{"id":655,"date":"2022-12-02T00:26:02","date_gmt":"2022-12-01T16:26:02","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=655"},"modified":"2022-12-02T00:26:02","modified_gmt":"2022-12-01T16:26:02","slug":"%e5%a6%82%e4%bd%95%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e6%89%b9%e5%87%86%e7%94%9f%e7%89%a9%e8%8d%af%ef%bc%9f-%e4%b8%ad%e5%92%8c%e7%82%ad%e7%96%bd%e6%9d%86%e8%8f%8c%e6%af%92%e7%b4%a0-raxibacumab","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=655","title":{"rendered":"\u5982\u4f55\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u751f\u7269\u836f\uff1f| \u4e2d\u548c\u70ad\u75bd\u6746\u83cc\u6bd2\u7d20 | Raxibacumab\u96f7\u6614\u5e93\u5355\u6297 Obiltoxaximab\u5965\u6258\u6614\u5355\u6297"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>Raxibacumab\u96f7\u6614\u5e93\u5355\u6297\u7531GSK\u516c\u53f8\u7814\u53d1\uff0c2012\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p>ANTHIM<sup>\u00ae<\/sup>&nbsp;Obiltoxaximab \u5965\u6258\u6614\u5355\u6297\u7531Elusys\u516c\u53f8\u7814\u53d1\uff0c2016\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p>\u4e24\u79cd\u836f\u7269\u5747\u4e3a\u4e2d\u548c\u70ad\u75bd\u6746\u83cc\u6bd2\u7d20\u4fdd\u62a4\u6027\u6297\u539fPA\u3002\u56fd\u5185\u5747\u672a\u4e0a\u5e02\u7533\u62a5\uff0c\u4e2d\u6587\u540d\u4ec5\u6765\u81ea\u4e8e\u7f51\u7edc\u3002<em>1<\/em>\u4f5c\u7528\u673a\u5236<\/p>\n\n\n\n<p><strong>\u7f8e\u56fd\u70ad\u75bd\u653b\u51fb\u4e8b\u4ef6<\/strong><\/p>\n\n\n\n<p>2001\u5e749\u6708\uff0c\u7f8e\u56fd\u53d1\u751f\u4e00\u8d77\u751f\u5316\u6050\u6016\u4e8b\u4ef6\uff0c\u6709\u4eba\u628a\u542b\u6709\u70ad\u75bd\u6746\u83cc\u7684\u4fe1\u4ef6\u5bc4\u7ed9\u6570\u4e2a\u65b0\u95fb\u5a92\u4f53\u529e\u516c\u5ba4\u4ee5\u53ca\u4e24\u540d\u6c11\u4e3b\u515a\u53c2\u8bae\u5458\u3002\u5bfc\u81f422\u4eba\u611f\u67d3\u70ad\u75bd\u75c5\uff0c\u4e94\u4eba\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p>2008\u5e74\u8054\u90a6\u8c03\u67e5\u5c40\u5c06\u5acc\u7591\u4eba\u9501\u5b9a\u5e03\u9c81\u65af\u00b7\u7231\u5fb7\u534e\u5179\u00b7\u827e\u6587\u65af\uff08Bruce Edwards Ivins\uff09\u3002\u827e\u6587\u65af\u66fe\u7ecf\u5728\u653f\u5e9c\u751f\u7269\u9632\u5fa1\u5b9e\u9a8c\u5ba4\u5de5\u4f5c\uff0c\u4ed6\u5f97\u77e5\u6d88\u606f\u540e\u670d\u836f\u81ea\u6740\u3002<\/p>\n\n\n\n<p><strong>\u4ec0\u4e48\u662f\u70ad\u75bd\u75c5\uff1f<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image.png\" alt=\"\" class=\"wp-image-656\" width=\"492\" height=\"284\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image.png 704w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-300x173.png 300w\" sizes=\"auto, (max-width: 492px) 100vw, 492px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.chinacdc.cn\/jkzt\/crb\/zl\/tj\/<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u70ad\u75bd\u662f\u7531\u70ad\u75bd\u82bd\u5b62\u6746\u83cc\uff08Bacillus anthracis\uff09\u5f15\u8d77\u7684\u4f20\u67d3\u6027\u75be\u75c5\u3002<\/p>\n\n\n\n<p>\u8be5\u75c5\u662f\u725b\u3001\u9a6c\u3001\u7f8a\u7b49\u52a8\u7269\u4f20\u67d3\u75c5\uff0c\u4f46\u5076\u5c14\u4e5f\u53ef\u4f20\u67d3\u7ed9\u4ece\u4e8b\u76ae\u9769\u3001\u755c\u7267\u5de5\u4f5c\u7684\u4eba\u5458\uff0c\u8be5\u7ec6\u83cc\u7531Robert