{"id":831,"date":"2023-03-30T17:06:17","date_gmt":"2023-03-30T09:06:17","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=831"},"modified":"2023-03-30T17:06:17","modified_gmt":"2023-03-30T09:06:17","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-4%e6%ac%becd19-car-t-%e9%98%bf%e5%9f%ba%e4%bb%91%e8%b5%9b%e3%80%81%e7%91%9e%e5%9f%ba%e5%a5%a5%e4%bb%91%e8%b5%9b%e3%80%81%e6%9b%bf","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=831","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | 4\u6b3eCD19 CAR-T | \u963f\u57fa\u4ed1\u8d5b\u3001\u745e\u57fa\u5965\u4ed1\u8d5b\u3001\u66ff\u57fa\u4ed1\u8d5b\uff0c\u5e03\u57fa\u5965\u4ed1\u8d5b | \u5927B\u7ec6\u80de\u6dcb\u5df4\u7624"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>CAR-T \u662f\u4e00\u79cd\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6280\u672f\uff0c\u5168\u79f0\u4e3a\u201c\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\u6cbb\u7597\u201d\uff0c\u662f\u5229\u7528\u60a3\u8005\u81ea\u8eab\u7684T\u7ec6\u80de\uff0c\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u6539\u9020\uff0c\u4f7f\u5176\u80fd\u591f\u8bc6\u522b\u5e76\u653b\u51fb\u764c\u7ec6\u80de\u3002<\/p>\n\n\n\n<p>\u622a\u6b62\u76ee\u524d\u5df2\u7ecf\u67094\u6b3e\u9776\u70b9CD19\u7684CAR-T\u836f\u7269\u4e0a\u5e02\uff0c\u5206\u522b\u4e3a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KYMRIAH<sup>\u00ae<\/sup>&nbsp;<strong>Ti<\/strong><strong>sagenlecleucel (Tisa-cel)<\/strong>\uff0c\u4f5c\u4e3a\u7b2c\u4e00\u6b3e\u4e0a\u5e02\u7684CAR-T\u836f\u7269\uff0c\u7531 Novartis \u516c\u53f8\u5f00\u53d1\uff0c2017\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u3002\u5c1a\u672a\u5728\u56fd\u5185\u5f15\u8fdb\uff0c\u97f3\u8bd1\u4e3a\u66ff\u57fa\u4ed1\u8d5b\uff08\u65e0\u51fa\u5904\uff09\uff1b<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>YESCARTA<sup>\u00ae<\/sup>&nbsp;<strong>Axicabtagene ciloleucel(Axi-cel)<\/strong>\uff08<strong>\u5955\u51ef\u8fbe<sup>\u00ae<\/sup>\u963f\u57fa\u4ed1\u8d5b<\/strong>\uff09\u3002\u7531\u5409\u5229\u5fb7\u65d7\u4e0bKite\u516c\u53f8\u5f00\u53d1\uff0c2017\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u3002\u56fd\u5185\u7531\u590d\u661f\u533b\u836f\u65d7\u4e0b\u590d\u661f\u51ef\u7279\u5f15\u8fdb\uff0c2021\u5e74\u5728\u56fd\u5185\u83b7\u6279\uff1b<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>TECARTUS<sup>\u00ae<\/sup>&nbsp;<strong>Brexucabtagene autoleucel(Brexu-cel)&nbsp;<\/strong>\u540c\u6837\u7531\u5409\u5229\u5fb7\u65d7\u4e0bKite\u516c\u53f8\u5f00\u53d1\uff0c2020\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u3002\u5c1a\u672a\u5728\u56fd\u5185\u5f15\u8fdb\uff0c\u97f3\u8bd1\u4e3a\u5e03\u57fa\u5965\u4ed1\u8d5b\uff08\u65e0\u51fa\u5904\uff09\uff1b<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>BREYANZI<sup>\u00ae<\/sup>&nbsp;<strong>Lisocabtagene maraleucel\uff08Liso-cel\uff09<\/strong>\u3002\u7531BMS\u65d7\u4e0b Juno\u516c\u53f8\u5f00\u53d1\uff0c2021\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u3002\u56fd\u5185\u7531\u836f\u660e\u65d7\u4e0b\u836f\u660e\u5de8\u8bfa\u5f15\u8fdb\uff0c2021\u5e74\uff0c<strong>\u500d\u8bfa\u8fbe<sup>\u00ae<\/sup>\u745e\u57fa\u5965\u4ed1\u8d5b\uff08Relma-cel\uff09<\/strong>\u5728\u56fd\u5185\u83b7\u6279\u3002Relma-cel\u4ee5\u4e0e Liso-cel \u76f8\u540c\u7684 CAR \u7ed3\u6784\u4f53\u4e3a\u57fa\u7840\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4ee5\u4e0a4\u6b3eCAR-T\u836f\u7269\u9776\u70b9\u5747\u4e3aCD-19\uff0c\u9002\u5e94\u75c7\u5747\u4e3aB\u7ec6\u80de\u76f8\u5173\u6076\u6027\u80bf\u7624\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>T\u7ec6\u80de\u662f\u4eba\u4f53\u91cd\u8981\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5b83\u4eec\u5728\u514d\u75ab\u7cfb\u7edf\u4e2d\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u4f46\u662fT\u7ec6\u80de\u8868\u9762\u53d7\u4f53TCR\u4e0d\u80fd\u76f4\u63a5\u8bc6\u522b\u80bf\u7624\u6297\u539f\uff0c\u9700\u8981\u901a\u8fc7\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff08MHC\uff09\u5206\u5b50\u6765\u8bc6\u522b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CD4+ T\u7ec6\u80de\u8bc6\u522b\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08APC\uff09\u8868\u9762\u7684MHC II\u7c7b\u5206\u5b50\uff0c\u6fc0\u6d3bTh\u7ec6\u80de\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\uff1b<\/li>\n\n\n\n<li>CD8+ T\u7ec6\u80de\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u8868\u9762MHC I\u7c7b\u5206\u5b50\uff0c\u6fc0\u6d3b\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08CTL\uff09\u53d1\u6325\u6740\u4f24\u80bf\u7624\u7684\u4f5c\u7528\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7531\u4e8eTCR\u8bc6\u522b\u80bf\u7624\u6297\u539f\u53d7MHC I\u7c7b\u5206\u5b50\u9650\u5236\uff0c\u56e0\u6b64\u80bf\u7624\u7ec6\u80de\u5bb9\u6613\u88ab\u514d\u75ab\u7cfb\u7edf\u5ffd\u89c6\u3002<\/p>\n\n\n\n<p class=\"has-text-align-left\"><strong>T cell \u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u9700\u8981MHC\u53c2\u4e0e<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-14.png\" alt=\"\" class=\"wp-image-833\" width=\"610\" height=\"299\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-14.png 1017w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-14-300x147.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-14-768x377.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-14-880x432.png 880w\" sizes=\"auto, (max-width: 610px) 100vw, 610px\" \/><figcaption class=\"wp-element-caption\"><em>Trends Cancer\u00a0. 2022 Aug;8(8):629-631.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-left\"><strong>\u6297\u4f53\u8fde\u63a5T cell\u548c\u80bf\u7624\u7ec6\u80de<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-15.png\" alt=\"\" class=\"wp-image-834\" width=\"578\" height=\"311\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-15.png 1001w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-15-300x162.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-15-768x414.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-15-880x474.png 880w\" sizes=\"auto, (max-width: 578px) 100vw, 578px\" \/><figcaption class=\"wp-element-caption\"><em>Front Chem . 2020 Jul 23;8:622.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5e38\u89c1\u6297\u4f53\u836f\u7269\uff0cFab\u6bb5\u7684\u6297\u539f\u8bc6\u522b\u533a\uff0c\u53ef\u4ee5\u76f4\u63a5\u8bc6\u522b\u80bf\u7624\u6297\u539f\uff0c\u5176Fc\u6bb5\u53ef\u4e0eT\u7ec6\u80de\u8868\u9762Fc\u53d7\u4f53\u7ed3\u5408\uff0c\u95f4\u63a5\u5f15\u5bfcT\u7ec6\u80de\u81f3\u80bf\u7624\u7ec6\u80de\u5468\u56f4\uff0c\u53d1\u6325ADCC\u7b49\u4f5c\u7528\uff0c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u5982\u5c06\u6297\u4f53Fab\u6bb5\u6297\u539f\u8bc6\u522b\u8868\u4f4d\u76f4\u63a5\u5d4c\u5408\u8fdbT\u7ec6\u80de\u8868\u9762\uff0c\u8fd9\u6837T\u7ec6\u80de\u5c31\u80fd\u7ed5\u8fc7MHC\u5206\u5b50\u7684\u9650\u5236\uff0c\u76f4\u63a5\u8bc6\u522b\u80bf\u7624\u6297\u539f\uff0c\u53d1\u6325\u6740\u4f24\u4f5c\u7528\u3002<\/p>\n\n\n\n<p><strong>CAR-T \u7684\u7ed3\u6784<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-17-1024x491.png\" alt=\"\" class=\"wp-image-836\" width=\"694\" height=\"331\"\/><figcaption class=\"wp-element-caption\"><em><em>https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-022-01559-z#Fig1<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u5c06\u6297\u4f53Fab\u6bb5\u7684scFv\u57fa\u56e0\u4e0eCD3\u7684\u80de\u5185\u7ed3\u6784\u57fa\u56e0\u878d\u5408\uff0c\u6ce8\u5165T\u7ec6\u80de\u5185\u5e76\u5728T\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u3002<\/p>\n\n\n\n<p>\u8868\u8fbe\u7684CAR\u5177\u6709\u8bc6\u522b\u80bf\u7624\u6297\u539f\u7684\u80fd\u529b\uff0c\u800c\u80de\u5185CD3\u5219\u80fd\u5f15\u5bfcCAR-T\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u589e\u6b96\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u764c\u7ec6\u80de\u7684\u653b\u51fb\u3002<\/p>\n\n\n\n<p><strong>\u666e\u901aTCR-T\u548cCAR-T\u7ed3\u6784\u533a\u522b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-18-1024x627.png\" alt=\"\" class=\"wp-image-837\" width=\"658\" height=\"402\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-18-1024x627.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-18-300x184.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-18-880x539.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-18.png 1056w\" sizes=\"auto, (max-width: 658px) 100vw, 658px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/premier-research.com\/blog-a-brief-introduction-to-car-t-cell-therapy\/<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u7ecf\u8fc7\u6539\u9020\u540e\u7684CAT-T\u7ec6\u80de\u53ef\u4ee5\u76f4\u63a5\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u80bf\u7624\u6297\u539f\uff0c\u6446\u8131MHC I\u7c7b\u5206\u5b50\u7684\u9650\u5236\u3002<\/p>\n\n\n\n<p><strong>CAR-T \u5236\u5907\u8fc7\u7a0b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-19-1024x642.png\" alt=\"\" class=\"wp-image-838\" width=\"682\" height=\"427\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-19-1024x642.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-19-300x188.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-19-768x481.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-19-1218x763.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-19-880x552.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-19.png 1396w\" sizes=\"auto, (max-width: 682px) 100vw, 682px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/immunotherapy\/t-cell-transfer-therapy<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>1. \u91c7\u96c6\u60a3\u8005\u7684T\u7ec6\u80de<\/li>\n\n\n\n<li>2. \u5236\u5907\u9776\u70b9\uff08\u5982CD19\uff09\u7684CAR\u57fa\u56e0\uff0c\u5e76\u6ce8\u5165T\u7ec6\u80de<\/li>\n\n\n\n<li>3. T\u7ec6\u80de\u5185\u8868\u8fbeCAR\u57fa\u56e0\uff0c\u5236\u5907CAR-T<\/li>\n\n\n\n<li>4. \u7ec6\u80de\u57f9\u517b\uff0c\u4f53\u5916\u6269\u589e\u548c\u7eaf\u5316CAR-T<\/li>\n\n\n\n<li>5. \u5c06\u5236\u5907\u7684CAR-T\u8f93\u9001\u56de\u60a3\u8005\u4f53\u5185<\/li>\n\n\n\n<li>6. CAR-T\u5728\u60a3\u8005\u4f53\u5185\u8bc6\u522b\u6297\u539f\uff0c\u6740\u4f24\u80bf\u7624\u7ec6\u80de<\/li>\n<\/ul>\n\n\n\n<p><strong>CAR-T \u7684\u8fed\u4ee3<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-20-1024x556.png\" alt=\"\" class=\"wp-image-839\" width=\"696\" height=\"378\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-20-1024x556.