{"id":1231,"date":"2023-09-12T13:22:04","date_gmt":"2023-09-12T05:22:04","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1231"},"modified":"2023-09-12T13:25:12","modified_gmt":"2023-09-12T05:25:12","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91psma-rdc%ef%bc%88%e6%a0%b8%e8%8d%af%ef%bc%89-pluvicto-lutetium-lu-177-vipivotide-tetraxetan-%e5%8e%bb","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1231","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776\u5411PSMA RDC\uff08\u6838\u836f\uff09| PLUVICTO\u00ae lutetium Lu 177 vipivotide tetraxetan | \u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a\u764c"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PLUVICTO\u00ae lutetium Lu 177 vipivotide tetraxetan \u662f\u4e00\u6b3e\u9776\u5411\u80bf\u7624\u7ec6\u80de\u8868\u9762PSMA\uff08\u524d\u5217\u817a\u7279\u5f02\u6027\u819c\u6297\u539f\uff09\uff0c\u8fdb\u800c\u91ca\u653e\u653e\u5c04\u6027\u9565177\uff08Lutetium-177\uff09\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u7684RDC\u6838\u836f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u7531\u8bfa\u534e\u516c\u53f8\u5f00\u53d1\uff0c2022\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u56fd\u5185\u5c1a\u672a\u4e0a\u5e02\uff0c\u6839\u636e\u82f1\u6587\u540d\u6211\u6682\u79f0\u5b83\u4e3a\u9565\u9c81177\u80bd\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PSMA \u6297\u539f<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PSMA\uff08Prostate-Specific Membrane Antigen\uff0c\u524d\u5217\u817a\u7279\u5f02\u6027\u819c\u6297\u539f\uff09\u662f\u4e00\u79cd\u86cb\u767d\u8d28\u6297\u539f\uff0c\u901a\u5e38\u5728\u524d\u5217\u817a\u7ec4\u7ec7\u548c\u4e00\u4e9b\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e0a\u9ad8\u5ea6\u8868\u8fbe\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PSMA\u4e34\u5e8a\u4e0a\u6709\u591a\u79cd\u7528\u9014\uff1a<\/strong><\/p>\n\n\n\n<ul 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class=\"wp-block-paragraph\"><strong>RDC\u6838\u836f\u673a\u5236<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u524d\u9762\u66fe\u7ecf\u4ecb\u7ecd\u8fc7\u53e6\u4e00\u6b3e\u9776\u5411CD20\u7684RDC\u6838\u836fIbritumomab tiuxetan\u66ff\u4f0a\u83ab\u5355\u6297\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-13.png\" alt=\"\" class=\"wp-image-1232\" style=\"width:608px;height:365px\" width=\"608\" height=\"365\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-13.png 1020w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-13-300x180.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-13-768x460.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-13-880x527.png 880w\" sizes=\"auto, (max-width: 608px) 100vw, 608px\" \/><figcaption class=\"wp-element-caption\"><em><em>https:\/\/www.biochempeg.com\/article\/266.html<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">RDC\u836f\u7269\u7c7b\u4f3c\u4e8eADC\u836f\u7269\uff0c\u662f\u7531\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u548c\u7279\u5f02\u6027\u80bf\u7624\u9776\u70b9\u7684\u5355\u6297\u7ec4\u6210\uff0c\u5982\u66ff\u4f0a\u83ab\u5355\u6297\u7531\u948790\u8fde\u63a5\u6297CD20\u5355\u6297\u3001\u9565\u9c81177\u80bd\u7531\u9565177\u8fde\u63a5\u9776\u5411\u7ed3\u5408PSMA\u7684\u80bd\u7ec4\u6210\u3002\u5730\u6cbf\u7740\u795e\u7ecf\u7ea4\u7ef4\u4f20\u5bfc\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u836f\u7269\u5177\u6709\u4ee5\u4e0b\u4e00\u4e9b\u7279\u70b9\uff1a<\/p>\n\n\n\n<ul 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class=\"wp-block-paragraph\"><strong>\u9565\u9c81177\u80bd\u4f5c\u7528\u673a\u5236\u00a0<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-14-1024x600.png\" alt=\"\" class=\"wp-image-1233\" style=\"width:650px;height:381px\" width=\"650\" height=\"381\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-14-1024x600.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-14-300x176.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-14-768x450.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-14-880x515.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-14.png 1170w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.hcp.novartis.com\/products\/pluvicto\/psma-positive-mcrpc\/mechanism-of-action\/<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">1\u3001\u591a\u80bdvipivotide tetraxetan\u4e0e\u6cbb\u7597\u6027\u653e\u5c04\u6027\u540c\u4f4d\u7d20Lutetium-177\u7ed3\u5408\u6210\u836f\u7269\u3002<br>2\u3001\u836f\u7269\u4e0e\u8868\u8fbe\u5728\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e0a\u7684PSMA\u7ed3\u5408\u540e\uff0c\u53d1\u751f\u5185\u541e\u4f5c\u7528\u8fdb\u5165\u7ec6\u80de\u5185\u90e8\u3002<br>3\u3001\u836f\u7269\u91ca\u653e\u51fa\u7ec6\u80de\u6bd2\u6027\u653e\u5c04\u6027\u6838\u7d20Lutetium-177\uff0c\u91ca\u653e\u03b2\u5c04\u7ebf\u7834\u574fDNA\u3002\u8f90\u5c04\u8def\u5f84\u957f\u5ea6\u5f88\u77ed\uff0c\u7ea6\u4e3a2\u6beb\u7c73\uff0c\u4ec5\u5bfc\u81f4\u9776\u5411\u7ec6\u80de\u53ca\u5468\u56f4\u7ec6\u80de\u4e2d\u5355\u94fe\u548c\u53cc\u94feDNA\u65ad\u88c2\u3002<br>4\u3001\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<h2 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sizes=\"auto, (max-width: 648px) 100vw, 648px\" \/><figcaption class=\"wp-element-caption\"><em>\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9565\u9c81177\u80bdFDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5df2\u63a5\u53d7\u96c4\u6fc0\u7d20\u53d7\u4f53\uff08AR\uff09\u901a\u8def\u6291\u5236\u836f\u7269\u548c\u7d2b\u6749\u9187\u7c7b\u5316\u7597\u7684PSMA\u9633\u6027\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-1-gap.jpg\" 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