{"id":931,"date":"2023-04-23T18:28:55","date_gmt":"2023-04-23T10:28:55","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=931"},"modified":"2023-04-23T18:28:55","modified_gmt":"2023-04-23T10:28:55","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6cd33-adc-gemtuzumab-ozogamicin-%e5%a5%a5%e5%8a%a0%e5%90%89%e5%a6%a5%e7%8f%a0%e5%8d%95%e6%8a%97-%e6%80%a5%e6%80%a7","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=931","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776CD33 ADC | Gemtuzumab ozogamicin \u5965\u52a0\u5409\u59a5\u73e0\u5355\u6297 | \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gemtuzumab ozogamicin&nbsp;\u4e5f\u662f\u7531\u8f89\u745e\u516c\u53f8\u5f00\u53d1\u7684\u4e00\u6b3e\u6297\u4f53\u5076\u8054\u836f\u7269(ADC)\uff0c\u7531\u9776\u5411CD33\u7684\u5355\u514b\u9686\u6297\u4f53\u4e0e\u7ec6\u80de\u6bd2\u5236\u5242\u523a\u5b62\u9709\u7d20\u5076\u8054\u800c\u6210\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u66fe\u4e8e2000\u5e74\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7531\u4e8e\u5b58\u5728\u4e00\u5b9a\u5b89\u5168\u9690\u60a3\uff0c\u8f89\u745e\u4e8e2010\u5e74\u4e3b\u52a8\u5c06\u836f\u7269\u9000\u5e02\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u8c03\u6574\u5242\u91cf\u5e76\u5f00\u5c55\u5927\u91cf\u4e34\u5e8a\u8bd5\u9a8c\u540e\uff0cGemtuzumab ozogamicin \u4e8e2017\u5e74\u88abFDA\u91cd\u65b0\u6279\u51c6\u7528\u4e8e\u521d\u8bca\u53ca\u590d\u53d1\u96be\u6cbb\u6027CD33\u9633\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\uff08MYLOTARG<sup>\u00ae<\/sup>&nbsp;Gemtuzumab ozogamicin\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u76ee\u524d\u5728\u56fd\u5185\u672a\u6ce8\u518c\u7533\u62a5\uff0c\u7531\u4e8e\u7ed3\u6784\u4e0e\u8f89\u745e\u53e6\u4e00\u6b3e\u4e0a\u5e02\u836f\u7269\uff08inotuzumab ozogamicin \u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\uff09\u7c7b\u4f3c\uff0c\u56e0\u6b64\u6309\u7167\u5176\u547d\u540d\uff0c\u6682\u5c06gemtuzumab ozogamicin\u8bd1\u4e3a\u5965\u52a0\u5409\u59a5\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8840\u7ec6\u80de\u7ec4\u6210<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-36-1024x820.png\" alt=\"\" class=\"wp-image-933\" width=\"692\" height=\"554\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-36-1024x820.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-36-300x240.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-36-768x615.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-36-880x705.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-36.png 1200w\" sizes=\"auto, (max-width: 692px) 100vw, 692px\" \/><figcaption class=\"wp-element-caption\"><em><em>NCCN Guidelines for patients: Chronic Lymphocytic Leukemia<\/em><\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u8840\u7ec6\u80de\u5747\u5206\u5316\u81ea\u9020\u8840\u5e72\u7ec6\u80de\uff0c\u5305\u62ec\u7ea2\u7ec6\u80de\uff0c\u767d\u7ec6\u80de\u548c\u8840\u5c0f\u677f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u524d\u9762\u51e0\u7bc7\u4e2d\u8bb2\u8ff0\u7684CD19\uff0cCD20\uff0cCD22\uff0cCD30\u7b49\u5747\u4e3a\u6dcb\u5df4\u7cfb\u7ec6\u80de\u7279\u522b\u662fB\u6dcb\u5df4\u7ec6\u80de\u8868\u9762\u7684\u7279\u5f81\u6297\u539f\u3002\uff08\u5982\u8f89\u745e\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\uff0c\u9776\u5411CD22\uff0c\u6cbb\u7597\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CD33\u6297\u539f\u5206\u5b50\u8868\u8fbe\u4e8e\u9ad3\u7cfb\u7ec6\u80de\uff0c\u7279\u522b\u9ad8\u8868\u8fbe\u4e8e\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7ec6\u80de\u9762\u8868\uff0885%~90%\uff09\uff0c\u4e14\u4f4e\u8868\u8fbe\u4e8e\u6b63\u5e38\u9020\u8840\u7ec6\u80de\uff0c\u56e0\u6b64\u6781\u5177AML\u9776\u5411\u6cbb\u7597\u4ef7\u503c\u3002<br><br>\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6b63\u5e38\u60c5\u51b5\u4e0b\u53d1\u80b2\u4e3a\u51e0\u7c7b\u767d\u7ec6\u80de\uff08\u5982\u4e2d\u6027\u7c92\u7ec6\u80de\u3001\u55dc\u78b1\u6027\u7c92\u7ec6\u80de\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\uff09\uff0c\u7ec6\u80de\u53d1\u751f\u6076\u53d8\u5e76\u5feb\u901f\u66ff\u4ee3\u9aa8\u9ad3\u4e2d\u6b63\u5e38\u7ec6\u80de\u7684\u4e00\u79cd\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gemtuzumab ozogamicin\u673a\u5236<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-37-1024x538.png\" alt=\"\" class=\"wp-image-934\" width=\"682\" height=\"358\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-37-1024x538.