{"id":1156,"date":"2023-08-21T16:11:02","date_gmt":"2023-08-21T08:11:02","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1156"},"modified":"2023-08-21T16:15:36","modified_gmt":"2023-08-21T08:15:36","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9pd-1-pd-l1%e6%8a%91%e5%88%b6%e5%89%82-%e5%b8%95%e5%8d%9a%e5%88%a9%e7%8f%a0%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1156","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u514d\u75ab\u68c0\u67e5\u70b9PD-1\/PD-L1\u6291\u5236\u5242 | \u5e15\u535a\u5229\u73e0\uff0c\u7eb3\u6b66\u5229\u5c24\uff0c\u963f\u66ff\u5229\u73e0\uff0c\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u7b49 | \u5404\u79cd\u80bf\u7624"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

\u524d\u4e24\u7bc7\u4ecb\u7ecd\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242CTLA-4\uff0c\u63a5\u4e0b\u6765\u662f\u53e6\u5916\u4e00\u7c7b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u5927\u540d\u9f0e\u9f0e\u7684PD-1\u548cPD-L1\u3002<\/p>\n\n\n\n

\u514d\u75ab\u6cbb\u7597\u662f\u5f53\u4e0b\u764c\u75c7\u6cbb\u7597\u7684\u70ed\u70b9\uff0c\u56fd\u5185\u5916\u5404\u5bb6\u533b\u836f\u516c\u53f8\u591a\u6709\u5e03\u5c40\uff0c\u4e3b\u8981\u5305\u62ec\uff1a<\/p>\n\n\n\n

PD-1\uff1a<\/strong><\/p>\n\n\n\n

\u53ef\u745e\u8fbe\u00ae \u5e15\u535a\u5229\u73e0\u5355\u6297\uff08KEYTRUDA\u00ae pembrolizumab\uff09\uff1a<\/em><\/strong><\/p>\n\n\n\n

\u7531\u9ed8\u6c99\u4e1c\u516c\u53f8\uff08Merck & Co., Inc.\uff09\u5f00\u53d1\uff0c\u4e8e2014\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u56fd\u51852018\u5e74\u4e0a\u5e02\u3002<\/p>\n\n\n\n

\u6b27\u72c4\u6c83\u00ae \u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08OPDIVO\u00ae nivolumab\uff09\uff1a<\/em><\/strong><\/p>\n\n\n\n

\u7531\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\uff08Bristol-Myers Squibb\uff09\u516c\u53f8\u5f00\u53d1\uff0c\u4e8e2014\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u56fd\u51852018\u5e74\u4e0a\u5e02\u3002<\/p>\n\n\n\n

LIBTAYO\u00ae cemiplimab<\/em><\/strong><\/p>\n\n\n\n

\u8d5b\u8bfa\u83f2\u516c\u53f8\u4ea7\u54c1\uff0c2018\u5e74\u83b7\u5f97FDA\u6279\u51c6\uff0c\u56fd\u5185\u6682\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

JEMPERLI\u00ae dostarlimab<\/em><\/strong><\/p>\n\n\n\n

GSK\u516c\u53f8\u4ea7\u54c1\uff0c2021\u5e74\u83b7\u5f97FDA\u6279\u51c6\uff0c\u56fd\u5185\u6682\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

ZYNYZ\u00ae retifanlimab<\/em><\/strong><\/p>\n\n\n\n

Incyte\u516c\u53f8\u4ea7\u54c1\uff0c2023\u5e74\u83b7\u5f97FDA\u6279\u51c6\uff0c\u56fd\u5185\u6682\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

PD-L1<\/strong><\/p>\n\n\n\n

\u6cf0\u5723\u5947\u00ae \u963f\u66ff\u5229\u73e0\u5355\u6297\uff08TECENTRIQ\u00ae atezolizumab\uff09\uff1a<\/em><\/strong><\/p>\n\n\n\n

\u7f57\u6c0f\uff08Roche\uff09\u516c\u53f8\u5f00\u53d1\uff0c\u4e8e2016\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u56fd\u51852020\u5e74\u4e0a\u5e02\u3002<\/p>\n\n\n\n

\u82f1\u98de\u51e1\u00ae \u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff08IMFINZI\u00ae durvalumab\uff09\uff1a<\/em><\/strong><\/p>\n\n\n\n

\u963f\u65af\u5229\u5eb7\uff08AZ\uff09\u516c\u53f8\u5f00\u53d1\uff0c\u4e8e2017\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u56fd\u51852019\u5e74\u4e0a\u5e02\u3002<\/p>\n\n\n\n

BAVENCIO\u00ae avelumab<\/em><\/strong><\/p>\n\n\n\n

\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\uff08Merck Serono\uff09\u5f00\u53d1\uff0c\u4e8e2017\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u56fd\u5185\u6682\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

\u53e6\u5916\u8fd8\u6709\u5927\u91cf\u7684\u56fd\u4ea7PD-1\uff0cPD-L1\u6291\u5236\u5242\uff0c\u7531\u4e8e\u5c1a\u672a\u5728FDA\u83b7\u6279\uff0c\u8fd9\u91cc\u4e0d\u518d\u5c55\u5f00\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

