{"id":715,"date":"2022-12-19T16:01:32","date_gmt":"2022-12-19T08:01:32","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=715"},"modified":"2024-03-26T11:55:52","modified_gmt":"2024-03-26T03:55:52","slug":"%e8%ae%b0%e4%bd%8f4%e6%ac%be%e9%a2%84%e9%98%b2%e5%81%8f%e5%a4%b4%e7%97%9b%e7%94%9f%e7%89%a9%e5%88%b6%e5%89%82-%e7%91%9e%e7%8e%9b%e5%a5%88%e7%8f%a0%e3%80%81%e5%8a%a0%e9%82%a3%e7%8f%a0%e3%80%81","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=715","title":{"rendered":"\u8bb0\u4f4f4\u6b3e\u9884\u9632\u504f\u5934\u75db\u751f\u7269\u5236\u5242 | \u745e\u739b\u5948\u73e0\u3001\u52a0\u90a3\u73e0\u3001\u4f9d\u745e\u5948\u5c24\u3001\u827e\u666e\u5948\u73e0\u5355\u6297 | \u200b\u9776\u5411\u964d\u9499\u7d20\u57fa\u56e0\u76f8\u5173\u80bd\uff08CGRP\uff09\u53d7\u4f53"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\u5171\u67094\u6b3e\u4f5c\u7528\u4e8e\u964d\u9499\u7d20\u57fa\u56e0\u76f8\u5173\u80bd\uff08CGRP\uff09\u53d7\u4f53\uff0c\u7528\u4e8e\u9884\u9632\u504f\u5934\u75db\u7684\u751f\u7269\u5236\u5242\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u5206\u522b\u4e3a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Teva\u516c\u53f8\u7684Ajovy<sup>\u00ae<\/sup>&nbsp;Fremanezumab\uff0c2018\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u5728\u4e2d\u56fd\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u5e73\u53f0\u6ce8\u518c\u6709\u4e00\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\uff08CTR20220109\uff09\uff0c\u4e2d\u6587\u540d\u4e3a\u745e\u739b\u5948\u73e0\u5355\u6297\u3002<\/li>\n\n\n\n<li>\u793c\u6765\u516c\u53f8\u7684Emgality<sup>\u00ae<\/sup>&nbsp;Galcanezumab\uff0c2018\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u4e00\u4e9b\u6587\u732e\u4e2d\u7684\u4e2d\u6587\u540d\u4e3a\u52a0\u90a3\u73e0\u5355\u6297\u3002<\/li>\n\n\n\n<li>\u8bfa\u534e\u548c\u5b89\u8fdb\u516c\u53f8\u7684Aimovig<sup>\u00ae<\/sup>&nbsp;Erenumab\uff0c2018\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u30022022\u5e747\u6708\u5df2\u5728\u5e7f\u5dde\u5927\u6e7e\u533a\u8fdb\u884c\u9996\u4f4d\u60a3\u8005\u6ce8\u5c04\uff0c\u5b98\u7f51\u4ecb\u7ecd\u4e2d\u4e2d\u6587\u540d\u4e3a\u4f9d\u745e\u5948\u5c24\u5355\u6297\u3002<\/li>\n\n\n\n<li>\u7075\u5317Lundbeck\u516c\u53f8\u7684Vyepti<sup>\u00ae<\/sup>&nbsp;Eptinezumab\uff0c 2020\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u30022022\u5e7411\u6708\u8fdb\u5165\u6d77\u5357\u535a\u9ccc \uff0c\u5b98\u7f51\u4ecb\u7ecd\u4e2d\u4e2d\u6587\u540d\u4e3a\u827e\u666e\u5948\u73e0\u5355\u6297\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u76ee\u524d\u4ee5\u4e0a4\u6b3e\u9884\u9632\u504f\u5934\u75db\u751f\u7269\u5236\u5242\uff0c\u5747\u6682\u672a\u5728\u56fd\u5185\u83b7\u6279\uff08\u90e8\u5206\u836f\u7269\u8fdb\u5165\u535a\u9ccc\u3001\u5927\u6e7e\u533a\u7b49\u653f\u7b56&#8221;\u5148\u884c\u533a&#8221;\uff09\uff0c\u5728CDE\u5904\u4e8e\u6ce8\u518c\u7533\u62a5\u9636\u6bb5\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>\u504f\u5934\u75db\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u4e09\u53c9\u795e\u7ecf\u8840\u7ba1\u6027\u5934\u75db\uff0c\u8868\u73b0\u4e3a\u4e00\u4fa7\u6216\u53cc\u4fa7\u640f\u52a8\u6027\u5267\u70c8\u5934\u75db\uff0c\u53ef\u80fd\u6301\u7eed4~72\u4e2a\u5c0f\u65f6\uff0c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5b9a\u4e49\u5176\u4e3a\u4eba\u7c7b\u7b2c\u4e8c\u4f4d\u7684\u81f4\u6b8b\u539f\u56e0\u3002<\/p>\n\n\n\n<p>\u9664\u75be\u75c5\u672c\u8eab\u9020\u6210\u635f\u5bb3\u4e4b\u5916\uff0c\u5f80\u5f80\u4f34\u6709\u591a\u79cd\u5e76\u53d1\u75c7\uff0c\u5305\u62ec\u6291\u90c1\u3001\u8111\u8840\u7ba1\u75c5\u3001\u7761\u7720\u969c\u788d\u7b49\uff0c\u7ed9\u60a3\u8005\u5e26\u6765\u75be\u75c5\u8d1f\u62c5\u3002<\/p>\n\n\n\n<p>\u6309\u7167\u56fd\u9645\u5934\u75db\u5206\u7c7b\u7b2c\u4e09\u7248 