{"id":1408,"date":"2024-10-09T10:47:21","date_gmt":"2024-10-09T02:47:21","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1408"},"modified":"2024-10-09T10:47:21","modified_gmt":"2024-10-09T02:47:21","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-il-31%e5%8f%97%e4%bd%93%e6%8b%ae%e6%8a%97%e5%89%82-nemolizumab-%e5%a5%88%e8%8e%ab%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97-%e7%bb%93","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1408","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | IL-31\u53d7\u4f53\u62ee\u6297\u5242 | Nemolizumab \u5948\u83ab\u5229\u73e0\u5355\u6297 | \u7ed3\u8282\u6027\u75d2\u75b9"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Nemolizumab\u662fGalderma\u516c\u53f8\u7814\u53d1\u7684\u4e00\u6b3eIL-31\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u901a\u8fc7\u963b\u65adIL-31\u4fe1\u53f7\u901a\u8def\uff0c\u663e\u8457\u51cf\u8f7b\u60a3\u8005\u7684\u7619\u75d2\u75c7\u72b6\uff0c\u5e76\u6539\u5584\u76ae\u80a4\u708e\u75c7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u4e8e2024\u5e748\u6708\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff08NEMLUVIO\u00ae nemolizumab\uff09\u3002\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u7ed3\u8282\u6027\u75d2\u75b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u836f\u7269\u56fd\u5185\u672a\u4e0a\u5e02\uff0c\u4e5f\u6682\u672a\u67e5\u8be2\u5230\u6ce8\u518c\u7533\u62a5\uff0c\u4e2d\u6587\u540d\u6682\u8bd1\u4e3a\u5948\u83ab\u5229\u73e0\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">IL-31\u7684\u4ea7\u751f\u53ca\u4f5c\u7528<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"575\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1024x575.png\" alt=\"\" class=\"wp-image-1409\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1024x575.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-300x168.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-768x431.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-880x494.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image.png 1183w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Drugs . 2021 Jun;81(8):895-905.<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>IL-31\u7684\u4ea7\u751f\uff1a<\/strong>IL-31\u7531\u591a\u79cd\u708e\u75c7\u7ec6\u80de\u4ea7\u751f\uff0c\u5305\u62ec\u5de8\u566c\u7ec6\u80de\u3001T\u7ec6\u80de\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u548c\u55dc\u78b1\u6027\u7c92\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u901a\u8fc7IL-31\u4e0e\u5176\u53d7\u4f53\uff08IL-31R\u03b1\uff09\u7ed3\u5408\uff0c\u5f71\u54cd\u76ae\u80a4\u7684\u591a\u4e2a\u65b9\u9762\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>IL-31\u53d7\u4f53\u9776\u70b9\uff1a<\/strong>IL-31\u901a\u8fc7\u4e0e\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\uff08Keratinocytes\uff09\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\uff08Eosinophils\uff09\u548c\u55dc\u78b1\u6027\u7c92\u7ec6\u80de\uff08Basophils\uff09\u7b49\u8868\u9762\u7684IL-31R\u7ed3\u5408\uff0c\u5bfc\u81f4\u76ae\u80a4\u5c4f\u969c\u529f\u80fd\u969c\u788d\u548c\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\uff08\u5982CCL2\uff0cIL-4\u3001IL-13\u7b49\uff09\u3002\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u8fdb\u4e00\u6b65\u52a0\u5267\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4f20\u9012\u7619\u75d2\uff1a<\/strong>\u76ae\u80a4\u4e2d\u7684\u81ea\u7531\u795e\u7ecf\u672b\u68a2\u5728IL-31\u4f5c\u7528\u4e0b\uff0c\u4f20\u9012\u7619\u75d2\u4fe1\u53f7\u3002\u8fd9\u4e9b\u4fe1\u53f7\u901a\u8fc7\u975e\u7ec4\u80fa\u9014\u5f84\u7684C\u7c7b\u7ea4\u7ef4\u4f20\u9012\u81f3\u810a\u9ad3\uff0c\u518d\u6cbf\u7740\u810a\u9ad3\u4e18\u8111\u675f\u4f20\u9012\u81f3\u5927\u8111\uff0c\u6700\u7ec8\u89e6\u53d1\u7619\u75d2\u611f\uff0c\u5e76\u5f15\u8d77\u7619\u75d2-\u6293\u6320\u5faa\u73af\uff08Itch-Scratch Cycle\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>IL-31\u7684\u4fe1\u53f7\u4f20\u5bfc<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"606\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1-1024x606.png\" alt=\"\" class=\"wp-image-1410\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1-1024x606.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1-300x178.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1-768x454.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1-880x521.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-1.png 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Drugs . 2021 Jun;81(8):895-905.