{"id":528,"date":"2022-10-28T23:02:17","date_gmt":"2022-10-28T15:02:17","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=528"},"modified":"2023-08-23T08:03:01","modified_gmt":"2023-08-23T00:03:01","slug":"%e5%a6%82%e4%bd%95%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e6%89%b9%e5%87%86%e7%94%9f%e7%89%a9%e8%8d%af%ef%bc%9f-pcsk9-sirna%e8%8d%af%e7%89%a9-inclisiran-%e5%9b%a0%e5%88%a9%e5%8f%b8%e7%84%b6","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=528","title":{"rendered":"\u5982\u4f55\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u751f\u7269\u836f\uff1f| PCSK9 siRNA\u836f\u7269 | \u82f1\u514b\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2 | \u5c0f\u5e72\u6270RNA\u957f\u6548\u964d\u80c6\u56fa\u9187"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u82f1\u514b\u53f8\u5170\u7531The Medicines Company\u516c\u53f8\u7814\u53d1\uff0c2020\u5e74\u8bfa\u534e\u516c\u53f8\u4ee597\u4ebf\u7f8e\u5143\u6536\u8d2dThe Medicines Company\u516c\u53f8\uff0c\u83b7\u5f97\u82f1\u514b\u53f8\u5170\u94a0\u7684\u6743\u76ca\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u82f1\u514b\u53f8\u5170\u4f7f\u7528\u5c0f\u5e72\u6270RNA\u6280\u672f\uff08siRNA\uff09\uff0c\u901a\u8fc7\u5e72\u6270PCSK9\u7684mRNA\uff0c\u963b\u6b62PCSK9\u86cb\u767d\u7684\u5408\u6210\uff0c\u4ece\u800c\u964d\u4f4e\u80c6\u56fa\u9187\u6c34\u5e73\u3002\u8be5\u836f2021\u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff08LEQVIO\u00ae inclisiran\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u4e8e2023\u5e748\u670823\u65e5\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\uff08\u4e50\u53ef\u4e3a\u00ae \u82f1\u514b\u53f8\u5170\u94a0\u6ce8\u5c04\u6db2\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5c0f\u5e72\u6270RNA(siRNA)\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-32-1024x522.png\" alt=\"\" class=\"wp-image-529\" style=\"width:660px;height:336px\" width=\"660\" height=\"336\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-32-1024x522.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-32-300x153.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-32-768x392.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-32-880x449.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-32.png 1194w\" sizes=\"auto, (max-width: 660px) 100vw, 660px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.alnylam.com\/our-science\/the-science-of-rnai<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u53cc\u94fesiRNA\u590d\u5408\u4f53\u8fdb\u5165\u7ec6\u80de\u5185\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u901a\u8fc7\u5173\u952eDicer\u9176\u7684\u4f5c\u7528\uff0c\u89e3\u65cb\u6210\u8fc7\u5ba2\u94fe\uff08\u56fe\u4e2d\u7ea2\u8272\uff09\uff0c\u4ee5\u53ca21\uff5e23nt\u53ca3&#8217;\u7aef\u7a81\u51fa\u7684\u5c0f\u5206\u5b50RNA\u7247\u6bb5\uff08\u56fe\u4e2d\u9ec4\u8272\uff09\uff0c\u5373siRNA\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u968f\u540esiRNA\u4e0e\u76ee\u6807\u86cb\u767d\u7684mRNA\u7ed3\u5408\uff0c\u4f7f\u76ee\u6807\u86cb\u767d\u7684mRNA\u964d\u89e3\uff0c\u4ece\u800c\u963b\u6b62mRNA\u7ffb\u8bd1\u6210\u76ee\u6807\u86cb\u767d\u8d28\u7684\u8fc7\u7a0b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u8be5\u836f\u4e2d\uff0c\u82f1\u514b\u53f8\u5170\u4f5c\u4e3asiRNA\u836f\u7269\uff0c\u964d\u89e3\u7684\u76ee\u6807\u86cb\u767d\u4e3aPCSK9\u86cb\u767d\u3002<\/p>\n\n\n\n<p class=\"has-cyan-bluish-gray-color has-text-color wp-block-paragraph\"><em>\u5173\u4e8ePCSK9\u7684\u4f5c\u7528\u673a\u5236\uff0c\u53ef\u4ee5\u8be6\u89c1\u4e0a\u4e00\u8282\u7684\u5185\u5bb9\u3002<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65e0\u8bba\u662f\u6291\u5236\u80c6\u56fa\u9187\u5408\u6210\u7684\u4ed6\u6c40\u7c7b\u836f\u7269\uff0c\u8fd8\u662f\u6291\u5236\u80c6\u56fa\u9187\u5438\u6536\u7684\u4f9d\u6298\u9ea6\u5e03\uff0c\u6700\u7ec8\u90fd\u901a\u8fc7\u8c03\u8282\u809d\u810f\u7ec6\u80de\u8868\u9762LDL\u53d7\u4f53\uff08LDLR\uff09\u7684\u6570\u91cf\uff0c\u8c03\u63a7\u8840\u6d46\u4e2d\u80c6\u56fa\u9187\u6c34\u5e73\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PCSK9\u964d\u80c6\u56fa\u9187\u673a\u5236<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"811\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-33-1024x811.png\" alt=\"\" class=\"wp-image-530\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-33-1024x811.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-33-300x238.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-33-768x609.