{"id":516,"date":"2022-10-25T19:02:56","date_gmt":"2022-10-25T11:02:56","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=516"},"modified":"2022-10-25T19:02:56","modified_gmt":"2022-10-25T11:02:56","slug":"%e5%a6%82%e4%bd%95%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e6%89%b9%e5%87%86%e7%94%9f%e7%89%a9%e8%8d%af%ef%bc%9f-pcsk9%e6%8a%91%e5%88%b6%e5%89%82-%e6%b3%a2%e7%ab%8b%e8%be%be%e9%98%bf%e5%88%a9","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=516","title":{"rendered":"\u5982\u4f55\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u751f\u7269\u836f\uff1f| PCSK9\u6291\u5236\u5242 | \u6ce2\u7acb\u8fbe\u00ae\u963f\u5229\u897f\u5c24\u5355\u6297\u3001\u745e\u767e\u5b89\u00ae\u4f9d\u6d1b\u5c24\u5355\u6297 | \u6cbb\u7597\u9ad8\u80c6\u56fa\u9187\u8840\u75c7"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5929\u5f00\u59cb\u8c08\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u5173\u751f\u7269\u5236\u5242\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u5df2\u7ecf\u4e0a\u5e02\u7684PCSK9\u6291\u5236\u5242\u6709\u4e24\u6b3e\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>\u8d5b\u8bfa\u83f2\u516c\u53f8\u7684\u6ce2\u7acb\u8fbe<sup>\u00ae<\/sup>\u963f\u5229\u897f\u5c24\u5355\u6297\uff08PRALUENT<sup>\u00ae<\/sup>\u00a0alirocumab\uff09\u00a0<\/li><li>\u5b89\u8fdb\u516c\u53f8\u7684\u745e\u767e\u5b89<sup>\u00ae<\/sup>\u4f9d\u6d1b\u5c24\u5355\u6297\uff08REPATHA<sup>\u00ae<\/sup>evolocumab\uff09<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e24\u4e2a\u836f\u7269\u5747\u4e8e2015\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u76ee\u524d\u56fd\u5185\u5df2\u83b7\u6279\u4e0a\u5e02\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4eba\u4f53\u5185\u80c6\u56fa\u9187\u8fd0\u8f93<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-28.png\" alt=\"\" class=\"wp-image-517\" width=\"378\" height=\"367\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-28.png 489w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-28-300x291.png 300w\" sizes=\"auto, (max-width: 378px) 100vw, 378px\" \/><figcaption>\u4eba\u4f53\u5185\u80c6\u56fa\u9187\u4ee5\u80c6\u56fa\u9187\u916f\u7684\u5f62\u5f0f\u8fd0\u8f93\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u80c6\u56fa\u9187\u916f\u4e3a\u4eb2\u8102\u6027\u7269\u8d28\uff0c\u4e0d\u6eb6\u4e8e\u4eb2\u6c34\u6027\u8840\u6d46\u3002\u56e0\u6b64\uff0c\u5faa\u73af\u4e2d\u7684\u80c6\u56fa\u9187\u916f\u4ee5<strong>\u8102\u86cb\u767d<\/strong>(lipoprotein, Lp)\u7684\u5f62\u5f0f\u8f6c\u8fd0\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8102\u86cb\u767d\u7684\u7ed3\u6784\u4e3a\u5916\u5c42\u78f7\u8102\u5355\u5206\u5b50\u819c\u7ed3\u6784\u3002\u4eb2\u6c34\u6027\u7684\u78f7\u9178\u916f\u5934\u90e8\u805a\u96c6\u671d\u5916\uff0c\u4f7f\u8102\u86cb\u767d\u53ef\u4ee5\u5728\u8840\u6d46\u4e2d\u8fd0\u8f93\u3002\u4e24\u4e2a\u94fe\u72b6\u8102\u80aa\u9178\u7ec4\u6210\u7684\u758f\u6c34\u6027\u5c3e\u90e8\u671d\u5185\uff0c\u5305\u88f9\u5b58\u50a8\u80c6\u56fa\u9187\u916f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u80c6\u56fa\u9187\u5728\u4eba\u4f53\u5185\u53d1\u6325\u63d0\u4f9b\u80fd\u91cf\u3001\u5f62\u6210\u751f\u7269\u819c\u7ed3\u6784\uff0c\u751f\u6210\u753e\u4f53\u6fc0\u7d20\u3001\u5f62\u6210\u80c6\u6c41\u9178\u7b49\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e24\u7c7b\u6700\u4e3b\u8981\u7684\u8102\u86cb\u767d\u4e3a\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08LDL\uff09\u548c\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\uff08HDL\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>LDL \u548c HDL<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-29-1024x503.png\" alt=\"\" class=\"wp-image-518\" width=\"589\" height=\"289\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-29-1024x503.