{"id":1324,"date":"2024-05-07T08:44:39","date_gmt":"2024-05-07T00:44:39","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1324"},"modified":"2024-05-07T08:44:39","modified_gmt":"2024-05-07T00:44:39","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-il-15%e6%bf%80%e5%8a%a8%e5%89%82-nogapendekin-alfa-inbakicept-%e9%9d%9e%e8%82%8c%e5%b1%82%e6%b5%b8%e6%b6%a6%e6%80%a7%e8%86%80","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1324","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | IL-15\u6fc0\u52a8\u5242 | Nogapendekin alfa inbakicept | \u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

ANKTIVA\u00ae Nogapendekin alfa inbakicept\u662fImmunityBio\u516c\u53f8\u7814\u53d1\u7684\u4e00\u6b3eIL-15\u7a81\u53d8\u4f53\u4e0e\u53d7\u4f53\u878d\u5408\u86cb\u767d\u7ed3\u5408\u800c\u6210\u7684IL-15\u53d7\u4f53\u6fc0\u52a8\u5242\u3002<\/p>\n\n\n\n

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\u836f\u7269\u5c1a\u672a\u5728\u56fd\u5185\u4e0a\u5e02\uff0c\u5728\u56fd\u5bb6\u836f\u5178\u59d4\u516c\u5e03\u7684\u300aWHO INN P-list\u751f\u7269\u5236\u54c1\u4e2d\u6587\u901a\u7528\u540d\u79f0\u516c\u793a\u7a3f\u300b\u7b2c120\u548c121\u7248\u4e2d\uff0c\u5c06\u5176\u547d\u540d\u4e3a\u8bfa\u683c\u767d\u4ecb\u7d20\u03b1\/\u56e0\u5947\u897f\u666e\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

IL-15\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/p>\n\n\n

\n
\"\"
Cells. 2023 Jun 12;12(12):1611.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

IL-15\u662f\u4e00\u79cd\u7531\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u5305\u62ec\u6d3b\u5316\u7684\u6811\u7a81\u7ec6\u80de\u3001\u5355\u6838\/\u5de8\u566c\u7ec6\u80de\u3001\u4e0a\u76ae\u7ec6\u80de\u4ee5\u53ca\u9aa8\u9ad3\u57fa\u8d28\u7ec6\u80de\u7b49\u3002<\/p>\n\n\n\n

IL-15\u5bf9\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u7cfb\u7684\u53d1\u5c55\u3001\u751f\u5b58\u548c\u589e\u6b96\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0cIL-15\u5728CD8+ T\u7ec6\u80de\u7684\u6269\u5c55\u548c\u751f\u5b58\u4e2d\u4e5f\u8d77\u5230\u91cd\u8981\u7684\u8c03\u8282\u4f5c\u7528\uff0c\u5305\u62ec\u8bb0\u5fc6\u5f62\u6210\u548c\u6dcb\u5df4\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u529f\u80fd\u3002<\/p>\n\n\n\n

IL-15\u4fe1\u53f7\u4f20\u5bfc<\/strong><\/p>\n\n\n

\n
\"\"
J Exp Med . 2020 Jan 6;217(1):e20191062.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

IL-15\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\u5305\u62ec\u4ee5\u4e0b\u51e0\u4e2a\u5173\u952e\u6b65\u9aa4\uff1a<\/p>\n\n\n\n

    \n
  1. JAK\/STAT\u9014\u5f84\uff1aIL-15\u901a\u8fc7\u6fc0\u6d3bJAK1\/3\u548cSTAT3\/5\uff0c\u5bfc\u81f4STAT\u86cb\u767d\u78f7\u9178\u5316\u5e76\u5f62\u6210\u4e8c\u805a\u4f53\uff0c\u8fdb\u800c\u8fdb\u5165\u7ec6\u80de\u6838\u5b9e\u73b0\u8f6c\u5f55\u6fc0\u6d3b\u3002<\/li>\n\n\n\n
  2. Shc\u9014\u5f84\uff1aIL-15\u80fd\u6fc0\u6d3b\u4e0eIL-2\/IL-15R\u03b2\u7ed3\u5408\u7684Shc\u9002\u914d\u86cb\u767d\uff0c\u89e6\u53d1\u5305\u62ecShc\u3001Grb2\u3001GAB2\u3001PI3K\u548cAkt\u5728\u5185\u7684\u4fe1\u53f7\u901a\u8def\u3002<\/li>\n\n\n\n
  3. RAS-RAF MAPK\u9014\u5f84\uff1aIL-15\u6fc0\u6d3bGrb2\u548cSOS\u5f62\u6210\u590d\u5408\u7269\uff0c\u542f\u52a8RAS-RAF MAPK\u901a\u8def\uff0c\u5f71\u54cd\u7ec6\u80de\u589e\u6b96\u3002<\/li>\n<\/ol>\n\n\n\n

