{"id":1372,"date":"2024-08-25T13:54:55","date_gmt":"2024-08-25T05:54:55","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1372"},"modified":"2024-08-25T13:54:55","modified_gmt":"2024-08-25T05:54:55","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e3%80%81%e4%bd%93%e9%87%8d%e7%ae%a1%e7%90%86-%e5%8f%b8%e7%be%8e%e6%a0%bc%e9%b2%81%e8%82%bds","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1372","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | 2\u578b\u7cd6\u5c3f\u75c5\u3001\u4f53\u91cd\u7ba1\u7406 | \u53f8\u7f8e\u683c\u9c81\u80bdSemaglutide | GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242"},"content":{"rendered":"\n<p>\u53f8\u7f8e\u683c\u9c81\u80bd\uff08Semaglutide\uff09\u662f\u7531\u4e39\u9ea6\u8bfa\u548c\u8bfa\u5fb7\u516c\u53f8\u7814\u53d1\u7684\u4e00\u6b3eGLP-1\uff08\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff09\u53d7\u4f53\u6fc0\u52a8\u5242\u3002<\/p>\n\n\n\n<p>\u53f8\u7f8e\u683c\u9c81\u80bd\u76ee\u524d\u5171\u6709\u4e09\u79cd\u5546\u54c1\u540d\u836f\u7269\uff0c\u5206\u522b\u662f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>OZEMPIC\u00ae\uff08\u8bfa\u548c\u6cf0\u00ae\uff09\uff0c2017\u5e74\u7f8e\u56fdFDA\u83b7\u6279\uff0c2021\u5e74\u5728\u56fd\u5185\u83b7\u6279\uff0c\u6ce8\u5c04\u7ed9\u836f\u7528\u4e8e\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u4ee5\u53ca\u964d\u4f4e\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u4e0d\u826f\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u3002<\/li>\n\n\n\n<li>RYBELSUS\u00ae\uff08\u8bfa\u548c\u5ffb\u00ae\uff09\uff0c2019\u5e74\u7f8e\u56fdFDA\u83b7\u6279\uff0c2024\u5e741\u6708\u5728\u56fd\u5185\u83b7\u6279\uff0c\u540c\u6837\u7528\u4e8e\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u3002\u4e0d\u540c\u7684\u662f\u8bfa\u548c\u5ffb\u00ae\u662f\u7247\u5242\uff0c\u53e3\u670d\u7ed9\u836f\u3002<\/li>\n\n\n\n<li>WEGOVY\u00ae\uff08\u8bfa\u548c\u76c8\u00ae\uff09\uff0c2021\u5e74\u7f8e\u56fdFDA\u83b7\u6279\uff0c2024\u5e746\u6708\u5728\u56fd\u5185\u83b7\u6279\uff0c\u7528\u4e8e\u8d85\u91cd\u60a3\u8005\u7684\u957f\u671f\u4f53\u91cd\u7ba1\u7406\uff08\u51cf\u80a5\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p><strong>GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242<\/strong><\/p>\n\n\n\n<p>GLP-1\u662f\u4e00\u79cd\u7531\u80a0\u9053L\u7ec6\u80de\u5206\u6ccc\u7684\u80bd\u7c7b\u6fc0\u7d20\uff0c\u4e3b\u8981\u5728\u9910\u540e\u91ca\u653e\uff0c\u4e0eGLP-1\u53d7\u4f53\u7ed3\u5408\u53d1\u6325\u591a\u9879\u751f\u7406\u529f\u80fd\u3002<\/p>\n\n\n\n<p><strong>1.1 \u964d\u4f4e\u8840\u7cd6\uff1a<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"463\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-8-1024x463.png\" alt=\"\" class=\"wp-image-1374\" style=\"width:694px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-8-1024x463.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-8-300x136.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-8-768x347.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-8-880x398.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-8.png 1148w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Cardiovasc Diabetol . 2014 Oct 22:13:142.