{"id":30,"date":"2022-06-11T21:41:27","date_gmt":"2022-06-11T13:41:27","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=30"},"modified":"2022-08-22T23:09:01","modified_gmt":"2022-08-22T15:09:01","slug":"%e5%9b%be%e5%83%8f%e8%ae%b0%e5%bf%86-%e5%91%a8%e6%9c%9f%e6%80%a7%e5%8f%91%e7%83%ad%ef%bc%8c%e5%bf%83%e5%8c%85%e7%82%8e%e7%ad%89%e7%94%9f%e7%89%a9%e8%8d%af-%e7%99%bd%e4%bb%8b%e7%b4%a0-1%ce%b1-1","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=30","title":{"rendered":"\u56fe\u50cf\u8bb0\u5fc6 | \u5468\u671f\u6027\u53d1\u70ed\uff0c\u5fc3\u5305\u708e\u7b49\u751f\u7269\u836f | \u767d\u4ecb\u7d20-1\u03b1\/1\u03b2\uff08IL-1\u03b1\/1\u03b2\uff09\u62ee\u6297\u5242 | Rilonacept \u5229\u90a3\u897f\u666e"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u7269\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u751f\u7269\u836f\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

\u518d\u751f\u5143\uff08Regeneron\uff09\u516c\u53f8\u7814\u53d1\u7684\u751f\u7269\u5236\u5242\u767d\u4ecb\u7d20-1\u03b1\/1\u03b2\u62ee\u6297\u5242ARCALYST\u00ae (rilonacept) \u5229\u90a3\u897f\u666e\uff0c\u8be5\u836f\u76ee\u524d\u672a\u5728\u56fd\u5185\u4e0a\u5e02\u3002<\/p>\n\n\n\n

\u8be5\u836f\u7269FDA\u6279\u51c6\u9002\u5e94\u75c7\u5305\u62ec\u4e0e\u524d\u6587\u5361\u90a3\u5355\u6297\u4e00\u81f4\u7684\u51b7\u5421\u5549\u76f8\u5173\u7684\u5468\u671f\u6027\u7efc\u5408\u5f81\uff0c\u4ee5\u53caIL-1\u53d7\u4f53\u62ee\u6297\u5242\u7f3a\u4e4f\u75c7\uff0c\u590d\u53d1\u6027\u5fc3\u5305\u708e\u3002<\/p>\n\n\n\n

Kiniksa\u516c\u53f8\u4e8e2017\u5e74\u4ece\u518d\u751f\u5143\u83b7\u5f97\u5229\u90a3\u897f\u666e\u7684\u6743\u5229\u3002<\/p>\n\n\n\n

2022\u5e74\u534e\u4e1c\u533b\u836f\u83b7\u5f97\u5176\u5728\u4e9a\u592a\u5730\u533a\u7684\u6743\u5229\u3002<\/p>\n\n\n\n

1\u3001\u878d\u5408\u86cb\u767d<\/h2>\n\n\n\n

\u878d\u5408\u86cb\u767d\u662f\u57fa\u56e0\u5de5\u7a0b\u5408\u6210\u7684\u751f\u7269\u5236\u5242\uff0c\u8fd9\u7c7b\u751f\u7269\u5236\u5242\u4ee5-cept\uff08-\u897f\u666e\uff09\u7ed3\u5c3e\u547d\u540d\uff0c\u5355\u514b\u9686\u6297\u4f53\u7684Fc\u7ed3\u6784\u57df\u4e0e\u53e6\u4e00\u751f\u7269\u6d3b\u6027\u86cb\u767d\u7ed3\u6784\u57df\u7ed3\u5408\uff0c\u5408\u6210\u5177\u6709\u72ec\u7279\u7ed3\u6784\u529f\u80fd\u7684\u878d\u5408\u86cb\u767d\u3002<\/p>\n\n\n\n

\u5229\u90a3\u897f\u666e\u7684\u7ed3\u6784<\/h3>\n\n\n
\n
\"\"
Biochemistry (Mosc). 2014 Dec;79(12):1308-21<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

