{"id":1192,"date":"2023-08-28T17:13:29","date_gmt":"2023-08-28T09:13:29","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1192"},"modified":"2023-08-28T17:13:30","modified_gmt":"2023-08-28T09:13:30","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-nectin-4-adc-enfortumab-vedotin-%e7%bb%b4%e6%81%a9%e5%a6%a5%e5%b0%a4%e5%8d%95%e6%8a%97-%e5%b0%bf%e8%b7%af%e4%b8%8a%e7%9a%ae","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1192","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | Nectin-4 ADC | Enfortumab vedotin \u7ef4\u6069\u59a5\u5c24\u5355\u6297 | \u5c3f\u8def\u4e0a\u76ae\u764c"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

Nectin-4\uff0c\u4e5f\u79f0\u4e3aPVRL4\uff0c\u662f\u4e00\u79cd\u7ec6\u80de\u9ecf\u9644\u86cb\u767d\uff0c\u5c5e\u4e8enectin\u5bb6\u65cf\u3002\u5b83\u5728\u7ec6\u80de\u95f4\u9ecf\u9644\u3001\u4fe1\u53f7\u4f20\u5bfc\u548c\u7ec6\u80de-\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

PADCEV\u00ae enfortumab vedotin \u7ef4\u6069\u59a5\u5c24\u5355\u6297\uff1a<\/strong><\/p>\n\n\n\n

\u76ee\u524d\u552f\u4e00\u4e0a\u5e02\u7684Nectin-4 ADC\u751f\u7269\u5236\u5242\uff0c\u7531\u5b89\u65af\u6cf0\u6765\uff08Astellas\uff09\u516c\u53f8\u7814\u53d1\u3002<\/p>\n\n\n\n

2019\u5e7412\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u76d1\u7763\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86enfortumab vedotin\u7684\u4f7f\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n

\u56fd\u5185\u836f\u7269\u5c1a\u672a\u4e0a\u5e02\uff0c2023\u5e74\u516c\u53f8\u5411CDE\u5b98\u7f51\u9012\u4ea4\u7684\u7533\u62a5\u6750\u6599\u4e2d\uff08JXSS2300022\uff09\uff0c\u4e2d\u6587\u540d\u4e3a\u7ef4\u6069\u59a5\u5c24\u5355\u6297\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

Nectin-4\u7684\u5206\u5b50\u7ed3\u6784\u4e3b\u8981\u5305\u62ec\u4ee5\u4e0b\u90e8\u5206\uff1a<\/p>\n\n\n\n

Nectin-4\u7684\u5206\u5b50\u7ed3\u6784<\/p>\n\n\n

\n
\"\"
Int J Oncol . 2021 Nov;59(5):93.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

\u80de\u5916\u7ed3\u6784\uff1a<\/strong><\/p>\n\n\n\n

Nectin-4\u7684\u80de\u5916\u7ed3\u6784\u5305\u62ec\u591a\u4e2a\u7ed3\u6784\u57df\uff0c\u5176\u4e2d\u6700\u91cd\u8981\u7684\u662fIg-like\uff08\u514d\u75ab\u7403\u86cb\u767d\u6837\uff09\u7ed3\u6784\u57df\u3002\u8fd9\u4e9b\u7ed3\u6784\u57df\u6709\u52a9\u4e8eNectin-4\u4e0e\u76f8\u90bb\u7ec6\u80de\u4e0a\u7684\u5176\u4ed6\u9ecf\u9644\u86cb\u767d\u6216\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u4ecb\u5bfc\u7ec6\u80de\u95f4\u7684\u9ecf\u9644\u3002Nectin-4\u901a\u5e38\u6709\u4e09\u4e2aIg-like\u7ed3\u6784\u57df\u3002<\/p>\n\n\n\n

\u80de\u5185\u7ed3\u6784\uff1a<\/strong><\/p>\n\n\n\n

Nectin-4\u7684\u80de\u5185\u7ed3\u6784\u5305\u62ec\u77ed\u80de\u5185\u533a\u57df\uff0c\u5b83\u4e0e\u7ec6\u80de\u5185\u4fe1\u53f7\u4f20\u5bfc\u4f19\u4f34\u5982Afadin\u7ed3\u5408\u3002\u8fd9\u4e9b\u7ed3\u5408\u6709\u52a9\u4e8e\u4f20\u9012\u4fe1\u53f7\uff0c\u5f71\u54cd\u7ec6\u80de\u7684\u529f\u80fd\u548c\u884c\u4e3a\u3002<\/p>\n\n\n\n