    \u8fd9\u4e9b\u9014\u5f84\u5171\u540c\u8c03\u63a7\u5305\u62ecc-Myc\u3001c-Fos\u3001c-Jun\u3001Bcl-2\u7b49\u591a\u79cd\u5173\u952e\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u8fdb\u800c\u5f71\u54cd\u7ec6\u80de\u7684\u751f\u957f\u3001\u5206\u5316\u548c\u5b58\u6d3b\u3002<\/p>\n\n\n\n

    Nogapendekin alfa inbakicept\u7ed3\u6784<\/strong><\/p>\n\n\n

    \n
    \"\"<\/figure>\n<\/div>\n\n\n

    \u836f\u7269\u4e3b\u8981\u5305\u62ec3\u4e2a\u533a\u57df\uff1a<\/p>\n\n\n\n

      \n
    1. IL-15N72D\uff1aANKTIVA\u00ae\u4e2d\u7684IL-15\u7ecf\u8fc7\u7a81\u53d8\uff0c\u5176\u4e2d\u5929\u51ac\u9170\u80fa\uff08Asparagine, N\uff09\u5728\u7b2c72\u4f4d\u88ab\u5929\u51ac\u6c28\u9178\uff08Aspartic acid, D\uff09\u6240\u66ff\u6362\u3002\u8fd9\u79cd\u7a81\u53d8\u663e\u8457\u589e\u5f3a\u4e86\u5176\u4e0eIL-2\/IL-15\u53d7\u4f53\u03b2\u94fe\u7684\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u4ece\u800c\u63d0\u9ad8\u4e86\u751f\u7269\u6d3b\u6027\u3002
      <\/li>\n\n\n\n
    2. IL-15R\u03b1\uff08IL-15\u53d7\u4f53\u03b1\u57df\uff09\uff1a\u8fd9\u662fIL-15\u7684\u5929\u7136\u7ed3\u5408\u4f34\u4fa3\uff0c\u5b83\u4e0eIL-15N72D\u5f62\u6210\u590d\u5408\u7269\u3002\u8be5\u53d7\u4f53\u57df\u6709\u52a9\u4e8eIL-15\u7684\u7a33\u5b9a\u548c\u589e\u5f3a\u5176\u4e0e\u53d7\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/li>\n\n\n\n
    3. IgG1 Fc\u6bb5\uff1aIL-15N72D\u4e0eIL-15R\u03b1\u590d\u5408\u7269\u8fd8\u4e0e\u4ebaIgG1\u7684Fc\u7247\u6bb5\u878d\u5408\u3002\u8fd9\u4e0d\u4ec5\u589e\u52a0\u4e86\u590d\u5408\u7269\u5728\u8840\u6e05\u4e2d\u7684\u534a\u8870\u671f\uff0c\u8fd8\u63d0\u9ad8\u4e86\u5176\u5728\u6dcb\u5df4\u7cfb\u7edf\u7684\u5206\u5e03\uff0c\u5e76\u80fd\u591f\u4e0e\u8868\u8fbeCD16\u7684NK\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7ed3\u5408\u3002Fc\u7247\u6bb5\u7684\u5f15\u5165\u662f\u4e3a\u4e86\u63d0\u9ad8\u7597\u6548\u5e76\u51cf\u5c11\u5242\u91cf\u9700\u6c42\uff0c\u540c\u65f6\u901a\u8fc7Fc\u53d7\u4f53\u4ecb\u5bfc\u7684\u7ec6\u80de\u541e\u566c\u4f5c\u7528\u589e\u5f3a\u5176\u514d\u75ab\u6d3b\u6027\u3002<\/li>\n<\/ol>\n\n\n\n

      Nogapendekin alfa inbakicept\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n

      \n
      \"\"
      ASCO GU 2021<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

      ANKTIVA\u00ae\u7684\u4f5c\u7528\u673a\u5236\u57fa\u4e8e\u5176\u4f5c\u4e3a\u4e00\u79cdIL-15\u8d85\u7ea7\u6fc0\u52a8\u5242\u7684\u529f\u80fd\uff0c\u5177\u4f53\u6d89\u53ca\u4ee5\u4e0b\u51e0\u4e2a\u5173\u952e\u65b9\u9762\uff1a<\/p>\n\n\n\n

