{"id":908,"date":"2023-04-19T00:13:56","date_gmt":"2023-04-18T16:13:56","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=908"},"modified":"2023-05-03T15:51:26","modified_gmt":"2023-05-03T07:51:26","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91cd22-adc-%e8%b4%9d%e5%8d%9a%e8%90%a8%e5%a5%a5%e5%8a%a0%e4%bc%8a%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=908","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776\u5411CD22 ADC | \u8d1d\u535a\u8428\u00ae\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u3001moxetumomab pasudotox"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u662f\u8f89\u745e\u548cCelltech\u5f00\u53d1\u7684\u4e00\u6b3e\u6297\u4f53\u5076\u8054\u836f\u7269(ADC)\uff0c\u7531\u9776\u5411CD22\u7684\u5355\u514b\u9686\u6297\u4f53\u4e0e\u7ec6\u80de\u6bd2\u5236\u5242\u523a\u5b62\u9709\u7d20\u5076\u8054\u800c\u6210\u3002<\/p>\n\n\n\n

2017\u5e74\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u5148\u540e\u5728\u6b27\u76df\u548cFDA\u83b7\u6279\u4e0a\u5e02\uff08BESPONSA\u00ae <\/sup>inotuzumab ozogamicin\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u524d\u4f53B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/p>\n\n\n\n

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Moxetumomab pasudotox \u7531\u963f\u65af\u5229\u5eb7\u516c\u53f8\u7814\u53d1\uff0c\u4e5f\u662f\u4e00\u6b3e\u9776\u5411CD22\u7684\u7ec6\u80de\u6bd2\u7d20ADC\u3002<\/p>\n\n\n\n

2018\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff08Lumoxiti\u00ae <\/sup>moxetumomab pasudotox\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u6bdb\u7ec6\u80de\u767d\u8840\u75c5\uff08hairy cell leukemia, HCL\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n

\u56fd\u5185\u5c1a\u672a\u4e0a\u5e02\uff0c\u6309\u7167\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u7684\u547d\u540d\u89c4\u5219\uff0c\u97f3\u8bd1\u4e3a\u5e15\u82cf\u83ab\u59a5\u83ab\u5355\u6297\uff08\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

B\u7ec6\u80de\u6210\u719f\u5404\u9636\u6bb5<\/strong><\/p>\n\n\n

\n
\"\"
J Neurol . 2022 Mar;269(3):1316-1334.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

CD22\u4e0eCD19\u4e00\u6837\uff0c\u51e0\u4e4e\u8868\u8fbe\u4e8eB\u7ec6\u80de\u6210\u719f\u7684\u6240\u6709\u9636\u6bb5\uff0c\u5e76\u4e14\u5728\u5927\u90e8\u5206B-ALL\u60a3\u8005\u7684\u764c\u7ec6\u80de\u4e0a\u90fd\u6709\u8868\u8fbe\u3002<\/p>\n\n\n\n

\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297<\/strong>\u7ed3\u6784<\/strong><\/p>\n\n\n

\n
\"\"
\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u8bf4\u660e\u4e66<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u662f\u4e00\u79cd\u9776\u5411 CD22 \u7684ADC\uff0c\u7531\u4e09\u4e2a\u90e8\u5206\u7ec4\u6210\uff1a<\/p>\n\n\n\n

