{"id":1207,"date":"2023-09-01T21:43:08","date_gmt":"2023-09-01T13:43:08","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1207"},"modified":"2023-09-01T21:43:09","modified_gmt":"2023-09-01T13:43:09","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-trop-2-adc-%e6%8b%93%e8%be%be%e7%bb%b4-%e6%88%88%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97-%e4%b9%b3%e8%85%ba%e7%99%8c","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1207","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | Trop-2 ADC | \u62d3\u8fbe\u7ef4\u00ae \u6208\u6c99\u59a5\u73e0\u5355\u6297 | \u4e73\u817a\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u7b49"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5e38\u89c4\u6cbb\u7597\u836f\u7269\u6548\u679c\u4e0d\u4f73\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trop-2\u901a\u5e38\u5b58\u5728\u4e8e\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u8868\u9762\uff0c\u5982\u4e73\u817a\u764c\uff0c\u5c3f\u8def\u4e0a\u76ae\u764c\u7b49\u3002\u56e0\u6b64\u53ef\u4ee5\u4f5c\u4e3a\u6297\u80bf\u7624\u6cbb\u7597\u7684\u9776\u70b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>TRODELVY\u00ae sacituzumab govitecan \u62d3\u8fbe\u7ef4\u00ae \u6208\u6c99\u59a5\u73e0\u5355\u6297<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u521d\u7531Immunomedics\u516c\u53f8\u5f00\u53d1\u30022019 \u5e74\uff0c\u56fd\u5185\u4e91\u9876\u65b0\u8000\u4ee5\u9996\u4ed8\u6b3e+\u91cc\u7a0b\u7891\u4ed8\u6b3e\u5f62\u5f0f\uff0c\u83b7\u5f97\u4e86TRODELVY\u00ae\u5728\u9664\u65e5\u672c\u5916\u4e9a\u6d32\u5730\u533a\u7684\u6743\u76ca\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2020\u5e74\uff0cImmunomedics\u516c\u53f8\u88ab\u5409\u5229\u5fb7\u516c\u53f8\u6536\u8d2d\u3002\u5e76\u4e0e\u5f53\u5e74TRODELVY\u00ae\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2022\u5e74\uff0c\u836f\u7269\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\uff08\u62d3\u8fbe\u7ef4\u00ae \u6208\u6c99\u59a5\u73e0\u5355\u6297\uff09\uff0c\u56fd\u5185\u4e0a\u5e02\u540e\u4e0d\u4e45\uff0c\u5409\u5229\u5fb7\u516c\u53f8\u56de\u6536\u4e86\u4e91\u9876\u65b0\u8000\u5728\u4e9a\u6d32\u7684\u836f\u7269\u6743\u76ca\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08Triple-Negative Breast Cancer\uff0cTNBC\uff09\u662f\u4e00\u79cd\u4e73\u817a\u764c\u4e9a\u578b\uff0c\u5176\u7279\u70b9\u662f\u4e73\u817a\u764c\u7ec6\u80de\u4e0d\u8868\u8fbe3\u7c7b\u5e38\u7528\u836f\u7269\u9776\u70b9\u53d7\u4f53\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09<\/li>\n\n\n\n<li>\u5b55\u6fc0\u7d20\u53d7\u4f53\uff08PR\uff09<\/li>\n\n\n\n<li>\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u53d7\u4f53<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e09\u4e2a\u53d7\u4f53\u7684\u7f3a\u5931\u4f7f\u5f97TNBC\u5bf9\u4f20\u7edf\u7684\u6fc0\u7d20\u6cbb\u7597\u548cHER2\u9776\u5411\u6cbb\u7597\u65e0\u6548\uff0c\u56e0\u6b64\u88ab\u79f0\u4e3a&#8221;\u4e09\u9634\u6027&#8221;\uff0c\u5927\u7ea615%\u7684\u4e73\u817a\u764c\u60a3\u8005\u4e3a\u4e09\u9634\u6027\u4e73\u817a\u764c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T<strong>rop-2\u00a0\u4f5c\u7528\u5f62\u5f0f<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1024x836.png\" alt=\"\" class=\"wp-image-1208\" style=\"width:634px;height:518px\" width=\"634\" height=\"518\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1024x836.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-300x245.