{"id":1121,"date":"2023-07-28T10:28:21","date_gmt":"2023-07-28T02:28:21","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1121"},"modified":"2023-07-28T10:28:21","modified_gmt":"2023-07-28T02:28:21","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e7%9c%bc%e7%a7%91%e7%94%a8vegfr-%e9%9b%b7%e7%8f%a0%e5%8d%95%e6%8a%97%e3%80%81%e9%98%bf%e6%9f%8f%e8%a5%bf%e6%99%ae%e3%80%81","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1121","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u773c\u79d1\u7528VEGFR | \u96f7\u73e0\u5355\u6297\u3001\u963f\u67cf\u897f\u666e\u3001\u5e03\u897f\u73e0\u5355\u6297\u3001\u6cd5\u745e\u897f\u5355\u6297 | \u773c\u5e95\u75c5"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">VEGFR\u4ee3\u8868\u201c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u201d\uff08Vascular Endothelial Growth Factor Receptor\uff09\u3002\u662f\u4e00\u7ec4\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\uff0c\u53c2\u4e0e\u8840\u7ba1\u751f\u6210\u3001\u5bf9\u8840\u7ba1\u901a\u900f\u6027\u548c\u8840\u7ba1\u7a33\u6001\u8d77\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7bc7\u4e3b\u8981\u4ecb\u7ecdVEGF \u6291\u5236\u5242\u7528\u4e8e\u6cbb\u7597\u773c\u5e95\u75c5\uff0c\u901a\u8fc7\u7ade\u4e89\u7ed3\u5408VEGF\uff0c\u6291\u5236\u773c\u5e95\u8840\u7ba1\u751f\u6210\uff0c\u4ece\u800c\u51cf\u8f7b\u89c6\u529b\u635f\u5bb3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524dFDA\u83b7\u6279\u4e0a\u5e02\u7528\u4e8e\u773c\u5e95\u75c5\u7684VEGFR\u751f\u7269\u5236\u5242\u4e3b\u8981\u67094\u6b3e\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8bfa\u9002\u5f97\u00ae \u96f7\u73e0\u5355\u6297<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>LUCENTIS\u00ae ranibizumab&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7f57\u6c0f\u516c\u53f8\u5f00\u53d1\uff0c2006 \u5e74\u83b7FDA\u6279\u51c6\uff0c\u76ee\u524d\u7528\u4e8e\u9ec4\u6591\u53d8\u6027\uff0c\u89c6\u7f51\u819c\u75c5\u53d8\u7b49\u773c\u5e95\u75c5\u3002\u56fd\u5185\u5df2\u4e0a\u5e02\uff0c\u7531\u8bfa\u534e\u516c\u53f8\u9500\u552e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u827e\u529b\u96c5\u00ae \u963f\u67cf\u897f\u666e<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>EYLEA\u00ae aflibercept<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u524d\u6587\u5df2\u7ecf\u4ecb\u7ecd\u4e86\u827e\u529b\u96c5\u00ae\u6210\u4e3a\u91cd\u78c5\u70b8\u5f39\u836f\u7269\u7684\u6545\u4e8b\uff0c\u5176\u7531\u518d\u751f\u5143\u548c\u62dc\u8033\u5171\u540c\u5f00\u53d1\uff0c2011\u5e74\u83b7FDA\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u773c\u5e95\u75be\u75c5\u3002\u56fd\u5185\u5df2\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>BEOVU\u00ae brolucizumab<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5e03\u897f\u73e0\u5355\u6297<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8bfa\u534e\u516c\u53f8\u5f00\u53d1\uff0c2019 \u5e74\u83b7FDA\u6279\u51c6\u7528\u4e8e\u9ec4\u6591\u53d8\u6027\uff0c\u9ec4\u6591\u6c34\u80bf\u7b49\u773c\u75c5\u3002\u56fd\u5185\u6682\u672a\u4e0a\u5e02\uff0c\u8bfa\u534e\u5b98\u7f51\u4e2d\u51fa\u73b0\u7684\u4e2d\u6587\u540d\u662f\u5e03\u897f\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>VABYSMO\u00ae faricimab<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u745e\u897f\u5355\u6297<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7f57\u6c0f\u516c\u53f82022\u5e74\u4e0a\u5e02\u7684VEGF\u00d7Ang-2\u53cc\u6297\uff0c\u7528\u4e8e\u6cbb\u7597\u9ec4\u6591\u53d8\u6027\uff0c\u9ec4\u6591\u6c34\u80bf\u7b49\u773c\u5e95\u75c5\u3002\u56fd\u5185\u6682\u672a\u4e0a\u5e02\uff0c\u7f57\u6c0f\u516c\u53f8\u5411CDE\u7533\u62a5\u7684\u6ce8\u518c\u6750\u6599\u4e2d\u7684\u540d\u5b57\u662f\u6cd5\u745e\u897f\u5355\u6297\uff08JXSS2300058\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e6\u5916\uff0c\u56fd\u5185\u5eb7\u5f18\