{"id":988,"date":"2023-05-26T12:43:01","date_gmt":"2023-05-26T04:43:01","guid":{"rendered":"https:\/\/xiaoenjiyao.com\/?p=988"},"modified":"2023-05-26T12:43:01","modified_gmt":"2023-05-26T04:43:01","slug":"%e8%ae%b0%e4%bd%8f%e6%89%80%e6%9c%89fda%e7%94%9f%e7%89%a9%e8%8d%af-%e9%9d%b6%e5%90%91cd20-x-cd3%e5%8f%8c%e6%8a%97-epcoritamab-%e5%bc%a5%e6%bc%ab%e6%80%a7%e5%a4%a7b%e7%bb%86%e8%83%9e%e6%b7%8b","status":"publish","type":"post","link":"https:\/\/xiaoenjiyao.com\/?p=988","title":{"rendered":"\u8bb0\u4f4f\u6240\u6709FDA\u751f\u7269\u836f | \u9776\u5411CD20 x CD3\u53cc\u6297 | Epcoritamab | \u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624(DLBCL)"},"content":{"rendered":"\n

\u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0\u4f4f\u6240\u6709FDA\u6279\u51c6\u4e0a\u5e02\u751f\u7269\u5236\u5242\u7684\u540d\u79f0\uff0c\u9776\u70b9\uff0c\u9002\u5e94\u75c7\u7b49\u4fe1\u606f\u3002<\/p>\n\n\n\n

\u4e0a\u4e2a\u6708\u521a\u5728\u524d\u6587\u8ba8\u8bba\u8fc7\u4e24\u6b3e\u9776\u5411 CD20 x CD3\u7684\u53cc\u6297\u836f\u7269 Mosunetuzumab \u548c Glofitamab\u3002<\/p>\n\n\n\n

\u65f6\u9694\u4e00\u6708\uff0c\u7b2c\u4e09\u6b3e CD20 x CD3\u53cc\u6297\uff0c\u827e\u4f2f\u7ef4\u516c\u53f8\u7684 Epcoritamab \u4e8e2023\u5e745\u670819\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff08EPKINLY\u00ae<\/sup>epcoritamab\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/p>\n\n\n\n

\u56fd\u5185Epcoritamab\u6682\u672a\u4e0a\u5e02\uff0c\u76ee\u524d\u5904\u4e8eIII\u671f\u4e34\u5e8a\u9636\u6bb5\uff0c\u672a\u67e5\u5230\u5b98\u65b9\u7684\u4e2d\u6587\u540d\uff0c\u6682\u79f0\u4e3a\u827e\u666e\u53ef\u59a5\u5355\u6297\uff08\u97f3\u8bd1\u65e0\u51fa\u5904\uff09\u3002<\/p>\n\n\n\n

1\u3001\u4f5c\u7528\u673a\u5236<\/h2>\n\n\n\n

Mosunetuzumab \u548c Glofitamab\u5747\u4e3a\u7f57\u6c0f\u516c\u53f8\u4ea7\u54c1\u3002\u800cEpcoritamab\u662f\u827e\u4f2f\u7ef4\u516c\u53f8\u4ea7\u54c1\uff0c\u662f\u76ae\u4e0b\u6ce8\u5c04\u7684\u53cc\u7279\u5f02\u6027CD3\u00d7CD20\u6297\u4f53\u3002<\/p>\n\n\n\n

\u5176\u91c7\u7528\u72ec\u7279\u7684DuoBody\u00ae<\/sup>\u5e73\u53f0\u6280\u672f\uff0c\u901a\u8fc7Fab\u81c2\u4ea4\u6362\u5236\u5907\uff0c\u65e2\u4fdd\u6301\u4e86\u539f\u59cbIgG1\u6297\u4f53\u7ed3\u6784\uff0c\u53c8\u5ef6\u957f\u4e86\u8840\u6d46\u534a\u8870\u671f\u3002<\/p>\n\n\n\n

\u76ee\u524d\u5df2\u4e0a\u5e02\u6216\u5728\u7814\u7684\u51e0\u6b3e\u6cbb\u7597B\u7ec6\u80de\u6dcb\u5df4\u7624\u53cc\u6297\u7684\u7ed3\u6784\u7279\u70b9\u5982\u4e0b\uff1a<\/p>\n\n\n\n

