{"id":1338,"date":"2024-06-12T12:32:06","date_gmt":"2024-06-12T04:32:06","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1338"},"modified":"2024-06-12T12:32:06","modified_gmt":"2024-06-12T04:32:06","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-dll3xcd3%e5%8f%8c%e6%8a%97-tarlatamab-%e5%a1%94%e6%8b%89%e5%a1%94%e5%8d%95%e6%8a%97-%e5%b9%bf%e6%b3%9b%e6%9c%9f%e5%b0%8f","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1338","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | DLL3\u00d7CD3\u53cc\u6297 | Tarlatamab \u5854\u62c9\u5854\u5355\u6297 | \u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c"},"content":{"rendered":"\n

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IMDELLTRA\u2122 tarlatamab\u662f\u7f8e\u56fd\u5b89\u8fdb\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u6b3e\u53cc\u7279\u5f02\u6027DLL3\u5bfc\u5411\u7684CD3 T\u7ec6\u80de\u7ed3\u5408\u5668\uff08BiTE\uff09\u3002<\/p>\n\n\n\n

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\u56fd\u5185\u767e\u6d4e\u795e\u5dde\u62e5\u6709\u8be5\u836f\u7684\u4e2d\u56fd\u5546\u4e1a\u5316\u6743\u76ca\u3002\u76ee\u524d\u836f\u7269\u5728\u56fd\u5185\u5c1a\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5c1a\u672a\u4e0a\u5e02\uff0c\u4e2d\u6587\u540d\u6682\u8bd1\u4e3a\u5854\u62c9\u5854\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

T\u7ec6\u80de\u7ed3\u5408\u5668\uff08BiTE\uff09<\/strong><\/p>\n\n\n

\n
\"\"
https:\/\/blog.dana-farber.org\/insight\/2019\/05\/how-are-bispecific-antibodies-being-used-to-treat-blood-cancers\/<\/figcaption><\/figure>\n<\/div>\n\n\n

BiTE\uff08Bispecific T-cell Engager\uff09T\u7ec6\u80de\u7ed3\u5408\u5668\u5206\u5b50\u5177\u6709\u4e24\u4e2a\u7279\u5f02\u6027\u7ed3\u5408\u57df\uff1a<\/p>\n\n\n\n

    \n
  • \u80bf\u7624\u6297\u539f\u7ed3\u5408\u57df\uff1a
    \u8fd9\u4e00\u90e8\u5206\u80fd\u591f\u7279\u5f02\u6027\u8bc6\u522b\u548c\u7ed3\u5408\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u6297\u539f\uff0c\u5982BCMA\uff08B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff09\u3001CD19\u6216DLL3\uff08Delta-like ligand 3\uff09\u3002<\/li>\n\n\n\n
  • T\u7ec6\u80de\u7ed3\u5408\u57df\uff1a
    \u8fd9\u4e00\u90e8\u5206\u9776\u5411T\u7ec6\u80de\u8868\u9762\u7684CD3\u53d7\u4f53\uff0c\u6fc0\u6d3bT\u7ec6\u80de\u5e76\u5f15\u5bfc\u5176\u63a5\u89e6\u5e76\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/li>\n<\/ul>\n\n\n\n

    BiTE\u5206\u5b50\u901a\u8fc7\u5176\u53cc\u7279\u5f02\u6027\u8bbe\u8ba1\u5728\u80bf\u7624\u7ec6\u80de\u548cT\u7ec6\u80de\u4e4b\u95f4\u5f62\u6210\u4e00\u5ea7\u201c\u5206\u5b50\u6865\u6881\u201d\uff0c\u5b9e\u73b0\u4ee5\u4e0b\u529f\u80fd\uff1a<\/p>\n\n\n\n

      \n
    • T\u7ec6\u80de\u5f15\u5bfc\u4e0e\u6fc0\u6d3b\uff1a
      \u5f53BiTE\u5206\u5b50\u7684\u4e24\u4e2a\u7ed3\u5408\u57df\u5206\u522b\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u6297\u539f\uff0c\u4ee5\u53caT\u7ec6\u80de\u8868\u9762CD3\u7ed3\u5408\u65f6\uff0cT\u7ec6\u80de\u88ab\u5f15\u5bfc\u81f3\u80bf\u7624\u7ec6\u80de\u8868\u9762\uff0c\u6fc0\u6d3b\u5176\u6740\u4f24\u529f\u80fd\u3002<\/li>\n\n\n\n
    • \u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff1a
      \u6fc0\u6d3b\u7684T\u7ec6\u80de\u5f00\u59cb\u589e\u6b96\u5e76\u5f62\u6210\u514d\u75ab\u7a81\u89e6\uff0c\u91ca\u653e\u7a7f\u5b54\u7d20\u548c\u9897\u7c92\u9176\uff0c\u8fd9\u4e9b\u7ec6\u80de\u6bd2\u6027\u5206\u5b50\u7834\u574f\u80bf\u7624\u7ec6\u80de\u819c\uff0c\u5bfc\u81f4\u5176\u6eb6\u89e3\u548c\u6b7b\u4ea1\u3002<\/li>\n<\/ul>\n\n\n\n

      DLL3 \u86cb\u767d<\/strong><\/p>\n\n\n

      \n
      \"\"
      Front Immunol . 2018 Jun 1:9:1230.<\/figcaption><\/figure>\n<\/div>\n\n\n

      DLL3\u86cb\u767d\u5c5e\u4e8eNotch \u914d\u4f53\u5bb6\u65cf\u6210\u5458\uff0cNotch \u914d\u4f53\u5bb6\u65cf\u4e3b\u8981\u5305\u62ec\u4e24\u5927\u7c7b\uff1a<\/p>\n\n\n\n

