{"id":123,"date":"2022-07-11T19:42:31","date_gmt":"2022-07-11T11:42:31","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=123"},"modified":"2022-08-28T21:22:17","modified_gmt":"2022-08-28T13:22:17","slug":"%e5%9b%be%e5%83%8f%e8%ae%b0%e5%bf%86-%e8%a7%86%e7%a5%9e%e7%bb%8f%e8%84%8a%e9%ab%93%e7%82%8e%e7%94%9f%e7%89%a9%e8%8d%af-%e7%99%bd%e4%bb%8b%e7%b4%a0-6r%ef%bc%88il-6r%ef%bc%89%e6%8b%ae%e6%8a%97","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=123","title":{"rendered":"\u56fe\u50cf\u8bb0\u5fc6 | \u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u751f\u7269\u836f | \u767d\u4ecb\u7d20-6R\uff08IL-6R\uff09\u62ee\u6297\u5242 | \u8428\u7279\u5229\u73e0\u5355\u6297 | \u5b89\u9002\u5e73 | Satralizumab"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u7269\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u751f\u7269\u836f\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>\u7f57\u6c0f\u516c\u53f8\u53e6\u4e00\u6b3eIL-6R\u62ee\u6297\u5242\uff0c\u5b89\u9002\u5e73<sup>\u00ae<\/sup>\u8428\u7279\u5229\u73e0\u5355\u6297 ENSPRYNG\u2122 (satralizumab-mwge)\uff0c\u56fd\u5185\u5df2\u4e0a\u5e02\uff0c\u76ee\u524dFDA\u548c\u56fd\u5185\u6279\u51c6\u7684\u9002\u5e94\u75c7\u4e3a\u6c34\u901a\u9053\u86cb\u767d 4\uff08AQP4\uff09\u6297\u4f53\u9633\u6027\u7684\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\uff08NMOSD\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>\u7f57\u6c0f\u516c\u53f8\u4e24\u6b3eIL-6R\u6291\u5236\u5242\uff0c\u5305\u62ec\u524d\u6587\u6240\u8ff0\u7684\u6258\u73e0\u5355\u62972010\u5e74\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p>10\u5e74\u78e8\u4e00\u5251\uff0c2020\u5e74\u4e0a\u5e02\u8428\u7279\u5229\u73e0\u5355\u6297\u3002\u4e24\u79cd\u5355\u6297\u5747\u4e3a\u9776\u5411IL-6\u53d7\u4f53\uff0c\u963b\u65ad\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\uff0c\u4f46\u662f\u4f5c\u7528\u673a\u5236\u6709\u6240\u4e0d\u540c\u3002<\/p>\n\n\n\n<p>\u4e24\u79cdIL-6R\u62ee\u6297\u5242\u533a\u522b<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-15.png\" alt=\"\" class=\"wp-image-157\" width=\"553\" height=\"347\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-15.png 956w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-15-300x189.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-15-880x554.png 880w\" sizes=\"auto, (max-width: 553px) 100vw, 553px\" \/><figcaption><em><em>J Neurol . 2021 Dec;268(12):4522-4536.<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6258\u73e0\u5355\u6297\u4e0e\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u7ed3\u5408\u540e\u5185\u541e\u8fdb\u5165\u7ec6\u80de\u5185\uff0c\u968f\u7740pH\u4e0b\u964d\u800c\u964d\u89e3\u3002<\/p>\n\n\n\n<p>\u8428\u7279\u5229\u73e0\u5355\u6297\u91c7\u7528\u518d\u5faa\u73af\u6297\u4f53\u6280\u672f\uff0c\u5185\u541e\u8fdb\u5165\u7ec6\u80de\u540e\uff0c\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u7ed3\u5408\u65b0\u751f\u513f\u53d7\u4f53FcRn\uff0c\u4f7f\u6297\u4f53\u514d\u4e8e\u88ab\u6eb6\u9176\u4f53\u964d\u89e3\uff0c\u53ef\u518d\u6b21\u5faa\u73af\u4f7f\u7528\uff0c\u4ece\u800c\u5ef6\u957f\u4e86\u836f\u7269\u534a\u8870\u671f\u3002<\/p>\n\n\n\n<p><strong>\u9002\u5e94\u75c7\u75be\u75c5\u6982\u8ff0\uff1a<\/strong><\/p>\n\n\n\n<p><strong>\u795e\u7ecf\u7ea4\u7ef4\u7ed3\u6784<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-16-1024x390.png\" alt=\"\" class=\"wp-image-158\" width=\"513\" height=\"195\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-16-1024x390.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-16-300x114.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-16-768x293.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-16-1218x464.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-16-880x335.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-16.png 1299w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/><figcaption><em>\u9ed8\u6c99\u4e1c\u8bca\u7597\u624b\u518c\uff1a\u8131\u810a\u9798\u75be\u75c5\u6982\u8ff0<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u795e\u7ecf\u7ea4\u7ef4\uff0c\u7531\u8102\u86cb\u767d\u7ec4\u7ec7\u5305\u88f9\uff0c\u5f62\u6210\u9ad3\u9798\u3002\u5c31\u50cf\u7535\u7ebf\u5468\u56f4\u7684\u7edd\u7f18\u4e00\u6837\uff0c\u9ad3\u9798\u4f7f\u795e\u7ecf\u4fe1\u53f7\u80fd\u591f\u5feb\u901f\u51c6\u786e\u5730\u6cbf\u7740\u795e\u7ecf\u7ea4\u7ef4\u4f20\u5bfc\u3002<\/p>\n\n\n\n<p>\u9ad3\u9798\u53d7\u635f\u65f6\uff0c\u795e\u7ecf\u7ea4\u7ef4\u4fbf\u4e0d\u80fd\u6b63\u5e38\u4f20\u5bfc\u7535\u51b2\u52a8\u3002\u5bfc\u81f4\u591a\u53d1\u6027\u786c\u5316\uff0c\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u7b49\u75be\u75c5\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><strong>\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-20-1024x321.png\" alt=\"\" class=\"wp-image-159\" width=\"833\" height=\"261\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-20-1024x321.