{"id":1354,"date":"2024-08-06T22:25:52","date_gmt":"2024-08-06T14:25:52","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1354"},"modified":"2024-08-07T08:30:59","modified_gmt":"2024-08-07T00:30:59","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%ef%bc%88ad%ef%bc%89-donanemab-%e5%a4%9a%e5%a5%88%e5%b0%bc%e5%8d%95%e6%8a%97","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1354","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09| Donanemab \u591a\u5948\u5c3c\u5355\u6297\u3001\u4ee5\u53ca\u963f\u675c\u5361\u5355\u6297\u3001\u4ed1\u5361\u5948\u5355\u6297"},"content":{"rendered":"\n<p>Donanemab\u662f\u7531\u7f8e\u56fd\u793c\u6765\u516c\u53f8\u7814\u53d1\u7684\u6297\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u836f\u7269\uff0c\u4e8e2024\u5e747\u6708\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff08KISUNLA\u00ae&nbsp;Donanemab\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u3002<\/p>\n\n\n\n<p>\u76ee\u524dDonanemab\u5728\u56fd\u5185\u5c1a\u672a\u83b7\u6279\uff0c\u4e2d\u6587\u540d\u6682\u8bd1\u4e3a\u591a\u5948\u5c3c\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08Alzheimer\u2019s disease; AD\uff09\uff0c\u4fd7\u79f0\u8001\u5e74\u75f4\u5446\uff0c\u662f\u4e00\u79cd\u53d1\u75c5\u8fdb\u7a0b\u7f13\u6162\u3001\u968f\u65f6\u95f4\u4e0d\u65ad\u6076\u5316\u7684\u795e\u7ecf\u9000\u5316\u6027\u75be\u75c5\u3002<\/p>\n\n\n\n<p><strong>\u4f20\u7edfAD\u6cbb\u7597\u836f\u7269<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"911\" height=\"646\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image.png\" alt=\"\" class=\"wp-image-1355\" style=\"width:644px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image.png 911w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-300x213.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-768x545.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-880x624.png 880w\" sizes=\"auto, (max-width: 911px) 100vw, 911px\" \/><figcaption class=\"wp-element-caption\"><em>Med Hypotheses . 2020&nbsp;Oct;143:109879.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>1\u3001\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\uff1a<\/strong><\/p>\n\n\n\n<p>\u4f9d\u636e\u80c6\u78b1\u80fd\u5047\u8bf4\uff0cAD\u60a3\u8005\u80c6\u78b1\u80fd\u795e\u7ecf\u4f20\u9012\u529f\u80fd\u964d\u4f4e\u3002<\/p>\n\n\n\n<p>\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242(AChEI)\u53ef\u901a\u8fc7\u51cf\u5c11\u4e59\u9170\u80c6\u78b1\u7684\u6c34\u89e3\u800c\u589e\u52a0\u7a81\u89e6\u95f4\u9699\u4e2d\u4e59\u9170\u80c6\u78b1(ACh)\u7684\u6d53\u5ea6\uff0c\u589e\u52a0AD\u60a3\u8005\u80c6\u78b1\u80fd\u795e\u7ecf\u4f20\u9012\u529f\u80fd\uff0c\u7f13\u89e3\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c7\u72b6\u3002<\/p>\n\n\n\n<p>\u5e38\u89c4\u6cbb\u7597\u836f\u7269\u5305\u62ec\uff1a\u591a\u5948\u54cc\u9f50\uff0c\u52a0\u5170\u4ed6\u654f\uff0c\u5229\u65af\u7684\u660e\u7b49\u3002<\/p>\n\n\n\n<p><strong>2\u3001NMDA\u8c37\u6c28\u9178\u53d7\u4f53\u6291\u5236\u5242\uff1a<\/strong><\/p>\n\n\n\n<p>\u4e0eAD\u60a3\u8005ACh\u795e\u7ecf\u529f\u80fd\u4f4e\u4e0b\u76f8\u53cd\uff0cNMDA\u53d7\u4f53\u8fc7\u5ea6\u6fc0\u6d3b\u5728AD\