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-29-300x147.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-29-768x377.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-29-880x432.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-29.png 1152w\" sizes=\"auto, (max-width: 589px) 100vw, 589px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff08LDL\uff09\u5c5e\u4e8e\u201c\u574f\u201d\u8102\u86cb\u767d\uff0c\u8102\u6838\u5185\u5bcc\u542b\u80c6\u56fa\u9187\u916f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u809d\u810f\u662f\u4eba\u4f53\u5408\u6210\u548c\u964d\u89e3\u80c6\u56fa\u9187\u7684\u573a\u6240\uff0c\u4eba\u4f53\u4ece\u98df\u7269\u4e2d\u5438\u6536\u7684\u80c6\u56fa\u9187\u548c\u809d\u810f\u4e2d\u5408\u6210\u7684\u80c6\u56fa\u9187\uff0c\u5728\u809d\u810f\u4e2d\u5408\u6210\u5bcc\u542b\u80c6\u56fa\u9187\u8102\u7684\u8102\u86cb\u767d\uff0c\u6700\u7ec8\u5927\u90e8\u5206\u5f62\u6210LDL\u9897\u7c92\uff0cLDL\u9897\u7c92\u5185\u7684\u80c6\u56fa\u9187\u916f\u79f0\u4e3aLDL-C\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u7ba1\u4e2dLDL\u9897\u7c92\u8fc7\u591a\uff0c\u4f1a\u5728\u8840\u7ba1\u58c1\u6c89\u79ef\uff0c\u8fdb\u800c\u5835\u585e\u8840\u7ba1\uff0c\u5f62\u6210\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027\u75be\u75c5\uff08\u5982\u7f3a\u8840\u6027\u5352\u4e2d\uff0c\u5fc3\u808c\u6897\u6b7b\u7b49\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\uff08HDL\uff09\u662f\u7a7a\u5fc3\u7684\u8102\u86cb\u767d\uff0c\u7531\u4e8e\u4f53\u79ef\u5c0f\uff0c\u5bc6\u5ea6\u5927\uff0c\u53ef\u4ee5\u81ea\u7531\u8fdb\u51fa\u8840\u7ba1\u58c1\uff0c\u628a\u6c89\u79ef\u4e8e\u8840\u7ba1\u58c1\u5185\u7684\u81f4\u75c5\u80c6\u56fa\u9187\u5e26\u51fa\u8840\u7ba1\u58c1\uff0c\u8d77\u5230\u6e05\u9664LDL\u6c89\u79ef\u7684\u4f5c\u7528\uff0c\u56e0\u6b64\u5c5e\u4e8e\u201c\u597d\u201d\u8102\u86cb\u767d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65e0\u8bba\u662f\u6291\u5236\u80c6\u56fa\u9187\u5408\u6210\u7684\u4ed6\u6c40\u7c7b\u836f\u7269\uff0c\u8fd8\u662f\u6291\u5236\u80c6\u56fa\u9187\u5438\u6536\u7684\u4f9d\u6298\u9ea6\u5e03\uff0c\u6700\u7ec8\u90fd\u901a\u8fc7\u8c03\u8282\u809d\u810f\u7ec6\u80de\u8868\u9762LDL\u53d7\u4f53\uff08LDLR\uff09\u7684\u6570\u91cf\uff0c\u8c03\u63a7\u8840\u6d46\u4e2d\u80c6\u56fa\u9187\u6c34\u5e73\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LDLR\u7531\u7ec6\u80de\u6838\u5185\u5408\u6210\uff0c\u8be5\u5408\u6210\u8fc7\u7a0b\u540c\u65f6\u4e5f\u751f\u6210\u5bf9LDLR\u6570\u91cf\u8d77\u8c03\u63a7\u4f5c\u7528\u7684\u524d\u86cb\u767d\u8f6c\u5316\u9176\u67af\u8349\u6eb6\u83cc\u7d209\uff08PCSK9\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>LDL\u9897\u7c92\u7684\u6e05\u9664<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-30.png\" alt=\"\" class=\"wp-image-519\" width=\"636\" height=\"512\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-30.png 996w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-30-300x242.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-30-768x618.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-30-880x709.png 880w\" sizes=\"auto, (max-width: 636px) 100vw, 636px\" \/><figcaption><em><em>Nat Rev Cardiol . 2014 Oct;11(10):563-75.<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">LDLR\u7ed3\u5408\u8840\u6d46\u4e2dLDL\u9897\u7c92\u540e\uff0c\u4e0ePCSK9\u7ed3\u5408\uff0c\u590d\u5408\u7269\u5185\u541e\u8fdb\u5165\u7ec6\u80de\u964d\u89e3\u3002\uff08\u56fea\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u963f\u5229\u897f\u5c24\u5355\u6297\u3001\u4f9d\u6d1b\u5c24\u5355\u6297\u4e0ePCSK9\u7ed3\u5408\uff0c\u6291\u5236PCSK9\u4e0eLDLR\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u963b\u6b62PCSK9\u4ecb\u5bfc\u7684LDLR\u964d\u89e3\uff0c\u4f7f\u5f97LDLR\u53ef\u91cd\u65b0\u5faa\u73af\u56de\u81f3\u809d\u7ec6\u80de\u8868\u9762\u3002\u589e\u52a0\u4e86LDLR\u7684\u6570\u91cf\uff0c\u4ece\u800c\u964d\u4f4eLDL-C\u6c34\u5e73\u3002\uff08\u56feb\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PCSK9\u6291\u5236\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-31-1024x473.png\" alt=\"\" class=\"wp-image-520\" width=\"685\" height=\"316\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-31-1024x473.