Koch\u57281877\u5e74\u9996\u6b21\u53d1\u73b0\u3002<\/p>\n\n\n\n<p>\u70ad\u75bd\u6746\u83cc\u7684\u82bd\u5b62\u53ef\u4ee5\u62b5\u5fa1\u5f88\u5f3a\u7684\u7d2b\u5916\u7ebf\uff0c\u9ad8\u6e29\u7b49\u6076\u52a3\u73af\u5883\uff0c\u5728\u9002\u5408\u7684\u73af\u5883\u4e0b\uff0c\u82bd\u5b62\u4f1a\u4ece\u65b0\u5f00\u59cb\u6d3b\u52a8\uff0c\u53d8\u6210\u6709\u611f\u67d3\u80fd\u529b\u70ad\u75bd\u6746\u83cc\u3002<\/p>\n\n\n\n<p>\u70ad\u75bd\u75c5\u60a3\u8005\u8d77\u521d\u4e3a\u201c\u6d41\u611f\u6837\u201d\u75c7\u72b6\uff0c\u8868\u73b0\u4e3a\u4f4e\u70e7\uff0c\u75b2\u4e4f\uff0c\u5168\u8eab\u4e0d\u9002\uff0c\u808c\u75db\uff0c\u54b3\u55fd\uff0c\u901a\u5e38\u6301\u7eed48\u5c0f\u65f6\u5de6\u53f3\u3002\u7136\u540e\u7a81\u7136\u53d1\u5c55\u6210\u4e00\u79cd\u6025\u6027\u75c5\u75c7\uff0c\u53ef\u8fc5\u901f\u51fa\u73b0\u660f\u8ff7\u548c\u6b7b\u4ea1\uff0c\u6b7b\u4ea1\u7387\u53ef\u8fbe90%\u4ee5\u4e0a\u3002<\/p>\n\n\n\n<p>\u7531\u4e8e\u70ad\u75bd\u6746\u83cc\u672c\u8eab\u662f\u4e00\u79cd\u9769\u5170\u9633\u6027\u83cc\uff0c\u56e0\u6b64\u6700\u76f4\u63a5\u7684\u6cbb\u7597\u65b9\u6cd5\u5c31\u662f\u6297\u751f\u7d20\u6cbb\u7597\u3002<\/p>\n\n\n\n<p>\u4f46\u662f\u70ad\u75bd\u75c5\u7684\u81f4\u547d\u6027\u5e76\u975e\u6765\u6e90\u4e8e\u7ec6\u83cc\u672c\u8eab\uff0c\u800c\u662f\u5b83\u6240\u4ea7\u751f\u7684\u70ad\u75bd\u6bd2\u7d20\u3002\u5373\u4f7f\u5229\u7528\u6297\u751f\u7d20\u6d88\u706d\u4e86\u4f53\u5185\u6240\u6709\u7ec6\u83cc\uff0c\u751f\u7269\u4f53\u4ecd\u4e0d\u53ef\u907f\u514d\u5730\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p><strong>\u70ad\u75bd\u6746\u83cc\u6bd2\u7d20<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-1.png\" alt=\"\" class=\"wp-image-657\" width=\"599\" height=\"433\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-1.png 952w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-1-300x217.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-1-768x556.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-1-880x637.png 880w\" sizes=\"auto, (max-width: 599px) 100vw, 599px\" \/><figcaption class=\"wp-element-caption\"><em>\u6765\u81eaCDC,\u00a0ACIP Anthrax Vaccine Work Group<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u70ad\u75bd\u6746\u83cc\u7684\u81f4\u547d\u6027\u6765\u81ea\u4e8e\u5b83\u5206\u6ccc\u7684\u4e09\u949f\u70ad\u75bd\u6bd2\u7d20\u3002<\/p>\n\n\n\n<p>1\u3001\u6c34\u80bf\u56e0\u5b50\uff08Edema Factor\uff0cEF\uff09\u662f\u4e00\u79cd\u817a\u82f7\u9178\u73af\u5316\u9176\uff0c\u5b83\u7684\u4f5c\u7528\u662f\u7834\u574f\u5bbf\u4e3b\u7684\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n\n\n\n<p>2\u3001\u81f4\u6b7b\u56e0\u5b50\uff08Lethal Factor\uff0cLF\uff09\u662f\u4e00\u79cd\u950c\u4f9d\u8d56\u7684\u86cb\u767d\u9176\uff0c\u5b83\u7684\u4f5c\u7528\u662f\u5bfc\u81f4\u7ec6\u80de\u6eb6\u89e3\u3002<\/p>\n\n\n\n<p>3\u3001\u4fdd\u62a4\u6027\u6297\u539f\uff08Protective