u4e2d\u7684\u6bd2\u6027\u4f5c\u7528\u76ee\u524d\u5df2\u7ecf\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n\n\n\n<p>\u7f8e\u91d1\u521a\u662f\u4e00\u79cd\u975e\u7ade\u4e89\u6027NMDA\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u901a\u8fc7\u963b\u65adNMDA\u53d7\u4f53\u7684\u8fc7\u5ea6\u6fc0\u6d3b\uff0c\u51cf\u5c11\u8c37\u6c28\u9178\u8bf1\u5bfc\u7684\u795e\u7ecf\u6bd2\u6027\uff0c\u4fdd\u62a4\u795e\u7ecf\u5143\uff0c\u51cf\u7f13\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u75c7\u72b6\u8fdb\u5c55\u3002<\/p>\n\n\n\n<p>\u65e0\u8bba\u662f\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\uff0c\u8fd8\u662fNMDA\u8c37\u6c28\u9178\u53d7\u4f53\u6291\u5236\u5242\uff0c\u76ee\u524d\u5747\u4ec5\u80fd\u7f13\u89e3\u75c7\u72b6\uff0c\u4e0d\u80fd\u4ece\u6839\u672c\u4e0a\u9006\u8f6cAD\u3002<\/p>\n\n\n\n<p><strong>\u73b0\u4ee3AD\u6cbb\u7597\u836f\u7269<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"796\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-1-1024x796.png\" alt=\"\" class=\"wp-image-1356\" style=\"width:646px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-1-1024x796.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-1-300x233.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-1-768x597.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-1-880x684.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-1.png 1166w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Molecules . 2020 Dec 8;25(24):5789.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u76ee\u524d\u8f83\u6d41\u884c\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5AD\u53d1\u75c5\u673a\u5236\u5047\u8bf4\u4e3b\u8981\u5305\u62ecTau\u86cb\u767d\u5047\u8bf4\uff0c\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u7ea7\u8054\u5047\u8bf4\u3002<\/p>\n\n\n\n<p>1\u3001\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u7ea7\u8054\u5047\u8bf4\uff1a<\/p>\n\n\n\n<p>\u76ee\u524d\u6700\u7ecf\u5178\u7684AD\u53d1\u75c5\u673a\u5236\u5b66\u8bf4\uff0c\u8ba4\u4e3a\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u5728\u795e\u7ecf\u5143\u80de\u5916\u8fc7\u5ea6\u6c89\u79ef\uff0c\u5728\u60a3\u8005\u5927\u8111\u76ae\u5c42\u5f62\u6210\u8001\u5e74\u6591\uff0c\u5bfc\u81f4\u75c5\u7406\u751f\u7406\u6539\u53d8\u3002<\/p>\n\n\n\n<p>\u6dc0\u7c89\u6837\u524d\u4f53\u86cb\u767d\uff08APP\uff09\u5728\u4eba\u4f53\u5185\u5408\u6210\u540e\uff0c\u901a\u8fc7\u03b2\u548c\u03b3\u5206\u6ccc\u9176\u7684\u526a\u5207\u8fdb\u884c\u4ee3\u8c22\u3002<\/p>\n\n\n\n<p>\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u6216\u5206\u6ccc\u9176\u529f\u80fd\u5f02\u5e38\uff0cAPP\u4ee3\u8c22\u751f\u6210\u7684A\u03b2\u589e\u591a\uff0c\u5bfc\u81f4\u5176\u5728\u795e\u7ecf\u5143\u80de\u5916\u6c89\u79ef\u3002\u8fd9\u4e00\u8fc7\u7a0b\u7ecf\u5386A\u03b242\u5355\u4f53\u3001A\u03b242\u5be1\u805a\u4f53\u3001A\u03b2\u6591\u5757\u5f62\u6210\uff0c\u6700\u7ec8\u5f62\u6210\u795e\u7ecf\u5143\u80de\u5916\u6c89\u79ef\u3002<\/p>\n\n\n\n<p>2\u3001Tau\u86cb\u767d\u5047\u8bf4\uff1a<\/p>\n\n\n\n<p>\u795e\u7ecf\u5143\u80de\u5185\uff0cTau\u86cb\u767d\u7ea4\u7ef4\u7f20\u7ed3\u662fAD\u7684\u7b2c\u4e8c\u5927\u75c5\u7406\u8868\u73b0\u3002