{"id":1134,"date":"2023-08-07T18:14:38","date_gmt":"2023-08-07T10:14:38","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1134"},"modified":"2023-08-07T18:15:58","modified_gmt":"2023-08-07T10:15:58","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9ctla-4%e6%8a%91%e5%88%b6%e5%89%82-%e4%bc%8a%e5%8c%b9%e6%9c%a8%e5%8d%95%e6%8a%97","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1134","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u514d\u75ab\u68c0\u67e5\u70b9CTLA-4\u6291\u5236\u5242 | \u4f0a\u5339\u6728\u5355\u6297\u3001\u66f2\u7f8e\u6728\u5355\u6297 | \u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7b49\u5b9e\u4f53\u7624"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5929\u4ecb\u7ecd\u4e24\u6b3e\u514d\u75ab\u68c0\u67e5\u70b9CTLA-4\u6291\u5236\u5242\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9038\u6c83\u00ae \u4f0a\u5339\u6728\u5355\u6297\uff08YERVOY\u00ae ipilimumab\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u7f8e\u56fd\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\uff08BMS\uff09\u5f00\u53d1\u30022011\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7b49\u5b9e\u4f53\u7624\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2021\u5e74\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\uff0c\u4e0eBMS\u81ea\u5bb6\u7684PD-1\u6291\u5236\u5242\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\uff0c\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u3001\u521d\u6cbb\u7684\u975e\u4e0a\u76ae\u6837\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>IMJUDO\u00ae tremelimumab\uff08\u66f2\u7f8e\u6728\u5355\u6297\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e5f\u662f\u4e00\u6b3eCTLA-4\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u7531\u963f\u65af\u5229\u5eb7\u516c\u53f8\uff08AZ\uff09\u5f00\u53d1\uff0c2022\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u3002\u4e5f\u4e0eAZ\u81ea\u5bb6\u7684PD-L1\u6291\u5236\u5242\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\uff0c\u6cbb\u7597\u809d\u7ec6\u80de\u764c\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u56fd\u5185\u5c1a\u672a\u4e0a\u5e02\uff0cAZ\u5b98\u7f512023\u5e74 4\u6708 07\u65e5\u7684\u4e00\u7bc7\u65b0\u95fb\u62a5\u9053\u4e2d\u547d\u540d\u4e3a\u66f2\u7f8e\u6728\u5355\u6297\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u63d0\u5230\u514d\u75ab\u68c0\u67e5\u70b9\uff0c\u4e0d\u5f97\u4e0d\u5148\u590d\u4e60\u4e0bT\u7ec6\u80de\u6fc0\u6d3b\u7684\u673a\u5236\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>T\u7ec6\u80de\u6fc0\u6d3b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1024x685.png\" alt=\"\" class=\"wp-image-1135\" width=\"634\" height=\"423\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1024x685.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-300x201.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-768x514.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1536x1027.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1218x815.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-880x589.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image.png 1776w\" sizes=\"auto, (max-width: 634px) 100vw, 634px\" \/><figcaption class=\"wp-element-caption\"><em>Theranostics . 2017 Aug 17;7(14):3504-3516.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">T\u7ec6\u80de\u7684\u6d3b\u5316\u8fc7\u7a0b\uff0c\u4e00\u822c\u9700\u8981\u901a\u8fc7\u4e09\u4e2a\u6fc0\u6d3b\u4fe1\u53f7\uff0c\u4ee5\u53ca\u4e00\u4e9b\u6291\u5236\u4fe1\u53f7\uff0c\u6765\u8c03\u8282\u5176\u514d\u75ab\u5e94\u7b54\u529f\u80fd\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e00\u4fe1\u53f7\uff1a<\/strong>T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u4e0e\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08\u5982\u6811\u7a81\u72b6\u7ec6\u80deDC\uff09\u4e0a\u7684\u6297\u539f\u7ed3\u5408\uff0c\u5f00\u59cb\u542f\u52a8\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e8c\u4fe1\u53f7\uff1a<\/strong>\u5373\u5171\u523a\u6fc0\u4fe1\u53f7\u3002\u5171\u523a\u6fc0\u4fe1\u53f7\u901a\u5e38\u6765\u81ea\u6297\u539f\u5448\u9012\u7ec6\u80de\u8868\u9762\u7684\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u4f8b\u5982B7\u5206\u5b50\u5bb6\u65cf(CD80\/86)\u4e0eCD28\u5206\u5b50\u5bb6\u65cf\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53ea\u6709\u5f53\u7b2c\u4e00\u4fe1\u53f7\u548c\u7b2c\u4e8c\u4fe1\u53f7\u540c\u65f6\u5b58\u5728\u65f6\uff0cT\u7ec6\u80de\u624d\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u5e76\u5f00\u59cb\u6269\u589e\u548c\u91ca\u653e\u7ec6\u80de\u56e0\u5b50\uff0c\u4ee5\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e09\u4fe1\u53f7\uff1a<\/strong>\u9664\u4e86\u7b2c\u4e00\u4fe1\u53f7\u548c\u7b2c\u4e8c\u4fe1\u53f7\u5916\uff0cT\u7ec6\u80de\u8fd8\u9700\u8981\u7b2c\u4e09\u4fe1\u53f7\uff0c\u5373\u7ec6\u80de\u56e0\u5b50\u4fe1\u53f7\uff0c\u6765\u5b9e\u73b0\u5b8c\u5168\u7684\u514d\u75ab\u5e94\u7b54\u3002\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u56e0\u5b50\u53ef\u4ee5\u8c03\u63a7T\u7ec6\u80de\u7684\u5206\u5316\u548c\u529f\u80fd\uff0c\u4f7f\u5176\u53d1\u6325\u4e0d\u540c\u7684\u514d\u75ab\u6548\u5e94\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5171\u6291\u5236\u4fe1\u53f7\uff1a<\/strong>\u5f53T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u4e0e\u6297\u539f\u7ed3\u5408\u5e76\u63a5\u6536\u5230\u7b2c\u4e00\u4fe1\u53f7\u540e\uff0c\u5982\u679c\u540c\u65