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LARTRUVO\u00ae olaratumab \u662f\u4e00\u79cd\u7531Eli Lilly and Company\uff08\u793c\u6765\u516c\u53f8\uff09\u5f00\u53d1\u7684\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u03b1\uff08PDGFR\u03b1\uff09\u6291\u5236\u5242\uff0c2016\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6f\u7ec4\u7ec7\u8089\u7624\u3002<\/p>\n\n\n\n

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\u56fd\u5185\u4e00\u4e9b\u6587\u732e\u4e2d\u5c06Olaratumab\u547d\u540d\u4e3a\u5965\u62c9\u5355\u6297\u3002\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

PDGF\u7684\u4f5c\u7528<\/strong><\/p>\n\n\n

\n
\"\"
P T . 2018 May;43(5):267-270.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

\u4e0eEGFR\u7c7b\u4f3c\uff0cPDGFR\u4e5f\u5c5e\u4e8e\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u662f\u4e00\u79cd\u7ec6\u80de\u8868\u9762\u53d7\u4f53\uff0c\u5b83\u5728\u7ec6\u80de\u751f\u957f\u3001\u5206\u5316\u548c\u4fee\u590d\u8fc7\u7a0b\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u4e3b\u8981\u4f5c\u7528\u5305\u62ec\uff1a<\/p>\n\n\n\n

\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff1a<\/strong>PDGFR\u662f\u4e00\u79cd\u4f4d\u4e8e\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5206\u4e3a\u03b1\u548c\u03b2\u4e24\u79cd\u4e9a\u578b\uff0c\u5373PDGFR\u03b1\u548cPDGFR\u03b2\u3002\u8fd9\u4e9b\u53d7\u4f53\u7684\u6fc0\u6d3b\u662f\u901a\u8fc7\u4e0e\u8840\u5c0f\u677f\u6e90\u751f\u957f\u56e0\u5b50\uff08PDGF A\u2013D\uff09\u5bb6\u65cf\u7684\u914d\u4f53\u7ed3\u5408\u800c\u5b9e\u73b0\u7684\u3002<\/p>\n\n\n\n

PDGF\/PDGFR\u4fe1\u53f7\u901a\u8def\uff1a<\/strong>PDGF\/PDGFR\u4fe1\u53f7\u901a\u8def\u5728\u591a\u79cd\u751f\u7406\u548c\u75c5\u7406\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u5b83\u5728\u6b63\u5e38\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5206\u5316\u548c\u751f\u957f\u3001\u8840\u7ba1\u751f\u6210\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u7b49\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u5bf9\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u5f71\u54cd<\/strong>\uff1aPDGF\/PDGFR\u4fe1\u53f7\u901a\u8def\u5bf9\u4e8e\u6b63\u5e38\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u5206\u5316\u548c\u751f\u957f\u81f3\u5173\u91cd\u8981\u3002\u8fd9\u610f\u5473\u7740\u5b83\u5728\u7ef4\u6301\u7ec4\u7ec7\u7684\u7a33\u6001\u548c\u4fee\u590d\u53d7\u635f\u7ec4\u7ec7\u65b9\u9762\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u5bf9\u8840\u7ba1\u751f\u6210\u548c\u4f24\u53e3\u6108\u5408\u7684\u5f71\u54cd\uff1a<\/strong>PDGF\/PDGFR\u4fe1\u53f7\u901a\u8def\u8fd8\u5728\u8840\u7ba1\u751f\u6210\u548c\u4f24\u53e3\u6108\u5408\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u5b83\u4fc3\u8fdb\u4e86\u65b0\u8840\u7ba1\u7684\u5f62\u6210\uff0c\u8fd9\u5bf9\u4e8e\u53d7\u635f\u7ec4\u7ec7\u7684\u4fee\u590d\u548c\u4f24\u53e3\u6108\u5408\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n

Olaratumab\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

Olaratumab\u662f\u4e00\u79cd\u5168\u4eba\u6e90IgG1\u5355\u514b\u9686\u6297\u4f53\uff0c\u5177\u6709\u9ad8\u4eb2\u548c\u529b\u7ed3\u5408\u4ebaPDGFR\u03b1\u5e76\u963b\u65adPDGFs\uff08\u8840\u5c0f\u677f\u6e90\u6027\u751f\u957f\u56e0\u5b50\uff09\u5982PDGF-AA\u3001PDGF-BB\u548cPDGF-CC\u914d\u4f53\u4e0e\u53d7\u4f53\u7684\u7ed3\u5408\u3002<\/p>\n\n\n\n

PDGFR\u03b1\u548cPDGFs\u7684\u5171\u8868\u8fbe\u5bfc\u81f4\u81ea\u5206\u6ccc\u4ecb\u5bfc\u7684\u7ec6\u80de\u751f\u957f\uff0c\u4e0e\u8089\u7624\u548c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6709\u5173\u3002PDGFR\u03b1\u5728\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u8868\u8fbe\uff0c\u5176\u5f02\u5e38\u6fc0\u6d3b\u53ef\u80fd\u4fc3\u8fdb\u764c\u75c7\u7684\u53d1\u5c55\u548c\u6269\u6563\u3002<\/p>\n\n\n\n

2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

\u5361\u666e\u8d5b\u73e0\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/p>\n\n\n\n

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<\/p>\n\n\n\n

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\n
\"\"<\/figure>\n<\/div>\n\n\n

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