<\/strong><\/p>\n\n\n\n

VEGF-A \u662f\u6700\u91cd\u8981\u7684 VEGF\u4e9a\u578b\uff0c\u5728\u80bf\u7624\u8840\u7ba1\u751f\u6210\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/p>\n\n\n\n

VEGF-B \u4e3b\u8981\u5728\u6dcb\u5df4\u7ba1\u4e2d\u8868\u8fbe\uff0c\u5728\u6dcb\u5df4\u7ba1\u751f\u6210\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

VEGF-C \u548c VEGF-D \u4e3b\u8981\u5728\u514d\u75ab\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u5728\u514d\u75ab\u53cd\u5e94\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

VEGF-E \u5728\u80ce\u513f\u53d1\u80b2\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

VEGF\u53d7\u4f53\u4e3b\u8981\u5305\u62ecVEGFR1\u3001VEGFR2\u3001VEGFR3\u3002\u4ed6\u4eec\u4e0eVEGR\u5bf9\u5e94\u7ed3\u5408\u5173\u7cfb\u5982\u56fe\u3002<\/p>\n\n\n\n

\u5728\u80bf\u7624\u751f\u957f\u8fc7\u7a0b\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\u4f1a\u4ea7\u751f\u5927\u91cf\u7684VEGF\uff0c\u523a\u6fc0\u5468\u56f4\u7ec4\u7ec7\u4e2d\u7684\u8840\u7ba1\u751f\u6210\uff0c\u4e3a\u80bf\u7624\u63d0\u4f9b\u8425\u517b\u548c\u6c27\u6c14\uff0c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u548c\u8f6c\u79fb\u3002<\/p>\n\n\n\n

VEGFR\u6291\u5236\u5242\u662f\u4e00\u7c7b\u9488\u5bf9VEGFR\u7684\u836f\u7269\uff0c\u53ef\u4ee5\u963b\u65adVEGF\u4e0e\u5176\u53d7\u4f53VEGFR\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236\u8840\u7ba1\u751f\u6210\u548c\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\uff0c\u7528\u4e8e\u6cbb\u7597\u4e00\u4e9b\u6076\u6027\u80bf\u7624\uff0c\u5982\u80ba\u764c\u3001\u80be\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u7b49\u3002<\/p>\n\n\n\n

\u76ee\u524d\u5df2\u7ecf\u83b7\u6279\u4e0a\u5e02\u7684VEGFR\u76f8\u5173\u7684\u751f\u7269\u5236\u5242\u67096\u6b3e\uff08\u5305\u62ec\u80bf\u7624\u548c\u773c\u75c5\uff09\uff0c\u6bcf\u4e00\u6b3e\u7684\u6297\u4f53\u7ed3\u6784\u90fd\u4e0d\u540c\u3002<\/p>\n\n\n\n

\u5173\u4e8e6\u6b3eVEGFR\u751f\u7269\u5236\u5242\u7684\u7ed3\u6784\u7279\u70b9\uff0c\u5c06\u5728\u4e0b\u4e00\u7ae0\u63cf\u8ff0\u3002<\/p>\n\n\n\n

3\u6b3e\u6297\u80bf\u7624VEGFR\u751f\u7269\u5236\u5242\u9776\u70b9<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

\u8d1d\u4f10\u73e0\u5355\u6297\u548c\u963f\u67cf\u897f\u666e\uff0c\u5176\u4f5c\u7528\u9776\u70b9\u5747\u4e3a\u7ec6\u80de\u56e0\u5b50VEGF\uff0c\u800c\u96f7\u83ab\u897f\u5c24\u5355\u6297\u53ef\u7279\u5f02\u6027\u7ed3\u5408VEGF\u53d7\u4f532\uff08VEGFR-2\uff09\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n\n

2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

3\u6b3eVEGFR\u751f\u7269\u5236\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

\n
\"\"
\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
\n
\"\"
\u5317\u6d0b\u519b\u963f\u571f\u4f2f\u8eab\u60a3\u80bf\u7624\uff0c\u8001\u848b\u4e3a\u9996\u7684\u5317\u4f10\u519b\u4e58\u673a\u53d1\u51fa\u5fc5\u6740\u95ea\u7535\u201c\u83ab\u987b\u6709\u201d\uff0c\u6253\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\uff0c\u7ed3\u675f\u4e86\u5206\u88c2\u5c40\u52bf\uff0c\u5b9e\u73b0\u4e2d\u534e\u5f62\u5f0f\u7edf\u4e00\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

\u5317\u4f10\u519b\u4ee3\u8868\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u95ea\u7535\u201c\u83ab\u987b\u6709\u201d\u4ee3\u8868\u96f7\u83ab\u897f\u5c24\u5355\u6297\uff0c\u963f\u571f\u4f2f\u4ee3\u8868\u963f\u67cf\u897f\u666e\u3002<\/p>\n\n\n\n

\u8840\u7ba1\u4ee3\u8868\u9776\u70b9VEGFR\u3002<\/p>\n\n\n\n

\u80bf\u7624\u4ee3\u8868\u6297\u5b9e\u4f53\u7624\u751f\u7269\u836f\u3002<\/p>\n\n\n\n

\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"

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