{"id":676,"date":"2022-12-09T12:27:30","date_gmt":"2022-12-09T04:27:30","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=676"},"modified":"2022-12-09T12:27:30","modified_gmt":"2022-12-09T04:27:30","slug":"%e5%a6%82%e4%bd%95%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e6%89%b9%e5%87%86%e7%94%9f%e7%89%a9%e8%8d%af%ef%bc%9f-rankl%e6%8b%ae%e6%8a%97%e5%89%82-%e6%99%ae%e7%bd%97%e5%8a%9b%e5%ae%89%e5%8a%a0","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=676","title":{"rendered":"\u5982\u4f55\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u751f\u7269\u836f\uff1f| RANKL\u62ee\u6297\u5242 | \u666e\u7f57\u529b\u00ae\u5b89\u52a0\u7ef4\u00ae\u5730\u8212\u5355\u6297| 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class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>\u4eba\u4f53\u7684\u9aa8\u9abc\u5177\u6709\u8db3\u591f\u7684\u521a\u5ea6\u548c\u97e7\u6027\uff0c\u4e3b\u8981\u901a\u8fc7\u7834\u9aa8\u7ec6\u80de\u9aa8\u5438\u6536\u548c\u6210\u9aa8\u7ec6\u80de\u9aa8\u5f62\u6210\u7684\u52a8\u6001\u5e73\u8861\u7ef4\u6301\u3002<\/p>\n\n\n\n<p><strong>\u9aa8\u5438\u6536\u548c\u9aa8\u5f62\u6210<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-11-1024x751.png\" alt=\"\" class=\"wp-image-677\" width=\"584\" height=\"428\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-11-1024x751.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-11-300x220.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-11-768x563.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-11-880x646.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-11.png 1198w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/><figcaption class=\"wp-element-caption\"><em>Rheumatology (Oxford) . 2009 Oct;48 Suppl 4:iv3-8.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>\u9aa8\u5438\u6536\u5f62\u6210\u76844\u4e2a\u9636\u6bb5\uff1a<\/strong><\/p>\n\n\n\n<p>1\u3001\u9759\u6b62\/\u6fc0\u6d3b\u9636\u6bb5<br>2\u3001\u5438\u6536\u9636\u6bb5\u7834\u9aa8\u7ec6\u80de\u6fc0\u6d3b\uff0c\u5438\u6536\u53d7\u635f\u6216\u8001\u5316\u7684\u9aa8\u8d28\u3002<br>3\u3001\u9006\u8f6c\u9636\u6bb5\u7834\u9aa8\u7ec6\u80de\u51cb\u4ea1\uff0c\u6210\u9aa8\u7ec6\u80de\u6fc0\u6d3b\uff0c\u4fee\u590d\u7531\u7834\u9aa8\u7ec6\u80de\u9020\u6210\u7684\u635f\u4f24\u3002<br>4\u3001\u5f62\u6210\u9636\u6bb5\u6210\u9aa8\u7ec6\u80de\u5b8c\u5168\u4fee\u590d\u9aa8\u8d28\uff0c\u91cd\u65b0\u8fdb\u5165\u9759\u6b62\u9636\u6bb5\u3002<\/p>\n\n\n\n<p><strong>\u7834\u9aa8\u548c\u6210\u9aa8\u7ec6\u80de\u5e73\u8861<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-12-1024x575.png\" alt=\"\" class=\"wp-image-678\" width=\"661\" height=\"370\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-12-1024x575.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-12-300x169.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-12.png 1468w\" sizes=\"auto, (max-width: 661px) 100vw, 661px\" \/><figcaption class=\"wp-element-caption\"><em>J Bone Oncol . 2022 Feb 7;33:100416.\u00a0<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u6210\u9aa8\u7ec6\u80de\u5206\u6ccc\u7684\u6838\u56e0\u5b50-\u03baB\u53d7\u4f53\u6d3b\u5316\u56e0\u5b50\u914d\u4f53\uff08receptor activator of NF-kappa B ligand\uff0c<strong>RANKL<\/strong>\uff09\uff0c\u4e0e\u7834\u9aa8\u7ec6\u80de\u8868\u9762\u7684RANKL\u53d7\u4f53\u7ed3\u5408\u540e\uff0c\u6fc0\u6d3b\u7834\u9aa8\u7ec6\u80de\uff0c\u53d1\u6325\u9aa8\u5438\u6536\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u9aa8\u4fdd\u62a4\u7d20\uff08osteoprotegerin\uff0cOPG\uff09\u80fd\u5931\u6d3bRANKL\uff0c\u8c03\u63a7RANKL\u7684\u6570\u91cf\uff0c\u4f7f\u6210\u9aa8\u7ec6\u80de\u548c\u7834\u9aa8\u7ec6\u80de\u5904\u4e8e\u52a8\u6001\u5e73\u8861\u4e4b\u4e2d\u3002<\/p>\n\n\n\n<p><strong>\u7834\u9aa8\u548c\u6210\u9aa8\u7ec6\u80de\u5e73\u8861\u7834\u574f<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-17-1024x598.png\" alt=\"\" class=\"wp-image-684\" width=\"654\" height=\"381\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-17-1024x598.