\u8de8\u819c\u7ed3\u6784\uff1a<\/strong><\/p>\n\n\n\n

Nectin-4\u662f\u4e00\u79cd\u8de8\u819c\u86cb\u767d\uff0c\u5b83\u7684\u8de8\u819c\u533a\u57df\u5c06\u80de\u5916\u7ed3\u6784\u57df\u4e0e\u80de\u5185\u7ed3\u6784\u57df\u8fde\u63a5\u5728\u4e00\u8d77\u3002<\/p>\n\n\n\n

\u7cd6\u57fa\u5316\u4fee\u9970\uff1a<\/strong><\/p>\n\n\n\n

Nectin-4\u901a\u5e38\u4f1a\u7ecf\u5386\u7cd6\u57fa\u5316\u4fee\u9970\uff0c\u8fd9\u662f\u5728\u5206\u5b50\u8868\u9762\u6dfb\u52a0\u7cd6\u5206\u5b50\u7684\u8fc7\u7a0b\u3002\u8fd9\u4e9b\u7cd6\u57fa\u53ef\u4ee5\u5f71\u54cd\u5176\u5728\u7ec6\u80de\u9ecf\u9644\u548c\u4fe1\u53f7\u4f20\u5bfc\u4e2d\u7684\u529f\u80fd\u3002<\/p>\n\n\n\n

\u603b\u7684\u6765\u8bf4\uff0cNectin-4\u7684\u5206\u5b50\u7ed3\u6784\u7531\u591a\u4e2a\u529f\u80fd\u6027\u57df\u7ec4\u6210\uff0c\u8fd9\u4e9b\u57df\u4f7f\u5176\u80fd\u591f\u5728\u7ec6\u80de\u95f4\u9ecf\u9644\u3001\u4fe1\u53f7\u4f20\u5bfc\u548c\u4e0e\u5176\u4ed6\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u8fd9\u79cd\u590d\u6742\u7684\u5206\u5b50\u7ed3\u6784\u4f7fNectin-4\u6210\u4e3a\u4e86\u5728\u7ec6\u80de\u9ecf\u9644\u548c\u7ec6\u80de\u95f4\u901a\u4fe1\u4e2d\u7684\u91cd\u8981\u89d2\u8272\u3002<\/p>\n\n\n\n

Nectin-4\u7684\u4f5c\u7528\u673a\u5236<\/p>\n\n\n

\n
\"\"
Int J Oncol . 2021 Nov;59(5):93.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

Nectin\u5728\u7ec6\u80de\u95f4\u9ecf\u9644\u7ed3\u6784\u5f62\u6210\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u76f8\u5173\u7684\u4fe1\u53f7\u4f20\u5bfc\u3002\u4e3b\u8981\u5305\u62ec\uff1a<\/p>\n\n\n\n

Nectin\u8bf1\u5bfc\u7684\u4fe1\u53f7\u4f20\u5bfc\uff1a<\/strong>Nectin\u662f\u7ec6\u80de\u8868\u9762\u7684\u86cb\u767d\u8d28\uff0c\u5b83\u5728\u7ec6\u80de\u95f4\u9ecf\u9644\u7ed3\u6784\u7684\u5f62\u6210\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002Nectin\u901a\u8fc7\u4e0e\u5176\u4ed6\u7ec6\u80de\u4e0a\u7684Nectin\u76f8\u4e92\u4f5c\u7528\uff0c\u4ecb\u5bfc\u4e86\u7ec6\u80de\u4e4b\u95f4\u7684\u9ecf\u9644\u3002<\/p>\n\n\n\n

\u521d\u6b65\u7ec6\u80de\u95f4\u9ecf\u9644\u6b65\u9aa4\uff1a<\/strong>Nectin\u5728\u7ec6\u80de\u95f4\u9ecf\u9644\u7ed3\u6784\u7684\u5f62\u6210\u7684\u521d\u6b65\u6b65\u9aa4\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u4e00\u65e6\u7ec6\u80de\u4e4b\u95f4\u7684Nectin\u76f8\u4e92\u4f5c\u7528\u5efa\u7acb\uff0c\u9ecf\u9644\u590d\u5408\u7269\u4f1a\u88ab\u62db\u52df\u5230\u76f8\u5e94\u7684\u7c98\u9644\u4f4d\u70b9\u4e0a\u3002<\/p>\n\n\n\n

