{"id":1439,"date":"2024-12-09T13:18:37","date_gmt":"2024-12-09T05:18:37","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1439"},"modified":"2024-12-09T13:18:38","modified_gmt":"2024-12-09T05:18:38","slug":"%e8%ae%b0%e4%bd%8ffda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91claudin18-2-zolbetuximab%e4%bd%90%e8%b4%9d%e5%a6%a5%e6%98%94%e5%8d%95%e6%8a%97-%e8%83%83%e7%99%8c%e4%b8%8e%e8%83%83%e9%a3%9f","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1439","title":{"rendered":"\u8bb0\u4f4fFDA\u751f\u7269\u836f | \u9776\u5411Claudin18.2 | Zolbetuximab\u4f50\u8d1d\u59a5\u6614\u5355\u6297 | \u80c3\u764c\u4e0e\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Zolbetuximab\u662f\u7531\u65e5\u672c\u5b89\u65af\u6cf0\u6765\u5236\u836f\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u6b3e\u9776\u5411Claudin18.2\u7684\u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u4e8e2024\u5e7410\u6708\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff08VYLOY\u00ae &nbsp;Zolbetuximab\uff09\uff0c\u7528\u4e8e\u6cbb\u7597Claudin18.2\u8868\u8fbe\u9633\u6027\u7684\u80c3\u764c\u4e0e\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">VYLOY\u662f\u7f8e\u56fd\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u4e00\u4e2a\u5f97\u5230FDA\u6279\u51c6\u7684Claudin18.2\u9776\u5411\u836f\u7269\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u836f\u7269\u5728\u56fd\u5185\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5c1a\u672a\u4e0a\u5e02\uff0c\u4e2d\u6587\u540d\u6682\u8bd1\u4e3a\u4f50\u8d1d\u59a5\u6614\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Claudin (CLDN) \u662f\u4e00\u7c7b\u5f62\u6210\u7d27\u5bc6\u8fde\u63a5\u7684\u4e3b\u8981\u819c\u86cb\u767d\u5bb6\u65cf\uff0c\u5177\u6709\u4ee5\u4e0b\u7279\u70b9\u548c\u529f\u80fd\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Claudin\u86cb\u767d\u7ed3\u6784\u7279\u5f81<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"789\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-1-1024x789.png\" alt=\"\" class=\"wp-image-1441\" style=\"width:676px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-1-1024x789.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-1-300x231.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-1-768x591.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-1-880x678.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-1.png 1066w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Front Pharmacol . 2018 Sep 13:9:404.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Claudin \u662f\u5206\u5b50\u91cf\u4e3a20\u81f327 kDa\u7684\u8de8\u819c\u86cb\u767d\uff0c\u5177\u6709\u56db\u4e2a\u8de8\u819c\u7ed3\u6784\u57df\u548c\u4e24\u4e2a\u7ec6\u80de\u5916\u73af\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u7ec6\u80de\u95f4\u7684\u7d27\u5bc6\u8fde\u63a5\u4e2d\uff0cClaudin\u5bb6\u65cf\u7684\u6210\u5458\u4f1a\u805a\u96c6\u5728\u4e00\u8d77\uff0c\u5f62\u6210\u4e00\u4e2a\u9009\u62e9\u6027\u900f\u8fc7\u7684\u5c4f\u969c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bcf\u4e2aClaudin\u5206\u5b50\u901a\u8fc7\u5176\u8de8\u819c\u7ed3\u6784\u8de8\u8d8a\u7ec6\u80de\u819c\uff0c\u4e0e\u90bb\u8fd1\u7ec6\u80de\u7684Claudin\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u7ef4\u6301\u7ec6\u80de\u95f4\u7684\u7d27\u5bc6\u8fde\u63a5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cClaudin\u201d\u4e00\u8bcd\u6e90\u81ea\u62c9\u4e01\u8bcd\u201cclaudere\u201d\uff0c\u610f\u4e3a\u201c\u5173\u95ed\u201d\uff0c\u53cd\u6620\u4e86\u5176\u5bc6\u5c01\u529f\u80fd\u3002\u4e0d\u540c\u7c7b\u578b\u7684 Claudin \u5728\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u5177\u6709\u7279\u5f02\u6027\u8868\u8fbe\u3002\u4f8b\u5982\uff0c\u6b63\u5e38\u80c3\u7c98\u819c\u8868\u8fbe CLDN1-5\u3001CLDN7-12\u3001CLDN16 \u548c CLDN18.2\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6076\u6027\u7ec4\u7ec7\u4e2d\uff0cClaudin \u7684\u8868\u8fbe\u6a21\u5f0f\u53d1\u751f\u53d8\u5316\uff0c\u6d89\u53ca\u764c\u75c7\u7684\u8fdb\u5c55\u3001\u4fb5\u88ad\u548c\u8f6c\u79fb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Zolbetuximab\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"476\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3-1024x476.png\" alt=\"\" class=\"wp-image-1443\" style=\"width:772px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3-1024x476.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3-300x139.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3-768x357.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3-1536x713.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3-1218x566.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3-880x409.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-3.png 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Ther Adv Med Oncol . 