<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5f53\u4eba\u4f53\u6444\u5165\u98df\u7269\uff08\u5982\u56fe\u4e2d\u6c49\u5821\uff09\u540e\uff0c\u80a0\u9053\u7ec6\u80de\u4f1a\u91ca\u653e\u4e00\u79cd\u53eb\u505a\u80a0\u4fc3\u80f0\u7d20\u7684\u6fc0\u7d20\uff0c\u80a0\u4fc3\u80f0\u7d20\u4e3b\u8981\u5305\u62ec\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd\u20111\uff08GLP\u20111\uff09\u548c\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u4fc3\u80f0\u5c9b\u7d20\u91ca\u653e\u591a\u80bd\uff08GIP\uff09\u3002<\/p>\n\n\n\n<p>\u5173\u4e8eGIP\u7684\u5185\u5bb9\u5c06\u5728\u4e0b\u7bc7\u4ecb\u7ecd\uff0c\u8fd9\u91cc\u6211\u4eec\u4e3b\u8981\u4ecb\u7ecdGLP-1\u3002<\/p>\n\n\n\n<p>GLP-1\u4f5c\u7528\u4e8e\u80f0\u817a\u7684\u03b2\u7ec6\u80de\uff0c\u523a\u6fc0\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002\u540c\u65f6\uff0c\u5b83\u8fd8\u80fd\u6291\u5236\u80f0\u817a\u03b1\u7ec6\u80de\u5206\u6ccc\u80f0\u9ad8\u8840\u7cd6\u7d20\uff0c\u4ece\u800c\u964d\u4f4e\u8840\u7cd6\u3002<\/p>\n\n\n\n<p>DPP-4\u662f\u4eba\u4f53\u5185\u8d1f\u8d23\u964d\u89e3GLP-1\u7684\u9176\u3002DPP-4\u6291\u5236\u5242\uff08\u5982\u897f\u683c\u5217\u6c40\u3001\u7ef4\u683c\u5217\u6c40\u3001\u6c99\u683c\u5217\u6c40\u3001\u963f\u683c\u5217\u6c40\u548c\u5229\u683c\u5217\u6c40\u7b49\uff09\u901a\u8fc7\u6291\u5236DPP-4\u7684\u6d3b\u6027\uff0c\u5ef6\u7f13GLP-1\u7684\u964d\u89e3\u3002\u8fd9\u7c7b\u836f\u7269\u4e5f\u5e7f\u6cdb\u5e94\u7528\u4e8e2\u578b\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u4e2d\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\u5df2\u7ecf\u4e0a\u5e02\u7684GLP-1\u6fc0\u52a8\u5242\u7c7b2\u578b\u7cd6\u5c3f\u75c5\u836f\u7269\u4e3b\u8981\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u767e\u8fbe\u626c\u00ae \u827e\u585e\u90a3\u80bdExenatide\uff08AZ\uff09- \u7b2c\u4e00\u4e2a\u83b7\u5f97FDA\u6279\u51c6\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u534a\u8870\u671f\u77ed\uff0c\u9910\u524d\u4f7f\u7528\u3002<\/li>\n\n\n\n<li>\u8bfa\u548c\u529b\u00ae \u5229\u62c9\u9c81\u80bdLiraglutide\uff08Novo\uff09- \u00a0\u7b2c\u4e8c\u4e2a\u4e0a\u5e02\u7684GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u540e\u6765\u4e5f\u88ab\u6279\u51c6\u7528\u4e8e\u957f\u671f\u4f53\u91cd\u7ba1\u7406\u3002<\/li>\n\n\n\n<li>\u5ea6\u6613\u8fbe\u00ae \u5ea6\u62c9\u7cd6\u80bdDulaglutide\uff08Lilly\uff09- \u534a\u8870\u671f\u5ef6\u957f\uff0c\u6bcf\u5468\u4e00\u6b21\u7684\u7ed9\u836f\uff0c\u957f\u6548GLP-1\u6fc0\u52a8\u5242\u3002<\/li>\n\n\n\n<li>\u5229\u65f6\u654f\u00ae \u5229\u53f8\u90a3\u80bdLixisenatide\uff08Sanofi\uff09 &#8211; \u4e0e\u5229\u62c9\u9c81\u80bd\u7c7b\u4f3c\u3002<\/li>\n\n\n\n<li>\u8bfa\u548c\u6cf0\u00ae \u53f8\u7f8e\u683c\u9c81\u80bdSemaglutide\uff08Novo\uff09- \u534a\u8870\u671f\u5ef6\u957f\uff0c\u6bcf\u5468\u4e00\u6b21\u7684\u7ed9\u836f\uff0c\u957f\u6548GLP-1\u6fc0\u52a8\u5242\u3002<\/li>\n\n\n\n<li>\u8bfa\u548c\u5ffb\u00ae \u53f8\u7f8e\u683c\u9c81\u80bdSemaglutide\uff08Novo\uff09- \u975e\u6ce8\u5c04\uff08\u53e3\u670d\u7247\u5242\uff09\u5f62\u5f0f\u3002<\/li>\n\n\n\n<li>\u7a46\u5cf0\u8fbe\u00ae \u66ff\u5c14\u6cca\u80bd Tirzepatide \uff08Lilly\uff09 &#8211; GLP-1\u3001GIP\u53cc\u9776\u70b9\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cGLP\u20111\u548cGIP\u7684\u4f5c\u7528\u90fd\u662f\u8461\u8404\u7cd6\u6d53\u5ea6\u4f9d\u8d56\u7684\uff0c\u5f53\u5904\u4e8e\u6b63\u5e38\u8840\u7cd6\u6216\u4f4e\u8840\u7cd6\u6d53\u5ea6\u72b6\u6001\u65f6\uff0cGLP\u20111\u548cGIP\u4e0d\u4f1a\u523a\u6fc0\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u56e0\u6b64\uff0c\u4e0d\u4f1a\u5f15\u8d77\u4e25\u91cd\u4f4e\u8840\u7cd6\u7684\u53d1\u751f\u3002<\/p>\n\n\n\n<p><strong>1.2 \u63a7\u5236\u4f53\u91cd\uff1a<\/strong><\/p>\n\n\n\n<p>\u4eba\u4f53\u4e2d\u591a\u4e2a\u5668\u5b98\u5747\u6709GLP-1\u53d7\u4f53\uff0c\u53d1\u6325\u591a\u9879\u751f\u7406\u529f\u80fd\u3002<strong><\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"738\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-9-1024x738.png\" alt=\"\" class=\"wp-image-1375\" style=\"width:676px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-9-1024x738.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-9-300x216.