{"id":956,"date":"2023-05-13T17:44:56","date_gmt":"2023-05-13T09:44:56","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=956"},"modified":"2023-05-13T17:44:56","modified_gmt":"2023-05-13T09:44:56","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91cd52-alemtuzumab-%e9%98%bf%e4%bb%91%e7%8f%a0%e5%8d%95%e6%8a%97-%e6%85%a2%e6%80%a7%e6%b7%8b%e5%b7%b4%e7%bb%86","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=956","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776\u5411CD52 | Alemtuzumab \u963f\u4ed1\u73e0\u5355\u6297 | \u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001\u591a\u53d1\u6027\u786c\u5316"},"content":{"rendered":"\n<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n<p>Alemtuzumab\u7531\u8d5b\u8bfa\u83f2\u65d7\u4e0bGenzyme\u516c\u53f8\u751f\u4ea7\u7814\u53d1\u7684\u4e00\u6b3e\u9776\u5411CD52\u7684\u5355\u6297\uff0c2001\u5e74\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u6839\u636e\u9002\u5e94\u75c7\u4e0d\u540c\uff0c\u6709\u4e24\u4e2a\u5546\u54c1\u540d\uff1a<\/p>\n\n\n\n<p>LEMTRADA<sup>\u00ae<\/sup>&nbsp;\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316<\/p>\n\n\n\n<p>CAMPATH<sup>\u00ae<\/sup>\u7528\u4e8e\u6cbb\u7597B\u7ec6\u80de\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<\/p>\n\n\n\n<p>\u8be5\u836f\u5728\u56fd\u5185\u672a\u4e0a\u5e02\uff0c\u6839\u636e2016\u5e74CDE\u53d7\u7406\u7533\u62a5(JXSL1600074)\u663e\u793a\uff0c\u4e2d\u6587\u540d\u4e3a\u963f\u4ed1\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n<p><strong>CD52 \u9776\u70b9<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7-1024x606.png\" alt=\"\" class=\"wp-image-957\" width=\"676\" height=\"400\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7-1024x606.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7-300x177.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7-768x454.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7-1536x909.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7-1218x720.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7-880x521.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-7.png 1606w\" sizes=\"auto, (max-width: 676px) 100vw, 676px\" \/><figcaption class=\"wp-element-caption\"><em>Gallo et al. Multiple Sclerosis and Demyelinating Disorders (2017) 2:7<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>CD52\u5e7f\u6cdb\u8868\u8fbe\u4e8eB\u7ec6\u80de\u548cT\u7ec6\u80de\u8868\u9762\uff0c\u5728\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u548c\u5176\u4ed6\u767d\u7ec6\u80de\u4e0a\u4e5f\u6709\u8f83\u5c11\u8868\u8fbe\u3002<\/p>\n\n\n\n<p><strong>\u963f\u4ed1\u73e0\u5355\u6297\u6d88\u8017\u6dcb\u5df4\u7ec6\u80de<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8-1024x569.png\" alt=\"\" class=\"wp-image-958\" width=\"684\" height=\"380\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8-1024x569.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8-300x167.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8-768x426.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8-1536x853.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8-1218x676.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8-880x489.