ICHD-3\uff0c\u5934\u75db\u4e00\u822c\u5206\u4e3a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u539f\u53d1\u6027\u5934\u75db\uff1a\uff08\u504f\u5934\u75db\u3001\u7d27\u5f20\u578b\u5934\u75db\u3001\u4e09\u53c9\u795e\u7ecf\u81ea\u4e3b\u795e\u7ecf\u6027\u5934\u75db-\u53d1\u4f5c\u6027\u4e1b\u96c6\u6027\u5934\u75db\uff09<\/li>\n\n\n\n<li>\u7ee7\u53d1\u6027\u5934\u75db<\/li>\n\n\n\n<li>\u75db\u6027\u9885\u795e\u7ecf\u75c5\u53d8\u548c\u5176\u4ed6\u9762\u75db\u53ca\u5176\u4ed6\u7c7b\u578b\u5934\u75db<\/li>\n<\/ul>\n\n\n\n<p>\u4e0e\u524d\u6587\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e00\u6837\uff0c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e00\u822c\u90fd\u8f83\u590d\u6742\uff0c\u53d1\u75c5\u673a\u5236\u5f80\u5f80\u8fd8\u6ca1\u6709\u7814\u7a76\u6e05\u695a\uff0c\u76ee\u524d\u9488\u5bf9\u504f\u5934\u75db\u7684\u53ef\u80fd\u53d1\u75c5\u673a\u5236\u7684\u836f\u7269\u4e3b\u8981\u5305\u62ec\uff1a<\/p>\n\n\n\n<p><strong>\u504f\u5934\u75db\u836f\u7269<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"720\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/03\/image-1024x720.png\" alt=\"\" class=\"wp-image-1311\" style=\"width:710px;height:auto\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/03\/image-1024x720.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/03\/image-300x211.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/03\/image-768x540.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/03\/image-1218x856.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/03\/image-880x618.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2024\/03\/image.png 1426w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p><strong>1\u3001\u9009\u62e9\u60275-\u7f9f\u8272\u80fa\uff085-HT1\uff09\u53d7\u4f53\u6fc0\u52a8\u5242\uff1a<\/strong><\/p>\n\n\n\n<p>\u901a\u8fc7\u6fc0\u52a8\u4e09\u53c9\u795e\u7ecf\u8282\u7ec6\u80de\u8868\u97625-\u7f9f\u8272\u80fa\uff085-HT&nbsp;1B\/1D\uff09\u53d7\u4f53\uff0c\u6536\u7f29\u8111\u8840\u7ba1\u3001\u6291\u5236\u795e\u7ecf\u75db\u89c9\u4f20\u9012\uff0c\u53d1\u6325\u6b62\u75db\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u4e3b\u8981\u836f\u7269\u5305\u62ec\u4e3a\u66f2\u666e\u5766\u7c7b\uff08\u8212\u9a6c\u66f2\u666e\u5766\u3001\u4f50\u7c73\u66f2\u666e\u5766\u7b49\uff09<\/p>\n\n\n\n<p><strong>2\u3001\u6291\u5236CGRP<\/strong><\/p>\n\n\n\n<p>\u964d\u9499\u7d20\u57fa\u56e0\u76f8\u5173\u80bd(calcitonin gene-related peptid,CGRP)\u662f\u4e00\u4e2a\u542b\u670937\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u611f\u89c9\u795e\u7ecf\u6e90\u6027\u7684\u591a\u80bd\uff0c\u5e7f\u6cdb\u5206\u5e03\u4e8e\u4e2d\u67a2(\u4e3b\u8981\u662f\u4e09\u53c9\u795e\u7ecf\u8840\u7ba1\u7cfb\u7edf\u3001\u4e18\u8111\u548c\u5c0f\u8111)\u3002<\/p>\n\n\n\n<p>CGRP\u662f\u4e00\u79cd\u5f3a\u6548\u7684\u8840\u7ba1\u6269\u5f20\u5242\uff0c\u5b83\u4e3b\u8981\u7531\u611f\u89c9\u795e\u7ecf\uff08\u5982\u4e09\u53c9\u795e\u7ecf\uff09\u91ca\u653e\uff0c\u5e76\u7275\u6d89\u75bc\u75db\u901a\u8def