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-20-300x163.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-20-768x417.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-20-1218x661.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-20-880x477.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-20.png 1305w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" \/><figcaption class=\"wp-element-caption\"><em>Anticancer Res . 2021 Mar;41(3):1143-1156.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u7b2c\u4e00\u4ee3CAR-T\u662f\u5229\u7528\u5355\u4e00\u7684\u6297\u539f\u7ed3\u6784\u57df\uff0c\u56e0\u5176\u4fe1\u53f7\u4f20\u5bfc\u4e0d\u8db3\uff0c\u5bfc\u81f4\u6548\u679c\u6b20\u4f73\u3002<\/p>\n\n\n\n<p>\u7b2c\u4e8c\u4ee3CAR-T\u901a\u8fc7\u6dfb\u52a0\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u5982CD28 \u6216 4-1BB\u7b49\uff0c\u6765\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u4ece\u800c\u589e\u5f3aCAR-T\u7ec6\u80de\u7684\u6d3b\u6027\u548c\u6301\u4e45\u6027\u3002<\/p>\n\n\n\n<p>\u7b2c\u4e09\u4ee3CAR-T\u540c\u65f6\u6dfb\u52a0\u4e24\u4e2a\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u4f7fCAR-T\u7ec6\u80de\u80fd\u591f\u66f4\u597d\u5730\u8fdb\u884c\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u589e\u5f3a\u6cbb\u7597\u6548\u679c\u3002<\/p>\n\n\n\n<p>\u7b2c\u56db\u4ee3CAR-T\u5728\u7b2c\u4e09\u4ee3\u57fa\u7840\u4e0a\u589e\u52a0\u8bc6\u522b\u80bf\u7624\u5fae\u73af\u5883\u7684\u5206\u5b50\uff0c\u5982IL-12\u7b49\uff0c\u80fd\u91ca\u653e\u66f4\u591a\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u6fc0\u6d3b\u66f4\u591a\u514d\u75ab\u7ec6\u80de\u3002\u79f0\u4e3aT\u7ec6\u80de\u91cd\u5b9a\u5411\u7528\u4e8e\u901a\u7528\u7ec6\u80de\u56e0\u5b50\u6740\u4f24(T-cells\u00a0redirected for universal\u00a0cytokine\u00a0killing\uff1bTRUCKs\uff09\u3002<\/p>\n\n\n\n<p>\u7b2c\u4e94\u4ee3CAR-T\u7597\u6cd5\u5c06CAR-T\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\uff08\u5982\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u7b49\uff09\u8fdb\u884c\u7ec4\u5408\uff0c\u80fd\u591f\u66f4\u6709\u6548\u5730\u8bc6\u522b\u548c\u653b\u51fb\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<p><strong>\u5df2\u4e0a\u5e024\u6b3eCAR-T\u7684\u7ed3\u6784<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-21-1024x506.png\" alt=\"\" class=\"wp-image-840\" width=\"686\" height=\"339\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-21-1024x506.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-21-300x148.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-21-768x380.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-21-1218x602.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-21-880x435.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-21.png 1418w\" sizes=\"auto, (max-width: 686px) 100vw, 686px\" \/><figcaption class=\"wp-element-caption\">https:\/\/doi.org\/10.1016\/j.jncc.2021.07.001<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u76ee\u524d\u5df2\u7ecf\u4e0a\u5e02\u76844\u6b3eCAR-T\u5747\u4e3a\u7b2c\u4e8c\u4ee3\u836f\u7269\u3002\u5176\u80de\u5185\u5171\u523a\u6fc0\u5206\u5b50\u4e3aCD28\u62164-1BB\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-22-1024x535.png\" alt=\"\" class=\"wp-image-841\" width=\"754\" height=\"393\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-22-1024x535.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-22-300x157.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-22-768x401.