{"id":1250,"date":"2023-09-23T15:01:09","date_gmt":"2023-09-23T07:01:09","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1250"},"modified":"2023-09-23T15:03:32","modified_gmt":"2023-09-23T07:03:32","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e5%8f%b6%e9%85%b8%e5%8f%97%e4%bd%93%ce%b1fr%ce%b1-mirvetuximab-soravtansine-%e7%b4%a2%e7%b1%b3%e5%a6%a5%e6%98%94%e5%8d%95","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1250","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u53f6\u9178\u53d7\u4f53\u03b1(FR\u03b1) | mirvetuximab soravtansine \u7d22\u7c73\u59a5\u6614\u5355\u6297 | \u5375\u5de2\u764c"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>ELAHERETM\u00ae mirvetuximab soravtansine \u662f\u7f8e\u56fdImmunoGen\u516c\u53f8\u5f00\u53d1\u7684\u5168\u7403\u9996\u4e2a\u9488\u5bf9\u53f6\u9178\u53d7\u4f53\u03b1\uff08FR\u03b1\uff09\u9633\u6027\u5375\u5de2\u764c\u7684ADC\u836f\u7269\u3002<\/p>\n\n\n\n<p>\u836f\u7269\u4e8e2022\u5e74\u83b7\u5f97FDA\u52a0\u901f\u6279\u51c6\u4e0a\u5e02\u3002\u534e\u4e1c\u533b\u836f\u62e5\u6709ELAHERETM\u00ae\u5728\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\u7684\u72ec\u5bb6\u6743\u76ca\u3002<\/p>\n\n\n\n<p>\u56fd\u5185\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u4e2d\u6587\u540d\u97f3\u8bd1\u4e3a\u7d22\u7c73\u59a5\u6614\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>Mirvetuximab soravtansine \u662f\u4e00\u79cd\u6297\u4f53-\u6bd2\u6027\u836f\u7269\u7ed3\u5408\u7684\u836f\u7269\uff08Antibody-Drug Conjugate\uff0cADC\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u53f6\u9178\u53d7\u4f53\u03b1\uff08FR\u03b1\uff09\u9633\u6027\u7684\u5375\u5de2\u764c\u3002<\/p>\n\n\n\n<p>\u5b83\u88ab\u8ba4\u4e3a\u662f\u9996\u4e2a\u9488\u5bf9FR\u03b1\u9ad8\u8868\u8fbe\u5375\u5de2\u764c\u7684ADC\u836f\u7269\u3002FR\u03b1\u5728\u5927\u591a\u6570\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u3002<\/p>\n\n\n\n<p><strong>Mirvetuximab soravtansine\u7ed3\u6784<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-19-1024x481.png\" alt=\"\" class=\"wp-image-1251\" style=\"width:616px;height:289px\" width=\"616\" height=\"289\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-19-1024x481.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-19-300x141.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-19-768x361.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-19-1218x572.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-19-880x413.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-19.png 1246w\" sizes=\"auto, (max-width: 616px) 100vw, 616px\" \/><figcaption class=\"wp-element-caption\"><em>Pharmaceuticals (Basel) . 2020 Sep 14;13(9):245.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>\u6297\u4f53\u90e8\u5206\uff1a<\/strong>\u8fd9\u662fADC\u7684\u9776\u5411\u6210\u5206\uff0c\u5b83\u662f\u4e00\u4e2a\u6297\u4f53\uff0c\u901a\u5e38\u662f\u9488\u5bf9\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u6297\u539f\u6216\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\u3002\u5728Mirvetuximab