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-8.png 1754w\" sizes=\"auto, (max-width: 684px) 100vw, 684px\" \/><figcaption class=\"wp-element-caption\"><em>Gallo et al. Multiple Sclerosis and Demyelinating Disorders (2017) 2:7<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u963f\u4ed1\u73e0\u5355\u6297\u662f\u4e00\u79cd\u9488\u5bf9CD52\u7684\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u4e3b\u8981\u901a\u8fc7\uff1a<br>\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08ADCC\uff09\uff1b<br>\u8865\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08CDC\uff09\uff1b<br>\u7b49\u4f5c\u7528\uff0c\u9009\u62e9\u6027\u6d88\u8017\u5faa\u73af\u4e2d\u7684\u6dcb\u5df4\u7ec6\u80de\uff08T\u7ec6\u80de\u548cB\u7ec6\u80de\uff09\u3002<\/p>\n\n\n\n<p>\u836f\u7269\u5bf9\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u548c\u514d\u75ab\u56e0\u5b50\u7684\u5f71\u54cd\u8f83\u5c0f\uff0c\u8fd9\u6709\u52a9\u4e8e\u7ef4\u6301\u514d\u75ab\u7cfb\u7edf\u7684\u6574\u4f53\u529f\u80fd\u3002<\/p>\n\n\n\n<p><strong>\u6dcb\u5df4\u7ec6\u80de\u518d\u751f\u8fc7\u7a0b<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-10-1024x488.png\" alt=\"\" class=\"wp-image-960\" width=\"744\" height=\"354\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-10-1024x488.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-10-300x143.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-10-768x366.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-10-1218x580.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-10-880x419.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-10.png 1536w\" sizes=\"auto, (max-width: 744px) 100vw, 744px\" \/><figcaption class=\"wp-element-caption\"><em>Ther Adv Neurol Disord . 2015 Jan;8(1):31-45.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u6dcb\u5df4\u7ec6\u80de\u7ed3\u5408\u963f\u4ed1\u73e0\u5355\u6297\u88ab\u6d88\u8017\u540e\uff0c\u4f1a\u968f\u4e4b\u51fa\u73b0\u518d\u751f\uff0cB\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u901a\u5e38\u5728\u6cbb\u7597\u540e6\u4e2a\u6708\u6062\u590d\u5230\u57fa\u7ebf\u6c34\u5e73\uff0cT\u7ec6\u80de\u8ba1\u6570\u901a\u5e38\u5728\u6cbb\u7597\u540e12\u4e2a\u6708\u63a5\u8fd1\u6b63\u5e38\u6c34\u5e73\u3002<\/p>\n\n\n\n<p>\u591a\u53d1\u6027\u786c\u5316\uff08Multiple Sclerosis\uff0cMS\uff09\u662f\u4e00\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5373\u514d\u75ab\u7cfb\u7edf\u9519\u8bef\u5730\u653b\u51fb\u4eba\u4f53\u81ea\u8eab\u7ec4\u7ec7\u3002<\/p>\n\n\n\n<p>\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684B\u6dcb\u5df4\u7ec6\u80de\u548cT\u6dcb\u5df4\u7ec6\u80de\u88ab\u5f02\u5e38\u6fc0\u6d3b\uff0c\u5206\u522b\u4ea7\u751f\u81ea\u8eab\u6297\u4f53\u548cTh\u7ec6\u80de\u56e0\u5b50\u3002\u81ea\u8eab\u6297\u4f53\u6216\u7ec6\u80de\u56e0\u5b50\u9519\u8bef\u5730\u653b\u51fb\u9ad3\u9798\uff0c\u5373\u795e\u7ecf\u5143\u8f74\u7a81\u5468\u56f4\u7684\u4fdd\u62a4\u6027\u8102\u8d28\u5c42\uff0c\u5bfc\u81f4\u9ad3\u9798\u53d7\u635f\u6216\u7834\u574f\u3002<\/p>\n\n\n\n<p>\u9ad3\u9798\u7684\u53d7\u635f\u4f1a\u5bfc\u81f4\u795e\u7ecf\u4fe1\u53f7\u4f20\u8f93\u53d7\u963b\u6216\u4e2d\u65ad\uff0c\u4ece\u800c\u5f15\u53d1\u4e86\u591a\u53d1\u6027\u786c\u5316\u7684\u75c7\u72b6\uff0c\u5305\u62ec\u89c6\u529b\u6a21\u7cca\u3001\u80a2\u4f53\u65e0\u529b\u3001\u611f\u89c9\u5f02\u5e38\u7b49\u3002<\/p>\n\n\n\n<p><strong>\u963f\u4ed1\u73e0\u5355\u6297\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11-1024x643.png\" alt=\"\" class=\"wp-image-961\" width=\"694\" height=\"435\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11-1024x643.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11-300x188.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11-768x482.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11-1536x964.png 1536w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11-1218x765.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11-880x552.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-11.png 1918w\" sizes=\"auto, (max-width: 694px) 100vw, 694px\" \/><figcaption class=\"wp-element-caption\"><em>Lancet Neurol . 