{"id":921,"date":"2023-04-21T20:25:14","date_gmt":"2023-04-21T12:25:14","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=921"},"modified":"2023-04-21T20:25:14","modified_gmt":"2023-04-21T12:25:14","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91cd30-adc-%e5%ae%89%e9%80%82%e5%88%a9%e7%bb%b4%e5%b8%83%e5%a6%a5%e6%98%94%e5%8d%95%e6%8a%97-%e9%97%b4","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=921","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776\u5411CD30 ADC | \u5b89\u9002\u5229\u00ae\u7ef4\u5e03\u59a5\u6614\u5355\u6297 | \u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u8548\u6837\u771f\u83cc\u75c5\u7b49"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ef4\u5e03\u59a5\u6614\u5355\u6297\uff08Brentuximab vedotin\uff0cAdcetris\uff09\u662f\u7531\u65e5\u672c\u6b66\u7530\u5236\u836f\u548c\u7f8e\u56fd\u897f\u96c5\u56fe\u9057\u4f20\u5b66\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684\u4e00\u6b3e\u9776\u5411CD30\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u7531 brentuximab \u548c\u5fae\u7ba1\u7834\u574f\u5242\uff08\u5355\u7532\u57fa auristatin E\uff0cMMAE\uff09\u5076\u8054\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u4e8e2011\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\uff08Adcetris<sup>\u00ae&nbsp;<\/sup>Brentuximab vedotin\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\uff08sALCL\uff09\u3001\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u3001\u539f\u53d1\u6027\u76ae\u80a4\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\uff08pcALCL\uff09\u6216\u8548\u6837\u771f\u83cc\u75c5\uff08MF\uff09\u7b49\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u56fd\u5185\uff0c2020\u5e745\u6708\uff0c\u836f\u7269\u83b7\u5f97NMPA\u6279\u51c6\u4e0a\u5e02\uff08\u5b89\u9002\u5229<sup>\u00ae\u00a0<\/sup>\u7ef4\u5e03\u59a5\u6614\u5355\u6297\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">CD30\uff0c\u4e5f\u79f0\u4e3aKi-1\u6297\u539f\u6216TNF receptor superfamily member 8 (TNFRSF8)\uff0c\u662f\u4e00\u79cd\u8de8\u819c\u86cb\u767d\uff0c\u5c5e\u4e8e\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u8d85\u5bb6\u65cf\u7684\u6210\u5458\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1982\u5e74\uff0cSchwab\u7b49\u9996\u6b21\u5728\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08HL\uff09\u80bf\u7624\u7ec6\u80de Reed-Sternberg\uff08RS\uff09\u7ec6\u80de\u4e0a\u53d1\u73b0\uff0c\u5176\u4ee5\u4e09\u805a\u4f53\u5f62\u5f0f\u5b58\u5728\u5e76\u8868\u8fbe\u4e8e\u7ec6\u80de\u8868\u9762\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CD30\u4e09\u805a\u4f53\u7684\u62d3\u6251\u6a21\u578b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-31.png\" alt=\"\" class=\"wp-image-922\" width=\"674\" height=\"263\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-31.png 909w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-31-300x117.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-31-768x300.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-31-880x344.png 880w\" sizes=\"auto, (max-width: 674px) 100vw, 674px\" \/><figcaption class=\"wp-element-caption\"><em>J Mol Recognit . 2003 Jan-Feb;16(1):28-36.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">CD30\u4ec5\u5728\u6d3b\u5316\u7684B\u548cT\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u5728\u975e\u6dcb\u5df4\u7624\u7ec4\u7ec7\u4e2d\u4ec5\u5f31\u8868\u8fbe\uff0c\u4f46\u5728\u591a\u79cd\u6dcb\u5df4\u7624\u7ec4\u7ec7\u4e2d\u5219\u8868\u73b0\u4e3a\u5f3a\u9633\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CD30\u7684\u8868\u8fbe\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u4e0a\u8c03\u5bf9\u8c03\u4ea1\u4fe1\u53f7\u7684\u654f\u611f\u6027\u5e76\u4e0b\u8c03\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\u548c\u5b58\u6d3b\uff0c\u5e76\u5728\u7ec6\u80de\u5206\u5316\u548c\u8c03\u8282\u7ec6\u80de\u6b7b\u4ea1\u4fe1\u53f7\u65b9\u9762\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CD30\u901a\u8fc7\u4e0d\u540c\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u5982\u6838\u8f6c\u5f55\u56e0\u5b50kappa B\uff08NK-\u03baB\uff09\u7b49\uff0c\u53d1\u6325\u4f5c\u7528\uff0c\u6700\u7ec8\u5bfc\u81f4CD30\u8868\u8fbe\u4e0a\u8c03\uff0c\u4f7f\u7ec6\u80de\u83b7\u5f97\u751f\u5b58\u4f18\u52bf\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u7ed3\u6784<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32-1024x421.png\" alt=\"\" class=\"wp-image-923\" width=\"734\" height=\"302\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32-1024x421.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32-300x123.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32-768x316.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32-1536x632.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32-1218x501.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32-880x362.