\u3002<\/p>\n\n\n\n<p>\u4e0e5-HT1\u53d7\u4f53\u6fc0\u6d3b\u540e\u4f5c\u7528\u76f8\u53cd\uff0cCGRP\u91ca\u653e\u540e\u4e0e\u8111\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u8868\u9762\u7684CGRP\u53d7\u4f53\u7ed3\u5408\uff0c\u5f15\u8d77\u8111\u8840\u7ba1\u6269\u5f20\uff0c\u6291\u5236\u8be5\u8fc7\u7a0b\u53ef\u4ee5\u7f13\u89e3\u5934\u75db\u3002<\/p>\n\n\n\n<p><strong>\u4e3b\u8981\u836f\u7269\u5305\u62ec\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CGRP\u62ee\u6297\u5242\u7c7b\u6297\u4f53\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n<p>Fremanezumab\u745e\u739b\u5948\u73e0\u5355\u6297\uff08Teva\uff09<\/p>\n\n\n\n<p>Galcanezumab\u52a0\u90a3\u73e0\u5355\u6297\uff08Lilly\uff09<\/p>\n\n\n\n<p>Eptinezumab\u827e\u666e\u5948\u73e0\u5355\u6297\uff08Lundbeck\uff09<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CGRP\u53d7\u4f53\u62ee\u6297\u5242\u7c7b\u6297\u4f53\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n<p>Erenumab\u4f9d\u745e\u5948\u5c24\u5355\u6297\uff08Novartis\uff09<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CGRP\u53d7\u4f53\u62ee\u6297\u5242\u7c7b\u5c0f\u5206\u5b50\u836f\u7269\uff1a<\/strong><\/li>\n<\/ul>\n\n\n\n<p>Atogepant\u3001Rimegepant\u3001Ubrogepant<\/p>\n\n\n\n<p><strong>4\u6b3eCGRP\u5355\u6297<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"897\" height=\"620\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-32.png\" alt=\"\" class=\"wp-image-717\" style=\"width:540px;height:373px\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-32.png 897w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-32-300x207.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-32-768x531.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-32-880x608.png 880w\" sizes=\"auto, (max-width: 897px) 100vw, 897px\" \/><figcaption class=\"wp-element-caption\"><em>Nat Rev Neurol . 2018 Jun;14(6):338-350.<\/em>4<\/figcaption><\/figure>\n<\/div>\n\n\n<p>4\u6b3eCGRP\u5355\u6297\u7ed9\u836f\u65f6\u95f4\u4e0d\u540c\uff0c\u836f\u7269\u6548\u679c\u7c7b\u4f3c\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><strong>CGRP\u62ee\u6297\u5242FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"565\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-33-1024x565.png\" alt=\"\" class=\"wp-image-718\" style=\"width:623px;height:343px\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-33-1024x565.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-33-300x166.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-33-768x424.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-33-1218x673.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-33-880x486.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/image-33.png 1360w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>\u6240\u6709\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>4\u6b3e\u5355\u6297\u836f\u7269FDA\u5747\u83b7\u6279\u9884\u9632\u504f\u5934\u75db\u9002\u5e94\u75c7\uff0c\u52a0\u90a3\u5355\u6297\u8fd8\u83b7\u6279\u6cbb\u7597\u53d1\u4f5c\u6027\u4e1b\u96c6\u6027\u5934\u75db\u9002\u5e94\u75c7\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/CGRP-no-gap.jpg\" data-gif=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2022\/12\/CGRP-no.gif\" alt=\"\" class=\"wp-image-720\" style=\"width:612px;height:453px\"\/><figcaption 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