Antigen\uff0cPA\uff09\uff0c\u5b83\u7684\u4e3b\u8981\u4f5c\u7528\u662f\u548c\u5bbf\u4e3b\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u5e76\u8f93\u9001EF\u53caLF\u8fdb\u5165\u7ec6\u80de\u4ece\u800c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p>\u6709\u8da3\u7684\u662f\u8fd9\u4e09\u79cd\u70ad\u75bd\u6bd2\u7d20\u5728\u5355\u72ec\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u4e0d\u4ea7\u751f\u6bd2\u6027\uff0c\u56e0\u4e3aPA\u672c\u8eab\u5e76\u6ca1\u6709\u6bd2\u6027\uff0c\u800cLF\u3001EF\u4e0d\u80fd\u88ab\u7ec6\u80de\u6444\u53d6\u3002<\/p>\n\n\n\n<p>\u4f46\u5f53PA\u4e0eLF\u6216EF\u540c\u65f6\u5b58\u5728\u65f6\uff0cPA\u4f1a\u548c\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u7ed3\u5408\uff0c\u5e76\u4e0eLF\u3001EF\u5f62\u6210\u591a\u805a\u4f53\uff0c\u4ece\u800c\u5c06LF\u3001EF\u8f6c\u8fd0\u5165\u7ec6\u80de\uff0c\u53d1\u6325\u6bd2\u6027\u3002<\/p>\n\n\n\n<p><strong>\u6cbb\u7597\u6297\u4f53<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-2.png\" alt=\"\" class=\"wp-image-658\" width=\"587\" height=\"454\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-2.png 904w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-2-300x232.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-2-768x595.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-2-880x681.png 880w\" sizes=\"auto, (max-width: 587px) 100vw, 587px\" \/><figcaption class=\"wp-element-caption\"><em>\u6765\u81eaCDC,\u00a0ACIP Anthrax Vaccine Work Group<\/em>Raxibacumab<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u96f7\u6614\u5e93\u5355\u6297\u3001Obiltoxaximab\u5965\u6258\u6614\u5355\u6297\u7684\u4f5c\u7528\u673a\u5236\u4e3a\uff1a<\/p>\n\n\n\n<p>\u7279\u5f02\u6027\u9776\u5411\u70ad\u75bd\u6746\u83cc\u5206\u6ccc\u7684\u4fdd\u62a4\u6027\u6297\u539fPA\uff0c\u963b\u65ad\u5176\u4e0e\u53d7\u4f53\u7ed3\u5408\uff0c\u4ece\u800c\u963b\u65ad\u6c34\u80bf\u56e0\u5b50EF\u548c\u81f4\u6b7b\u56e0\u5b50LF\u5411\u7ec6\u80de\u5185\u8f6c\u8fd0\uff0c\u65e0\u6cd5\u8fdb\u5165\u7ec6\u80de\u5185\u90e8\u7684EF\u548cLF\u5f88\u5feb\u88ab\u673a\u4f53\u7684\u86cb\u767d\u6c34\u89e3\u9176\u6c34\u89e3\uff0c\u4e27\u5931\u6bd2\u6027\u3002<\/p>\n\n\n\n<p>\u7531\u4e8e\u96f7\u6614\u5e93\u5355\u6297\u3001\u5965\u6258\u6614\u5355\u6297\u4ec5\u964d\u4f4e\u70ad\u75bd\u6746\u83cc\u6bd2\u7d20\u7684\u6bd2\u6027\uff0c\u5e76\u4e0d\u80fd\u76f4\u63a5\u6740\u706d\u70ad\u75bd\u6746\u83cc\uff0c\u9700\u8981\u548c\u6297\u751f\u7d20\u8054\u7528\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><strong>FDA\u6279\u51c6\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-3-1024x268.png\" alt=\"\" class=\"wp-image-659\" width=\"518\" height=\"135\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-3-1024x268.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-3-300x78.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-3-768x201.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-3-880x230.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-3.png 1166w\" sizes=\"auto, (max-width: 518px) 100vw, 518px\" \/><figcaption class=\"wp-element-caption\"><em>\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>Raxibacumab \u96f7\u6614\u5e93\u5355\u6297<\/p>\n\n\n\n<p>ANTHIM\u00aeObiltoxaximab\u5965\u6258\u6614\u5355\u6297<\/p>\n\n\n\n<p>FDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n<p>\u6210\u5e74\u548c\u513f\u7ae5\u5438\u5165\u6027\u70ad\u75bd\u75c5<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-5-1024x643.png\" alt=\"\" class=\"wp-image-661\" width=\"588\" height=\"369\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-5-1024x643.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-5-300x188.png 300w, 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