\u4fe1\u53f7\u4f20\u5bfc\u590d\u5408\u7269\u7684\u4f5c\u7528\uff1a\u5728\u7ec6\u80de\u9ecf\u9644\u590d\u5408\u7269\u5f62\u6210\u540e\uff0cNectin\/Afadin\u590d\u5408\u7269\u548cE-cadherin\/catenin\u590d\u5408\u7269\u901a\u8fc7Afadin\u548c\u03b1-catenin\u7b49\u4fe1\u53f7\u4f20\u5bfc\u590d\u5408\u7269\u53d1\u6325\u4f5c\u7528\u3002\u8fd9\u4e9b\u590d\u5408\u7269\u542f\u52a8\u4e86\u4e00\u4e2a\u4fe1\u53f7\u7ea7\u8054\uff0c\u5305\u62ecc-Src\u3001C3G\u3001Crk\u3001PI3K\u548cVav2\u7b49\u5206\u5b50\u3002<\/p>\n\n\n\n

\u5206\u5b50\u7684\u8c03\u63a7\uff1a<\/strong>\u8fd9\u4e2a\u4fe1\u53f7\u7ea7\u8054\u6700\u7ec8\u5f71\u54cd\u4e86\u5206\u5b50\u5982Rap1\u3001Cdc42\u548cRac\u7b49\u7684\u8c03\u63a7\u3002\u8fd9\u4e9b\u5206\u5b50\u7684\u8c03\u63a7\u5bfc\u81f4\u4e86\u7ec6\u80de\u9aa8\u67b6\uff0c\u5c24\u5176\u662f\u808c\u52a8\u86cb\u767d\u7ec6\u80de\u9aa8\u67b6\u7684\u91cd\u65b0\u6392\u5217\u3002<\/p>\n\n\n\n

\u603b\u4e4b\uff0cNectin\u901a\u8fc7\u5728\u7ec6\u80de\u95f4\u5efa\u7acb\u521d\u6b65\u7684\u9ecf\u9644\u4f5c\u7528\uff0c\u5f15\u53d1\u4e86\u590d\u6742\u7684\u4fe1\u53f7\u4f20\u5bfc\u7ea7\u8054\uff0c\u6700\u7ec8\u5bfc\u81f4\u7ec6\u80de\u9aa8\u67b6\u7684\u91cd\u65b0\u6392\u5217\uff0c\u4ece\u800c\u4fc3\u8fdb\u7ec6\u80de\u95f4\u9ecf\u9644\u7ed3\u6784\u7684\u5f62\u6210\u3002\u8fd9\u4e00\u8fc7\u7a0b\u5bf9\u4e8e\u7ec4\u7ec7\u7684\u5b8c\u6574\u6027\u548c\u7ec6\u80de\u95f4\u901a\u4fe1\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n

enfortumab vedotin\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n

\n
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Ann\u00a0Pharmacother . 2021 Jun;55(6):772-782.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

enfortumab vedotin \u7684\u7ed3\u6784\u7531\u4e09\u90e8\u5206\u7ec4\u6210\uff1a\u6297\u4f53\u3001\u8fde\u63a5\u5b50\u548c\u7ec6\u80de\u6bd2\u7d20\u836f\u7269\u90e8\u5206\u3002<\/p>\n\n\n\n

\u6297\u4f53\u90e8\u5206\uff1a<\/strong>\u662f\u9488\u5bf9\u4ebaNectin-4\u7684\u7279\u5f02\u6027\u6297\u4f53\u3002<\/p>\n\n\n\n

\u8fde\u63a5\u5b50\u90e8\u5206\uff1a<\/strong>\u6297\u4f53\u90e8\u5206\u901a\u8fc7\u53ef\u88ab\u86cb\u767d\u9176\u6c34\u89e3\u7684\u8fde\u63a5\u5b50\u8fde\u63a5\u836f\u7269\uff0c\u8be5\u8fde\u63a5\u5b50\u5177\u6709\u4e00\u5b9a\u7684\u7a33\u5b9a\u6027\uff0c\u4f7f\u5176\u5728\u8840\u6db2\u4e2d\u4e0d\u4f1a\u8fc7\u65e9\u5206\u79bb\u3002<\/p>\n\n\n\n