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-768x627.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-880x718.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image.png 1103w\" sizes=\"auto, (max-width: 634px) 100vw, 634px\" \/><figcaption class=\"wp-element-caption\"><em>Cancers (Basel) . 2023 Mar 13;15(6):1744.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Trop-2\uff08\u6ecb\u517b\u5c42\u7ec6\u80de\u8868\u9762\u6297\u539f-2\uff09\u662f\u4e00\u4e2a\u8de8\u819c\u7cd6\u86cb\u767d\uff0c\u5176mRNA\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u4e5f\u53ef\u68c0\u6d4b\u5230\uff0c\u4e3b\u8981\u5206\u5e03\u5728\u4e0a\u76ae\u7ec6\u80de\u4e2d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7136\u800c\uff0c\u5728\u591a\u79cd\u6076\u6027\u80bf\u7624\uff0c\u5982\u4e73\u817a\u764c\uff0c\u5c3f\u8def\u4e0a\u76ae\u764c\u7b49\uff0cTrop-2\u7684\u8868\u8fbe\u660e\u663e\u4e0a\u8c03\u3002\u8fd9\u79cd\u4e0a\u8c03\u53d7\u5230\u591a\u79cd\u8f6c\u5f55\u56e0\u5b50\u7684\u8c03\u63a7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trop-2\u7684\u529f\u80fd\u591a\u6837\uff0c\u5305\u62ec\u4e0e\u8840\u6e05IGF\u7ed3\u5408\u5e76\u53c2\u4e0e\u4fe1\u53f7\u8f6c\u5bfc\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trop-2\u901a\u8fc7\u5176\u80de\u8d28\u5c3e\u90e8\u4e0e JAK \u6fc0\u9176\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6fc0\u6d3b JAK-STAT \u901a\u8def\u3002JAK-STAT \u901a\u8def\u7684\u6fc0\u6d3b\u53ef\u4ee5\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u751f\u957f\u3001\u589e\u6b96\u3001\u8f6c\u79fb\u548c\u8010\u836f\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trop-2\u53ef\u4e0ePI3K\u6fc0\u9176\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6fc0\u6d3b PI3K \u901a\u8def\u3002PI3K \u901a\u8def\u53ef\u4ee5\u4fc3\u8fdb\u7ec6\u80de\u751f\u957f\u3001\u589e\u6b96\u3001\u5b58\u6d3b\u548c\u8f6c\u79fb\u3002<br>\u6b64\u5916\uff0c\u4f5c\u4e3a\u4e0a\u76ae\u7ec6\u80de\u819c\u8868\u9762\u7684\u53d7\u4f53\uff0cTrop-2\u8fd8\u80fd\u8de8\u819c\u4f20\u5bfc\u7ec6\u80de\u5185\u9499\u4fe1\u53f7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6208\u6c99\u59a5\u73e0\u5355\u6297\u7ed3\u6784<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1.png\" alt=\"\" class=\"wp-image-1209\" style=\"width:650px;height:488px\" width=\"650\" height=\"488\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1.png 1019w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1-300x225.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1-768x576.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1-880x660.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1-360x270.png 360w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\"><em>Future Oncol . 2020 Apr;16(12):705-715.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u6208\u6c99\u59a5\u73e0\u5355\u6297\u7531\u4eba\u6e90\u5316\u6297\u4f53sacituzumab\u548c\u5c0f\u5206\u5b50\u6bd2\u7d20\u836f\u7269SN-38\u7ec4\u6210\uff0c\u540e\u8005\u662f\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\uff0c\u901a\u8fc7\u8fde\u63a5\u5b50\u4e0e\u6297\u4f53\u5171\u4ef7\u7ed3\u5408\u3002<br>\u836f\u7406\u6570\u636e\u8868\u660e\uff0c\u6208\u6c99\u59a5\u73e0\u5355\u6297\u80fd\u591f\u7ed3\u5408\u5230\u8868\u8fbeTrop-2\u7684\u764c\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u8fde\u63a5\u5b50\u6c34\u89e3\u91ca\u653e\u51faSN-38\u3002<br>SN-38\u4