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-31-300x138.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-31-768x354.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-31-880x406.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-31.png 1103w\" sizes=\"auto, (max-width: 685px) 100vw, 685px\" \/><figcaption><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#660eb7\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u6ce2\u7acb\u8fbe\u00ae\u963f\u5229\u897f\u5c24\u5355\u6297<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1\u3001\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u9884\u9632\uff08\u6210\u4eba\uff09<br>2\u3001\u539f\u53d1\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7(\u5305\u62ec\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u548c\u975e\u5bb6\u65cf\u6027)\u548c\u6df7\u5408\u578b\u8840\u8102\u5f02\u5e38\uff08\u6210\u4eba\uff09<br>3\u3001\u7eaf\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u6210\u4eba\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u745e\u767e\u5b89\u00ae\u4f9d\u6d1b\u5c24\u5355\u6297<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1\u3001\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u98ce\u9669\uff08\u6210\u4eba\uff09<br>2\u3001\u539f\u53d1\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7(\u5305\u62ec\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7)\u548c\u6df7\u5408\u578b\u8840\u8102\u5f02\u5e38\uff0810\u5c81\u53ca\u4ee5\u4e0a FDA)\u3001\u6210\u4eba(\u56fd\u5185)<br>3\u3001\u7eaf\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff0810\u5c81\u53ca\u4ee5\u4e0aFDA)\u3001\uff0812\u5c81\u53ca\u4ee5\u4e0a\u56fd\u5185)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/PCSK9-no-1-gap.jpg\" data-gif=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/PCSK9-no-1.gif\" alt=\"\" class=\"wp-image-522\" width=\"575\" height=\"419\"\/><figcaption>\u8682\u8681\u4e0a\u5e02\u5931\u8d25\uff0c\u9a6c\u4e91\u6c14\u5730\u62ff\u8d77\u4e00\u7b50\u897f\u67da\u7838\u5230\u4e86\u7535\u8111\u4e0a\uff0c\u7535\u8111\u51fa\u73b0\u4e86\u4f24\u53e3\uff0c\u6d41\u51fa\u4e86\u8840\u6db2\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u7535\u8111\uff08PC\uff09\u51fa\u73b0\u4f24\u53e3\uff08SK\uff09\uff0c\u53d6\u62fc\u97f3\u4ee3\u8868\u836f\u7269\u9776\u70b9\u4e3aPCSK9\u6291\u5236\u5242\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9a6c\u4e91\u4ee3\u8868\u963f\u91cc+\u4e3e\u8d77\u897f\u67da\uff0c\u4ee3\u8868\u963f\u5229\u897f\u5c24\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3e\u8d77\u7684\u4e00\u645e\u897f\u67da\uff0c\u4ee3\u8868\u4f9d\u6d1b\u5c24\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6d41\u51fa\u7684\u8840\u6db2\u91cc\u6709\u80c6\u56fa\u9187\uff0c\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7\uff0c\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":523,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-516","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=516"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/516\/revisions"}],"predecessor-version":[{"id":524,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/516\/revisions\/524"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/523"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}