{"id":1144,"date":"2023-08-08T22:54:50","date_gmt":"2023-08-08T14:54:50","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1144"},"modified":"2023-08-08T22:54:51","modified_gmt":"2023-08-08T14:54:51","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-ctla-4%e8%9e%8d%e5%90%88%e8%9b%8b%e7%99%bd-%e9%98%bf%e5%b7%b4%e8%a5%bf%e6%99%ae%e3%80%81-belatacept-%e8%b4%9d%e6%8b%89%e8%a5%bf","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1144","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | CTLA-4\u878d\u5408\u86cb\u767d | \u963f\u5df4\u897f\u666e\u3001 belatacept \u8d1d\u62c9\u897f\u666e | \u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7b49\u81ea\u8eab\u514d\u75ab\u75c5"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>\u4e0a\u4e00\u7bc7\u4ecb\u7ecd\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6291\u5236T\u7ec6\u80de\u8868\u9762\u5171\u6291\u5236\u5206\u5b50CTLA-4\uff0c\u589e\u52a0T\u7ec6\u80de\u6d3b\u6027\uff0c\u4ece\u800c\u5b9e\u73b0\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u672c\u7bc7\u4ecb\u7ecd\u4e24\u6b3e\u836f\u7269\u4e5f\u5229\u7528CTLA-4\u9776\u70b9\uff0c\u4f46\u4f5c\u7528\u6548\u679c\u76f8\u53cd\u3002<\/p>\n\n\n\n<p>\u5c06CTLA-4\u5236\u5907\u6210\u878d\u5408\u86cb\u767d\u5f62\u5f0f\u7684\u6e38\u79bb\u53d7\u4f53\uff0c\u7528\u4e8e\u6291\u5236T\u7ec6\u80de\u8868\u9762\u7684B7\u7b2c\u4e8c\u4fe1\u53f7\u5206\u5b50\uff0c\u4ee5\u5b9e\u73b0T\u7ec6\u80de\u7684\u6291\u5236\uff0c\u7528\u4e8e\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/p>\n\n\n\n<p><strong>\u6069\u745e\u8212\u00ae \u963f\u5df4\u897f\u666e\uff08Orencia\u00ae Abatacept\uff09\uff1a<\/strong><\/p>\n\n\n\n<p>\u7531\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u516c\u53f8\u5f00\u53d1\u548c\u751f\u4ea7\u3002\u4e8e2005\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002\u56fd\u51852020\u5e74\u83b7\u6279\uff0c\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u3002<\/p>\n\n\n\n<p><strong>NULOJIX\u00ae belatacept\uff08\u8d1d\u62c9\u897f\u666e\uff09\uff1a<\/strong><\/p>\n\n\n\n<p>belatacept\uff08\u8d1d\u62c9\u897f\u666e\uff09\u4e5f\u662f\u7531BMS\u516c\u53f8\u5f00\u53d1\uff0c2011\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u9884\u9632\u80be\u79fb\u690d\u5668\u5b98\u6392\u65a5\u3002\u56fd\u5185\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p>\u56fd\u5185\u5eb7\u5b81\u6770\u745e\u516c\u53f8\u7684KN019\uff0c\u662fbelatacept\u7684\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u76ee\u524d\u5904\u4e8eII\u671f\u4e34\u5e8a\u9636\u6bb5\uff0cKN019\u7684\u4e2d\u6587\u540d\u4e3a\u8d1d\u62c9\u897f\u666e\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p><strong>T\u7ec6\u80de\u6fc0\u6d3b\u8fc7\u7a0b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-4.png\" alt=\"\" class=\"wp-image-1145\" width=\"559\" height=\"499\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-4.png 559w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-4-300x268.png 300w\" sizes=\"auto, (max-width: 559px) 100vw, 559px\" \/><figcaption class=\"wp-element-caption\">Nat Clin Pract Rheumatol . 2006 Dec;2(12):654-60.<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u524d\u7bc7\u4e2d\u5df2\u7ecf\u4ecb\u7ecd\uff0cT\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u4e0e\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08\u5982\u6811\u7a81\u72b6\u7ec6\u80deDC\uff09\u4e0a\u7684\u6297\u539f\u7ed3\u5408\uff0c\u542f\u52a8\u7b2c\u4e00\u4fe1\u53f7\u3002<\/p>\n\n\n\n<p>T\u7ec6\u80de\u8868\u9762\u8fd8\u5b58\u5728\u5171\u523a\u6fc0\u53d7\u4f53\uff0c\u5982CD28\uff0c\u548c\u6297\u539f\u9012\u5448\u7ec6\u80de\u8868\u9762\u7684\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u5982B7\u5206\u5b50\u5bb6\u65cf(CD80\/86)\u76f8\u4e92\u4f5c\u7528\uff0c\u542f\u52a8\u7b2c\u4e8c\u4fe1\u53f7\u3002<\/p>\n\n\n\n<p>\u53ea\u6709\u5f53\u7b2c\u4e00\u4fe1\u53f7\u548c\u7b2c\u4e8c\u4fe1\u53f7\u540c\u65f6\u5b58\u5728\u65f6\uff0cT\u7ec6\u80de\u624d\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u5e76\u5f00\u59cb\u6269\u589e\u548c\u91ca\u653e\u7ec6\u80de\u56e0\u5b50\uff0c\u4ee5\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p>\u53e6\u5916\uff0cT\u7ec6\u80de\u8868\u9762\u8fd8\u5b58\u5728\u5171\u6291\u5236\u53d7\u4f53\uff0c\u6700\u4e3a\u5e38\u89c1\u7684\u5171\u6291\u5236\u53d7\u4f53\u662fCTLA-4\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f4\uff09\u548cPD-1\uff08\u7a0b\u5e8f\u6027\u6b7b\u4ea11\uff09\u3002<\/p>\n\n\n\n<p>\u5982CTLA-4\u4e0eB7(CD80\/86)\u7ed3\u5408\u542f\u52a8\u6291\u5236\u4fe1\u53f7\uff0cT\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u514d\u75ab\u5e94\u7b54\u4f1a\u53d7\u5230\u6291\u5236\u3002<\/p>\n\n\n\n<p>\u963f\u5df4\u897f\u666e\u7684\u7ed3\u6784<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-5-1024x595.png\" alt=\"\" class=\"wp-image-1146\" width=\"702\" height=\"408\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-5-1024x595.