\u590d\u4e60\u4e00\u4e0b\u524d\u7bc7\u4e2d\u4ecb\u7ecd\u8fc7\u7684\uff0cT\u7ec6\u80de\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u4fe1\u53f7\u4f20\u5bfc\uff1a<\/p>\n\n\n\n

T\u7ec6\u80de\u6fc0\u6d3b\u4fe1\u53f7\u4f20\u5bfc<\/strong><\/p>\n\n\n

\n
\"\"
Theranostics . 2017 Aug 17;7(14):3504-3516.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

T\u7ec6\u80de\u7684\u6d3b\u5316\u8fc7\u7a0b\uff0c\u4e00\u822c\u9700\u8981\u901a\u8fc7\u6fc0\u6d3b\u4fe1\u53f7\uff0c\u4ee5\u53ca\u6291\u5236\u4fe1\u53f7\uff0c\u5171\u540c\u8c03\u8282\u5176\u514d\u75ab\u5e94\u7b54\u529f\u80fd\u3002<\/p>\n\n\n\n

\u7b2c\u4e00\u4fe1\u53f7\uff1a<\/strong>T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u4e0e\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08\u5982\u6811\u7a81\u72b6\u7ec6\u80deDC\uff09\u4e0a\u7684\u6297\u539f\u7ed3\u5408\uff0c\u5f00\u59cb\u542f\u52a8\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n

\u7b2c\u4e8c\u4fe1\u53f7\uff1a<\/strong>\u5373\u5171\u523a\u6fc0\u4fe1\u53f7\u3002\u5171\u523a\u6fc0\u4fe1\u53f7\u901a\u5e38\u6765\u81ea\u6297\u539f\u5448\u9012\u7ec6\u80de\u8868\u9762\u7684\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u4f8b\u5982B7\u5206\u5b50\u5bb6\u65cf(CD80\/86)\u4e0eCD28\u5206\u5b50\u5bb6\u65cf\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u53ea\u6709\u5f53\u7b2c\u4e00\u4fe1\u53f7\u548c\u7b2c\u4e8c\u4fe1\u53f7\u540c\u65f6\u5b58\u5728\u65f6\uff0cT\u7ec6\u80de\u624d\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u5e76\u5f00\u59cb\u6269\u589e\u548c\u91ca\u653e\u7ec6\u80de\u56e0\u5b50\uff0c\u4ee5\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n\n\n\n

\u7b2c\u4e09\u4fe1\u53f7\uff1a<\/strong>\u9664\u4e86\u7b2c\u4e00\u4fe1\u53f7\u548c\u7b2c\u4e8c\u4fe1\u53f7\u5916\uff0cT\u7ec6\u80de\u8fd8\u9700\u8981\u7b2c\u4e09\u4fe1\u53f7\uff0c\u5373\u7ec6\u80de\u56e0\u5b50\u4fe1\u53f7\uff0c\u6765\u5b9e\u73b0\u5b8c\u5168\u7684\u514d\u75ab\u5e94\u7b54\u3002\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u56e0\u5b50\u53ef\u4ee5\u8c03\u63a7T\u7ec6\u80de\u7684\u5206\u5316\u548c\u529f\u80fd\uff0c\u4f7f\u5176\u53d1\u6325\u4e0d\u540c\u7684\u514d\u75ab\u6548\u5e94\u3002<\/p>\n\n\n\n

\u5171\u6291\u5236\u4fe1\u53f7\uff1a<\/strong>\u5171\u6291\u5236\u4fe1\u53f7\u662f\u4e00\u79cd\u81ea\u6211\u8c03\u8282\u673a\u5236\uff0c\u7528\u4e8e\u63a7\u5236\u548c\u5e73\u8861\u514d\u75ab\u5e94\u7b54\u7684\u5f3a\u5ea6\u548c\u6301\u7eed\u65f6\u95f4\u3002\u5b83\u9632\u6b62\u8fc7\u5ea6\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u907f\u514d\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u81ea\u8eab\u7ec4\u7ec7\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u751f\u3002<\/p>\n\n\n\n

\u5171\u6291\u5236\u4fe1\u53f7\u7684\u4f5c\u7528\u4e3b\u8981\u901a\u8fc7\u5171\u6291\u5236\u53d7\u4f53\u5b9e\u73b0\uff0c\u6700\u4e3a\u5e38\u89c1\u7684\u5171\u6291\u5236\u53d7\u4f53\u662fCTLA-4\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f4\uff09\u548cPD-1\uff08\u7a0b\u5e8f\u6027\u6b7b\u4ea11\uff09\u3002<\/p>\n\n\n\n

PD-1\u3001PD-L1\u6291\u5236\u5242\u4f5c\u7528\u673a\u5236<\/p>\n\n\n

\n
\"\"
Cancers (Basel) . 2020 Jul 7;12(7):1826.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