        \n
      • Serrate \u7c7b\u540c\u6e90\u7269(Jag1\u3001Jag2)\uff1b<\/li>\n\n\n\n
      • Delta \u7c7b\u540c\u6e90\u7269\uff08DLL1\u3001DLL4\u3001DLL3\uff09\u3002<\/li>\n<\/ul>\n\n\n\n

        DLL3\u7531DSL\u7ed3\u6784\u57df\u3001\u516d\u4e2a\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08EGF\uff09\u6837\u91cd\u590d\u548c\u4e00\u4e2a\u8de8\u819c\u7ed3\u6784\u57df\u7ec4\u6210\u3002<\/p>\n\n\n\n

        \u5176\u4e2dDSL\u7ed3\u6784\u57df\u4f4d\u4e8e\u86cb\u767d\u7684N\u7aef\uff0c\u53c2\u4e0eNotch\u53d7\u4f53\u7684\u7ed3\u5408\uff0c\u8be5\u7ed3\u6784\u57df\u5728Notch\u914d\u4f53\u5bb6\u65cf\u4e2d\u9ad8\u5ea6\u4fdd\u5b88\u3002<\/p>\n\n\n\n

        \u5c3d\u7ba1DLL3\u5c5e\u4e8eDelta\u7c7b\u540c\u6e90\u7269\uff0c\u4f46\u5b83\u7684\u529f\u80fd\u4e0eDLL1\u548cDLL4\u6709\u6240\u4e0d\u540c\u3002<\/p>\n\n\n\n

        DLL3\u4e3b\u8981\u5728\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u548c\u5176\u4ed6\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\u4e2d\u9ad8\u8868\u8fbe\uff0c\u800c\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u51e0\u4e4e\u4e0d\u8868\u8fbe\u3002\u8fd9\u79cd\u7279\u6027\u4f7fDLL3\u6210\u4e3a\u764c\u75c7\u9776\u5411\u6cbb\u7597\u7684\u7406\u60f3\u5019\u9009\u3002<\/p>\n\n\n\n

        Tarlatamab\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n

        \n
        \"\"
        https:\/\/tarlatamabclinicaltrials.com\/about-tarlatamab<\/figcaption><\/figure>\n<\/div>\n\n\n

        Tarlatamab\u7684\u5de5\u4f5c\u65b9\u5f0f\u4e3a\u5e2e\u52a9\u673a\u4f53\u7684\u514d\u75ab\u7ec6\u80de\u5bfb\u627e\u3001\u7ed3\u5408\u548c\u653b\u51fb\u764c\u7ec6\u80de\u3002\u5177\u4f53\u4e3a\u5bfb\u627e\u3001\u7ed3\u5408\u548c\u653b\u51fb\u4e09\u4e2a\u6b65\u9aa4\uff1a<\/p>\n\n\n\n

          \n
        1. \u5bfb\u627e\uff08Find\uff09\uff1aTarlatamab\u5728\u4f53\u5185\u79fb\u52a8\uff0c\u5bfb\u627eT\u7ec6\u80de\u548c\u764c\u7ec6\u80de\u3002<\/li>\n\n\n\n
        2. \u7ed3\u5408\uff08Attach\uff09\uff1aTarlatamab\u540c\u65f6\u7ed3\u5408T\u7ec6\u80de\u548c\u764c\u7ec6\u80de\uff0c\u5e76\u5c06\u5b83\u4eec\u62c9\u8fd1\u3002\u8fd9\u79cd\u6865\u63a5\u4f5c\u7528\u4f7f\u5f97T\u7ec6\u80de\u80fd\u591f\u8fd1\u8ddd\u79bb\u63a5\u89e6\u764c\u7ec6\u80de\uff0c\u4ece\u800c\u51c6\u5907\u53d1\u52a8\u653b\u51fb\u3002<\/li>\n\n\n\n
        3. \u653b\u51fb\uff08Attack\uff09Tarlatamab\u4f7fT\u7ec6\u80de\u653b\u51fb\u764c\u7ec6\u80de\uff0c\u523a\u6fc0T\u7ec6\u80de\u589e\u6b96\u5e76\u653b\u51fb\u5176\u4ed6\u764c\u7ec6\u80de\u3002<\/li>\n<\/ol>\n\n\n\n

          2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

          Tarlatamab\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027DLL3\u5bfc\u5411\u7684CD3 T\u7ec6\u80de\u63a5\u5408\u6297\u4f53\uff0c\u9002\u7528\u4e8e\u63a5\u53d7\u94c2\u7c7b\u5316\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n\n\n\n

          3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
          \n
          \"\"
          \u4e24\u5ea7\u5b9d\u5854\u76f8\u4e92\u62c9\u626f\uff0c\u5929\u7a7a\u5f00\u59cb\u6253\u96f7\u4e86\uff0c\u5b9d\u5854\u60ca\u5413\u7684\u6389\u4e0b\u5c0f\u7ec6\u80de\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

          \u4e00\u5ea7\u5854\u62c9\u7740\u53e6\u4e00\u5ea7\u5854\uff0c\u4ee3\u8868\u836f\u7269\u540d\u79f0\u5854\u62c9\u5854\u5355\u6297\u3002<\/p>\n\n\n\n

          \u6253\u96f7\u4e86\uff08DLL\uff09\u4ee3\u8868\u836f\u7269\u9776\u70b9DLL3\u00d7CD3\u53cc\u6297\u3002<\/p>\n\n\n\n

          \u6389\u843d\u7684\u5c0f\u7ec6\u80de\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7\uff0c\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n\n\n\n

          \u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"

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