\u6cbb\u7597B\u7ec6\u80de\u6dcb\u5df4\u7624\u53cc\u6297<\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

(A) \u8d1d\u6797\u59a5\u6b27\u5355\u6297\u662f\u7b2c\u4e00\u4e2a\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u5f15\u5bfc\u5242(BiTE)\uff0c\u5b83\u662f\u4e00\u4e2a\u4e32\u8054\u7684\u5355\u94fe\u53d8\u91cf\u7247\u6bb5(scFv)\u3002<\/p>\n\n\n\n

(B) CD3xCD19 BiTE\u4e0e\u4e00\u4e2a\u9759\u9ed8\u7684\u7ed3\u6676\u7247\u6bb5\uff08FC\uff09\u90e8\u5206\u8fde\u63a5\uff0c\u5f62\u6210\u534a\u8870\u671f\u5ef6\u957f\u7684BiTE\u3002<\/p>\n\n\n\n

(C, D) “Knob into hole”\u6280\u672f\uff0c\u6709\u52a9\u4e8emosunetuzumab\u548cglofitamab\u7684FC\u90e8\u5206\u6b63\u786e\u914d\u5bf9\uff1bglofitamab\u5177\u6709\u4e00\u4e2a\u4e0d\u5bf9\u79f0\u76842:1\u683c\u5f0f\uff0c\u5305\u62ec\u5bf9CD20\u7684\u53cc\u4ef7\u7ed3\u5408\u548c\u5bf9CD3\u7684\u5355\u4ef7\u7ed3\u5408\u3002<\/p>\n\n\n\n

(E) Odronextamab\u7684\u8bbe\u8ba1\u5229\u7528\u4e86\u514d\u75ab\u7403\u86cb\u767d\u540c\u578b\u4f53\u5bf9\u86cb\u767dA\u7684\u4eb2\u548c\u529b\u5dee\u5f02\u4ee5\u53ca\u5171\u7528\u8f7b\u94fe\u7684\u4f7f\u7528\uff0c\u836f\u7269\u5c1a\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

(F) DuoBody\u00ae\u6280\u672f\uff0c\u901a\u8fc7Fab\u81c2\u4ea4\u6362\uff0c\u6bcf\u4e2a\u4eb2\u672c\u6297\u4f53\u5728\u91cd\u94fe3\uff08CH3\uff09\u533a\u57df\u7684\u6052\u5b9a\u533a\u57df\u5305\u542b\u5355\u4e00\u7684\u5339\u914d\u70b9\u7a81\u53d8\uff0c\u8fd9\u5141\u8bb8\u836f\u7269\u4f53\u5916\u5206\u79bb\u540e\u91cd\u7ec4\u3002<\/p>\n\n\n\n

(G) Plamotamab\u4f7f\u7528\u7684FC\u57df\u53d8\u4f53\u80fd\u81ea\u53d1\u5f62\u6210\u7a33\u5b9a\u7684\u3001\u5f02\u6e90\u4e8c\u805a\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u836f\u7269\u5c1a\u672a\u4e0a\u5e02\u3002<\/p>\n\n\n\n

Epcoritamab\u673a\u5236<\/strong><\/p>\n\n\n\n

\"\"
https:\/\/www.abbviescience.com\/pipeline.html<\/em><\/figcaption><\/figure>\n\n\n\n

CD20\u662f\u4e34\u5e8a\u4e0a\u5e7f\u6cdb\u8868\u8fbe\u4e8e\u5404\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u7684\u9776\u70b9\u3002<\/p>\n\n\n\n

Epcoritamab\u4e0eCD20 B\u7ec6\u80de\u4ee5\u53caCD3 T\u7ec6\u80de\u540c\u65f6\u7ed3\u5408\uff0c\u6fc0\u6d3b\u548c\u6269\u589eT\u7ec6\u80de\uff0c\u5e76\u4ecb\u5bfcCD20\u9633\u6027\u6076\u6027B\u7ec6\u80de\u7684T\u7ec6\u80de\u4ecb\u5bfc\u6740\u4f24\u3002<\/p>\n\n\n\n