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-17-300x175.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-17-768x448.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-17-1218x711.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-17-880x514.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-17.png 1310w\" sizes=\"auto, (max-width: 654px) 100vw, 654px\" \/><figcaption class=\"wp-element-caption\"><em>J Bone Oncol . 2022 Feb 7;33:100416.\u00a0<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5f53\u673a\u4f53\u53d1\u751f\u9aa8\u80bf\u7624\uff0c\u6216\u96cc\u6fc0\u7d20\u6c34\u5e73\u4e0b\u964d\uff08\u5982\u7edd\u7ecf\u540e\u5987\u5973\uff09\u7b49\u75c5\u7406\u56e0\u7d20\u65f6\uff0c\u6210\u9aa8\u7ec6\u80de\u5206\u6cccRANKL\u589e\u52a0\uff0c\u5bfc\u81f4\u66f4\u591a\u7684RANKL\u4e0e\u7834\u9aa8\u7ec6\u80de\u8868\u9762\u7684RANKL\u53d7\u4f53\u7ed3\u5408\uff0c\u6fc0\u6d3b\u66f4\u591a\u7684\u7834\u9aa8\u7ec6\u80de\uff0c\u5e73\u8861\u88ab\u6253\u7834\uff0c\u9020\u6210\u9aa8\u8d28\u6d41\u5931\u3002<\/p>\n\n\n\n<p><strong>\u5730\u8212\u5355\u6297\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-14-1024x616.png\" alt=\"\" class=\"wp-image-680\" width=\"658\" height=\"396\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-14-1024x616.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-14-300x180.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-14-768x462.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-14-880x529.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-14.png 1206w\" sizes=\"auto, (max-width: 658px) 100vw, 658px\" \/><figcaption class=\"wp-element-caption\"><em>J Bone Oncol . 2022 Feb 7;33:100416.\u00a0<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5730\u8212\u5355\u6297\u7684\u4f5c\u7528\u7c7b\u4f3c\u9aa8\u4fdd\u62a4\u7d20OPG\uff0c\u6ce8\u5c04\u5165\u4eba\u4f53\u540e\uff0c\u7ed3\u5408\u8fc7\u91cf\u7684RANKL\uff0c\u91cd\u65b0\u5efa\u7acb\u6210\u9aa8\u7ec6\u80de\u548c\u7834\u9aa8\u7ec6\u80de\u7684\u5e73\u8861\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><strong>\u5730\u8212\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-15.png\" alt=\"\" class=\"wp-image-681\" width=\"678\" height=\"333\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-15.png 980w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-15-300x147.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-15-768x377.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-15-880x432.png 880w\" sizes=\"auto, (max-width: 678px) 100vw, 678px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#6004b6\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>\u666e\u7f57\u529b<sup>\u00ae<\/sup>\u5730\u8212\u5355\u6297\u56fd\u5185\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7528\u4e8e\u9aa8\u6298\u9ad8\u98ce\u9669\u7684\u7edd\u7ecf\u540e\u5987\u5973\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u3002\u5728\u7edd\u7ecf\u540e\u5987\u5973\u4e2d\uff0c\u672c\u54c1\u53ef\u663e\u8457\u964d\u4f4e\u690e\u4f53\u3001\u975e\u690e\u4f53\u548c\u9acb\u90e8\u9aa8\u6298\u7684\u98ce\u9669\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5b89\u52a0\u7ef4<sup>\u00ae<\/sup>\u5730\u8212\u5355\u6297\u56fd\u5185\u6279\u51c6\u9002\u5e94\u75c7\u4e3a\uff1a<\/strong><\/p>\n\n\n\n<ul 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