{"id":1504,"date":"2025-07-13T22:26:27","date_gmt":"2025-07-13T14:26:27","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=1504"},"modified":"2025-07-13T22:26:28","modified_gmt":"2025-07-13T14:26:28","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-c-met-adc-telisotuzumab-vedotin-%e7%bb%b4%e7%89%b9%e5%88%a9%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97-%e9%9d%9e%e5%b0%8f%e7%bb%86","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=1504","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | c-MET ADC | Telisotuzumab vedotin \u7ef4\u7279\u5229\u59a5\u73e0\u5355\u6297 | \u975e\u5c0f\u7ec6\u80de\u80ba\u764c"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>Telisotuzumab vedotin\uff08\u5546\u54c1\u540d\uff1aEMRELIS\u2122\uff09\u662f\u7531\u7f8e\u56fd\u827e\u4f2f\u7ef4\u516c\u53f8\uff08AbbVie\uff09\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u6b3e\u9776\u5411c-MET\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u3002\u8be5\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n<p>Telisotuzumab vedotin \u4e8e2025\u5e745\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\u4e0a\u5e02\uff0c\u6210\u4e3a\u9996\u6b3e\u4e13\u95e8\u7528\u4e8e\u6cbb\u7597\u9ad8c-Met\u86cb\u767d\u8868\u8fbeNSCLC\u60a3\u8005\u7684c-Met\u9776\u5411ADC\u836f\u7269\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\u8be5\u836f\u56fd\u5185\u5904\u4e8e\u6ce8\u518c\u7533\u62a5\u9636\u6bb5\uff0c\u5c1a\u672a\u4e0a\u5e02\uff0c\u6309\u7167ADC\u547d\u540d\u4e60\u60ef\uff0c\u6682\u8bd1\u4e3a\u7ef4\u7279\u5229\u59a5\u73e0\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"826\" height=\"507\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image.png\" alt=\"\" class=\"wp-image-1505\" style=\"width:638px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image.png 826w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-300x184.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-768x471.png 768w\" sizes=\"auto, (max-width: 826px) 100vw, 826px\" \/><figcaption class=\"wp-element-caption\"><em>J Egypt Natl Canc Inst . 2025 Mar 3;37(1):6.&nbsp;<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>Telisotuzumab vedotin\u7531\u4e09\u90e8\u5206\u6784\u6210\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6297\u4f53\u90e8\u5206\uff08Antibody\uff09<\/strong>\uff1a\u7279\u5f02\u6027\u8bc6\u522b\u5e76\u7ed3\u5408\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u7ec4\u7ec7\u56e0\u5b50c-MET\u3002<\/li>\n\n\n\n<li><strong>\u8fde\u63a5\u5b50\uff08Linker\uff09<\/strong>\uff1a\u53ef\u5207\u5272\u7684 mc-val-cit-PABC \u7c7b\u578b\u8fde\u63a5\u5b50\uff0c\u5728\u7ec6\u80de\u5185\u88ab\u9176\u964d\u89e3\u540e\u91ca\u653e\u6bd2\u7d20\u3002 &nbsp;<\/li>\n\n\n\n<li><strong>\u8f7d\u8377\u90e8\u5206\uff08Payload\uff09<\/strong>\uff1aMMAE\uff08monomethyl auristatin E\uff09\uff0c\u662f\u4e00\u79cd\u5fae\u7ba1\u6291\u5236\u5242\uff0c\u7834\u574f\u7ec6\u80de\u6709\u4e1d\u5206\u88c2\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u76ee\u524d\uff0c\u5df2\u6709\u591a\u6b3e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e3b\u8981\u6297\u4f53\u5076\u8054\u836f\u7269\u4e0a\u5e02\u6216\u5728\u7814\uff0c\u8fd9\u4e9b\u836f\u7269\u7684\u7ed3\u6784\u529f\u80fd\u793a\u610f\u56fe\u5982\u4e0b\uff1a<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"538\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1-1024x538.png\" alt=\"\" class=\"wp-image-1506\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1-1024x538.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1-300x158.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1-768x404.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1-1536x807.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1-1218x640.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1-880x463.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-1.png 1836w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Cancer Treat Rev . 2025 Mar:134:102902.