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-5-300x174.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-5-768x446.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-5-880x511.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-5.png 1048w\" sizes=\"auto, (max-width: 702px) 100vw, 702px\" \/><\/figure>\n<\/div>\n\n\n<p>\u963f\u5df4\u897f\u666e\u662f\u4e00\u79cd\u53ef\u6eb6\u6027\u878d\u5408\u86cb\u767d\uff0c\u5b83\u7531\u4e24\u90e8\u5206\u7ec4\u6210\uff1a<\/p>\n\n\n\n<p>\u4e0a\u534a\u90e8\u5206\u4e3aT\u7ec6\u80de\u8868\u9762\u7684CTLA-4\u53d7\u4f53\uff0c\u7528\u4e8e\u8c03\u8282T\u7ec6\u80de\u7684\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n<p>\u4e0b\u534a\u90e8\u5206\u4e3aIgG1\u6297\u4f53\u7684Fc\u90e8\u5206\uff0c\u7528\u4e8e\u589e\u52a0\u836f\u7269\u7684\u534a\u8870\u671f\u548c\u7a33\u5b9a\u6027\u3002<\/p>\n\n\n\n<p><strong>\u963f\u5df4\u897f\u666e\u7684\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-6.png\" alt=\"\" class=\"wp-image-1147\" width=\"668\" height=\"388\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-6.png 898w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-6-300x174.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-6-768x446.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-6-880x512.png 880w\" sizes=\"auto, (max-width: 668px) 100vw, 668px\" \/><figcaption class=\"wp-element-caption\"><em>Nat Clin Pract Rheumatol . 2006 Dec;2(12):654-60.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u6291\u5236CTLA-4\uff0c\u4ece\u800c\u6fc0\u6d3b\u514d\u75ab\u4e0d\u540c\uff0c\u963f\u5df4\u897f\u666e\u7ed3\u6784\u7684\u4e0a\u534a\u90e8\u5206\u5c31\u662fT\u7ec6\u80de\u8868\u9762\u7684CTLA-4\uff0c\u56e0\u6b64\u80fd\u53d1\u6325CTLA-4\u7684\u529f\u80fd\uff0c\u4e0eAPC\u8868\u9762\u7684B7\uff08CD80\/CD86)\u7ed3\u5408\uff0c\u963b\u65adCD28\u7684\u7b2c\u4e8c\u4fe1\u53f7\uff0c\u6291\u5236T\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\u53ef\u4ee5\u7528\u6765\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff0c\u5982\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09\u548c\u94f6\u5c51\u75c5\u5173\u8282\u708e\uff08PsA\uff09\u7b49\u3002<\/p>\n\n\n\n<p>\u4f53\u5916\u8bd5\u9a8c\u4e2d\uff0c\u963f\u5df4\u897f\u666e\u8fd8\u53ef\u51cf\u5c11T\u7ec6\u80de\u589e\u6b96\uff0c\u6291\u5236TNF\u03b1\u3001\u5e72\u6270\u7d20-\u03b3\u3001\u767d\u4ecb\u7d20-2\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u3002<\/p>\n\n\n\n<p>Belatacept\uff08\u8d1d\u62c9\u897f\u666e\uff09<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-7-1024x665.png\" alt=\"\" class=\"wp-image-1148\" width=\"666\" height=\"432\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-7-1024x665.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-7-300x195.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-7-768x499.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-7-880x572.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-7.png 1219w\" sizes=\"auto, (max-width: 666px) 100vw, 666px\" \/><figcaption class=\"wp-element-caption\"><em>Transplantation . 2009 Mar 27;87(6):926-33.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>Belatacept\uff08\u8d1d\u62c9\u897f\u666e\uff09\u662f\u963f\u5df4\u897f\u666e\u7684\u6539\u8fdb\u7248\u672c\uff0c\u4e24\u8005\u4ec5\u76f8\u5dee2\u4e2a\u6c28\u57fa\u9178\uff0c\u4f46\u5176\u6d3b\u6027\u76f8\u5f53\u4e8e\u963f\u5df4\u897f\u666e\u768410\u500d\uff0c\u80fd\u6709\u6548\u5730\u963b\u65adCD28\u4ecb\u5bfc\u7684T\u7ec6\u80de\u5171\u523a\u6fc0\u4fe1\u53f7\u4f20\u9012\u3002<\/p>\n\n\n\n<p>\u5728\u9884\u9632\u80be\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u65b9\u9762\uff0cbelatacept\uff08\u8d1d\u62c9\u897f\u666e\uff09\u663e\u793a\u51fa\u6bd4\u963f\u5df4\u897f\u666e\u66f4\u663e\u8457\u7684\u6548\u679c\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><strong>CTLA-4\u878d\u5408\u86cb\u767dFDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-8-1024x432.png\" alt=\"\" class=\"wp-image-1149\" width=\"626\" height=\"264\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-8-1024x432.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-8-300x127.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-8-768x324.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-8-1218x514.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-8-880x372.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-8.png 1272w\" sizes=\"auto, (max-width: 626px) 100vw, 626px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#49157a\" 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