\u836f\u7269\u90e8\u5206\uff1a<\/strong>\u662f\u4e00\u79cd\u5fae\u7ba1\u6bd2\u7d20\uff0c\u79f0\u4e3a\u5355\u7532\u57fa\u82a6\u4e1d\u66ff\u56e0E\uff08MMAE\uff09\uff0c\u5176\u53ef\u4ee5\u901a\u8fc7\u6297\u4f53\u4e0eNectin-4\u7ed3\u5408\u540e\u91ca\u653e\u5230\u7ec6\u80de\u5185\u90e8\uff0c\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u5f53enfortumab vedotin\u4e0eNectin-4\u7ed3\u5408\u540e\uff0c\u5185\u5316\u8fdb\u5165\u7ec6\u80de\u5185\uff0c\u5e76\u5728\u6eb6\u9176\u4f53\u4e2d\u88ab\u86cb\u767d\u9176\u88c2\u89e3\uff0c\u91ca\u653e\u51fa\u7ec6\u80de\u6bd2\u7d20MMAE\u3002MMAE\u4e0e\u5fae\u7ba1\u7ed3\u5408\uff0c\u6291\u5236\u7ec6\u80de\u7684\u5206\u88c2\u8fc7\u7a0b\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n\n\n\n

2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u4e2d\uff0cNectin\u7684\u9ad8\u8868\u8fbe\u53ef\u80fd\u4e0e\u80bf\u7624\u7ec6\u80de\u7684\u9ecf\u9644\u3001\u8fc1\u79fb\u548c\u6d78\u6da6\u6709\u5173\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u53c2\u4e0e\u4e86\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u7ec6\u80de\u4e0e\u57fa\u8d28\u4e4b\u95f4\u7684\u9ecf\u9644\uff0c\u8fd9\u662f\u80bf\u7624\u53d1\u5c55\u548c\u6269\u6563\u7684\u5173\u952e\u6b65\u9aa4\u3002<\/p>\n\n\n\n

\u7ef4\u6069\u59a5\u5c24\u5355\u6297F<\/strong>DA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

\n
\"\"
\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

enfortumab vedotin \u7ef4\u6069\u59a5\u5c24\u5355\u6297\uff0cFDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n

    \n
  • \u66fe\u63a5\u53d7\u8fc7PD-1\u6216PD-L1\u6291\u5236\u5242\u548c\u542b\u94c2\u5316\u7597\uff0c\u6216\u4e0d\u9002\u5408\u4f7f\u7528\u987a\u94c2\u5316\u7597\u5e76\u4e14\u4e4b\u524d\u5df2\u63a5\u53d7\u4e86\u4e00\u79cd\u6216\u591a\u79cd\u6cbb\u7597\u65b9\u6848\u3002<\/li>\n\n\n\n
  • \u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08PD-1\uff09\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u4e0d\u80fd\u4f7f\u7528\u987a\u94c2\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u6210\u4eba\u60a3\u8005\u3002<\/li>\n<\/ul>\n\n\n\n

    3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
    \n
    \"\"
    \u8759\u8760\u4fa0 \u5e03\u9c81\u65af\u00b7\u97e6\u6069\uff0c\u5728DC\u4e16\u754c\u91cc\u5b9e\u529b\u504f\u5f31\uff0c\u7ecf\u5e38\u62d6\u6cb9\u74f6\uff0c\u4ed6\u90c1\u95f7\u7684\u8fb9\u5438\u70df\uff0c\u8fb9\u6492\u5c3f\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

    \u97e6\u6069\u62d6\u6cb9\u74f6\uff0c\u4ee3\u8868\u836f\u7269\u7ef4\u6069\u59a5\u5c24\u5355\u6297\u3002<\/p>\n\n\n\n

    \u8759\u8760\u4fa0\u5c5e\u4e8eDC\u5b87\u5b99\uff0c\u4ee3\u8868\u836f\u7269\u5c5e\u4e8eADC\u836f\u7269<\/p>\n\n\n\n

    \u70df\u8349\u4e2d\u7684\u5c3c\u53e4\u4e01\uff0c\u4ee3\u8868\u836f\u7269\u9776\u70b9nectin-4\u3002<\/p>\n\n\n\n

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