\u5f53CD3 T\u7ec6\u80de\u4e0eCD20\u6076\u6027B\u7ec6\u80de\u53cc\u7279\u5f02\u6027\u7ed3\u5408\u65f6\uff0c\u5f62\u6210\u514d\u75ab\u7a81\u89e6\uff0c\u5bfc\u81f4\u6076\u6027B\u7ec6\u80de\u7684\u7a7f\u5b54\u7d20\/\u9897\u7c92\u9176B\u8bf1\u5bfc\u7684\u51cb\u4ea1\u3002<\/p>\n\n\n\n

2\u3001\u9002\u5e94\u75c7<\/h2>\n\n\n\n

3\u6b3eCD20XCD3\u53cc\u6297FDA\u9002\u5e94\u75c7<\/strong><\/p>\n\n\n\n

\"\"
\u8be5\u836f\u7269\u76ee\u524d\u56fd\u5185\u6682\u672a\u6279\u51c6\u4e0a\u5e02<\/em><\/figcaption><\/figure>\n\n\n\n

\u76ee\u524d3\u6b3eCD20 x CD3\u53cc\u6297\u83b7\u6279\u9002\u5e94\u75c7\u6c47\u603b\u5982\u4e0b<\/p>\n\n\n\n

Epcoritamab \u827e\u666e\u53ef\u59a5\u5355\u6297\uff1a<\/strong><\/p>\n\n\n\n

    \n
  • \u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624<\/li>\n<\/ul>\n\n\n\n

    Mosunetuzumab \u83ab\u59a5\u73e0\u5355\u6297\uff1a<\/strong><\/p>\n\n\n\n

      \n
    • \u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624<\/li>\n<\/ul>\n\n\n\n

      Glofitamab \u683c\u7f57\u83f2\u59a5\u5355\u6297\uff1a\uff08EMA\u83b7\u6279\uff0cFDA\u6682\u672a\u83b7\u6279\uff09<\/strong><\/p>\n\n\n\n

        \n
      • \u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624<\/li>\n\n\n\n
      • \u5957\u7ec6\u80de\u6dcb\u5df4\u7624<\/li>\n<\/ul>\n\n\n\n

        3\u3001\u56fe\u50cf\u8bb0\u5fc6<\/h2>\n\n\n\n
        \"\"
        \u9a91\u7740\u6469\u6258\u7684\u732a\uff0c\u88ab\u7231\u6253\u6251\u514b\u7684\u6536\u8d39\u5458\u6321\u8def\uff0c\u6536\u8fc7\u8def\u8d39\u3002<\/figcaption><\/figure>\n\n\n\n

        \u4e09\u89d2\u5f62\u6536\u8d39\u5458\u4ee3\u8868CD3\uff0c\u624b\u4e0a\u7684\u94c3\u94db\u662f\u6211\u7684\u6570\u5b57\u7f16\u780120\uff0c\u4ee3\u8868CD20 x CD3\u53cc\u6297\u3002<\/p>\n\n\n\n

        \u7231<\/strong>\u6253\u6251\u514b<\/strong>\u4ee3\u8868\u827e\u666e\u53ef<\/strong>\u59a5\u5355\u6297\u3001\u6469\u6258\u732a<\/strong>\u4ee3\u8868\u83ab\u59a5\u73e0<\/strong>\u5355\u6297\u3001\u8fc7\u8def\u8d39<\/strong>\u4ee3\u8868\u683c\u7f57\u83f2<\/strong>\u59a5\u5355\u6297\u3002<\/p>\n\n\n\n

        B\u578b\u94c3\u94db\uff0c\u4ee3\u8868\u6291\u5236B\u7ec6\u80de\u836f\u7269\uff0c\u5982\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/p>\n\n\n\n

        \u4f60\u8bb0\u4f4f\u4e86\u4e48<\/p>\n","protected":false},"excerpt":{"rendered":"

        \u7528\u56fe\u50cf\u8bb0\u5fc6\u7684\u65b9\u6cd5\uff0c\u4e00\u4e2a\u836f\u4e00\u5f20\u56fe\uff0c\u8bb0…<\/p>\n","protected":false},"author":1,"featured_media":994,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-988","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","wpcat-3-id"],"_links":{"self":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/988","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=988"}],"version-history":[{"count":1,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/988\/revisions"}],"predecessor-version":[{"id":995,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/posts\/988\/revisions\/995"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=\/wp\/v2\/media\/994"}],"wp:attachment":[{"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=988"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=988"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaoenjiyao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=988"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}