soravtansine\u4e2d\uff0c\u6297\u4f53\u662f\u9488\u5bf9\u53f6\u9178\u53d7\u4f53\u7684\u6297\u4f53\u3002<\/p>\n\n\n\n<p><strong>\u836f\u7269\u90e8\u5206\uff08DM4\uff09\uff1a<\/strong>ADC\u7684\u836f\u7269\u8d1f\u8f7d\u90e8\u5206\uff0c\u8fd9\u91ccDM4\u88ab\u7528\u4f5c\u7ec6\u80de\u6bd2\u836f\u7269\uff0c\u7528\u4e8e\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002DM4\u5c5e\u4e8e\u5fae\u7ba1\u6291\u5236\u5242\u7684\u4e00\u79cd\uff0c\u53ef\u4ee5\u963b\u6b62\u7ec6\u80de\u5185\u5fae\u7ba1\u7684\u52a8\u6001\u7a33\u5b9a\uff0c\u4ece\u800c\u963b\u6b62\u7ec6\u80de\u7684\u5206\u88c2\u548c\u751f\u957f\u3002<\/p>\n\n\n\n<p><strong>\u53ef\u5207\u5272\u8fde\u63a5\u5b50\uff1a<\/strong>ADC\u4e2d\u7684\u8fde\u63a5\u5668\u662f\u5c06\u6297\u4f53\u4e0e\u836f\u7269\u90e8\u5206\u8fde\u63a5\u5728\u4e00\u8d77\u7684\u5173\u952e\u7ec4\u4ef6\u3002Mirvetuximab soravtansine\u4f7f\u7528\u4e86\u4e00\u79cd\u53ef\u5207\u5272\u8fde\u63a5\u5668\uff0c\u5728\u7279\u5b9a\u6761\u4ef6\u4e0b\u53ef\u4ee5\u88ab\u5207\u5272\uff0c\u91ca\u653e\u836f\u7269\u8d1f\u8f7d\u4ee5\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<p><strong>\u5316\u5b66\u4fee\u9970\uff1a<\/strong>\u4e3a\u4e86\u63d0\u9ad8ADC\u7684\u7a33\u5b9a\u6027\u548c\u751f\u7269\u6d3b\u6027\uff0cMirvetuximab soravtansine\u5bf9\u8fde\u63a5\u5668\u8fdb\u884c\u4e86\u5316\u5b66\u4fee\u9970\uff0c\u5728\u8fde\u63a5\u5668\u7684\u4e8c\u786b\u952e\u7684\u03b1\u4f4d\u7f6e\u5f15\u5165\u4e86\u4e24\u4e2a\u7532\u57fa\u57fa\u56e2\uff0c\u5e76\u6dfb\u52a0\u4e86\u4e00\u4e2a\u78fa\u9170\u57fa\u57fa\u56e2\uff0c\u4ee5\u63d0\u9ad8\u8fde\u63a5\u5668\u7684\u4eb2\u6c34\u6027\uff0c\u4ece\u800c\u6539\u5584\u4e86\u836f\u7269\u90e8\u5206\u7684\u4e0e\u4e4b\u7684\u7ed3\u5408\u3002<\/p>\n\n\n\n<p><strong>Mirvetuximab soravtansine\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-20-1024x381.png\" alt=\"\" class=\"wp-image-1252\" style=\"width:628px;height:234px\" width=\"628\" height=\"234\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-20-1024x381.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-20-300x112.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-20-768x286.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-20-1218x453.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-20-880x328.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-20.png 1394w\" sizes=\"auto, (max-width: 628px) 100vw, 628px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.elaherehcp.com\/about-elahere#moa<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>\u9776\u5411\u7ed3\u5408\uff1a<\/strong>Mirvetuximab soravtansine\u7684\u6297\u4f53\u90e8\u5206\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u53d7\u4f53FR\u03b1\u7ed3\u5408\u3002<\/p>\n\n\n\n<p><strong>\u5185\u541e\u4f5c\u7528\uff1a<\/strong>\u4e0eFR\u03b1\u53d7\u4f53\u7ed3\u5408\u540e\uff0c\u836f\u7269\u88ab\u5185\u541e\u5230\u7ec6\u80de\u5185\u90e8\u3002<\/p>\n\n\n\n<p><strong>\u91ca\u653eDM4\uff1a<\/strong>DM4\u662f\u4e00\u79cd\u5f3a\u6548\u7684\u7ec6\u80de\u6bd2\u6027\u5fae\u7ba1\u6291\u5236\u5242\uff0c\u80de\u5185\u91ca\u653e\u540e\uff0c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p><strong>DM4\u6269\u6563\uff1a<\/strong>DM4\u6269\u6563\u7a7f\u8fc7\u7ec6\u80de\u819c\uff0c\u6740\u6b7b\u90bb\u8fd1\u7684\u7ec6\u80de\uff08\u65c1\u89c2\u8005\u6548\u5e94\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p>FR\u03b1\u662f\u4e00\u79cd\u53f6\u9178\u8f6c\u8fd0\u86cb\u767d\uff0c\u572890%\u7684\u5375\u5de2\u764c\u60a3\u8005\u4e2d\u8868\u8fbe\uff0c\u5e76\u4e14\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u6709\u9650\uff0c\u56e0\u6b64\u6210\u4e3a\u4e00\u4e2a\u6709\u5438\u5f15\u529b\u7684\u6cbb\u7597\u9776\u70b9\u3002\u7ea635