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>&nbsp;<\/strong><\/td><td><strong>\u9776\u70b9<\/strong><\/td><td><strong>Payload<\/strong><\/td><td><strong>FDA<\/strong><\/td><td><strong>\u4e2d\u56fd<\/strong><\/td><\/tr><tr><td><strong>Telisotuzumab Vedotin<\/strong><\/td><td>c-MET<\/td><td>MMAE<\/td><td>EMRELIS\u00ae<\/td><td>\u5c1a\u672a\u83b7\u6279<\/td><\/tr><tr><td><strong>Patritumab<\/strong><strong> <\/strong><strong>Deruxtecan<\/strong><\/td><td>HER3<\/td><td>Dxd<\/td><td>\u5c1a\u672a\u83b7\u6279<\/td><td>\u5c1a\u672a\u83b7\u6279<\/td><\/tr><tr><td><strong>Trastuzumab <\/strong><strong>Deruxtecan<\/strong><\/td><td>HER2<\/td><td>Dxd<\/td><td>Enhertu\u00ae<\/td><td>\u4f18\u8d6b\u5f97\u00ae \u5fb7\u66f2\u59a5\u73e0\u5355\u6297<\/td><\/tr><tr><td><strong>Datopotamab<\/strong><strong> <\/strong><strong>Deruxtecan<\/strong><\/td><td>TROP2<\/td><td>Dxd<\/td><td>Datroway\u00ae<\/td><td>\u5c1a\u672a\u83b7\u6279<\/td><\/tr><tr><td><strong>Sacituzumab <\/strong><strong>Govitecan<\/strong><\/td><td>TROP2<\/td><td>\u4f0a\u7acb\u66ff\u5eb7<\/td><td>Trodelvy\u00ae<\/td><td>\u62d3\u8fbe\u7ef4\u00ae \u6208\u6c99\u59a5\u73e0\u5355\u6297<\/td><\/tr><tr><td><strong>Sacituzumab <\/strong><strong>Tirumotecan<\/strong><\/td><td>TROP2<\/td><td><\/td><td>\u5c1a\u672a\u83b7\u6279<\/td><td>\u5c1a\u672a\u83b7\u6279<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>c-MET\u86cb\u767d<\/strong>\uff1a<\/p>\n\n\n\n<p>c-MET\uff08\u53c8\u79f0MET\u6216HGFR\uff09\uff0c\u662f\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08HGF\uff09\u53d7\u4f53\uff0c\u662f\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\u3002<\/p>\n\n\n\n<p>c-Met\u5728\u80da\u80ce\u53d1\u80b2\u3001\u4f24\u53e3\u6108\u5408\u7b49\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u751f\u7406\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u4f46\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\uff0cc-Met\u901a\u8fc7\u8fc7\u8868\u8fbe\u3001\u6269\u589e\u6216\u7a81\u53d8\u6fc0\u6d3b\uff0c\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\u3001\u4fb5\u88ad\u3001\u8f6c\u79fb\u548c\u8010\u836f\u3002c-Met\u8fc7\u8868\u8fbe\u53ef\u4f5c\u4e3a\u80bf\u7624\u9a71\u52a8\u56e0\u7d20\u53ca\u9884\u540e\u4e0d\u826f\u6807\u5fd7\u7269\uff0c\u7279\u522b\u5728NSCLC\u4e2d\u8f83\u4e3a\u5e38\u89c1\u3002<\/p>\n\n\n\n<p>Telisotuzumab vedotin\u4f5c\u4e3a\u9996\u4e2a\u9776\u5411c-Met\u7684ADC\uff0c\u9009\u62e9\u6027\u9012\u9001MMAE\u81f3c-Met\u9ad8\u8868\u8fbe\u7ec6\u80de\uff0c\u5c55\u73b0\u51fa\u7cbe\u51c6\u3001\u9ad8\u6548\u3001\u4f4e\u8131\u9776\u7684\u6297\u80bf\u7624\u7b56\u7565\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p>EMRELIS\u2122\u662f\u4e00\u79cd\u9776\u5411 c-MET\u7684\u6297\u4f53\u4e0e\u5fae\u7ba1\u6291\u5236\u5242\u5076\u8054\u836f\uff0cFDA\u76ee\u524d\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n<p>\u7ecfFDA\u6279\u51c6\u68c0\u6d4b\u786e\u8ba4\uff0c\u80bf\u7624\u7ec6\u80de\u4e2d\u6709 \u226550% \u533a\u57df\u5448\u5f3a\u9633\u6027\uff083+\uff09c-Met\u86cb\u767d\u8868\u8fbe\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u4e14\u5df2\u63a5\u53d7\u8fc7\u65e2\u5f80\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u3002<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"676\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2-1024x676.png\" alt=\"\" class=\"wp-image-1507\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2-1024x676.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2-300x198.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2-768x507.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2-1536x1014.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2-1218x804.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2-880x581.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2025\/07\/image-2.png 1938w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>\u4e00\u7fa4\u5c0f\u732a\u4e2d\u95f4\uff0c\u80ba\u9047\u89c1\u4e86\u552f\u4e00\u7684\u7279\u522b\u7684\u4e00\u5934\u732a\u3002<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u552f\u4e00\u7684\u7279\u522b\u7684\u4e00\u5934\u732a\uff0c\u4ee3\u8868\u836f\u7269\u540d\u79f0\uff0c\u7ef4\u7279\u5229\u59a5\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u80ba\u4ee3\u8868\u9002\u5e94\u75c7\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n\n\n\n<p>\u4ed6\u4eec\u5728C\u4f4d\u76f8\u9047\uff0c\u4ee3\u8868\u9776\u70b9\uff0cc-MET\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1510,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1504"}],"version-history":[{"count":2,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1504\/revisions"}],"predecessor-version":[{"id":1509,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/1504\/revisions\/1509"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1510"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}