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-9-768x553.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-9-1218x878.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-9-880x634.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-9.png 1270w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Cardiovasc Diabetol . 2014 Oct 22:13:142.\u00a0<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5176\u63a7\u5236\u4f53\u91cd\u4e3b\u8981\u901a\u8fc7\u4ee5\u4e0b\u9014\u5f84\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>GLP-1\u4f5c\u7528\u4e8e\u5927\u8111\u4e2d\u67a2\u795e\u7ecf\uff0c\u51cf\u5c11\u98df\u6b32\u3001\u589e\u52a0\u9971\u8179\u611f\uff0c\u5e76\u4e14\u589e\u52a0\u673a\u4f53\u80fd\u91cf\u6d88\u8017\u3002<\/li>\n\n\n\n<li>GLP-1\u5ef6\u7f13\u80c3\u6392\u7a7a\uff0c\u8ba9\u98df\u7269\u66f4\u591a\u65f6\u95f4\u505c\u7559\u5728\u80c3\u4e2d\uff0c\u8fdb\u4e00\u6b65\u589e\u52a0\u9971\u8179\u611f\uff0c\u5e76\u964d\u4f4e\u80c3\u80a0\u9053\u5438\u6536\u3002<\/li>\n\n\n\n<li>GLP-1\u4fc3\u8fdb\u8102\u80aa\u5206\u89e3\uff0c\u6709\u52a9\u4e8e\u51cf\u5c11\u8102\u80aa\u50a8\u5b58\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u53f8\u7f8e\u683c\u9c81\u80bd\u51cf\u91cd\u6548\u679c<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"782\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-10-1024x782.png\" alt=\"\" class=\"wp-image-1376\" style=\"width:678px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-10-1024x782.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-10-300x229.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-10-768x586.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-10-880x672.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-10.png 1180w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>JAMA . 2021 Apr 13;325(14):1414-1425.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6839\u636e\u53f8\u7f8e\u683c\u9c81\u80bd\uff08\u8bfa\u548c\u76c8\u00ae\uff09\u7684\u4e00\u9879\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76\uff08STEP 4\uff09\u7ed3\u679c\uff1a<\/p>\n\n\n\n<p>\u5728\u6700\u521d20\u5468\u7684\u6cbb\u7597\u540e\uff0c\u6240\u6709\u53c2\u4e0e\u8005\u7684\u4f53\u91cd\u5e73\u5747\u4e0b\u964d\u8d85\u8fc710%\u3002<\/p>\n\n\n\n<p>\u5728\u968f\u540e\u768448\u5468\u5185\uff0c\u7ee7\u7eed\u4f7f\u7528\u53f8\u7f8e\u683c\u9c81\u80bd\u7684\u53c2\u4e0e\u8005\u4f53\u91cd\u7ee7\u7eed\u4e0b\u964d\uff0c\u5230\u7b2c68\u5468\u65f6\u4f53\u91cd\u5e73\u5747\u4e0b\u964d\u7ea617%\u3002<\/p>\n\n\n\n<p>\u800c20\u5468\u540e\u505c\u836f\u7684\u53c2\u4e0e\u8005\u4f53\u91cd\u9010\u6e10\u56de\u5347\uff0c\u6700\u7ec868\u5468\u65f6\u4f53\u91cd\u4e0b\u964d\u5e45\u5ea6\u7f29\u5c0f\u5230\u7ea65%\u3002<\/p>\n\n\n\n<p><strong>\u53f8\u7f8e\u683c\u9c81\u80bd\u51cf\u91cd\u4e0d\u826f\u53cd\u5e94<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"968\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-11-1024x968.png\" alt=\"\" class=\"wp-image-1377\" style=\"width:588px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-11-1024x968.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-11-300x284.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-11-768x726.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-11-1218x1152.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-11-880x832.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/08\/image-11.png 1290w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>JAMA . 2021 Apr 13;325(14):1414-1425.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u540c\u6837\u6839\u636e\u8bfa\u548c\u76c8\u00ae\u7684STEP 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