{"id":863,"date":"2023-04-05T11:47:06","date_gmt":"2023-04-05T03:47:06","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=863"},"modified":"2023-04-05T11:47:06","modified_gmt":"2023-04-05T03:47:06","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91cd20-%e4%bd%b3%e7%bd%97%e5%8d%8e%e5%a5%a5%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97-%e6%bb%a4%e6%b3%a1","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=863","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776\u5411CD20 | \u4f73\u7f57\u534e\u00ae\u5965\u59a5\u73e0\u5355\u6297 | \u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624FL\u3001\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5CLL"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>\u5965\u59a5\u73e0\u5355\u6297\u662f\u7531\u745e\u58eb\u7f57\u6c0f\u516c\u53f8\u7814\u53d1\uff0c2013\u5e74\u83b7\u7f8e\u56fd FDA \u6279\u51c6\u4e0a\u5e02\uff08GAZYVA<sup>\u00ae<\/sup>&nbsp;Obinutuzumab\uff09\uff0c\u5728\u6b27\u6d32\u5546\u54c1\u540d\u4e3aGAZYVARO\u3002<\/p>\n\n\n\n<p>\u5965\u59a5\u73e0\u5355\u6297\u662f\u7b2c\u4e09\u4ee3\u6297CD20\u5355\u6297\uff08\u7b2c\u4e00\u4ee3\u5229\u59a5\u6614\u5355\u6297\uff0c\u7b2c\u4e8c\u4ee3\u5965\u6cd5\u59a5\u6728\u5355\u6297\uff09\uff0c2021 \u5e74\u5728\u4e2d\u56fd\u4e0a\u5e02\uff08\u4f73\u7f57\u534e<sup>\u00ae<\/sup>\u5965\u59a5\u73e0\u5355\u6297\uff09\uff0c\u4f5c\u4e3a\u7f57\u6c0f\u7b2c\u4e8c\u6b3eCD20\u836f\u7269\uff0c\u5907\u53d7\u4e1a\u754c\u5173\u6ce8\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p>CD20\u5355\u6297\u901a\u8fc7\u7ed3\u5408B\u7ec6\u80de\u8868\u9762CD20\u6297\u539f\uff0c\u8bc6\u522b\u5e76\u6740\u4f24CD20\u9633\u6027\u7684B\u7ec6\u80de\uff0c\u662f\u6cbb\u7597B\u7ec6\u80de\u76f8\u5173\u75be\u75c5\u7684\u91cd\u8981\u836f\u7269\u4e4b\u4e00\u3002<\/p>\n\n\n\n<p><strong>\u6297\u4f53\u5f15\u8d77\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u4e3b\u8981\u5305\u62ec\uff1a<\/strong><\/p>\n\n\n\n<p><strong>\u6297\u4f53\u53d1\u6325\u4f5c\u7528\u7684\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-1024x895.png\" alt=\"\" class=\"wp-image-864\" width=\"618\" height=\"540\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-1024x895.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-300x262.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-768x671.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-880x769.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image.png 1151w\" sizes=\"auto, (max-width: 618px) 100vw, 618px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.nature.com\/articles\/d42473-018-00278-8<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>CDC\u4f5c\u7528<\/strong>(\u8865\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff1bcomplement-dependent cytotoxicity):\u00a0<br>\u6297\u539f\u6297\u4f53\u7ed3\u5408\u540e\uff0c\u6fc0\u6d3b\u8865\u4f53\u7cfb\u7edf\uff0c\u5f62\u6210\u819c\u653b\u51fb\u590d\u5408\u7269\uff08MAC\uff09\uff0c\u5bfc\u81f4\u7ec6\u80de\u819c\u7834\u88c2\u548c\u7ec6\u80de\u6eb6\u89e3\u3002<\/p>\n\n\n\n<p><strong>ADCC\u4f5c\u7528<\/strong>\uff08\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff1bantibody-dependent cell-mediated cytotoxicity):\u00a0<br>\u6297\u4f53Fc\u6bb5\u4e0e\u514d\u75ab\u7ec6\u80de\u4e0a\u7684Fc\u53d7\u4f53\u7ed3\u5408\uff0c\u52df\u96c6\u548c\u6fc0\u6d3b\u514d\u75ab\u7ec6\u80de\uff0c\u5982\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\uff0c\u91ca\u653e\u7a7f\u5b54\u7d20\u3001\u9897\u7c92\u9176\u7b49\u65b9\u5f0f\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<p><strong>ADCP\u4f5c\u7528<\/strong>(\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u541e\u566c\u4f5c\u7528\uff1bantibody-dependent cellular