{"id":1463,"date":"2025-01-17T22:36:05","date_gmt":"2025-01-17T14:36:05","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1463"},"modified":"2025-01-17T22:36:06","modified_gmt":"2025-01-17T14:36:06","slug":"fda%e9%a6%96%e4%b8%aa%e8%8e%b7%e6%89%b9her3%e9%9d%b6%e5%90%91%e8%8d%af-her2-x-her3%e5%8f%8c%e6%8a%97-zenocutuzumab-nrg1%e8%9e%8d%e5%90%88%e9%98%b3%e6%80%a7%e5%ae%9e%e4%bd%93%e7%98%a4","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1463","title":{"rendered":"FDA\u9996\u4e2a\u83b7\u6279HER3\u9776\u5411\u836f | HER2 \u00d7 HER3\u53cc\u6297 | Zenocutuzumab | NRG1\u878d\u5408\u9633\u6027\u5b9e\u4f53\u7624"},"content":{"rendered":"\n<p>Zenocutuzumab\u662f\u7531Molecular Partners\u516c\u53f8\u7814\u53d1\u7684\u4e00\u6b3eHER2\u00d7HER3\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u6279\u7684 HER3\u9776\u5411\u836f\u3002<\/p>\n\n\n\n<p>\u836f\u7269\u4e8e2024\u5e7412\u6708\u83b7FDA\u6279\u51c6\uff08BIZENGRI\u00aeZenocutuzumab\uff09\uff0c\u9002\u7528\u4e8e\u6cbb\u7597NRG1\u878d\u5408\u9633\u6027\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u80f0\u817a\u764c\u7b49\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\u8be5\u836f\u7269\u5c1a\u672a\u5728\u56fd\u5185\u4e0a\u5e02\uff0c\u4e2d\u6587\u540d\u6682\u8bd1\u4e3a\u6cfd\u8bfa\u5e93\u59a5\u73e0\uff0c\u6216\u6cfd\u59a5\u73e0\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>\u524d\u4e00\u7bc7\u5185\u5bb9\u5df2\u7ecf\u8bb2\u8ff0\u4e8611\u6708\u83b7\u6279\u7684Zanidatamab \u6cfd\u5c3c\u8fbe\u59a5\u5355\u6297\uff0c\u4e3aHER2\u53cc\u6297\uff0c\u9776\u70b9\u4e3aHER2\u4e2d\u7684\u4e24\u4e2a\u4e0d\u540c\u4f4d\u70b9\u3002<\/p>\n\n\n\n<p>\u800c\u672c\u7bc7\u4e2d\uff0cZenocutuzumab\u4e3aHER2 \u00d7 HER3\u53cc\u6297\uff0c\u9776\u70b9\u4e3aHER2\u548cHER3\u3002<\/p>\n\n\n\n<p>HER3\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u9ad8\u8868\u8fbe\uff0c\u5305\u62ec\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u80f0\u817a\u764c\u548c\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u8fd9\u4f7f\u5176\u6210\u4e3a\u4e00\u4e2a\u5907\u53d7\u5173\u6ce8\u7684\u80bf\u7624\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u4e0eHER\u5bb6\u65cf\u7684\u5176\u4ed6\u6210\u5458\uff08\u5982HER2\u548cEGFR\uff09\u76f8\u6bd4\uff0cHER3\u80de\u5185\u916a\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u6781\u5f31\uff0c\u65e0\u6cd5\u72ec\u7acb\u5f62\u6210\u4e8c\u805a\u4f53\u6765\u6fc0\u6d3b\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u3002\u56e0\u6b64\u9700\u8981\u4e0e\u5176\u4ed6HER\u5bb6\u65cf\u6210\u5458\uff08\u5982HER2\uff09\u5f62\u6210\u5f02\u6e90\u4e8c\u805a\u4f53\u624d\u80fd\u53d1\u6325\u529f\u80fd\u3002<\/p>\n\n\n\n<p>\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0cNRG1\uff08\u795e\u7ecf\u8c03\u8282\u86cb\u767d1\uff09\u4f5c\u4e3aHER3\u7684\u9ad8\u4eb2\u548c\u529b\u914d\u4f53\uff0c\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"611\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1024x611.png\" alt=\"\" class=\"wp-image-1464\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1024x611.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-300x179.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-768x458.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1218x727.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-880x525.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image.png 1516w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Future Oncol . 2024;20(16):1057-1067.<\/em><\/figcaption><\/figure>\n\n\n\n<p>\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0cNRG1\u4e0eHER3\u7ed3\u5408\u540e\uff0c\u8bf1\u5bfcHER3\u4e0eHER2\u5f62\u6210\u5f02\u6e90\u4e8c\u805a\u4f53\uff0c\u6fc0\u6d3b\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff0c\u8c03\u63a7\u7ec6\u80de\u7684\u589e\u6b96\u3001\u5206\u5316\u548c\u5b58\u6d3b\u3002\u56e0\u6b64\uff0cNRG1\u7684\u53c2\u4e0e\u5bf9\u4e8eHER3\u529f\u80fd\u7684\u5b9e\u73b0\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<p>\u5728\u67d0\u4e9b\u764c\u75c7\u7c7b\u578b\u4e2d\uff0cNRG1 \u57fa\u56e0\u878d\u5408\u4f1a\u5bfc\u81f4 NRG1 \u4e0e HER3 \u7684\u5f02\u5e38\u76f8\u4e92\u4f5c\u7528\uff0c\u6301\u7eed\u6fc0\u6d3b HER2\/HER3 \u5f02\u4e8c\u805a\u4f53\uff0c\u4fc3\u8fdb\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\u3002<\/p>\n\n\n\n<p>Zenocutuzumab \u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u65e8\u5728\u540c\u65f6\u9776\u5411 HER2 \u548c HER3 \u53d7\u4f53\uff0c\u963b\u65ad NRG1\uff08\u795e\u7ecf\u8c03\u8282\u86cb\u767d 1\uff09\u4e0e HER3 \u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6291\u5236 HER2\/HER3 \u5f02\u4e8c\u805a\u4f53\u7684\u5f62\u6210\uff0c\u8fdb\u800c\u963b\u65ad\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff08PI3K\/AKT\uff09\uff0c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u3002<\/p>\n\n\n\n<p>Zenocutuzumab \u7684\u4f5c\u7528\u673a\u5236\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7ed3\u5408 HER2\uff1aZenocutuzumab \u7684\u4e00\u90e8\u5206\u4e0e HER2 \u53d7\u4f53\u7ed3\u5408\uff0c\u8d77\u5230\u951a\u5b9a\u4f5c\u7528\u3002<\/li>\n\n\n\n<li>\u963b\u65ad NRG1 \u4e0e HER3 \u7684\u7ed3\u5408\uff1a\u901a\u8fc7\u5176\u53e6\u4e00\u90e8\u5206\uff0cZenocutuzumab \u963b\u6b62 NRG1 \u4e0e HER3 \u7684\u7ed3\u5408\uff0c\u9632\u6b62 HER2\/HER3 \u5f02\u4e8c\u805a\u4f53\u7684\u5f62\u6210\u3002<\/li>\n\n\n\n<li>\u6291\u5236\u4e0b\u6e38\u4fe1\u53f7\u4f20\u5bfc\uff1a\u901a\u8fc7\u963b\u65ad HER2\/HER3 \u5f02\u4e8c\u805a\u4f53\u7684\u5f62\u6210\uff0cZenocutuzumab \u6291\u5236\u4e0b\u6e38 PI3K\/AKT \u548c MAPK \u4fe1\u53f7\u901a\u8def\u7684\u6fc0\u6d3b\uff0c\u51cf\u5c11\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u548c\u5b58\u6d3b\u3002<\/li>\n\n\n\n<li>\u6b64\u5916\uff0cZenocutuzumab \u8fd8\u7ecf\u8fc7\u7cd6\u57fa\u5316\u4fee\u9970\uff0c\u589e\u5f3a\u4e86\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u7684\u6e05\u9664\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p>Zenocutuzumab \u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027HER2\u548cHER3\u5bfc\u5411\u7684\u6297\u4f53\uff0c\u9002\u5e94\u75c7\u5982\u4e0b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7528\u4e8e\u6cbb\u7597\u643a\u5e26 (NRG1) \u57fa\u56e0\u878d\u5408\u4e14\u5728\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6027\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/li>\n\n\n\n<li>\u7528\u4e8e\u6cbb\u7597\u643a\u5e26(NRG1) \u57fa\u56e0\u878d\u5408\u4e14\u5728\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6027\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u80f0\u817a\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"689\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1-1024x689.png\" alt=\"\" class=\"wp-image-1465\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1-1024x689.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1-300x202.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1-768x517.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1-1536x1034.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1-1218x820.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1-880x592.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/01\/image-1.png 1824w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>\u7518\u8517\u5730\u8def\u53e3\uff0c\u4e00\u8fb92\u4e2a\u571f\u8457\u5973\u5b69\uff0c\u53e6\u4e00\u8fb93\u4e2a\u571f\u8457\u5973\u5b69\uff0c\u56f4\u7740\u4e00\u56e2\u80bf\u7624\u5403\u7518\u8517\u3002<\/em><\/figcaption><\/figure>\n\n\n\n<p>Y\u578b\u8def\u53e3\u4e24\u8fb9\u76842\u4e2a\u5973\u5b69\uff0c3\u4e2a\u5973\u5b69\uff0c\u4ee3\u8868\u836f\u7269\u7ed3\u6784HER2 \u00d7 HER3\u53cc\u6297\u3002<\/p>\n\n\n\n<p>\u7518\u8517\u5730\u7684\u571f\u8457\u5973\u5b69\uff0c\u4ee3\u8868\u836f\u7269\u540d\u79f0\uff0c\u6cfd\u59a5\u73e0\u5355\u6297\uff08\u6cfd\u8bfa\u5e93\u59a5\u73e0\u5355\u6297\uff09\u3002<\/p>\n\n\n\n<p>\u80bf\u7624\u4ee3\u8868\u836f\u7269\u4e3a\u6cbb\u7597HER3\u76f8\u5173\u7684\u5b9e\u4f53\u7624\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zenocutuzumab\u662f\u7531Mo&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1466,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1463","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1463"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1463\/revisions"}],"predecessor-version":[{"id":1467,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1463\/revisions\/1467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1466"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}