{"id":437,"date":"2022-09-26T22:24:08","date_gmt":"2022-09-26T14:24:08","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=437"},"modified":"2022-09-26T22:26:15","modified_gmt":"2022-09-26T14:26:15","slug":"%e5%a6%82%e4%bd%95%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e6%89%b9%e5%87%86%e7%94%9f%e7%89%a9%e8%8d%af%ef%bc%9f-ifnar%e6%8b%ae%e6%8a%97%e5%89%82-anifrolumab%e9%98%bf%e5%b0%bc%e5%88%a9%e5%b0%a4","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=437","title":{"rendered":"\u5982\u4f55\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u751f\u7269\u836f\uff1f| IFNAR\u62ee\u6297\u5242 | Anifrolumab\u963f\u5c3c\u5229\u5c24\u5355\u6297 | \u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u751f\u7269\u836f\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

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\u81ea\u4ece2011\u5e74\u845b\u5170\u7d20\u53f2\u514b \uff08GSK\uff09\u7684BLyS\u62ee\u6297\u5242\uff0c\u8d1d\u5229\u5c24\u5355\u6297\u83b7\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u4e4b\u540e\u4e00\u76f4\u6ca1\u6709SLE\u65b0\u836f\u4e0a\u5e02\u300210\u5e74\u540eAnifrolumab\u7684\u83b7\u6279\uff0c\u52bf\u5fc5\u5c06\u5411GSK\u7684\u8d1d\u5229\u5c24\u5355\u6297\u53d1\u51fa\u6311\u6218\u3002<\/p>\n\n\n\n

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\u7531\u4e8e\u76ee\u524dAnifrolumab\u56fd\u5185\u672a\u4e0a\u5e02\uff0c\u4e5f\u672a\u89c1\u5b98\u65b9\u4e2d\u6587\u901a\u7528\u540d\uff0c\u6309\u7167\u547d\u540d\u89c4\u5219\uff0c\u6682\u4e14\u53eb\u5b83\u963f\u5c3c\u5229\u5c24\u5355\u6297\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08systemic lupus erythematosus\uff0cSLE\uff09\u662f\u4e00\u79cd\u81ea\u8eab\u514d\u75ab\u75c5\uff0c\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u673a\u4f53\u5065\u5eb7\u7ec4\u7ec7\uff0c\u5bfc\u81f4\u5305\u62ec\u75bc\u75db\u3001\u76ae\u75b9\u3001\u75b2\u52b3\u3001\u5173\u952e\u80bf\u80c0\u3001\u53d1\u70e7\u3001\u957f\u671f\u5668\u5b98\u635f\u4f24\u7b49\u4e00\u7cfb\u5217\u75c7\u72b6\u3002<\/p>\n\n\n\n

\u524d\u4e00\u8282\u4e2d\u63d0\u5230\uff0cSLE\u60a3\u8005\u4f53\u5185B\u7ec6\u80de\u5904\u4e8e\u9ad8\u5ea6\u6d3b\u5316\u72b6\u6001\uff0c\u5bfc\u81f4\u673a\u4f53\u4ea7\u751f\u5927\u91cf\u7684\u81ea\u8eab\u6297\u4f53\u3002\u56e0\u6b64\uff0c\u4f7f\u7528B\u6dcb\u5df4\u7ec6\u80de\u523a\u6fc0\u56e0\u5b50\uff08BLyS\uff09\u62ee\u6297\u5242-\u8d1d\u5229\u5c24\u5355\u6297\uff0c\u963b\u65ad\u53ef\u6eb6\u6027BLyS\u4e0eB\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53\u7ed3\u5408\uff0c\u964d\u4f4e\u8fc7\u591a\u6297\u4f53\u7684\u4ea7\u751f\u3002<\/p>\n\n\n\n

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SLE\u751f\u7269\u5236\u5242\u9776\u70b9<\/strong><\/p>\n\n\n

\n
\"\"
Nat Rev Nephrol . 2022 Jul;18(7):415-416.<\/em>Anifrolumab<\/figcaption><\/figure>\n<\/div>\n\n\n

\u963f\u5c3c\u5229\u5c24\u5355\u6297\u662f\u4e00\u79cd\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e0e\u6210\u719f\u6811\u7a81\u72b6\u7ec6\u80de\u8868\u9762I\u578b\u5e72\u6270\u7d20\u53d7\u4f53\u7ed3\u5408\uff0c\u963b\u65ad\u5305\u62ecIFN-\u03b1\u3001IFN-\u03b2\u5728\u5185\u7684\u6240\u6709I\u578b\u5e72\u6270\u7d20\u7684\u6d3b\u6027\u3002I\u578b\u5e72\u6270\u7d20\u662f\u53c2\u4e0e\u708e\u75c7\u901a\u8def\u7684\u7ec6\u80de\u56e0\u5b50\u300260%-80%\u7684SLE\u6210\u4eba\u60a3\u8005\u5177\u6709\u5347\u9ad8\u7684I\u578b\u5e72\u6270\u7d20\u57fa\u56e0\u6807\u5fd7\u3002<\/p>\n\n\n\n

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2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

\u963f\u5c3c\u5229\u5c24\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

\n
\"\"
\u8be5\u836f\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

Anifrolumab\u963f\u5c3c\u5229\u5c24\u5355\u6297FDA\u6279\u51c6\u7528\u4e8e\u6210\u4eba\u4e2d\u91cd\u5ea6\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3002<\/p>\n\n\n\n

3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
\n
\"\"
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\u5e72\u6270\u5668\u4ee3\u8868\u836f\u7269\u9776\u70b9\uff0c\u5e72\u6270\u7d20\u53d7\u4f53INFAR\u3002<\/p>\n\n\n\n

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\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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