        \n
      1. \u589e\u5f3aIL-15\u7684\u751f\u7269\u6d3b\u6027\uff1aANKTIVA\u00ae\u4e2d\u7684IL-15N72D\u7a81\u53d8\u5f62\u5f0f\u901a\u8fc7\u63d0\u9ad8\u4e0eIL-2\/IL-15\u53d7\u4f53\u03b2\u94fe\u7684\u4eb2\u548c\u529b\uff0c\u4ece\u800c\u589e\u5f3a\u4e86IL-15\u7684\u751f\u7269\u6d3b\u6027\u3002\u8fd9\u79cd\u7a81\u53d8\u4f7fIL-15\u80fd\u66f4\u6709\u6548\u5730\u6fc0\u6d3b\u4e0e\u5176\u76f8\u5e94\u53d7\u4f53\u7ed3\u5408\u7684\u514d\u75ab\u7ec6\u80de\u3002<\/li>\n\n\n\n
      2. \u4fc3\u8fdbNK\u7ec6\u80de\u548cCD8+ T\u7ec6\u80de\u7684\u6d3b\u5316\u4e0e\u6269\u5f20\uff1aANKTIVA\u00ae\u80fd\u663e\u8457\u4fc3\u8fdbNK\u7ec6\u80de\u548cCD8+ T\u7ec6\u80de\u7684\u6269\u5f20\u548c\u6d3b\u5316\u3002<\/li>\n\n\n\n
      3. \u589e\u52a0\u5728\u4f53\u5185\u7684\u7a33\u5b9a\u6027\u548c\u5206\u5e03\uff1a\u901a\u8fc7\u4e0eIgG1 Fc\u7247\u6bb5\u7684\u878d\u5408\uff0cANKTIVA\u00ae\u7684\u534a\u8870\u671f\u5f97\u5230\u663e\u8457\u63d0\u9ad8\uff0c\u4f7f\u5176\u80fd\u5728\u4f53\u5185\u66f4\u957f\u65f6\u95f4\u5730\u4fdd\u6301\u6d3b\u6027\u3002<\/li>\n\n\n\n
      4. \u4fc3\u8fdb\u8bb0\u5fc6T\u7ec6\u80de\u7684\u5f62\u6210\u548c\u529f\u80fd\uff1aANKTIVA\u00ae\u4e0d\u4ec5\u4fc3\u8fdb\u514d\u75ab\u7ec6\u80de\u7684\u7acb\u5373\u53cd\u5e94\uff0c\u8fd8\u6709\u52a9\u4e8e\u8bb0\u5fc6T\u7ec6\u80de\u7684\u5f62\u6210\u548c\u529f\u80fd\uff0c\u8fd9\u5bf9\u957f\u671f\u514d\u75ab\u4fdd\u62a4\u7279\u522b\u91cd\u8981\u3002<\/li>\n<\/ol>\n\n\n\n

        2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

        ANKTIVA\u00ae\u4f5c\u4e3a\u4e00\u79cdIL-15\u8d85\u7ea7\u6fc0\u52a8\u5242\u878d\u5408\u86cb\u767d\uff0c\u5176\u6297\u80bf\u7624\u7684\u4f5c\u7528\u673a\u5236\u4e3a\u6fc0\u6d3b\u4eba\u4f53\u5185\u7684\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n\n\n\n

        \u836f\u7269\u6b63\u5728\u4e34\u5e8a\u7814\u53d1\u7528\u4e8e\u591a\u79cd\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u8180\u80f1\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001Lynch \u7efc\u5408\u75c7\u3001\u5375\u5de2\u764c\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u665a\u671f\u5b9e\u4f53\u7624\u3001\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548cHIV\u7b49\u3002<\/p>\n\n\n\n

        \u76ee\u524dFDA\u5df2\u7ecf\u83b7\u6279\u7684\u9002\u5e94\u75c7\u4e3a\uff1a<\/strong><\/p>\n\n\n\n

        \u4e0e\u5361\u4ecb\u82d7\uff08BCG\uff09\u8054\u5408\u4f7f\u7528\uff0c\u7528\u4e8e\u6cbb\u7597BCG\u4e0d\u5e94\u7b54\u7684\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\uff08NMIBC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u5177\u4f53\u4e3a\u539f\u4f4d\u764c\uff08CIS\uff09\u60a3\u8005\uff0c\u4e0d\u8bba\u662f\u5426\u4f34\u6709\u4e73\u5934\u72b6\u80bf\u7624\u3002<\/p>\n\n\n\n

        3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
        \n
        \"\"
        \u963f\u8bfa\u54e5\u7a7f\u7740\u9e66\u9e49\u8863\uff0c\u56f4\u7740\u767d\u8272\u7684\u56f4\u5dfe\uff0c\u5bf9\u7740\u94f6\u5668\u5c3f\u58f6\u6492\u5c3f\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

        \u9e66\u9e49\u662f\u6211\u7684\u6570\u5b57\u7f16\u780115\uff0c\u4ee3\u8868\u9776\u70b9IL-15\u6fc0\u52a8\u5242\u3002<\/p>\n\n\n\n

        \u8bfa\u54e5\u56f4\u7740\u767d\u8272\u56f4\u5dfe\uff0c\u4ee3\u8868\u8bfa\u683c\u767d\u4ecb\u7d20\uff0c\u94f6\u5668\u4ee3\u8868\u56e0\u5947\u897f\u666e\uff0c\u5408\u8d77\u6765\u4e3a\u836f\u7269\u540d\u79f0\uff0c\u8bfa\u683c\u767d\u4ecb\u7d20\u03b1\/\u56e0\u5947\u897f\u666e\u3002<\/p>\n\n\n\n

        \u6492\u5c3f\u4ee3\u8868\u9002\u5e94\u75c7\u8180\u80f1\u764c\u3002<\/p>\n\n\n\n

        \u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"

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