f6\u53d7\u5230\u5171\u6291\u5236\u4fe1\u53f7\u7684\u4f5c\u7528\uff0cT\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u514d\u75ab\u5e94\u7b54\u4f1a\u53d7\u5230\u6291\u5236\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5171\u6291\u5236\u4fe1\u53f7\u662f\u4e00\u79cd\u81ea\u6211\u8c03\u8282\u673a\u5236\uff0c\u7528\u4e8e\u63a7\u5236\u548c\u5e73\u8861\u514d\u75ab\u5e94\u7b54\u7684\u5f3a\u5ea6\u548c\u6301\u7eed\u65f6\u95f4\u3002\u5b83\u9632\u6b62\u8fc7\u5ea6\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u907f\u514d\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u81ea\u8eab\u7ec4\u7ec7\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u751f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5171\u6291\u5236\u4fe1\u53f7\u7684\u4f5c\u7528\u4e3b\u8981\u901a\u8fc7\u5171\u6291\u5236\u53d7\u4f53\u5b9e\u73b0\uff0c\u6700\u4e3a\u5e38\u89c1\u7684\u5171\u6291\u5236\u53d7\u4f53\u662fCTLA-4\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f4\uff09\u548cPD-1\uff08\u7a0b\u5e8f\u6027\u6b7b\u4ea11\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CTLA-4\u6291\u5236T\u7ec6\u80de\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1-1024x524.png\" alt=\"\" class=\"wp-image-1137\" width=\"720\" height=\"367\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1-1024x524.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1-300x154.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-1-768x393.png 768w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><figcaption class=\"wp-element-caption\"><em>Crit Rev Oncol Hematol . 2017 Mar;111:1-6.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">CTLA-4\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f4\uff09\u548cCD28\u5728\u7ed3\u6784\u4e0a\u76f8\u4f3c\uff0c\u90fd\u662fT\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\uff0c\u4f46\u5b83\u4eec\u7684\u4f5c\u7528\u673a\u5236\u76f8\u53cd\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CD28\u662f\u5171\u523a\u6fc0\u53d7\u4f53\uff0c\u5f53\u5176\u4e0eB7\uff08CD80\/CD86\uff09\u7ed3\u5408\u65f6\uff0c\u4f1a\u63d0\u4f9b\u7b2c\u4e8c\u4fe1\u53f7\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\uff0c\u4ece\u800c\u52a0\u5f3a\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u800cCTLA-4\u662f\u5171\u6291\u5236\u53d7\u4f53\uff0c\u5f53\u5176\u4e0eB7\u7ed3\u5408\u65f6\uff0c\u4f1a\u63d0\u4f9b\u5171\u6291\u5236\u4fe1\u53f7\uff0c\u6291\u5236T\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\uff0c\u4ece\u800c\u9650\u5236\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8eCTLA-4\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5b83\u5728\u80bf\u7624\u751f\u7269\u5b66\u4e2d\u4e5f\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u67d0\u4e9b\u80bf\u7624\u7ec6\u80de\u53ef\u80fd\u5229\u7528CTLA-4\u7684\u5171\u6291\u5236\u4f5c\u7528\u6765\u9003\u907f\u514d\u75ab\u653b\u51fb\uff0c\u6291\u5236T\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u4ece\u800c\u9650\u5236\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4f0a\u5339\u6728\u5355\u6297\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-2.png\" alt=\"\" class=\"wp-image-1138\" width=\"504\" height=\"401\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-2.png 502w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-2-300x239.png 300w\" sizes=\"auto, (max-width: 504px) 100vw, 504px\" \/><figcaption class=\"wp-element-caption\"><em>Crit Rev Oncol Hematol . 2017 Mar;111:1-6.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u4f0a\u5339\u6728\u5355\u6297\u662f\u4e00\u79cdCTLA-4\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u901a\u8fc7\u963b\u65adCTLA-4\u901a\u8def\uff0c\u6062\u590dT\u7ec6\u80de\u7684\u7b2c\u4e8c\u4fe1\u53f7\uff0c\u589e\u52a0\u6d3b\u6027\u6548\u5e94T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u4ece\u800c\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u653b\u51fb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tremelimumab\uff08\u66f2\u7f8e\u6728\u5355\u6297\uff09\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u76f8\u6bd4\u4e0a\u5e02\u65f6\u95f4\u8f83\u665a\uff0c\u4f46\u662f\u4f5c\u7528\u9776\u70b9\u4e00\u81f4\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CTLA-4\u6291\u5236\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-3.png\" alt=\"\" class=\"wp-image-1139\" width=\"692\" height=\"453\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-3.png 926w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-3-300x197.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-3-768x503.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-3-880x577.png 880w\" sizes=\"auto, (max-width: 692px) 100vw, 692px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#51118d\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u4f0a\u5339\u6728\u5355\u6297\u56fd\u5185\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a\u8054\u5408\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u3001\u521d\u6cbb\u7684\u975e\u4e0a\u76ae\u6837\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" 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class=\"wp-block-paragraph\">\u80f8\u53e3\u7684\u80bf\u7624\uff0c\u4ee3\u8868\u56fd\u5185\u83b7\u6279\u7684\u9002\u5e94\u75c7\uff0c\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7b49\u6076\u6027\u80bf\u7624\u3002<\/p>\n\n\n\n<p 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