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-32.png 1542w\" sizes=\"auto, (max-width: 734px) 100vw, 734px\" \/><figcaption class=\"wp-element-caption\"><em><em>https:\/\/www.adcreview.com\/brentuximab-vedotin-sgn35\/<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u7684\u7ed3\u6784\u7531\u4e09\u90e8\u5206\u7ec4\u6210\uff1a\u6297\u4f53\u3001\u8fde\u63a5\u5b50\u548c\u836f\u7269\u90e8\u5206\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297\u4f53\u90e8\u5206\u662f\u9488\u5bf9\u4ebaCD30\u7684\u7279\u5f02\u6027\u6297\u4f53Brentuximab\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fde\u63a5\u5b50\u90e8\u5206\uff1a\u6297\u4f53\u90e8\u5206\u901a\u8fc7\u53ef\u88ab\u86cb\u767d\u9176\u6c34\u89e3\u7684\u8fde\u63a5\u5b50\u8fde\u63a5\u836f\u7269\uff0c\u8be5\u8fde\u63a5\u5b50\u5177\u6709\u4e00\u5b9a\u7684\u7a33\u5b9a\u6027\uff0c\u4f7f\u5176\u5728\u8840\u6db2\u4e2d\u4e0d\u4f1a\u8fc7\u65e9\u5206\u79bb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u90e8\u5206\u662f\u4e00\u79cd\u5fae\u7ba1\u6bd2\u7d20\uff0c\u79f0\u4e3a\u5355\u7532\u57fa\u82a6\u4e1d\u66ff\u56e0E\uff08MMAE\uff09\uff0c\u5176\u53ef\u4ee5\u901a\u8fc7\u6297\u4f53\u4e0eCD30\u7ed3\u5408\u540e\u91ca\u653e\u5230\u7ec6\u80de\u5185\u90e8\uff0c\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5927\u7ea6\u6bcf\u4e2a\u6297\u4f53\u5206\u5b50\u4e0a\u8fde\u63a5\u77404\u4e2aMMAE\u5206\u5b50\uff0c\u8fd9\u6837\u7684\u7ed3\u6784\u4f7f\u5f97\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u5177\u6709\u9ad8\u6548\u7684\u9776\u5411\u4f5c\u7528\uff0c\u5e76\u4e14\u53ef\u4ee5\u5728\u9776\u7ec6\u80de\u5185\u90e8\u91ca\u653e\u51fa\u9ad8\u6d53\u5ea6\u7684MMAE\u4ee5\u53d1\u6325\u836f\u7269\u6548\u5e94\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ef4\u5e03\u59a5\u6614\u5355\u6297<\/strong><strong>\u4f5c\u7528\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-33-1024x679.png\" alt=\"\" class=\"wp-image-924\" width=\"700\" height=\"463\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-33-1024x679.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-33-300x199.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-33-768x509.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-33-880x583.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-33.png 1201w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><figcaption class=\"wp-element-caption\">https:\/\/www.researchgate.net\/publication\/268021753<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u7ef4\u5e03\u59a5\u6614\u5355\u6297\u9776\u5411CD30\u9633\u6027\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u5c06\u5fae\u7ba1\u7834\u574f\u5242MMAE\u91ca\u653e\u5230\u80bf\u7624\u7ec6\u80de\u5185\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53CD30\u6297\u4f53\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762CD30\u7ed3\u5408\u540e\uff0cCD30\u590d\u5408\u7269\u88ab\u7ec6\u80de\u5185\u541e\u5e76\u8f6c\u8fd0\u81f3\u6eb6\u9176\u4f53\u3002\u8fde\u63a5\u6865\u88ab\u964d\u89e3\uff0cMMAE\u88ab\u91ca\u653e\u5230\u7ec6\u80de\u5185\u90e8\uff0c\u4e0e\u7ec6\u80de\u5185\u7684\u5fae\u7ba1\u86cb\u767d\u7ed3\u5408\u5e76\u7834\u574f\u5fae\u7ba1\u7f51\u7edc\u3002\u8fd9\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u505c\u6ede\u5728G2\/M\u7ec6\u80de\u5468\u671f\u5e76\u6700\u7ec8\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b64\u5916\uff0cMMAE\u8fd8\u80fd\u4eceCD30\u9633\u6027\u6dcb\u5df4\u7624\u7ec6\u80de\u6269\u6563\u5230\u5468\u56f4\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u53d1\u6325\u65c1\u89c2\u8005\u6548\u5e94\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-34-1024x254.png\" alt=\"\" class=\"wp-image-925\" width=\"626\" height=\"155\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-34-1024x254.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-34-300x74.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-34-768x190.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-34-1218x302.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-34-880x218.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-34.png 1230w\" sizes=\"auto, (max-width: 626px) 100vw, 626px\" \/><figcaption class=\"wp-element-caption\"><em><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#51128c\" class=\"has-inline-color\">\u7d2b\u8272\u4ee3\u8868\u76ee\u524d\u56fd\u5185\u5df2\u6279\u51c6<\/mark><\/strong><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624(anaplastic large cell lymphoma \uff0c ALCL) \u4ea6\u79f0 ki-1 \u6dcb\u5df4\u7624\uff0c\u7ec6\u80de\u5f62\u6001\u7c7b\u4f3c\u91cc\u5fb7-\u65af\u7279\u6069\u4f2f\u683c\uff08Reed-Sternberg\uff0cR-S\uff09 \u7ec6\u80de\uff0c\u56e0\u6b64\u7ecf\u5e38\u4e0e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u6df7\u6dc6\u3002\u7ec6\u80de\u5448 CD30+ 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