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-22-880x460.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-22.png 1091w\" sizes=\"auto, (max-width: 754px) 100vw, 754px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#590f9f\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>Tisagenlecleucel (Tisa-cel) \u9002\u5e94\u75c7\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u524d\u4f53B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(ALL)(\u4e0d\u8d85\u8fc725\u5c81)<\/li>\n\n\n\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624(r\/r LBCL)(\u6210\u4eba)<\/li>\n\n\n\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624(FL)(\u6210\u4eba)<\/li>\n<\/ul>\n\n\n\n<p><strong>\u963f\u57fa\u4ed1\u8d5b (Axi-cel) \u9002\u5e94\u75c7\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624(r\/r LBCL)(\u6210\u4eba)<\/li>\n<\/ul>\n\n\n\n<p><strong>Brexucabtagene autoleucel (Brexu-cel) \u9002\u5e94\u75c7\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624(MCL)(\u6210\u4eba)<\/li>\n\n\n\n<li>\u524d\u4f53B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(ALL)(\u6210\u4eba)<\/li>\n<\/ul>\n\n\n\n<p><strong>\u745e\u57fa\u5965\u4ed1\u8d5b (Relma-cel) \u9002\u5e94\u75c7\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624(r\/r LBCL)(\u6210\u4eba)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23-1024x753.png\" alt=\"\" class=\"wp-image-842\" width=\"630\" height=\"463\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23-1024x753.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23-300x221.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23-768x565.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23-1536x1130.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23-1218x896.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23-880x647.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/03\/image-23.png 1566w\" sizes=\"auto, (max-width: 630px) 100vw, 630px\" \/><figcaption class=\"wp-element-caption\">\u6218\u795e\u963f\u745e\u65af\u88ab\u86c7\u602a\u6253\u8d25\uff0c\u53ea\u80fd\u5750\u56de\u66ff\u8865\u5e2d\uff0c\u66ff\u8865\u5e2d\u662f\u7531\u8d2d\u7269\u8f66\u505a\u6210\u7684\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>B<\/strong>\u578b\u7684<strong>\u5927\u86c7(\u6570\u5b57\u7f16\u780119)<\/strong>\uff0c\u4ee3\u8868\u836f\u7269\u9776\u70b9<strong>CD19<\/strong>\uff0c\u4ee5\u53ca\u9002\u5e94\u75c7<strong>\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624<\/strong>\u3002<\/p>\n\n\n\n<p>\u8d2d\u7269\u8f66\u7684\u82f1\u6587<strong>cart<\/strong>\u4ee3\u8868<strong>CAR-T<\/strong>\u836f\u7269\u3002<\/p>\n\n\n\n<p>\u6218\u795e<strong>\u963f\u745e<\/strong>\u65af\uff0c\u5750\u5728<strong>\u66ff\u8865<\/strong>\u5e2d\uff0c\u4ee3\u88684\u4e2a\u836f\u7269\u7684\u7b2c\u4e00\u4e2a\u5b57\uff0c<strong>\u963f<\/strong>\u57fa\u4ed1\u8d5b\uff0c<strong>\u745e<\/strong>\u57fa\u5965\u4ed1\u8d5b\uff0c<strong>\u66ff<\/strong>\u57fa\u4ed1\u8d5b\uff0c<strong>\u5e03<\/strong>\u57fa\u5965\u4ed1\u8d5b\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":844,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=831"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/831\/revisions"}],"predecessor-version":[{"id":845,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/831\/revisions\/845"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/844"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}