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-33-1218x965.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-33-880x697.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/10\/image-33.png 1440w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em><em>Nat Rev Cardiol . 2014 Oct;11(10):563-75.<\/em><\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">LDLR\u7531\u7ec6\u80de\u6838\u5185\u5408\u6210\uff0c\u8be5\u5408\u6210\u8fc7\u7a0b\u540c\u65f6\u4e5f\u751f\u6210\u5bf9LDLR\u6570\u91cf\u8d77\u8c03\u63a7\u4f5c\u7528\u7684\u524d\u86cb\u767d\u8f6c\u5316\u9176\u67af\u8349\u6eb6\u83cc\u7d209\uff08PCSK9\uff09\u3002LDLR\u7ed3\u5408\u8840\u6d46\u4e2dLDL\u9897\u7c92\u540e\uff0c\u4e0ePCSK9\u7ed3\u5408\uff0c\u590d\u5408\u7269\u5185\u541e\u8fdb\u5165\u7ec6\u80de\u964d\u89e3\u3002\uff08\u56fea\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PCSK9\u6291\u5236\u5242\uff08\u963f\u5229\u897f\u5c24\u5355\u6297\u3001\u4f9d\u6d1b\u5c24\u5355\u6297\uff09\uff0c\u6216siRNA\u836f\u7269\u82f1\u514b\u53f8\u5170\uff0c\u901a\u8fc7\u4e0d\u540c\u7684\u673a\u5236\u964d\u4f4ePCSK9\u6c34\u5e73\uff0c\u4ece\u800c\u963b\u6b62PCSK9\u4ecb\u5bfc\u7684LDLR\u964d\u89e3\uff0c\u4f7f\u5f97LDLR\u53ef\u91cd\u65b0\u5faa\u73af\u56de\u81f3\u809d\u7ec6\u80de\u8868\u9762\u3002\u589e\u52a0\u4e86LDLR\u7684\u6570\u91cf\uff0c\u4ece\u800c\u964d\u4f4eLDL-C\u6c34\u5e73\u3002\uff08\u56feb\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u82f1\u514b\u53f8\u5170FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"274\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-16-1024x274.png\" alt=\"\" class=\"wp-image-1168\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-16-1024x274.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-16-300x80.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-16-768x206.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-16-880x236.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-16.png 1128w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u82f1\u514b\u53f8\u5170 FDA\u6279\u51c6\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff08ASCVD\uff09<\/li>\n\n\n\n<li>\u6742\u5408\u5b50\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08HeFH\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u82f1\u514b\u53f8\u5170\u4e34\u5e8a\u6700\u5927\u7684\u7279\u70b9\u5728\u4e8e\u5176\u957f\u6548\u4f5c\u7528\uff0c\u4e00\u5e74\u53ea\u9700\u8981\u6253\u4e24\u9488\uff0c\u5c31\u53ef\u4ee5\u6709\u6548\u63a7\u5236\u8840\u8102\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-17-1024x660.png\" alt=\"\" class=\"wp-image-1169\" style=\"width:612px;height:394px\" width=\"612\" height=\"394\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-17-1024x660.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-17-300x193.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-17-768x495.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-17-1218x785.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-17-880x567.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/08\/image-17.png 1456w\" sizes=\"auto, (max-width: 612px) 100vw, 612px\" \/><figcaption class=\"wp-element-caption\">\u62e5\u6709\u6781\u5927\u5f15\u529b\u7684\u9ed1\u6d1e\u7a81\u7136\u81ea\u71c3\uff0c\u7acb\u523b\u55b7\u5c04\u51fa\u706b\u7130\u5c04\u5230PC\u4e0a\uff0c\u9020\u6210\u4e86\u4f24\u53e3\uff0c\u6d41\u51fa\u4e86\u5e26\u80c6\u56fa\u9187\u7684\u8840\u6db2\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u9ed1\u6d1e\u5f15\u529b\u7acb\u523b\u81ea\u71c3\uff0c\u4ee3\u8868\u836f\u7269\u540d\u79f0\u82f1\u514b\u53f8\u5170\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7535\u8111PC\u7684\u4f24\u53e3\uff08SK\uff09\uff0c\u4ee3\u8868\u9776\u70b9PCSK9 siRNA\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u80c6\u56fa\u9187\u4ee3\u8868\u836f\u7269\u9002\u5e94\u75c7\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1172,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-528","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=528"}],"version-history":[{"count":3,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/528\/revisions"}],"predecessor-version":[{"id":1171,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/528\/revisions\/1171"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/1172"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=528"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=528"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}