T\u7ec6\u80de\u8868\u8fbe\u7684PD-1\u53d7\u4f53\uff0c\u901a\u8fc7\u4e0e\u5176\u914d\u4f53PD-L1\u3001PD-L2\u7ed3\u5408\uff0c\u53ef\u4ee5\u6291\u5236T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u7ec6\u80de\u56e0\u5b50\u751f\u6210\u3002<\/p>\n\n\n\n

\u67d0\u4e9b\u80bf\u7624\u7ec6\u80de\u4e0a\u8c03\u8868\u8fbePD-1\u914d\u4f53\uff0c\u901a\u8fc7\u8fd9\u4e00\u4fe1\u53f7\u901a\u8def\uff0c\u53ef\u4ee5\u6291\u5236\u6fc0\u6d3b\u72b6\u6001\u7684T\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u76d1\u89c6\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u5982\u5e15\u535a\u5229\u73e0\u5355\u6297\u662f\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u591f\u4e0ePD-1\u53d7\u4f53\u7ed3\u5408\uff0c\u963b\u65adPD-1\u4e0ePD-L1\u3001PD-L2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u89e3\u9664PD-1\u901a\u8def\u4ecb\u5bfc\u7684\u514d\u75ab\u5e94\u7b54\u6291\u5236\uff0c\u5305\u62ec\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u5728\u5c0f\u9f20\u540c\u6e90\u7684\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u963b\u65adPD-1\u6d3b\u6027\u663e\u793a\u51fa\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u6548\u679c\u3002<\/p>\n\n\n\n

\u963b\u65adPD-L1\u7684\u836f\u7269\u5982\u963f\u66ff\u5229\u73e0\u5355\u6297\u7b49\uff0c\u901a\u8fc7\u4e0ePD-L1\u7ed3\u5408\uff0c\u540c\u6837\u963b\u65adPD-1\u4e0ePD-L1\u3001PD-L2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8d77\u5230\u540c\u6837\u7684\u6548\u679c\u3002<\/p>\n\n\n\n

2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

\u514d\u75ab\u6cbb\u7597\u7684\u6838\u5fc3\u601d\u60f3\u662f\u91cd\u65b0\u6fc0\u6d3b\u673a\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u62b5\u6297\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n

\u56e0\u6b64\u514d\u75ab\u6cbb\u7597\u7406\u8bba\u4e0a\u53ef\u4ee5\u4e0d\u9650\u764c\u79cd\uff0c\u8bc6\u522b\u5e76\u653b\u51fb\u591a\u79cd\u80bf\u7624\u7ec6\u80de\uff0c\u8fbe\u5230\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u6269\u6563\u7684\u76ee\u7684\u3002<\/p>\n\n\n\n

\u73b0\u5c06\u622a\u6b622023\u5e748\u670821\u65e5\uff0cFDA\u5df2\u7ecf\u83b7\u6279\u7684PD-1\u548cPD-L1\u836f\u7269\u7684\u9002\u5e94\u75c7\u603b\u7ed3\u5982\u4e0b\uff1a<\/p>\n\n\n\n

PD-1\u6291\u5236\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

PD-L1\u6291\u5236\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
\n
\"\"
\u6709\u4eba\u53c2\u52a0\u6d3e\u5bf9\uff0c\u4e70\u4e86\u4e00\u624b\u5e15\u7684\u73bb\u7483\u73e0\uff0c\u62ff\u8d77\u6765\u4e00\u770b\uff0c\u5168\u662fA\u8d27\uff0c\u53ea\u80fd\u7533\u8bf77\u5929\u65e0\u7406\u7531\u9000\u6b3e\u3002<\/figcaption><\/figure>\n<\/div>\n\n
\n
\"\"
\u6d3e\u5bf9\u4e2d\u6709\u4eba\u7ad9\u7acb\u4f4f\u201c\u963f\u568f\u201d\uff0c\u6709\u4eba\u76f4\u63a5\u4e2d\u6bd2\uff0c\u539f\u6765\u662f\u5403\u4e86\u5e26\u6bd2\u7684\u597d\u4e3d\u53cb\u6d3e\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

\u53c2\u52a0\u6d3e\u5bf9\u4ee3\u8868PD-1\u3001PD-L1\u3002<\/p>\n\n\n\n

\u56fe\u4e00\u4e2d\u624b\u5e15<\/strong>\u4e0a\u7684\u73bb\u7483\u73e0<\/strong>\uff0c\u4ee3\u8868\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u62ff<\/strong>\u8d77\u6765\u540e\u65e0\u7406\u7531<\/strong>\u9000\u6b3e\uff0c\u4ee3\u8868\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u3002<\/p>\n\n\n\n

\u56fe\u4e8c\u4e2d\u201c\u963f\u568f\u201d\u6253\u562d\u6d95\u7ad9\u7acb\u4f4f<\/strong>\u7684\u4eba\u4ee3\u8868\u963f\u66ff\u5229\u73e0\u5355\u6297\uff0c\u6342\u7740\u809a\u5b50\u6bd2\u53d1<\/strong>\u548c\u540e\u9762\u7684\u597d\u4e3d\u53cb<\/strong>\uff0c\u4ee3\u8868\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u3002<\/p>\n\n\n\n

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