{"id":1242,"date":"2023-09-15T12:17:19","date_gmt":"2023-09-15T04:17:19","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1242"},"modified":"2023-09-15T12:17:20","modified_gmt":"2023-09-15T04:17:20","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91tf-adc-tivdak-tisotumab-vedotin-%e7%bb%b4%e6%9b%bf%e7%b4%a2%e5%a6%a5%e5%8d%95%e6%8a%97-%e5%ae%ab","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1242","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776\u5411TF ADC | TIVDAK\u00ae tisotumab vedotin \u7ef4\u66ff\u7d22\u59a5\u5355\u6297 | \u5bab\u9888\u764c"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>TIVDAK\u00ae tisotumab vedotin\u3002\u662f\u4e00\u79cd\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff0c\u7531Genmab\u516c\u53f8\u7684\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u9488\u5bf9\u7ec6\u80de\u8868\u9762\u7684\u7ec4\u7ec7\u56e0\u5b50\uff08TF\uff09\uff0c\u4ee5\u53caSeagen\u516c\u53f8\u7684ADC\u6280\u672f\u7ec4\u6210\u3002<\/p>\n\n\n\n<p>2021\u5e74\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u52a0\u901f\u6279\u51c6\u4e86Tisotumab vedotin\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n<p>\u56fd\u5185\uff0c\u518d\u9f0e\u533b\u836f\u83b7\u5f97\u836f\u7269\u5728\u4e2d\u56fd\u5185\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u72ec\u5bb6\u6388\u6743\u3002\u76ee\u524d\u5904\u4e8e\u6ce8\u518c\u7533\u62a5\u9636\u6bb5\uff0c\u4e2d\u6587\u540d\u6682\u8bd1\u4e3a\u7ef4\u66ff\u7d22\u59a5\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>\u7ec4\u7ec7\u56e0\u5b50\uff08Tissue Factor\uff0cTF\uff09\uff0c\u4e5f\u88ab\u79f0\u4e3a\u51dd\u8840\u56e0\u5b50III\u3002<\/p>\n\n\n\n<p>\u5176\u4eba\u4f53\u5185\u4e3b\u8981\u751f\u7406\u529f\u80fd\u662f\u5728\u8840\u7ba1\u6216\u7ec4\u7ec7\u53d7\u5230\u635f\u4f24\u65f6\uff0c\u901a\u8fc7\u4e0e\u51dd\u8840\u56e0\u5b50VIIa\u7ed3\u5408\uff0c\u5f62\u6210TF-VIIa\u590d\u5408\u7269\uff0c\u4ece\u800c\u542f\u52a8\u5916\u6e90\u6027\u51dd\u8840\u9014\u5f84\u3002\u8fd9\u4e00\u8fc7\u7a0b\u6700\u7ec8\u5bfc\u81f4\u7ea4\u7ef4\u86cb\u767d\u751f\u6210\uff0c\u5f62\u6210\u8840\u6813\uff0c\u4ece\u800c\u505c\u6b62\u51fa\u8840\u3002<\/p>\n\n\n\n<p>\u5728\u67d0\u4e9b\u764c\u75c7\u4e2d\uff0cTF\u7684\u5f02\u5e38\u9ad8\u8868\u8fbe\u5df2\u88ab\u89c2\u5bdf\u5230\uff0c\u7279\u522b\u662f\u5728\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u4e2d\u3002\u8fd9\u79cd\u8fc7\u5ea6\u8868\u8fbe\u53ef\u80fd\u4e0e\u80bf\u7624\u7684\u8840\u7ba1\u751f\u6210\u3001\u751f\u957f\u548c\u8f6c\u79fb\u6709\u5173\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u7684\u7814\u7a76\u663e\u793a\uff0c\u5728\u591a\u79cd\u764c\u75c7\u4e2d\uff0c\u5305\u62ec\u5bab\u9888\u764c\u3001\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u524d\u5217\u817a\u764c\u548c\u5375\u5de2\u764c\u7b49\uff0c\u80bf\u7624\u7ec6\u80de\u4ee5\u53ca\u5b83\u4eec\u7684\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u90fd\u5b58\u5728\u7ec4\u7ec7\u56e0\u5b50\uff08TF\uff09\u7684\u5f02\u5e38\u589e\u52a0\u3002<\/p>\n\n\n\n<p><strong>tisotumab vedotin\u7ed3\u6784\u53ca\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-16-1024x542.png\" alt=\"\" class=\"wp-image-1243\" style=\"width:694px;height:367px\" width=\"694\" height=\"367\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-16-1024x542.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-16-300x159.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-16-768x406.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-16-880x466.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-16.png 1064w\" sizes=\"auto, (max-width: 694px) 100vw, 694px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.creativebiolabs.net\/tisotumab-vedotin-overview.htm<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>tisotumab vedotin \u7684\u7ed3\u6784\u7531\u4e09\u90e8\u5206\u7ec4\u6210\uff1a\u6297\u4f53\u3001\u8fde\u63a5\u5b50\u548c\u7ec6\u80de\u6bd2\u7d20\u836f\u7269\u90e8\u5206\u3002<\/p>\n\n\n\n<p><strong>\u6297\u4f53\u90e8\u5206\uff1a<\/strong><br>\u662f\u9488\u5bf9\u4ebaTF 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vedotin\u4e0eTF\u7ed3\u5408\u540e\uff0c\u5185\u5316\u8fdb\u5165\u7ec6\u80de\u5185\uff0c\u5e76\u5728\u6eb6\u9176\u4f53\u4e2d\u88ab\u86cb\u767d\u9176\u88c2\u89e3\uff0c\u91ca\u653e\u51fa\u7ec6\u80de\u6bd2\u7d20MMAE\u3002MMAE\u4e0e\u5fae\u7ba1\u7ed3\u5408\uff0c\u6291\u5236\u7ec6\u80de\u7684\u5206\u88c2\u8fc7\u7a0b\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p>\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5df2\u7ecf\u4ecb\u7ecd\u4e864\u6b3e\u6297\u4f53\u8fde\u63a5MMAE\u6bd2\u7d20vedotin\u7684ADC\u836f\u7269\u3002<\/p>\n\n\n\n<p><strong>MMAE\u6bd2\u7d20vedotin\u7684ADC\u836f\u7269<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-17-1024x502.png\" alt=\"\" class=\"wp-image-1244\" style=\"width:736px;height:361px\" width=\"736\" 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src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18-1024x638.png\" alt=\"\" class=\"wp-image-1245\" style=\"width:696px;height:434px\" width=\"696\" height=\"434\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18-1024x638.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18-300x187.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18-768x478.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18-1536x956.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18-1218x758.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18-880x548.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-18.png 1542w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" \/><figcaption 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