%\u7684\u5375\u5de2\u764c\u60a3\u8005\u5177\u6709\u9ad8\u6c34\u5e73\u7684FR\u03b1\u8868\u8fbe\u3002<\/p>\n\n\n\n<p>\u7531\u4e8e\u5316\u7597\u540e\u5176\u8868\u8fbe\u76f8\u5bf9\u4e0d\u53d8\uff0c\u56e0\u6b64\u53ef\u4ee5\u5728\u8bca\u65ad\u6216\u8fdb\u5c55\u65f6\u6d4b\u8bd5FR\u03b1\u3002\u968f\u7740ELAHERE\u7684\u6279\u51c6\uff0cFR\u03b1\u6210\u4e3a\u94c2\u7c7b\u8010\u836f\u6027\u5375\u5de2\u764c\u53ef\u884c\u7684\u6cbb\u7597\u9776\u70b9\u4e4b\u4e00\u3002<\/p>\n\n\n\n<p><strong>\u5361\u666e\u8d5b\u73e0\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-21-1024x183.png\" alt=\"\" class=\"wp-image-1253\" style=\"width:680px;height:122px\" width=\"680\" height=\"122\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-21-1024x183.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-21-300x54.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-21-768x138.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-21-1218x218.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-21-880x158.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-21.png 1412w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/><figcaption class=\"wp-element-caption\"><em>\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>Mirvetuximab soravtansine\u9002\u7528\u4e8e\u6cbb\u7597\u6210\u5e74\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u7684\u53f6\u9178\u53d7\u4f53-\u03b1\uff08FR\u03b1\uff09\u4e3a\u9633\u6027\u3001\u94c2\u7c7b\u8010\u836f\u7684\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\uff0c\u5e76\u4e14\u5df2\u63a5\u53d7\u4e86\u4e00\u5230\u4e09\u4e2a\u5148\u524d\u7684\u7cfb\u7edf\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-23-1024x783.png\" alt=\"\u6b64\u56fe\u7247\u7684alt\u5c5e\u6027\u4e3a\u7a7a\uff1b\u6587\u4ef6\u540d\u4e3abf244575-b778-4266-a83b-decccdd5be05\" class=\"wp-image-1255\" style=\"width:612px;height:468px\" width=\"612\" height=\"468\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-23-1024x783.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-23-300x229.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-23-768x587.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-23-1218x931.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-23-880x673.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/09\/image-23.png 1224w\" sizes=\"auto, (max-width: 612px) 100vw, 612px\" \/><figcaption class=\"wp-element-caption\">\u7d22\u5c3c\u514b\u62ff\u7740\u6811\u53f6\u505a\u7684\u62d6\u628a\uff0c\u62d6\u6d17\u9e21\u86cb\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6811\u53f6\u4ee3\u8868\u836f\u7269\u9776\u70b9\u53f6\u9178\u53d7\u4f53\u03b1\u3002<\/p>\n\n\n\n<p>\u7d22\u5c3c\u514b\u62d6\u6d17\u5730\uff0c\u4ee3\u8868\u836f\u7269\u540d\u79f0\u7d22\u7c73\u59a5\u6614\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u9e21\u86cb\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7\u5375\u5de2\u764c\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1257,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1250","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1250"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1250\/revisions"}],"predecessor-version":[{"id":1256,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1250\/revisions\/1256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1257"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}