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\u76841\u7c7b\u751f\u7269\u65b0\u836f\uff0c<strong>\u5eb7\u67cf\u897f\u666e<\/strong>\uff0c\u5728\u56fd\u5185\u773c\u5e95\u75c5\u5e02\u573a\u5360\u6709\u7387\u548c\u96f7\u73e0\u5355\u6297\u76f8\u5f53\u3002\u4f46\u7531\u4e8e\u5176\u5c1a\u672a\u5728FDA\u83b7\u6279\uff0c\u6240\u4ee5\u672c\u7bc7\u4e0d\u505a\u4ecb\u7ecd\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6291\u5236\u65b0\u751f\u8840\u7ba1\u80fd\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3002\u5728\u773c\u5e95\u75c5\u53d8\u4e2d\uff0c\u5982\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08wet AMD\uff09\u3001\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u53d8\uff08diabetic retinopathy\uff09\u7b49\u4e5f\u6d89\u53ca\u5f02\u5e38\u8840\u7ba1\u751f\u6210\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">VEGF\u6291\u5236\u5242\u53ef\u4ee5\u7528\u6765\u6291\u5236\u5f02\u5e38\u8840\u7ba1\u751f\u6210\uff0c\u51cf\u5c11\u89c6\u7f51\u819c\u75c5\u53d8\u7684\u8fdb\u5c55\uff0c\u4fdd\u62a4\u89c6\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u5df2\u7ecf\u83b7\u6279\u4e0a\u5e02\u7684VEGFR\u76f8\u5173\u751f\u7269\u5236\u5242\u67096\u6b3e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ece\u6700\u521d\u7684IgG\u5355\u6297\uff0c\u5230\u76ee\u524d\u70ed\u95e8\u7684scFv\u5355\u94fe\u6297\u4f53\u7247\u6bb5\uff0c\u6216\u8005\u53cc\u6297\uff0c\u6bcf\u4e00\u6b3e\u90fd\u4ee3\u8868\u4e86\u76ee\u524d\u751f\u7269\u5236\u5242\u7684\u7ecf\u5178\u7ed3\u6784\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>VEGFR\u751f\u7269\u5236\u5242\u7684\u7ed3\u6784<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-27.png\" alt=\"\" class=\"wp-image-1122\" width=\"608\" height=\"572\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-27.png 946w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-27-300x282.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-27-768x723.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-27-880x828.png 880w\" sizes=\"auto, (max-width: 608px) 100vw, 608px\" \/><figcaption class=\"wp-element-caption\"><em>Int J Mol Sci . 2023 May 31;24(11):9591.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8d1d\u4f10\u73e0\u5355\u6297<\/strong>\u662f\u7b2c\u4e00\u4e2a\u4eba\u6e90\u5316\u6297VEGF\u7684IgG\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e0eVEGF\u7ed3\u5408\uff0c\u963b\u6b62 VEGF \u4e0e\u5185\u76ae\u7ec6\u80de\u8868\u9762 VEGF \u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8d1d\u4f10\u73e0\u5355\u6297\u76ee\u524d\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\u6cbb\u7597\u76f8\u5173\u5b9e\u4f53\u7624\uff0c\u7528\u4e8e\u773c\u5e95\u75c5\u4e3a\u8d85\u9002\u5e94\u75c7\u7528\u836f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8e\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u5206\u5b50\u91cf\u5927\uff0c\u79d1\u5b66\u5bb6\u9700\u8981\u5f00\u53d1\u66f4\u5c0f\u7684\u6297VEGF\u6297\u4f53\uff0c\u4ee5\u4fbf\u836f\u7269\u80fd\u591f\u76f4\u63a5\u6ce8\u5c04\u5230\u773c\u775b\u73bb\u7483\u4f53\u5185\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u96f7\u73e0\u5355\u6297<\/strong>\u662f\u4e00\u79cd\u4ec5\u6709Fab\u6bb5\u7684\u5355\u94fe\u6297\u4f53\uff0c\u5176\u6ca1\u6709Fc\u6bb5\uff0c\u610f\u5473\u7740\u5176\u5206\u5b50\u91cf\u66f4\u5c0f\uff0c\u5177\u6709\u66f4\u77ed\u7684\u534a\u8870\u671f\uff0c\u5e76\u4e14\u4e0d\u4f1a\u5f15\u53d1\u514d\u75ab\u7cfb\u7edf\u7684\u6fc0\u6d3b\u3002\u8fd9\u4f7f\u5f97\u5b83\u6210\u4e3a\u6cbb\u7597\u773c\u775b\u75be\u75c5\u7684\u7406\u60f3\u9009\u62e9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Brolucizumab\u00a0\u5e03\u897f\u73e0\u5355\u6297<\/strong>\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u94fe\u6297\u4f53\u7247\u6bb5\uff08scfv\uff09\u3002\u4ec5\u4fdd\u7559\u4e24\u4e2a\u53ef\u53d8\u533a\uff0c\u6bd4\u96f7\u73e0\u5355\u6297\u66f4\u5c0f\uff0c\u5e76\u5177\u6709\u5f88\u9ad8\u7684\u4eb2\u548c\u529b\uff0c\u66f4\u9002\u5408\u773c\u90e8\u7ed9\u836f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u963f\u67cf\u897f\u666e<\/strong>\u662f\u4e00\u79cd\u53ef\u6eb6\u6027\u53d7\u4f53\u878d\u5408\u86cb\u767d\uff0c\u7531\u4eba\u6e90\u5316\u7684IgG1 