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-20-300x94.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-20-768x241.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-20-1218x382.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-20-880x276.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-20.png 1387w\" sizes=\"auto, (max-width: 833px) 100vw, 833px\" \/><figcaption><em><em>NeurolNeurochir&nbsp;Pol.&nbsp;2019;53(5):317-326.<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5f53\u53d1\u751f\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u65f6\uff0c\u6297\u4f53\u653b\u51fb\u4f4d\u4e8e\u795e\u7ecf\u7ec6\u80de\u8868\u9762\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e0a\u7684\u6c34\u901a\u9053\u86cb\u767d&nbsp;4\uff08AQP4\uff09\uff0c\u5bfc\u81f4\u795e\u7ecf\u7ea4\u7ef4\u5916\u7684\u9ad3\u9798\u53d7\u635f\uff0c\u53d1\u751f\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\uff08NMOSD\uff09\u3002<\/p>\n\n\n\n<p>\u76ee\u524dFDA\u6279\u51c6\u4e09\u7c7b\u836f\u7269\u6cbb\u7597\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\uff0c\u5206\u522b\u4e3a\uff1a<\/p>\n\n\n\n<p>1\u3001\u8428\u7279\u5229\u73e0\u5355\u6297\uff0c\u9776\u70b9IL-6R\uff0c\u6291\u5236B\u7ec6\u80deT\u7ec6\u80de\u3002<\/p>\n\n\n\n<p>2\u3001AZ\u65d7\u4e0b\u4e9a\u529b\u5144\u516c\u53f8\u7684\u4f9d\u5e93\u73e0\u5355\u6297\uff0c\u9776\u70b9\u4e3a\u8865\u4f53C5\u3002\u8be5\u836f\u7269\u56fd\u5185\u5df2\u4e0a\u5e02\uff0c\u4f46NMOSD\u7684\u9002\u5e94\u75c7\u76ee\u524d\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p>3\u30012022\u5e743\u6708\u521a\u521a\u83b7\u5f97\u56fd\u5185\u6279\u51c6\u7684\u4f0a\u5948\u5229\u73e0\u5355\u6297\uff0c\u9776\u70b9\u4e3a\u6291\u5236CD19\u7684B\u7ec6\u80de\u3002<\/p>\n\n\n\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u622a\u6b62\u76ee\u524d\u8428\u7279\u5229\u73e0\u5355\u6297\u5728FDA\u8bf4\u660e\u4e66\u4e2d\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n<p><strong>\u6210\u4eba<\/strong>\u6c34\u901a\u9053\u86cb\u767d 4\uff08AQP4\uff09\u6297\u4f53\u9633\u6027\u7684\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\uff08NMOSD\uff09\u7684\u6cbb\u7597\u3002<\/p>\n\n\n\n<p>\u800c\u56fd\u5185\u83b7\u6279\u8bf4\u660e\u4e66\u4e2d\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n<p><strong>\u226512 \u5c81\u9752\u5c11\u5e74\u53ca\u6210\u4eba\u60a3\u8005<\/strong>\u6c34\u901a\u9053\u86cb\u767d 4\uff08AQP4\uff09\u6297\u4f53\u9633\u6027\u7684\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\uff08NMOSD\uff09\u7684\u6cbb\u7597\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/IL-6-sat-no-1-gap.jpg\" data-gif=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/IL-6-sat-no-1.gif\" alt=\"\" class=\"wp-image-164\" width=\"519\" height=\"374\"\/><figcaption>\u524d\u6587\u4e2d\uff0c\u603b\u5175\u592b\u4eba\u8bde\u4e0b\u4e00\u9897\u73e0\u5b50\uff0c\u6b64\u6b21\u843d\u5730\u540e\u53d8\u6210\u4e86\u4e00\u4e2a\u8428\u7279\uff08\u6e38\u620f\u9b54\u517d\u4e16\u754c\u4e2d\u4eba\u7269\uff0c\u6ca1\u73a9\u8fc7\u7684\u53ef\u4ee5\u7528\u6c99\u7279\u963f\u62c9\u4f2f\u4eba\u7b49\u5176\u4ed6\u56fe\u50cf\u4ee3\u66ff\uff09\uff0c\u5b83\u7684\u4e24\u773c\u95ea\u7740\u51f6\u5149\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5b55\u5987\u662f\u6211\u7684\u6570\u5b57\u7f16\u78016\uff0c\u4ee3\u8868IL-6R\u62ee\u6297\u5242\u3002<\/p>\n\n\n\n<p>\u8428\u7279\u7684\u722a\u5b50\u975e\u5e38\u950b\u5229\uff0c\u5e76\u4e14\u5b83\u7531\u73e0\u5b50\u53d8\u5316\u800c\u6765\uff0c\u8fd9\u91cc\u4ee3\u8868\u8428\u7279\u5229\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u95ea\u5149\u7684\u773c\u775b\u4ee3\u8868\u9002\u5e94\u75c7\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u7269\u4e00\u5f20\u56fe\uff0c&#8230;<\/p>\n","protected":false},"author":1,"featured_media":165,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[4],"class_list":["post-123","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","tag-4","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=123"}],"version-history":[{"count":5,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/123\/revisions"}],"predecessor-version":[{"id":296,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/123\/revisions\/296"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/165"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}