\u5229\u90a3\u897f\u666e\u7531\u7ec6\u80de\u819c\u4e0aIL-1\u53d7\u4f531\uff08IL-1R1\uff09\u80de\u5916\u90e8\u5206\uff0c\u548cIL-1\u53d7\u4f53\u8f85\u52a9\u86cb\u767d\uff08IL-1RAcP\uff09\uff0c\u5448\u7ebf\u6027\u8fde\u63a5\u81f3\u4ebaIgG1\u7684Fc\u7ed3\u5408\u57df\u7ec4\u6210\u3002<\/p>\n\n\n\n

\u7531\u4e8e\u5229\u90a3\u897f\u666e\u7531IL-1\u53d7\u4f53\u80de\u5916\u7ed3\u6784\u57df\u7ec4\u6210\uff0c\u56e0\u6b64\u9664\u4e86\u80fd\u548c\u5361\u90a3\u5355\u6297\u4e00\u6837\u7ed3\u5408IL-1\u03b2\u5916\uff0c\u8fd8\u80fd\u7ed3\u5408IL-1\u03b1\uff0c\u6291\u5236IL-1\u7684\u4fe1\u53f7\u4f20\u5bfc\uff0c\u4ece\u800c\u963b\u65ad\u5b83\u4eec\u4e0e\u7ec6\u80de\u8868\u9762IL-1\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n\n\n\n

2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n
\n
\"\"
\u5229\u90a3\u897f\u666eFDA\u6279\u51c6\u7684\u9002\u5e94\u75c7<\/figcaption><\/figure>\n<\/div>\n\n\n

2008\u83b7FDA\u6279\u51c6\u7528\u4e8e\u51b7\u5421\u5549\u76f8\u5173\u7684\u5468\u671f\u6027\u7efc\u5408\u5f81(CAPS)\u3002<\/p>\n\n\n\n

\u5305\u62ec\u5bb6\u65cf\u6027\u5bd2\u51b7\u578b\u81ea\u8eab\u708e\u75c7\u7efc\u5408\u5f81(FCAS)\uff0c\u7a46-\u97e6\u4e8c\u6c0f\u7efc\u5408\u5f81 (MWS)\u3002<\/p>\n\n\n\n

2020\u5e74\u83b7\u6279\u7528\u4e8eIL-1\u53d7\u4f53\u62ee\u6297\u5242\u7f3a\u4e4f\u75c7(DIRA)\u3002<\/p>\n\n\n\n

2021\u5e74\u83b7\u6279\u590d\u53d1\u6027\u5fc3\u5305\u708e(RP)\u3002<\/p>\n\n\n\n

3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
\n
\"\"
\u7f51\u7403\u5973\u738b\u674e\u5a1c\uff0c\u5979\u628a\u7231\u5fc3\u5f53\u6210\u7f51\u7403\u6253\u5728\u4e86\u524d\u6587\u4e2d\u7684\u6811\u4e0a\uff0c\u4ea7\u751f\u7206\u70b8\uff0c\u6811\u4e5f\u7740\u706b\u4e86\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

\u674e\u5a1c\u53d6\u8c10\u97f3\u4ee3\u8868\u5229\u90a3\u897f\u666e\u3002<\/p>\n\n\n\n

\u6811\u4ee3\u8868\u6211\u7684\u6570\u5b57\u7f16\u78011\uff0c\u8fd9\u91cc\u4ee3\u8868IL-1\u03b1\/1\u03b2\u6291\u5236\u5242\u3002\u4e5f\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7IL-1\u53d7\u4f53\u62ee\u6297\u5242\u7f3a\u4e4f\u75c7\u3002<\/p>\n\n\n\n

\u7231\u5fc3\u548c\u706b\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7\u5fc3\u5305\u708e\u548c\u51b7\u5421\u5549\u76f8\u5173\u5468\u671f\u6027\u7efc\u5408\u5f81\u7684\u75c7\u72b6\uff0c\u5468\u671f\u6027\u53d1\u70ed\u3002<\/p>\n\n\n\n

\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u7269\u4e00\u5f20\u56fe\uff0c…<\/p>\n","protected":false},"author":1,"featured_media":261,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[4],"class_list":["post-30","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","tag-4","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/30","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=30"}],"version-history":[{"count":5,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/30\/revisions"}],"predecessor-version":[{"id":259,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/30\/revisions\/259"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/261"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=30"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=30"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=30"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}