2013 Nov;12(11):1115-26.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n<p>Alemtuzumab\u963f\u4ed1\u73e0\u5355\u6297\u53ef\u9009\u62e9\u6027\u5730\u7ed3\u5408B\u7ec6\u80de\u548cT\u7ec6\u80de\u8868\u9762\u7684CD52\u5206\u5b50\uff0c\u6291\u5236\u6dcb\u5df4\u7ec6\u80de\u7684\u5f02\u5e38\u6fc0\u6d3b\uff0c\u4ece\u800c\u5ef6\u7f13\u591a\u53d1\u6027\u786c\u5316\u7684\u53d1\u751f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n<p><strong>\u963f\u4ed1\u73e0\u5355\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-14-1024x299.png\" alt=\"\" class=\"wp-image-964\" width=\"680\" height=\"198\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-14-1024x299.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-14-300x88.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-14-768x224.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-14-880x257.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-14.png 1112w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/><figcaption class=\"wp-element-caption\"><strong><em>\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u672a\u4e0a\u5e02<\/em><\/strong><\/figcaption><\/figure>\n<\/div>\n\n\n<p>Alemtuzumab \u963f\u4ed1\u73e0\u5355\u6297 FDA\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n\n\n\n<p>LEMTRADA\u00ae \u591a\u53d1\u6027\u786c\u5316(MS)\uff0c\u5305\u62ec\u590d\u53d1\u7f13\u89e3\u578b\u548c\u7ee7\u53d1\u8fdb\u5c55\u578b;<\/p>\n\n\n\n<p>CAMPATH\u00ae B\u7ec6\u80de\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5 (B-CLL)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-13-1024x738.png\" alt=\"\" class=\"wp-image-963\" width=\"698\" height=\"503\" srcset=\"https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-13-1024x738.png 1024w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-13-300x216.png 300w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-13-768x554.png 768w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-13-1218x878.png 1218w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-13-880x634.png 880w, https:\/\/xiaoenjiyao.com\/wp-content\/uploads\/2023\/05\/image-13.png 1448w\" sizes=\"auto, (max-width: 698px) 100vw, 698px\" \/><figcaption class=\"wp-element-caption\">\u4e00\u53ea\u9a91\u7740\u72ec\u8f6e\u8f66\u7684\u732a\uff0c\u62ff\u7740\u91d1\u7b8d\u68d2\u5728\u6572\u9f13\uff0c\u5929\u7a7a\u4e2d\u4e0b\u7740\u5c0f\u96e8\uff0c\u732a\u8eab\u4f53\u6162\u6162\u7684\u88ab\u6dcb\u6e7f\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u9f13\u513f\u662f\u6211\u7684\u6570\u5b57\u7f16\u780152\uff0c\u4ee3\u8868\u836f\u7269\u9776\u70b9CD52\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u4e00\u53ea\u8f6e\u5b50\u4e0a\u7684\u73e0\uff0c\u4ee3\u8868\u836f\u7269\u540d\u79f0\uff0c\u963f\u4ed1\u73e0\u5355\u6297\u3002<\/p>\n\n\n\n<p>\u5c0f\u96e8\u4ee3\u8868\u6162\u6dcb\u3002\u6309\u7167\u524d\u6587\u7ea6\u5b9a\uff0c\u91d1\u7b8d\u68d2\u4ee3\u8868\u591a\u53d1\u6027\u786c\u5316\u3002<\/p>\n\n\n\n<p>\u4f60\u8bb0\u4f4f\u4e86\u4e48\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0&#8230;<\/p>\n","protected":false},"author":1,"featured_media":965,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-956","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=956"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/956\/revisions"}],"predecessor-version":[{"id":966,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/956\/revisions\/966"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/965"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}