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-37-300x157.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-37-768x403.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-37-1218x639.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-37-880x462.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-37.png 1362w\" sizes=\"auto, (max-width: 682px) 100vw, 682px\" \/><figcaption class=\"wp-element-caption\"><em>https:\/\/www.creativebiolabs.net\/inotuzumab-ozogamicin-overview.htm<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Gemtuzumab ozogamicin\u4e0e\u9776\u5411CD22\u7684ADC\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u6709\u8bb8\u591a\u76f8\u4f3c\u4e4b\u5904\uff0c\u5982\u7ec6\u80de\u6bd2\u7d20\uff08payload\uff09\u5747\u9009\u7528\u523a\u5b62\u9709\u7d20\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u836f\u7269\u4e0eCD33\u9633\u6027\u7684\u9ad3\u7cfb\u80bf\u7624\u7ec6\u80de\u7ed3\u5408\u540e\uff0c\u836f\u7269\u5185\u5316\u8fdb\u5165\u7ec6\u80de\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u5728\u6eb6\u9176\u4f53\u5185\u964d\u89e3\uff0c\u91ca\u653e\u7ec6\u80de\u6bd2\u5236\u5242\u523a\u5b62\u9709\u7d20\uff0c\u53ef\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u53cc\u94fe DNA \u65ad\u88c2\uff0c\u4ece\u800c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gemtuzumab ozogamicin\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-38.png\" alt=\"\" class=\"wp-image-935\" width=\"636\" height=\"116\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-38.png 1014w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-38-300x55.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-38-768x140.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/image-38-880x161.png 880w\" sizes=\"auto, (max-width: 636px) 100vw, 636px\" \/><figcaption class=\"wp-element-caption\"><em>\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Gemtuzumab ozogamicin \u5965\u52a0\u5409\u59a5\u73e0\u5355\u6297\u9002\u5e94\u75c7\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/CD33-GO-web-1-gap.jpg\" data-gif=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/04\/CD33-GO-web-1.gif\" alt=\"\" class=\"wp-image-938\" width=\"656\" height=\"484\"\/><figcaption class=\"wp-element-caption\">\u767d\u8840\u75c5\u975e\u5e38\u9669\u6076\uff0c\u9700\u8981\u91cd\u62f3\u4e00\u51fb\uff0c\u5feb\u901f\u6d88\u706d\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u524d\u6587\u4e2d\u6211\u4eec\u5df2\u7ecf\u8bb0\u4f4f\u4e86CD22 ADC\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u4e3a\u8f89\u745e\u516c\u53f8\u7684\u9776\u5411CD33 ADC\u5965\u52a0\u5409\u59a5\u73e0\u5355\u6297\u3002\u5176\u540d\u5b57\u533a\u522b\u4ec5\u4e3a\u4e2d\u95f4\u7684\u201c\u4f0a\u201d\u548c\u201c\u5409\u201d\u3002\u91cd\u62f3<strong>\u4e00\u51fb<\/strong>\uff0c\u201c\u4e00\u201d\u4ee3\u8868\u5965\u52a0<strong>\u4f0a<\/strong>\u59a5\u73e0\u5355\u6297\uff0c\u201c\u51fb\u201d\u4ee3\u8868\u5965\u52a0<strong>\u5409<\/strong>\u59a5\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">22 \u548c33\u4ee5\u98de\u5feb\u7684\u901f\u5ea6\u6253\u5728\u4e24\u7c7b\u9020\u8840\u5e72\u7ec6\u80de\u4e0a\uff0c\u5206\u522b\u4ee3\u8868CD22 \u9002\u5e94\u75c7\uff0c\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002CD33 \u9002\u5e94\u75c7\uff0c\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":937,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-931","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/931","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=931"}],"version-history":[{"count":2,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/931\/revisions"}],"predecessor-version":[{"id":939,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/931\/revisions\/939"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/937"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}