phagocytosis)\uff1a<br>\u6297\u4f53Fc\u6bb5\u4e0e\u514d\u75ab\u7ec6\u80de\u4e0a\u7684Fc\u53d7\u4f53\u7ed3\u5408\uff0c\u52df\u96c6\u548c\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\uff0c\u76f4\u63a5\u541e\u566c\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<p><strong>\u76f4\u63a5\u7ec6\u80de\u6bd2\u4f5c\u7528<\/strong>\uff1a<br>\u6297\u4f53\u901a\u8fc7\u76f4\u63a5\u7ed3\u5408CD20\u5206\u5b50\uff0c\u6fc0\u6d3b\u7ec6\u80de\u51cb\u4ea1\u4fe1\u53f7\uff0c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<p><strong>CD20\u7684 I \u578b\u548c II \u578b\u6297\u4f53<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-1.png\" alt=\"\" class=\"wp-image-865\" width=\"588\" height=\"380\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-1.png 968w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-1-300x195.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-1-768x498.png 768w\" sizes=\"auto, (max-width: 588px) 100vw, 588px\" \/><figcaption class=\"wp-element-caption\"><em>Front Oncol . 2018 Jun 4;8:163.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6839\u636eCD20\u5355\u6297\u4e0eCD20\u6297\u539f\u7ed3\u5408\u7684\u65b9\u5f0f\u548c\u6740\u4f24B\u7ec6\u80de\u7684\u673a\u5236\uff0cCD20\u5355\u6297\u53ef\u4ee5\u5206\u4e3aI\u578b\u6216II\u578b\u3002<\/p>\n\n\n\n<p>I\u578bCD20\u5355\u6297\u4e3b\u8981\u901a\u8fc7 CDC \u548c ADCC\uff0c\u4f46\u4e0d\u4f1a\u76f4\u63a5\u5f15\u8d77\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p>II\u578bCD20\u5355\u6297\u4e3b\u8981\u901a\u8fc7\u76f4\u63a5\u6fc0\u6d3b\u7ec6\u80de\u5185\u6b7b\u4ea1\u4fe1\u53f7\u901a\u8def\u5bfc\u81f4\u7ec6\u80de\u76f4\u63a5\u6b7b\u4ea1\uff0c\u53c2\u4e0eADCC\u6216ADCP\uff0c\u4f46\u8f83\u5c11\u53c2\u4e0eCDC\u3002<\/p>\n\n\n\n<p>\u5965\u59a5\u73e0\u5355\u6297\u4f5c\u4e3a\u7b2c\u4e09\u4ee3\u6297CD20\u5355\u6297\uff0c\u4e0e\u7b2c\u4e00\u4ee3CD20\u5355\u6297\u5229\u59a5\u6614\u5355\u6297\u76f8\u6bd4\uff0c\u5176Fc\u6bb5\u7ecf\u4fee\u9970\uff0c\u53ef\u4ee5\u589e\u5f3aADCC\u548cADCP\u6548\u5e94\uff0c\u964d\u4f4eCDC\u6548\u5e94\uff0c\u540c\u65f6\u4e5f\u53ef\u4ee5\u6fc0\u6d3b\u76f4\u63a5B\u7ec6\u80de\u6740\u4f24\u6548\u5e94\u3002<\/p>\n\n\n\n<p><strong>\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-2.png\" alt=\"\" class=\"wp-image-866\" width=\"602\" height=\"399\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-2.png 1017w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-2-300x199.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-2-768x510.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-2-880x584.png 880w\" sizes=\"auto, (max-width: 602px) 100vw, 602px\" \/><figcaption class=\"wp-element-caption\"><em>Radiographics . 2021 Sep-Oct;41(5):1283-1299.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08Follicular Lymphoma\uff0cFL\uff09\u662f\u4e00\u79cd\u6765\u6e90\u4e8e\u6dcb\u5df4\u7ed3\u6ee4\u6ce1\u4e2dB\u6dcb\u5df4\u7ec6\u80de\u7684\u6076\u6027\u80bf\u7624\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u6dcb\u5df4\u7ed3\u6ee4\u6ce1\u4e2d\u7684B\u7ec6\u80de\u4f1a\u7ecf\u5386\u751f\u957f\u3001\u5206\u5316\u548c\u6b7b\u4ea1\u7b49\u591a\u4e2a\u9636\u6bb5\uff0c\u6700\u7ec8\u6210\u719f\u4e3a\u80fd\u591f\u4ea7\u751f\u6297\u4f53\u7684\u6d46\u7ec6\u80de\u6216\u8bb0\u5fc6B\u7ec6\u80de\u3002<\/p>\n\n\n\n<p>\u800c\u5728FL\u60a3\u8005\u4e2d\uff0c\u8fd9\u4e9bB\u7ec6\u80de\u5728\u5206\u5316\u7684\u8fc7\u7a0b\u4e2d\u53d1\u751f\u4e86\u5f02\u5e38\uff0c\u5bfc\u81f4\u5b83\u4eec\u5931\u53bb\u4e86\u81ea\u6211\u8c03\u63a7\u7684\u80fd\u529b\uff0c\u7ee7\u7eed\u65e0\u9650\u5236\u5730\u589e\u6b96\u3002\u8fd9\u4e9b\u6076\u6027\u7684B\u7ec6\u80de\u4f1a\u805a\u96c6\u5728\u6dcb\u5df4\u7ed3\u5185\u5f62\u6210\u80bf\u7624\uff0c\u4e5f\u53ef\u80fd\u8513\u5ef6\u5230\u5176\u4ed6\u6dcb\u5df4\u7ec4\u7ec7\u3001\u813e\u810f\u3001