{"id":36,"date":"2022-06-16T19:46:07","date_gmt":"2022-06-16T11:46:07","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=36"},"modified":"2022-08-22T23:09:07","modified_gmt":"2022-08-22T15:09:07","slug":"%e5%9b%be%e5%83%8f%e8%ae%b0%e5%bf%86-3%e4%b8%aail-1%e7%b1%bb%e7%94%9f%e7%89%a9%e8%8d%af-%e5%8f%8ail-1r%e6%8b%ae%e6%8a%97%e5%89%82-anakinra-%e9%98%bf%e9%82%a3%e7%99%bd%e6%bb%9e%e7%b4%a0","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=36","title":{"rendered":"\u56fe\u50cf\u8bb0\u5fc6 | 3\u4e2aIL-1\u7c7b\u751f\u7269\u836f | \u53caIL-1R\u62ee\u6297\u5242 | Anakinra \u963f\u90a3\u767d\u6ede\u7d20"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u7269\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u751f\u7269\u836f\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>\u8bfa\u534e\u516c\u53f8\u7814\u5236\u7684\u767d\u4ecb\u7d20-1\u03b2(IL-1\u03b2)\u62ee\u6297\u5242ILARIS\u00ae (canakinumab) \u5361\u90a3\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u518d\u751f\u5143\uff08Regeneron\uff09\u516c\u53f8\u7814\u53d1\u7684\u751f\u7269\u5236\u5242IL-1\u03b1\/1\u03b2\u62ee\u6297\u5242ARCALYST\u00ae (rilonacept) \u5229\u90a3\u897f\u666e\u3002<\/p>\n\n\n\n<p>\u745e\u58eb\u7f55\u89c1\u75c5\u5236\u836f\u516c\u53f8Sobi\u7684IL-1\u53d7\u4f53\u62ee\u6297\u5242KINERET\u00ae (anakinra) \u963f\u90a3\u767d\u6ede\u7d20\u3002<\/p>\n\n\n\n<p>\u76ee\u524d3\u6b3eIL-1\u62ee\u6297\u5242\u7c7b\u751f\u7269\u5236\u5242\u56fd\u5185\u5747\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h_548055061_0\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>3\u6b3e\u767d\u4ecb\u7d20-1(IL-1)\u62ee\u6297\u5242\u7c7b\u751f\u7269\u5236\u5242\u4f5c\u7528\u9776\u70b9\u5404\u4e0d\u76f8\u540c\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-3-1024x791.png\" alt=\"\" class=\"wp-image-37\" width=\"520\" height=\"403\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-3-1024x791.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-3-300x232.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-3-768x593.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-3.png 1062w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><figcaption>3\u6b3eIL-1\u62ee\u6297\u5242\u4f5c\u7528\u9776\u70b9<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5361\u90a3\u5355\u6297\u4f5c\u4e3a\u5355\u514b\u9686\u6297\u4f53\u9776\u5411IL-1\u03b2<\/p>\n\n\n\n<p>\u5229\u90a3\u897f\u666e\u4f5c\u4e3a\u878d\u5408\u86cb\u767d\u9776\u5411IL-1\u03b1\uff0cIL-1\u03b2<\/p>\n\n\n\n<p>\u963f\u90a3\u767d\u6ede\u7d20\u4f5c\u4e3aIL-1\u7c7b\u4f3c\u7269\uff0c\u9776\u5411IL-1\u53d7\u4f53<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h_548055061_1\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><em>3\u6b3eIL-1\u62ee\u6297\u5242FDA\u6279\u51c6\u7684\u9002\u5e94\u75c7<\/em><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-4-1024x814.png\" alt=\"\" class=\"wp-image-38\" width=\"677\" height=\"539\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-4-1024x814.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-4-300x239.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-4-768x611.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-4-880x700.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-4.png 1128w\" sizes=\"auto, (max-width: 677px) 100vw, 677px\" \/><figcaption>3\u79cd\u836f\u7269\u76ee\u524d\u56fd\u5185\u5747\u672a\u4e0a\u5e02\uff0cFDA\u6279\u51c6\u9002\u5e94\u75c7\u5747\u4e3aIL-1\u5f15\u8d77\u7684\u53cd\u590d\u53d1\u70ed\uff0c\u5173\u8282\u708e\u7b49\u76f8\u5173\u75be\u75c5<\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>Canakinumab \u5361\u90a3\u5355\u6297\uff1a<\/strong><\/p>\n\n\n\n<p>\u5468\u671f\u6027\u53d1\u70ed\u7efc\u5408\u5f81\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>\u51b7\u5421\u5549\u76f8\u5173\u7684\u5468\u671f\u6027\u7efc\u5408\u5f81\uff08CAPS\uff09\uff08\u5bb6\u65cf\u6027\u5bd2\u51b7\u578b\u81ea\u8eab\u708e\u75c7\u7efc\u5408\u5f81\u3001\u7a46-\u97e6\u4e8c\u6c0f\u7efc\u5408\u5f81\uff09<\/em><\/li><li><em>\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u53d7\u4f53\u76f8\u5173\u6027\u5468\u671f\u70ed\u7efc\u5408\u5f81(TRAPS)<\/em><\/li><li><em>\u9ad8IgD\u7efc\u5408\u5f81(HIDS)\/\u7532\u7f9f\u620a\u9178\u6fc0\u9176\u7f3a\u4e4f\u75c7(MKD\uff09<\/em><\/li><li><em>\u5bb6\u65cf\u6027\u5730\u4e2d\u6d77\u70ed (FMF)<\/em><\/li><\/ul>\n\n\n\n<p>Still\u75c5\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>\u6210\u4ebaStill\u75c5\uff08AOSD\uff09<\/em><\/li><li><em>2\u5c81\u53ca\u4ee5\u4e0a\u5168\u8eab\u578b\u5e7c\u53d1\u6027\u5173\u8282\u708e(SJIA)\uff09<\/em><\/li><\/ul>\n\n\n\n<p><strong>Rilonacept \u5229\u90a3\u897f\u666e<\/strong><\/p>\n\n\n\n<p><em>\u51b7\u5421\u5549\u76f8\u5173\u7684\u5468\u671f\u6027\u7efc\u5408\u5f81\uff08CAPS\uff09\uff08\u5bb6\u65cf\u6027\u5bd2\u51b7\u578b\u81ea\u8eab\u708e\u75c7\u7efc\u5408\u5f81\u3001\u7a46-\u97e6\u4e8c\u6c0f\u7efc\u5408\u5f81\uff09<\/em><\/p>\n\n\n\n<p><em>IL-1\u53d7\u4f53\u62ee\u6297\u5242\u7f3a\u4e4f\u75c7(DIRA)<\/em><\/p>\n\n\n\n<p><em>\u590d\u53d1\u6027\u5fc3\u5305\u708e(RP)<\/em><\/p>\n\n\n\n<p><strong>Anakinra \u963f\u90a3\u767d\u6ede\u7d20<\/strong><\/p>\n\n\n\n<p><em>\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\uff08RA\uff09<\/em><\/p>\n\n\n\n<p><em>\u51b7\u5421\u5549\u76f8\u5173\u7684\u5468\u671f\u6027\u7efc\u5408\u5f81(CAPS)<\/em><\/p>\n\n\n\n<p><em>IL-1\u53d7\u4f53\u62ee\u6297\u5242\u7f3a\u4e4f\u75c7(DIRA)<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h_548055061_2\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-5.png\" alt=\"\" class=\"wp-image-39\" width=\"698\" height=\"411\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-5.png 930w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-5-300x177.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-5-768x453.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/08\/image-5-880x519.png 880w\" sizes=\"auto, (max-width: 698px) 100vw, 698px\" \/><figcaption><em>\u5929\u6c14\u708e\u70ed\uff0c\u7f51\u7403\u5973\u738b\u674e\u5a1c\uff0c\u62ce\u7740\u5979\u5fc3\u7231\u7684\u7231\u9a6c\u4ed5\u5305\u5305\uff0c\u5728\u4e00\u68f5\u6811\u4e0b\u8fb9\u4e58\u51c9\uff0c\u8fb9\u7b49\u5979\u7684\u608d\u9a6c\u5361\u8f66\u4e00\u56fe\u8bb03\u79cdIL-1\u62ee\u6297\u5242<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6811\u662f\u6211\u7684\u6570\u5b57\u7f16\u78011\uff0c\u8fd9\u91cc\u4ee3\u88683\u79cdIL-1\u53d7\u4f53\u62ee\u6297\u5242\u3002<\/p>\n\n\n\n<p>\u5361\u8f66\u4ee3\u8868\u5361\u90a3\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u674e\u5a1c\u53d6\u8c10\u97f3\u4ee3\u8868\u5229\u90a3\u897f\u666e\u3002<\/p>\n\n\n\n<p>\u7231\u9a6c\u4ed5\u5305\u5305\u53d6\u8c10\u97f3\u4ee3\u8868\u963f\u90a3\u767d\u6ede\u7d20<\/p>\n\n\n\n<p>\u592a\u9633\u548c\u9aa8\u5934\u4ee3\u8868IL-1\u62ee\u6297\u5242\u7c7b\u836f\u7269\u7684\u9002\u5e94\u75c7\uff0c\u53cd\u590d\u53d1\u70ed\u548c\u5173\u8282\u708e\u76f8\u5173\u7684\u75be\u75c5\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u7269\u4e00\u5f20\u56fe\uff0c&#8230;<\/p>\n","protected":false},"author":1,"featured_media":41,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[4],"class_list":["post-36","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","tag-4","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/36","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36"}],"version-history":[{"count":5,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/36\/revisions"}],"predecessor-version":[{"id":130,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/36\/revisions\/130"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/41"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}