    \n
  • \u5355\u514b\u9686\u6297\u4f53(\u5355\u6297)\uff1a\u4f0a\u73e0\u5355\u6297\uff0c\u53ef\u7279\u5f02\u6027\u8bc6\u522b\u4eba CD22\uff0c\u53ef\u4ee5\u7cbe\u51c6\u5bfc\u5411\u80bf\u7624\u7ec6\u80de\uff1b<\/li>\n\n\n\n
  • \u8fde\u63a5\u5b50\uff1a\u53ef\u4ee5\u5c06\u5355\u514b\u9686\u6297\u4f53\u548c\u7ec6\u80de\u6bd2\u5236\u5242\u8fde\u63a5\u5728\u4e00\u8d77\uff0c\u5e76\u4e14\u53ea\u5728\u9002\u5f53\u7684\u6761\u4ef6\u4e0b\uff08\u4f8b\u5982\u5728\u80bf\u7624\u7ec6\u80de\u5185\uff09\u624d\u80fd\u65ad\u5f00\uff0c\u4ece\u800c\u91ca\u653e\u7ec6\u80de\u6bd2\u5236\u5242\u5e76\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002<\/li>\n\n\n\n
  • \u7ec6\u80de\u6bd2\u6027\u836f\u7269\uff1aN-\u4e59\u9170-\u03b3-\u523a\u5b62\u9709\u7d20\uff0c\u53ef\u5bfc\u81f4\u764c\u7ec6\u80de\u53cc\u94fe DNA \u65ad\u88c2\u3002<\/li>\n<\/ul>\n\n\n\n

    \u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n

    \n
    \"\"
    https:\/\/www.creativebiolabs.net\/inotuzumab-ozogamicin-overview.htm<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

    \u5f53\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u4e0e\u6076\u6027B\u7ec6\u80de\u7684 CD22 \u6297\u539f\u7ed3\u5408\u540e\uff0c\u836f\u7269\u5185\u5316\u8fdb\u5165\u7ec6\u80de\u3002<\/p>\n\n\n\n

    \u836f\u7269\u5728\u6eb6\u9176\u4f53\u5185\u964d\u89e3\uff0c\u91ca\u653e\u7ec6\u80de\u6bd2\u5236\u5242\u523a\u5b62\u9709\u7d20\uff0c\u53ef\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u53cc\u94fe DNA \u65ad\u88c2\uff0c\u4ece\u800c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n

    Moxetumomab pasudotox \u662f\u53e6\u4e00\u6b3e\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u7684CD22 ADC\u836f\u7269\u3002\u9002\u5e94\u75c7\u662f\u6bdb\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/p>\n\n\n\n

    \u6bdb\u7ec6\u80de\u767d\u8840\u75c5\uff08hairy cell leukemia, HCL\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u7684\uff0c\u751f\u957f\u7f13\u6162\u7684\u8840\u764c\uff0c\u5b83\u4e5f\u662f\u7531\u9aa8\u9ad3\u751f\u6210\u8fc7\u591a\u7684B\u6dcb\u5df4\u7ec6\u80de\u9020\u6210\u7684\u3002<\/p>\n\n\n\n

    HCL\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u751a\u81f3\u81f4\u547d\u7684\u5065\u5eb7\u72b6\u51b5\uff0c\u5305\u62ec\u611f\u67d3\u3001\u51fa\u8840\u548c\u8d2b\u8840\u3002\u867d\u7136\u5f88\u591a\u60a3\u8005\u6700\u521d\u4f1a\u5bf9\u7597\u6cd5\u4ea7\u751f\u53cd\u5e94\uff0c\u4f46\u662f\u9ad8\u8fbe40%\u7684\u60a3\u8005\u4f1a\u590d\u53d1\uff0c\u590d\u53d1\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u975e\u5e38\u6709\u9650\u3002<\/p>\n\n\n\n

    Moxetumomab pasudotox\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n

    \n
    \"\"
    https:\/\/www.creativebiolabs.net\/moxetumomab-pasudotox-overview.htm<\/em>Moxetumomab pasudotox<\/figcaption><\/figure>\n<\/div>\n\n\n

    Moxetumomab pasudotox<\/strong>\u7684\u7ed3\u6784\u4e0e\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u7c7b\u4f3c\uff0c\u533a\u522b\u4e3a\uff0c\u5176\u8fde\u63a5\u7684\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u4e3a\u5047\u5355\u80de\u83cc\u5916\u6bd2\u7d20A (PE38)<\/strong>\uff0c\u8fd9\u79cd\u6bd2\u7d20\u4f1a\u6291\u5236\u86cb\u767d\u8d28\u5408\u6210<\/strong>\uff0c\u4ece\u800c\u5bfc\u81f4\u9ad8CD22\u8868\u8fbe\u7684\u764c\u7ec6\u80de\u8fdb\u5165\u51cb\u4ea1\u3002<\/p>\n\n\n\n