e0e\u62d3\u6251\u5f02\u6784\u9176I\u76f8\u4e92\u4f5c\u7528\uff0c\u9632\u6b62\u5176\u8bf1\u5bfc\u5355\u94fe\u65ad\u88c2\u7684\u91cd\u8fde\u3002\u7531\u6b64\u4ea7\u751f\u7684DNA\u635f\u4f24\u5bfc\u81f4\u51cb\u4ea1\u548c\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6208\u6c99\u59a5\u73e0\u5355\u6297\u4f5c\u7528\u673a\u5236<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-2-1024x731.png\" alt=\"\" class=\"wp-image-1210\" style=\"width:656px;height:469px\" width=\"656\" height=\"469\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-2-1024x731.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-2-300x214.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-2-768x548.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-2-1218x870.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-2-880x628.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-2.png 1511w\" sizes=\"auto, (max-width: 656px) 100vw, 656px\" \/><figcaption class=\"wp-element-caption\"><em>Future Oncol . 2020 Apr;16(12):705-715.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u6208\u6c99\u59a5\u73e0\u5355\u6297\u662f\u4e00\u79cdADC\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u4e73\u817a\u764c\u548c\u5c3f\u8def\u4e0a\u76ae\u764c\u3002\u5b83\u7684\u4f5c\u7528\u673a\u5236\u5982\u4e0b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9776\u5411\u764c\u7ec6\u80de\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6208\u6c99\u59a5\u73e0\u5355\u6297\u7684\u6297\u4f53\u90e8\u5206\u4f1a\u7ed3\u5408\u5230\u764c\u7ec6\u80de\u8868\u9762\u4e0a\u8fc7\u5ea6\u8868\u8fbe\u7684Trop-2\u53d7\u4f53\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5185\u5316\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6208\u6c99\u59a5\u73e0\u5355\u6297\u7ed3\u5408\u5230Trop-2\u53d7\u4f53\u4e0a\u540e\uff0c\u764c\u7ec6\u80de\u4f1a\u5c06\u5176\u5185\u5316\uff0c\u5c06\u8fd9\u79cd\u6297\u4f53\u836f\u7269\u5f15\u5165\u7ec6\u80de\u5185\u90e8\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u91ca\u653e\u6bd2\u7d20\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6208\u6c99\u59a5\u73e0\u5355\u6297\u7684\u836f\u7269\u90e8\u5206\u662f\u4f0a\u7acb\u66ff\u5eb7\uff08Irinotecan\uff09\u7684\u884d\u751f\u7269\u3002\u5185\u5316\u540e\uff0c\u836f\u7269\u6bd2\u7d20SN-38\u4f1a\u88ab\u91ca\u653e\u5230\u764c\u7ec6\u80de\u5185\u90e8\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6291\u5236\u764c\u7ec6\u80de\u751f\u957f\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SN-38\u963b\u6b62\u764c\u7ec6\u80de\u7684DNA\u590d\u5236\u548c\u4fee\u590d\uff0c\u4ece\u800c\u5bfc\u81f4\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6208\u6c99\u59a5\u73e0\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-3-1024x281.png\" alt=\"\" class=\"wp-image-1211\" style=\"width:622px;height:171px\" width=\"622\" height=\"171\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-3-1024x281.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-3-300x82.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-3-768x210.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-3-1218x334.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-3-880x241.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-3.png 1281w\" sizes=\"auto, (max-width: 622px) 100vw, 622px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#691cb2\" 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