\u9aa8\u9ad3\u548c\u8840\u6db2\u7b49\u90e8\u4f4d\u3002<\/p>\n\n\n\n<p>FL\u901a\u5e38\u662f\u4e00\u79cd\u7f13\u6162\u8fdb\u5c55\u7684\u75be\u75c5\uff0c\u60a3\u8005\u53ef\u80fd\u5728\u591a\u5e74\u751a\u81f3\u5341\u51e0\u5e74\u7684\u65f6\u95f4\u5185\u6ca1\u6709\u4efb\u4f55\u75c7\u72b6\uff0c\u56e0\u6b64\u5e38\u5e38\u88ab\u79f0\u4e3a\u201c\u65e0\u75c7\u72b6\u6027\u6dcb\u5df4\u7624\u201d\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u968f\u7740\u80bf\u7624\u7684\u589e\u5927\u548c\u8f6c\u79fb\uff0c\u60a3\u8005\u53ef\u80fd\u4f1a\u51fa\u73b0\u6dcb\u5df4\u7ed3\u80bf\u5927\u3001\u4e4f\u529b\u3001\u53d1\u70ed\u3001\u76d7\u6c57\u3001\u4f53\u91cd\u4e0b\u964d\u7b49\u75c7\u72b6\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0cFL\u8fd8\u53ef\u80fd\u8f6c\u5316\u4e3a\u9ad8\u5ea6\u6076\u6027\u7684\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08Diffuse Large B-Cell Lymphoma\uff0cDLBCL\uff09\uff0c\u6b64\u65f6\u75be\u75c5\u8fdb\u5c55\u8fc5\u901f\u4e14\u9884\u540e\u4e0d\u826f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><strong>\u5965\u59a5\u73e0\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-3-1024x206.png\" alt=\"\" class=\"wp-image-867\" width=\"634\" height=\"127\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-3-1024x206.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-3-300x60.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-3-768x154.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-3-1218x245.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-3-880x177.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-3.png 1358w\" sizes=\"auto, (max-width: 634px) 100vw, 634px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#6514b2\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p><strong>\u5965\u59a5\u73e0\u5355\u6297Obinutuzumab\u5728FDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e0e\u5316\u7597\u8054\u5408\uff0c\u7528\u4e8e\u521d\u6cbb\u7684 II \u671f\u4f34\u6709\u5de8\u5927\u80bf\u5757\u3001III \u671f\u6216 IV \u671f\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624(FL)\u6210\u4eba\u60a3\u8005\uff0c\u8fbe\u5230\u81f3\u5c11\u90e8\u5206\u7f13\u89e3\u7684\u60a3\u8005\u968f\u540e\u7528\u5965\u59a5\u73e0\u5355\u6297\u7ef4\u6301\u6cbb\u7597\u3002<\/li>\n\n\n\n<li>\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(CLL)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/CD20-Obi-web-gap.jpg\" data-gif=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/CD20-Obi-web.gif\" alt=\"\" class=\"wp-image-868\" width=\"614\" height=\"407\"\/><figcaption class=\"wp-element-caption\">B\u578b\u7684\u94c3\u94db\u55b7\u5c04\u51fa\u80a5\u7682\u6ce1\uff0c\u80a5\u7682\u6ce1\u91cc\u6709\u4e00\u9897\u8868\u9762\u51f9\u51f8\u4e0d\u5e73\u7684\u73e0\u5b50\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u94c3\u94db\u4ee3\u8868\u6570\u5b57\u7f16\u780120\uff0cB\u578b\u94c3\u94db\uff0c\u4ee3\u8868CD20\u9633\u6027\u7684B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/p>\n\n\n\n<p>\u80a5\u7682\u6ce1\u4ee3\u8868\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3002<\/p>\n\n\n\n<p><strong>\u51f9\u51f8<\/strong>\u4e0d\u5e73\u7684<strong>\u73e0<\/strong>\u5b50\uff0c\u53d6\u8c10\u97f3\u4ee3\u8868\u836f\u7269<strong>\u5965\u59a5\u73e0<\/strong>\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":869,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-863","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=863"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/863\/revisions"}],"predecessor-version":[{"id":870,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/863\/revisions\/870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/869"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}