<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5355\u4e2a\u53d7\u4f53\u4e0d\u80fd\u4f20\u9012\u4fe1\u53f7\uff0c\u7ed3\u5408\u6210\u4e8c\u805a\u4f53\u624d\u80fd\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IL-31\u901a\u8fc7\u7ed3\u5408IL-31R\u03b1\u548c\u6291\u7624\u7d20M\u53d7\u4f53\uff08OSMR\uff09\u5f62\u6210\u7684\u53d7\u4f53\u590d\u5408\u7269\uff0c\u6fc0\u6d3b\u7ec6\u80de\u5185\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IL-31\u4e0e\u53d7\u4f53\u7ed3\u5408\u540e\uff0c\u4e3b\u8981\u6fc0\u6d3b\u4ee5\u4e0b\u4e09\u6761\u7ec6\u80de\u5185\u4fe1\u53f7\u901a\u8def\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>JAK1\/2-STAT1\/3\/5\u901a\u8def\uff1a\u542f\u52a8\u57fa\u56e0\u8f6c\u5f55\uff0c\u8bf1\u5bfc\u4fc3\u708e\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u6700\u7ec8\u5f15\u53d1\u7619\u75d2\u548c\u708e\u75c7\u53cd\u5e94\u3002<\/li>\n\n\n\n<li>PI3K-AKT\u901a\u8def\uff1a\u4e3b\u8981\u8c03\u63a7\u7ec6\u80de\u7684\u751f\u5b58\u548c\u589e\u6b96\uff0c\u4e5f\u53c2\u4e0e\u5230\u795e\u7ecf\u672b\u68a2\u7684\u654f\u5316\u53cd\u5e94\u4e2d\uff0c\u4fc3\u8fdb\u7619\u75d2\u4fe1\u53f7\u7684\u4f20\u5bfc\u3002<\/li>\n\n\n\n<li>MAPK-ERK1\/2\u901a\u8def\uff1a\u8fd9\u6761\u901a\u8def\u540c\u6837\u5f71\u54cd\u57fa\u56e0\u8f6c\u5f55\u548c\u7ec6\u80de\u53cd\u5e94\uff0c\u53c2\u4e0e\u708e\u75c7\u548c\u795e\u7ecf\u654f\u5316\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">IL-31\u53d7\u4f53\u62ee\u6297\u5242<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"719\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-2-1024x719.png\" alt=\"\" class=\"wp-image-1411\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-2-1024x719.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-2-300x211.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-2-768x540.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-2-1218x856.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-2-880x618.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-2.png 1284w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Inflammopharmacology . 2024 Apr;32(2):991-1003.<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Nemolizumab\u662f\u4e00\u79cdIL-31\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u901a\u8fc7\u7279\u5f02\u6027\u7ed3\u5408\u5e76\u963b\u65adIL-31\u53d7\u4f53\u03b1\uff08IL-31R\u03b1\uff09\uff0c\u76f4\u63a5\u6291\u5236IL-31\u4e0e\u5176\u53d7\u4f53\u7684\u7ed3\u5408\uff0c\u5e72\u6270\u7619\u75d2\u548c\u708e\u75c7\u4fe1\u53f7\u7684\u4f20\u9012\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8e\u524d\u9762\u5df2\u7ecf\u63cf\u8ff0\u4e86IL-31\u662f\u901a\u8fc7IL-31R\u03b1\u548cOSMR\u7ed3\u5408\u5f62\u6210\u7684\u4e8c\u805a\u4f53\u624d\u80fd\u4f20\u5bfc\u4fe1\u53f7\uff0c\u56e0\u6b64\u901a\u8fc7\u963b\u65adOSMR\u4e5f\u80fd\u95f4\u63a5\u963b\u65adIL-31\u7684\u4fe1\u53f7\u4f20\u5bfc\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7f57\u6c0f\u516c\u53f8\u7684Vixarelimab\uff0c\u901a\u8fc7\u9776\u5411\u963b\u65adOSMR\u03b2\uff0c\u4ece\u800c\u963b\u65adIL-31\u4ee5\u53caOSM\u81ea\u8eab\u7684\u4e0b\u6e38\u708e\u75c7\u548c\u7619\u75d2\u4fe1\u53f7\u4f20\u5bfc\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vixarelimab\u76ee\u524d\u5728FDA\u548c\u56fd\u5185\u5747\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Nemolizumab\u4f5c\u4e3a\u767d\u7ec6\u80de\u4ecb\u7d20-31\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u4f34\u6709\u7ed3\u8282\u6027\u75d2\u75b9\uff08Prurigo Nodularis\uff0cPN\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"759\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-3-1024x759.png\" alt=\"\" class=\"wp-image-1412\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-3-1024x759.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-3-300x222.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-3-768x569.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-3-1218x902.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-3-880x652.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/10\/image-3.png 1296w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">\u9ca8\u9c7c\u8eab\u4e0a\u957f\u6ee1\u7ed3\u8282\uff0c\u8868\u60c5\u975e\u5e38\u7684\u75d2\u3002\u5b83\u62ff\u7740\u950b\u5229\u7684\u5200\u5b50\u5728\u73cd\u73e0\u4e0a\u78e8\uff0c\u4f46\u662f\u73cd\u73e0\u8010\u78e8\uff0c\u6beb\u53d1\u65e0\u635f\u3002<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ca8\u9c7c\u662f\u6570\u5b57\u7f16\u780131\uff0c\u4ee3\u8868\u836f\u7269\u9776\u70b9IL-31\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ca8\u9c7c\u8eab\u4e0a\u6709\u7ed3\u8282\u5e76\u4e14\u5f88\u75d2\uff0c\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7\uff0c\u7ed3\u8282\u6027\u75d2\u75b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u950b\u5229\u7684\u5200\u5b50\u548c\u8010\u78e8\u7684\u73cd\u73e0\uff0c\u4ee3\u8868\u5948\u83ab\u5229\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nemolizumab\u662fGalde&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1413,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1408","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1408"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1408\/revisions"}],"predecessor-version":[{"id":1414,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1408\/revisions\/1414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1413"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1408"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1408"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}