Fc\u7247\u6bb5\uff0c\u548c\u80fd\u4e0eVEGF\u7ed3\u5408\u7684\u53d7\u4f53\u7ec4\u5408\uff0c\u5f62\u6210\u53d7\u4f53\u9677\u9631\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Faricimab\u00a0\u6cd5\u745e\u897f\u5355\u6297<\/strong>\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u53ef\u4ee5\u540c\u65f6\u6291\u5236VEGF\u548cAng-2\u8fd9\u4e24\u4e2a\u91cd\u8981\u7684\u8840\u7ba1\u751f\u6210\u4fe1\u53f7\u901a\u8def\u3002\u8840\u7ba1\u751f\u6210\u7d20-2\uff08Ang-2\uff09\u4e5f\u662f\u4e00\u79cd\u53c2\u4e0e\u8840\u7ba1\u751f\u6210\u3001\u708e\u75c7\u3001\u80bf\u7624\u751f\u957f\u548c\u5176\u4ed6\u75be\u75c5\u7684\u91cd\u8981\u9776\u3002\u4ece\u800c\u66f4\u6709\u6548\u5730\u8c03\u8282\u8840\u7ba1\u751f\u6210\u548c\u8840\u7ba1\u901a\u900f\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e6\u5916\uff0c\u8fd8\u6709\u4e00\u6b3e\u6297\u80bf\u7624VEGF\u6291\u5236\u5242\uff0c<strong>\u96f7\u83ab\u897f\u5c24\u5355\u6297<\/strong>\uff0c\u4e3aIgG1\u6297\u4f53\uff0c\u4e0e\u4e0a\u97625\u6b3e\u836f\u7269\u7ed3\u5408\u7ec6\u80de\u56e0\u5b50\u4e0d\u540c\uff0c\u96f7\u83ab\u897f\u5c24\u5355\u6297\u901a\u8fc7\u7ade\u4e89\u7ed3\u5408VEGF\u53d7\u4f53\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>VEGFR\u751f\u7269\u5236\u5242\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-28-1024x849.png\" alt=\"\" class=\"wp-image-1123\" width=\"668\" height=\"554\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-28-1024x849.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-28-300x249.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-28-768x637.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-28-1218x1010.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-28-880x729.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-28.png 1414w\" sizes=\"auto, (max-width: 668px) 100vw, 668px\" \/><figcaption class=\"wp-element-caption\"><em>Cells . 2022 Nov 1;11(21):3453.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5404\u836f\u7269\u80fd\u4e0e\u4e0d\u540c\u7684VEGF\u4e9a\u578b\u7ed3\u5408\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Faricimab \u6cd5\u745e\u897f\u5355\u6297\u5177\u5907\u53cc\u6297\u7684\u7279\u70b9\uff0c\u56e0\u6b64\u80fd\u6291\u5236VEGF-A\u548cANG2\u53cc\u9776\u70b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u963f\u67cf\u897f\u666e\u53ef\u540c\u65f6\u963b\u65adVEGF-A\u3001VEGF-B\u4ee5\u53caPLGF\uff0c\u4e0e\u5176\u4ed6\u51e0\u6b3e\u836f\u7269\u76f8\u6bd4\uff0c\u5176\u4f5c\u7528\u9776\u70b9\u66f4\u5e7f\u6cdb\uff0c\u80fd\u591f\u66f4\u6709\u6548\u5730\u8c03\u8282\u591a\u79cd\u8840\u7ba1\u751f\u6210\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4ed6\u4e09\u6b3e\u836f\u7269\u80fd\u6291\u5236VEGF-A\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4\u6b3e\u773c\u5e95\u75c5VEGF\u751f\u7269\u5236\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-29.png\" alt=\"\" class=\"wp-image-1124\" width=\"646\" height=\"627\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-29.png 990w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-29-300x291.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-29-768x746.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-29-880x854.png 880w\" sizes=\"auto, (max-width: 646px) 100vw, 646px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#4d0f87\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/07\/image-31-1024x760.png\" alt=\"\" class=\"wp-image-1126\" width=\"682\" 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