2024 Jan 3:16:17588359231217967.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">CLDN18.2 \u662f Claudin \u5bb6\u65cf\u7684\u4e00\u79cd\u7279\u5f02\u4e9a\u578b\uff0c\u6b63\u5e38\u60c5\u51b5 CLDN18.2 \u4e3b\u8981\u5728\u6b63\u5e38\u80c3\u7c98\u819c\u7684\u5206\u5316\u4e0a\u76ae\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002\u5b83\u4f4d\u4e8e\u7d27\u5bc6\u8fde\u63a5\u7684\u9876\u7aef\u533a\u57df\uff0c\u4e0d\u66b4\u9732\u5728\u7ec6\u80de\u8868\u9762\uff0c\u56e0\u6b64\u4e0d\u6613\u88ab\u6297\u4f53\u9776\u5411\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u80c3\u764c\u7ec6\u80de\u4e2d\uff0c\u7531\u4e8e\u764c\u7ec6\u80de\u6781\u6027\u53d7\u635f\uff0cCLDN18.2 \u4ece\u7d27\u5bc6\u8fde\u63a5\u4f4d\u7f6e\u66b4\u9732\u5230\u6574\u4e2a\u7ec6\u80de\u8868\u9762\uff0c\u4f7f\u5176\u66f4\u5bb9\u6613\u88ab\u5355\u514b\u9686\u6297\u4f53\uff08\u5982 Zolbetuximab\uff09\u8bc6\u522b\u548c\u7ed3\u5408\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zolbetuximab \u662f\u9996\u4e2a\u4e13\u95e8\u9488\u5bf9 CLDN18.2 \u7684\u5d4c\u5408 IgG1 \u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u9776\u5411\u7ed3\u5408 CLDN18.2\u540e\uff0c\u6fc0\u6d3b\u4ee5\u4e0b\u4e24\u79cd\u514d\u75ab\u6548\u5e94\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\uff1a\u901a\u8fc7\u514d\u75ab\u6548\u5e94\u7ec6\u80de\uff08\u5982\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff09\u5bf9\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u653b\u51fb\u3002<\/li>\n\n\n\n<li>\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08CDC\uff09\uff1a\u901a\u8fc7\u8865\u4f53\u7cfb\u7edf\u5f15\u53d1\u80bf\u7624\u7ec6\u80de\u88c2\u89e3\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8e CLDN18.2 \u5728\u80c3\u764c\u53ca\u5176\u8f6c\u79fb\u7076\u4e2d\u7684\u8868\u8fbe\u548c\u8868\u9762\u66b4\u9732\uff0cZolbetuximab \u7b49\u9776\u5411\u7597\u6cd5\u80fd\u591f\u7cbe\u51c6\u8bc6\u522b\u548c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u540c\u65f6\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u5f71\u54cd\u8f83\u5c0f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u8bd5\u9a8c\uff08\u5982 SPOTLIGHT \u548c GLOW\uff09\u5df2\u8bc1\u660e Zolbetuximab \u8054\u5408\u5316\u7597\u80fd\u663e\u8457\u6539\u5584 CLDN18.2 \u9633\u6027\u80c3\u764c\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">VYLOY \u662f\u4e00\u79cd\u9488\u5bf9 Claudin 18.2 \u7684\u6eb6\u7ec6\u80de\u6297\u4f53\uff0c\u9002\u7528\u4e8e\u4ee5\u4e0b\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u5408\u542b\u6c1f\u5627\u5576\u7c7b\u548c\u94c2\u7c7b\u5316\u7597\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 2\uff08HER2\uff09\u9634\u6027\u4e14\u7ecf FDA \u6279\u51c6\u68c0\u6d4b\u786e\u8ba4\u4e3a Claudin (CLDN) 18.2 \u9633\u6027\u7684\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u817a\u764c\u6210\u5e74\u60a3\u8005\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"657\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5-1024x657.png\" alt=\"\" class=\"wp-image-1445\" style=\"width:700px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5-1024x657.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5-300x193.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5-768x493.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5-1536x986.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5-1218x782.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5-880x565.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/12\/image-5.png 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">\u5929\u7a7a\u5e03\u6ee1\u4e4c\u4e91\uff0c\u6076\u9f99\u6280\u5e08\u7ed9\u5ba2\u4eba\u505a\u80cc\uff0c\u628a\u809a\u5b50\u91cc\u7684\u706b\u7130\u5168\u90e8\u5410\u606f\u4e86\u51fa\u6765\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5e03\u6ee1cloud\u7684\u5929\u7a7a\uff0c\u4ee3\u8868\u836f\u7269\u9776\u70b9claudin 18.2\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6076\u9f99\u8fb9\u505a\u80cc\uff0c\u8fb9\u5410\u606f\uff0c\u4ee3\u8868\u836f\u7269\u540d\u79f0\u4f50\u8d1d\u59a5\u6614\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6076\u9f99\u80c3\u90e8\u7684\u706b\u7130\uff0c\u4ee3\u8868\u9002\u5e94\u75c7\uff0c\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zolbetuximab\u662f\u7531\u65e5\u672c\u5b89&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1446,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1439","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1439"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1439\/revisions"}],"predecessor-version":[{"id":1447,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1439\/revisions\/1447"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1446"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}