{"id":199,"date":"2022-08-01T22:06:48","date_gmt":"2022-08-01T14:06:48","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=199"},"modified":"2022-08-22T23:10:02","modified_gmt":"2022-08-22T15:10:02","slug":"%e5%9b%be%e5%83%8f%e8%ae%b0%e5%bf%86-%e9%93%b6%e5%b1%91%e7%97%85%e3%80%81-%e5%bc%ba%e7%9b%b4%e6%80%a7%e8%84%8a%e6%9f%b1%e7%82%8e%e7%94%9f%e7%89%a9%e8%8d%af%e7%99%bd%e4%bb%8b%e7%b4%a0-17ail-17a","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=199","title":{"rendered":"\u56fe\u50cf\u8bb0\u5fc6 | \u94f6\u5c51\u75c5\u3001 \u5f3a\u76f4\u6027\u810a\u67f1\u708e\u751f\u7269\u836f\u767d\u4ecb\u7d20-17A(IL-17A)\u62ee\u6297\u5242 | \u53f8\u5e93\u5947\u5c24\u5355\u6297 | \u53ef\u5584\u633asecukinumab"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u7269\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u751f\u7269\u836f\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>\u8bfa\u534e\u516c\u53f8\u7684\u751f\u7269\u5236\u5242\uff0c\u767d\u4ecb\u7d2017-A\uff08IL-17A\uff09\u62ee\u6297\u5242\uff0c\u53f8\u5e93\u5947\u5c24\u5355\u6297 COSENTYX<sup>\u00ae<\/sup>\u00a0(secukinumab) \uff0c\u56fd\u5185\u4e0a\u5e02\u7684\u5546\u54c1\u540d\u4e3a\u53ef\u5584\u633a<sup>\u00ae<\/sup>\u3002<\/p>\n\n\n\n<p>\u8be5\u836f\u56fd\u5185\u4e0a\u5e02\u524d\uff0c\u8bb8\u591a\u60a3\u8005\u81ea\u53d1\u53bb\u6d77\u5916\u8d2d\u4e70\uff0c\u5f53\u65f6\u5927\u5bb6\u53eb\u5b83\u82cf\u91d1\u5355\u6297\u3002\u53f8\u5e93\u5947\u5c24\u5355\u62972019\u5e74\u56fd\u5185\u4e0a\u5e02\uff0c\u76ee\u524d\u56fd\u5185\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\u6591\u5757\u72b6\u94f6\u5c51\u75c5\uff0c\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>IL-17\u5bb6\u65cf\u5305\u62ecIL-17A\u5230IL-17F\u516d\u4e2a\u6210\u5458\uff0c\u5176\u4e2dIL-17A\u662f\u7814\u7a76\u6700\u4e3a\u5e7f\u6cdb\u7684\u7ec6\u80de\u56e0\u5b50\u3002<\/p>\n\n\n\n<p><strong>IL-17A\u6765\u6e90<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-31.png\" alt=\"\" class=\"wp-image-200\" width=\"577\" height=\"341\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-31.png 990w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-31-300x178.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-31-768x455.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-31-880x521.png 880w\" sizes=\"auto, (max-width: 577px) 100vw, 577px\" \/><figcaption><em><em>https:\/\/www.cosentyxhcp.com\/rheumatology\/disease-understanding\/mechanism-of-action.html<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>IL-17A\u662f\u4e00\u79cd\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u4e3b\u8981\u7531\u7279\u5f02\u6027\u514d\u75ab\u7ecf\u521d\u59cbT\u7ec6\u80de\uff0c\u5206\u5316\u6210T\u8f85\u52a9\u7ec6\u80de17\uff08Th17\uff09\u5206\u6ccc\u3002\u4e5f\u53ef\u7531\u56fa\u6709\u514d\u75ab\u7ecf\u80a5\u5927\u7ec6\u80de\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u5148\u5929\u6027\u6dcb\u5df4\u7ec6\u80de\u7b49\u5206\u6ccc\u3002<\/p>\n\n\n\n<p>\u53f8\u5e93\u5947\u5c24\u5355\u6297\u9776\u5411IL-17A\uff0c\u963b\u65ad\u5176\u529f\u80fd\u3002<\/p>\n\n\n\n<p><strong>IL-17A\u7684\u4f5c\u7528<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-32-1024x690.png\" alt=\"\" class=\"wp-image-201\" width=\"588\" height=\"396\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-32-1024x690.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-32-300x202.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-32-768x517.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-32-880x593.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-32.png 1115w\" sizes=\"auto, (max-width: 588px) 100vw, 588px\" \/><figcaption><em><em>Clin Rev Allergy Immunol. 2018 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