    2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

    \u4e24\u6b3eCD22 ADC\u7684FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n

    \n
    \"\"
    \u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n

    \u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297 inotuzumab ozogamicin\u7684\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n

      \n
    • \u524d\u4f53B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5Pre-B ALL<\/li>\n<\/ul>\n\n\n\n

      Moxetumomab pasudotox \u5e15\u82cf\u83ab\u59a5\u83ab\u5355\u6297FDA\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n

        \n
      • \u6bdb\u7ec6\u80de\u767d\u8840\u75c5 HCL<\/li>\n<\/ul>\n\n\n\n

        3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n
        \n
        \"\"
        \u6811\u4e0a\u7ed3\u4e86\u4e24\u9897\u51f9\u51f8\u4e0d\u5e73\u7684\u73e0\u5b50\uff0c\u4e00\u4e2a\u5168\u8eab\u7fbd\u6bdb\u7684\u9e1f\u4eba\uff0c\u5f00\u7740\u6469\u6258\u8f66\u5728\u722c\u8fd9\u68f5\u6811\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

        \u4e24\u9897\u73e0\u5b50\u4ee3\u8868\u9776\u5411CD22\u7684\u5355\u6297\u3002\u4e5f\u4ee3\u8868\u836f\u7269\u662f\u7531\u6297\u4f53\u548c\u7ec6\u80de\u6bd2\u7d20\u4e24\u90e8\u5206\u7ec4\u6210\u7684ADC\u836f\u7269\u3002<\/p>\n\n\n\n

        \u524d\u6587\u5df2\u7ecf\u4ecb\u7ecd\u4e86\u5965\u59a5\u73e0\u5355\u6297\u3002\u7528\u4e00\u9897\u51f9\u51f8\u4e0d\u5e73\u7684\u73e0\u5b50\u4ee3\u8868\u836f\u7269\u3002<\/p>\n\n\n\n

        \u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297<\/strong>\uff0c\u56e0\u4e3a\u5728\u5965\u59a5\u73e0\u5355\u6297<\/strong>\u57fa\u7840\u4e0a\u52a0\u5165\u7ec6\u80de\u6bd2\u7d20\uff08\u53ea\u662f\u4fbf\u4e8e\u8bb0\u5fc6\uff0c\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u7684\u6297\u4f53\u90e8\u5206\u4e0e\u5965\u59a5\u73e0\u5355\u6297\u4e0d\u76f8\u540c\uff09\uff0c\u6240\u4ee5\u8fd9\u91cc\u73e0\u5b50+1\uff0c\u540d\u5b57\u53eb\u5965\u52a0\u4f0a<\/strong>\u59a5\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n

        \u5965\u59a5\u73e0\u5355\u6297\u53ea\u6709\u4e00\u9897\u73e0\u5b50\uff0c\u6240\u4ee5\u9002\u5e94\u75c7\u4e3a\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002\u800c\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u6709\u4e24\u9897\uff0c\u901f\u5ea6\u80af\u5b9a\u53d8\u5feb\uff0c\u56e0\u6b64\u9002\u5e94\u75c7\u4e3a\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/p>\n\n\n\n

        \u5728\u722c\u6811<\/strong>\u7684\u6469\u6258<\/strong>\u8f66\uff0c\u4ee3\u8868\u5e15\u82cf\u83ab\u59a5<\/strong>\u83ab\u5355\u6297\u3002<\/p>\n\n\n\n

        \u9e1f\u4eba\u7684\u7fbd\u6bdb\uff0c\u4ee3\u8868\u6bdb\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/p>\n\n\n\n

        \u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

        \u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0…<\/p>\n","protected":false},"author":1,"featured_media":915,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=908"}],"version-history":[{"count":3,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/908\/revisions"}],"predecessor-version":[{"id":954,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/908\/revisions\/954"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/915"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}