Tau\u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\u5bfc\u81f4\u6b63\u5e38\u7684\u5fae\u7ba1\u89e3\u805a\uff0c\u968f\u540e\u5bfc\u81f4\u7ec6\u80de\u51fa\u73b0\u6811\u7a81\u5fae\u7ba1\u4e22\u5931\uff0c\u7a81\u89e6\u529f\u80fd\u969c\u788d\uff0c\u76f4\u81f3\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p>\u867d\u7136\u76ee\u524d\u8fd8\u6ca1\u6709\u4e0a\u5e02\u7684Tau\u86cb\u767d\u9776\u5411\u6cbb\u7597\u836f\u7269\uff0c\u4f46\u8fd9\u79cd\u673a\u5236\u662f\u672a\u6765\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u7684\u4e00\u4e2a\u91cd\u8981\u7814\u7a76\u65b9\u5411\u3002<\/p>\n\n\n\n<p>\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u4e3a\u9776\u70b9\u7684\u836f\u7269<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1019\" height=\"744\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-2.png\" alt=\"\" class=\"wp-image-1357\" style=\"width:696px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-2.png 1019w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-2-300x219.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-2-768x561.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-2-880x643.png 880w\" sizes=\"auto, (max-width: 1019px) 100vw, 1019px\" \/><\/figure>\n<\/div>\n\n\n<p>\u4ee5\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u4e3a\u9776\u70b9\uff0c\u76ee\u524dFDA\u5df2\u7ecf\u83b7\u6279\u7684\u751f\u7269\u5236\u5242\u67093\u6b3e\uff1a<\/p>\n\n\n\n<p><strong>1\u3001Aducanumab\uff08\u963f\u675c\u5361\u5355\u6297\uff09<\/strong><\/p>\n\n\n\n<p>Aducanumab\u662f\u6e24\u5065\u516c\u53f8\u548c\u536b\u6750\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684\uff0c\u7528\u4e8e\u6cbb\u7597AD\u7684\u836f\u7269\u3002\u7531\u4e8e\u836f\u7269\u4e0a\u5e02\u540e\u4e89\u8bae\u4e0d\u65ad\uff0c\u536b\u6750\u516c\u53f8\u5df2\u9000\u8fd8Aducanumab\u7684\u6743\u76ca\uff0c\u96c6\u4e2d\u8d44\u6e90\u7814\u53d1\u53e6\u4e00\u4e2aAD\u836f\u7269Lecanemab\uff08\u4ed1\u5361\u5948\u5355\u6297\uff09\u3002<\/p>\n\n\n\n<p>Aducanumab\u7684\u4e34\u5e8a\u5b9e\u9a8c\u4e3b\u8981\u7ec8\u70b9\u9009\u53d6\u4e86 \u03b2 \u6dc0\u7c89\u6837\u86cb\u767d\u964d\u4f4e\u7684\u66ff\u4ee3\u7ec8\u70b9\uff0c\u800c\u975e\u8ba4\u77e5\u529f\u80fd\u63d0\u9ad8\u7684\u201c\u786c\u7ec8\u70b9\u201d\uff0c\u5e76\u4e14\u66ff\u4ee3\u7ec8\u70b9\u7684\u6548\u679c\u4e5f\u4e0d\u7406\u60f3\u3002<\/p>\n\n\n\n<p>2020\u5e74FDA\u53ec\u5f00\u4e13\u5bb6\u54a8\u8be2\u59d4\u5458\u4f1a\u8ba8\u8bbaAducanumab\u7684\u4e0a\u5e02\u8bf7\u6c42\uff0c10\u4eba\u4e13\u5bb6\u7ec48\u4eba\u53cd\u5bf9\uff0c2\u4eba\u5f03\u6743\u3002\u4f46\u662fFDA\u529b\u6392\u4f17\u8bae\uff0c\u4e0e2021\u5e74\u6279\u51c6\u8be5\u836f\u4e0a\u5e02(ADUHELM\u00ae aducanumab)\u3002<\/p>\n\n\n\n<p><strong>2\u3001Lecanemab\uff08\u4ed1\u5361\u5948\u5355\u6297\uff09<\/strong><\/p>\n\n\n\n<p>\u536b\u6750\u516c\u53f8\u653e\u5f03Aducanumab\u540e\uff0c\u5c06\u4e3b\u8981\u7cbe\u529b\u653e\u5728\u4e86Lecanemab\u4e0a\u3002<\/p>\n\n\n\n<p>\u8be5\u836f\u7269\u5728\u4e00\u9879\u4e3a\u671f18\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167III\u671f\u4e34\u5e8a\u7814\u7a76\uff08Clarity 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